Zfp345 (zinc finger protein 345) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Zfp345 (zinc finger protein 345) Mus musculus
Analyze
No known orthologs.
Symbol: Zfp345
Name: zinc finger protein 345
RGD ID: 1617892
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF320 (zinc finger protein 320); ZNF415 (zinc finger protein 415); and ZNF528 (zinc finger protein 528).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RP23-369H9.1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392150,312,911 - 150,326,983 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2150,312,211 - 150,327,011 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382150,470,991 - 150,485,063 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2150,470,991 - 150,485,091 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv372150,296,727 - 150,310,799 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362150,162,432 - 150,176,504 (-)NCBIMGSCv36mm8
Celera2151,705,091 - 151,718,923 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.52NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693  
PMID:21589869   PMID:21677750   PMID:21873635  


Genomics

Variants

.
Variants in Zfp345
647 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:221
Interacting mature miRNAs:230
Transcripts:ENSMUST00000109914
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse

Markers in Region
D5Mit392.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
Cytogenetic Map18A1UniSTS
Cytogenetic Map1G3UniSTS
Cytogenetic Map9A3UniSTS
Cytogenetic Map7F1UniSTS
Cytogenetic Map5C1UniSTS
Cytogenetic Map4D2.2UniSTS
Cytogenetic Map16A3UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map16B2UniSTS
Cytogenetic Map6F1UniSTS
Cytogenetic Map4B1UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map14C3UniSTS
Cytogenetic Map5C3.3UniSTS
Cytogenetic Map18A2UniSTS
Cytogenetic MapXF5UniSTS
Cytogenetic Map2G3UniSTS
Cytogenetic Map7A2UniSTS
Cytogenetic Map12A1.1UniSTS
Cytogenetic Map1H6UniSTS
Cytogenetic Map7D3UniSTS
Cytogenetic Map1G2UniSTS
Cytogenetic MapXF3UniSTS
Cytogenetic Map4D3UniSTS
Cytogenetic Map2F3UniSTS
Cytogenetic Map2A3UniSTS
Cytogenetic Map4D1UniSTS
Cytogenetic Map15A1UniSTS
Cytogenetic Map1A2UniSTS
Cytogenetic Map13A3.1UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map1D2.3UniSTS
Cytogenetic Map19C1UniSTS
Cytogenetic Map10D3UniSTS
Cytogenetic Map2H2UniSTS
Cytogenetic Map2E1UniSTS
cM Map528.0UniSTS
Whitehead Genetic518.6UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000109914   ⟹   ENSMUSP00000105540
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2150,312,211 - 150,327,011 (-)Ensembl
GRCm38.p6 Ensembl2150,470,991 - 150,485,091 (-)Ensembl
RefSeq Acc Id: NM_001034900   ⟹   NP_001030072
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392150,312,911 - 150,326,983 (-)NCBI
GRCm382150,470,991 - 150,485,063 (-)NCBI
MGSCv372150,296,727 - 150,310,799 (-)RGD
Celera2151,705,091 - 151,718,923 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001030072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI50851 (Get FASTA)   NCBI Sequence Viewer  
  AAI50853 (Get FASTA)   NCBI Sequence Viewer  
  BAE26080 (Get FASTA)   NCBI Sequence Viewer  
  EDL28562 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000105540
  ENSMUSP00000105540.2
RefSeq Acc Id: NP_001030072   ⟸   NM_001034900
- UniProtKB: A2AQA1 (UniProtKB/TrEMBL),   B2RX22 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000105540   ⟸   ENSMUST00000109914
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2AQA1-F1-model_v2 AlphaFold A2AQA1 1-561 view protein structure

Promoters
RGD ID:6833124
Promoter ID:MM_KWN:32193
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000109914
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362150,310,686 - 150,311,186 (-)MPROMDB
RGD ID:6879102
Promoter ID:EPDNEW_M3001
Type:initiation region
Name:Zfp345_1
Description:Mus musculus zinc finger protein 345 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382150,485,064 - 150,485,124EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3652219 AgrOrtholog
Ensembl Genes ENSMUSG00000074731 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109914 ENTREZGENE
  ENSMUST00000109914.2 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:545471 UniProtKB/TrEMBL
MGD MGI:3652219 ENTREZGENE
NCBI Gene 545471 ENTREZGENE
PANTHER ENDOTHELIAL ZINC FINGER PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp345 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A2AQA1 ENTREZGENE, UniProtKB/TrEMBL
  B2RX22 ENTREZGENE, UniProtKB/TrEMBL
  Q3UML8_MOUSE UniProtKB/TrEMBL