Zfp958 (zinc finger protein 958) - Rat Genome Database

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Gene: Zfp958 (zinc finger protein 958) Mus musculus
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Symbol: Zfp958
Name: zinc finger protein 958
RGD ID: 1614161
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in heart; limb; and limb mesenchyme. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF595 (zinc finger protein 595).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: zinc finger protein 878; zinc finger-like protein
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,663,170 - 4,682,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,663,167 - 4,680,231 (+)EnsemblGRCm39 Ensembl
GRCm3884,613,170 - 4,632,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,613,167 - 4,630,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,613,170 - 4,630,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,613,170 - 4,630,231 (+)NCBIMGSCv36mm8
Celera84,807,370 - 4,824,431 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp958Mousealpha-mannosidosis  ISOZNF878 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of alpha-mannosidaseClinVarPMID:28492532
Zfp958MouseCharcot-Marie-Tooth disease dominant intermediate B  ISOZNF878 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate BClinVarPMID:28492532
Zfp958Mouseepisodic ataxia type 2  ISOZNF878 (Homo sapiens)8554872ClinVar Annotator: match by term: Episodic ataxia type 2ClinVarPMID:28492532
Zfp958Mouseglutaric acidemia I  ISOZNF878 (Homo sapiens)8554872ClinVar Annotator: match by term: Glutaric aciduria and type 1ClinVarPMID:28492532

1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp958Mouse17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ZFP958 mRNACTDPMID:19484750
Zfp958Mouse2,3',4,4',5-Pentachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:31388691
Zfp958Mouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOZfp958 (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of ZFP958 mRNACTDPMID:33387578
Zfp958Mouse6-propyl-2-thiouracil decreases expressionISOZfp958 (Rattus norvegicus)6480464Propylthiouracil results in decreased expression of ZFP958 mRNACTDPMID:30047161
Zfp958Mouseaflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of ZFP958 mRNACTDPMID:19770486
Zfp958Mouseaflatoxin B1 increases expressionISOZfp958 (Rattus norvegicus)6480464Aflatoxin B1 results in increased expression of ZFP958 mRNACTDPMID:33354967
Zfp958Mouseamitrole decreases expressionISOZfp958 (Rattus norvegicus)6480464Amitrole results in decreased expression of ZFP958 mRNACTDPMID:30047161
Zfp958Mousebenzo[a]pyrene increases expressionEXP 6480464Benzo(a)pyrene results in increased expression of ZFP958 mRNACTDPMID:19770486
Zfp958Mousebenzo[a]pyrene increases methylationISOZNF878 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of ZNF878 exon and Benzo(a)pyrene results in increased methylation of ZNF878 promoterCTDPMID:27901495
Zfp958Mousebis(2-ethylhexyl) phthalate increases methylationEXP 6480464Diethylhexyl Phthalate results in increased methylation of ZFP958 geneCTDPMID:34319233
Zfp958Mousebisphenol A decreases expressionISOZfp958 (Rattus norvegicus)6480464bisphenol A results in decreased expression of ZFP958 mRNACTDPMID:25181051 and PMID:30816183
Zfp958Mousebisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of ZFP958 mRNACTDPMID:32156529
Zfp958Mousebisphenol A increases methylationISOZfp958 (Rattus norvegicus)6480464bisphenol A results in increased methylation of ZFP958 geneCTDPMID:28505145
Zfp958Mousecopper atom increases expressionISOZfp958 (Rattus norvegicus)6480464Copper results in increased expression of ZFP958 mRNACTDPMID:30556269
Zfp958Mousecopper(0) increases expressionISOZfp958 (Rattus norvegicus)6480464Copper results in increased expression of ZFP958 mRNACTDPMID:30556269
Zfp958MouseCuprizon decreases expressionISOZfp958 (Rattus norvegicus)6480464Cuprizone results in decreased expression of ZFP958 mRNACTDPMID:26577399
Zfp958Mousedecabromodiphenyl ether increases expressionISOZfp958 (Rattus norvegicus)6480464decabromobiphenyl ether results in increased expression of ZFP958 mRNACTDPMID:23640034
Zfp958Mousedibenzo[a,l]pyrene increases expressionEXP 6480464dibenzo(a and l)pyrene results in increased expression of ZFP958 mRNACTDPMID:25908611
Zfp958Mousedioxygen decreases expressionISOZNF878 (Homo sapiens)6480464Oxygen deficiency results in decreased expression of ZNF878 mRNACTDPMID:26516004
Zfp958Mouseethanol affects expressionEXP 6480464Ethanol affects the expression of ZFP958 mRNACTDPMID:30319688

1 to 20 of 35 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp958Mousenegative regulation of transcription by RNA polymerase II involved_inIBAPANTHER:PTN000578151 more ...2290270 GO_CentralGO_REF:0000033
Zfp958Mouseregulation of cytokine production involved_inIBAPANTHER:PTN000578151 more ...2290270 GO_CentralGO_REF:0000033
Zfp958Mouseregulation of immune system process involved_inIBAPANTHER:PTN000578151 more ...2290270 GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp958Mousenucleoplasm is_active_inIBAPANTHER:PTN002393396 more ...2290270 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Zfp958MouseDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIBAPANTHER:PTN002393396 more ...2290270 GO_CentralGO_REF:0000033
Zfp958MouseRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAPANTHER:PTN002393396 more ...2290270 GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20059953  
PMID:21873635  



Zfp958
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,663,170 - 4,682,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,663,167 - 4,680,231 (+)EnsemblGRCm39 Ensembl
GRCm3884,613,170 - 4,632,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,613,167 - 4,630,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,613,170 - 4,630,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,613,170 - 4,630,231 (+)NCBIMGSCv36mm8
Celera84,807,370 - 4,824,431 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.07NCBI
ZNF878
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,043,602 - 12,052,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,043,805 - 12,052,961 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,154,620 - 12,163,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,015,620 - 12,028,127 (-)NCBINCBI36Build 36hg18NCBI36
Celera1912,048,979 - 12,061,496 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,728,993 - 11,738,093 (-)NCBIHuRef
CHM1_11912,154,431 - 12,163,590 (-)NCBICHM1_1
T2T-CHM13v2.01912,171,809 - 12,181,178 (-)NCBIT2T-CHM13v2.0
Zfp958
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,751,230 - 8,773,114 (+)NCBIGRCr8
mRatBN7.2123,953,442 - 3,975,328 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,615,503 - 46,619,045 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl123,953,455 - 3,975,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx124,644,557 - 4,650,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0125,268,193 - 5,274,018 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0123,940,552 - 3,945,813 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0125,485,691 - 5,492,254 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl125,485,903 - 5,490,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0127,595,021 - 7,601,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41285,497 - 91,322 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera125,891,188 - 5,897,013 (-)NCBICelera
Cytogenetic Map12p12NCBI
ZNF878
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,958,226 - 16,973,860 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,958,188 - 15,973,658 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01911,592,589 - 11,602,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11912,361,219 - 12,369,278 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1912,361,219 - 12,369,278 (-)Ensemblpanpan1.1panPan2
ZNF878
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,869,044 - 10,877,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660748,939,631 - 8,955,040 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Zfp958
1014 total Variants

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSMUST00000073201
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse







Ensembl Acc Id: ENSMUST00000073201   ⟹   ENSMUSP00000072937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl84,675,840 - 4,679,380 (+)Ensembl
GRCm38.p6 Ensembl84,625,840 - 4,629,380 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202692   ⟹   ENSMUSP00000143842
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl84,663,167 - 4,680,231 (+)Ensembl
GRCm38.p6 Ensembl84,613,167 - 4,630,231 (+)Ensembl
RefSeq Acc Id: NM_001368404   ⟹   NP_001355333
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3984,663,340 - 4,682,572 (+)NCBI
GRCm3884,613,340 - 4,632,572 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001368405   ⟹   NP_001355334
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3984,663,258 - 4,682,572 (+)NCBI
GRCm3884,613,258 - 4,632,572 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145591   ⟹   NP_663566
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3984,663,170 - 4,682,572 (+)NCBI
GRCm3884,613,170 - 4,632,572 (+)NCBI
MGSCv3784,613,170 - 4,630,231 (+)RGD
Celera84,807,370 - 4,824,431 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_663566   ⟸   NM_145591
- Peptide Label: isoform 2
- UniProtKB: Q99LG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001355334   ⟸   NM_001368405
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001355333   ⟸   NM_001368404
- Peptide Label: isoform 1
Ensembl Acc Id: ENSMUSP00000143842   ⟸   ENSMUST00000202692
Ensembl Acc Id: ENSMUSP00000072937   ⟸   ENSMUST00000073201
C2H2-type   KRAB

Name Modeler Protein Id AA Range Protein Structure
AF-Q99LG7-F1-model_v2 AlphaFold Q99LG7 1-467 view protein structure

RGD ID:6842830
Promoter ID:MM_KWN:53547
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_145591
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3684,612,939 - 4,613,439 (+)MPROMDB
RGD ID:8666395
Promoter ID:EPDNEW_M11229
Type:initiation region
Name:Zfp958_1
Description:Mus musculus zinc finger protein 958 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3884,613,170 - 4,613,230EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000058748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073201 ENTREZGENE
  ENSMUST00000073201.6 UniProtKB/TrEMBL
  ENSMUST00000202692 ENTREZGENE
  ENSMUST00000202692.5 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
MGD MGI:2385298 ENTREZGENE
NCBI Gene 233987 ENTREZGENE
PANTHER MCG112779-RELATED UniProtKB/TrEMBL
  ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp958 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt F6R9A8_MOUSE UniProtKB/TrEMBL
  Q99LG7 ENTREZGENE, UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Zfp958  zinc finger protein 958  BC003267  cDNA sequence BC003267  Symbol and/or name change 5135510 APPROVED