Zfp958 (zinc finger protein 958) - Rat Genome Database

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Gene: Zfp958 (zinc finger protein 958) Mus musculus
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Symbol: Zfp958
Name: zinc finger protein 958
RGD ID: 1614161
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in heart; limb; and limb mesenchyme. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF708 (zinc finger protein 708).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: zinc finger protein 878; zinc finger-like protein
RGD Orthologs
Human
Rat
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,663,170 - 4,682,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,663,167 - 4,680,231 (+)EnsemblGRCm39 Ensembl
GRCm3884,613,170 - 4,632,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,613,167 - 4,630,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,613,170 - 4,630,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,613,170 - 4,630,231 (+)NCBIMGSCv36mm8
Celera84,807,370 - 4,824,431 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:20059953  
PMID:21873635  


Genomics

Comparative Map Data
Zfp958
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,663,170 - 4,682,572 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,663,167 - 4,680,231 (+)EnsemblGRCm39 Ensembl
GRCm3884,613,170 - 4,632,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,613,167 - 4,630,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,613,170 - 4,630,231 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,613,170 - 4,630,231 (+)NCBIMGSCv36mm8
Celera84,807,370 - 4,824,431 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.07NCBI
ZNF878
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,043,602 - 12,052,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,043,805 - 12,052,961 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,154,620 - 12,163,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,015,620 - 12,028,127 (-)NCBINCBI36Build 36hg18NCBI36
Celera1912,048,979 - 12,061,496 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1911,728,993 - 11,738,093 (-)NCBIHuRef
CHM1_11912,154,431 - 12,163,590 (-)NCBICHM1_1
T2T-CHM13v2.01912,171,809 - 12,181,178 (-)NCBIT2T-CHM13v2.0
Zfp958
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8128,751,230 - 8,773,114 (+)NCBIGRCr8
mRatBN7.2123,953,442 - 3,975,328 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,615,503 - 46,619,045 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl123,953,455 - 3,975,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx124,644,557 - 4,650,382 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0125,268,193 - 5,274,018 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0123,940,552 - 3,945,813 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0125,485,691 - 5,492,254 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl125,485,903 - 5,490,935 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0127,595,021 - 7,601,584 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41285,497 - 91,322 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera125,891,188 - 5,897,013 (-)NCBICelera
Cytogenetic Map12p12NCBI
ZNF878
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,958,226 - 16,973,860 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,958,188 - 15,973,658 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01911,592,589 - 11,602,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11912,361,219 - 12,369,278 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1912,361,219 - 12,369,278 (-)Ensemblpanpan1.1panPan2
ZNF878
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,869,044 - 10,877,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660748,939,631 - 8,955,040 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp958
413 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSMUST00000073201
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000073201   ⟹   ENSMUSP00000072937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl84,675,840 - 4,679,380 (+)Ensembl
GRCm38.p6 Ensembl84,625,840 - 4,629,380 (+)Ensembl
Ensembl Acc Id: ENSMUST00000202692   ⟹   ENSMUSP00000143842
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl84,663,167 - 4,680,231 (+)Ensembl
GRCm38.p6 Ensembl84,613,167 - 4,630,231 (+)Ensembl
RefSeq Acc Id: NM_001368404   ⟹   NP_001355333
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3984,663,340 - 4,682,572 (+)NCBI
GRCm3884,613,340 - 4,632,572 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001368405   ⟹   NP_001355334
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3984,663,258 - 4,682,572 (+)NCBI
GRCm3884,613,258 - 4,632,572 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145591   ⟹   NP_663566
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3984,663,170 - 4,682,572 (+)NCBI
GRCm3884,613,170 - 4,632,572 (+)NCBI
MGSCv3784,613,170 - 4,630,231 (+)RGD
Celera84,807,370 - 4,824,431 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_663566   ⟸   NM_145591
- Peptide Label: isoform 2
- UniProtKB: Q99LG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001355334   ⟸   NM_001368405
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001355333   ⟸   NM_001368404
- Peptide Label: isoform 1
Ensembl Acc Id: ENSMUSP00000143842   ⟸   ENSMUST00000202692
Ensembl Acc Id: ENSMUSP00000072937   ⟸   ENSMUST00000073201
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99LG7-F1-model_v2 AlphaFold Q99LG7 1-467 view protein structure

Promoters
RGD ID:6842830
Promoter ID:MM_KWN:53547
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_145591
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3684,612,939 - 4,613,439 (+)MPROMDB
RGD ID:8666395
Promoter ID:EPDNEW_M11229
Type:initiation region
Name:Zfp958_1
Description:Mus musculus zinc finger protein 958 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3884,613,170 - 4,613,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385298 AgrOrtholog
Ensembl Genes ENSMUSG00000058748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000073201 ENTREZGENE
  ENSMUST00000073201.6 UniProtKB/TrEMBL
  ENSMUST00000202692 ENTREZGENE
  ENSMUST00000202692.5 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro C2H2-ZF_domain UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Krueppel_C2H2_ZnF UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
MGD MGI:2385298 ENTREZGENE
NCBI Gene 233987 ENTREZGENE
PANTHER FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED UniProtKB/TrEMBL
  KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 628 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 747 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
  zf-H2C2_2 UniProtKB/TrEMBL
PhenoGen Zfp958 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt F6R9A8_MOUSE UniProtKB/TrEMBL
  Q99LG7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Zfp958  zinc finger protein 958  BC003267  cDNA sequence BC003267  Symbol and/or name change 5135510 APPROVED