NYNRIN (NYN domain and retroviral integrase containing) - Rat Genome Database

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Gene: NYNRIN (NYN domain and retroviral integrase containing) Homo sapiens
Analyze
Symbol: NYNRIN
Name: NYN domain and retroviral integrase containing
RGD ID: 1345252
HGNC Page HGNC:20165
Description: Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in DNA integration; DNA synthesis involved in DNA repair; and DNA-templated DNA replication. Predicted to be located in membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CGIN1; Cousin of GIN1; FLJ11811; KIAA1305; NYN domain and retroviral integrase catalytic domain-containing protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,399,003 - 24,419,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,399,003 - 24,419,283 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,868,209 - 24,888,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,937,832 - 23,958,334 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,946,953 - 23,958,328NCBI
Celera144,732,635 - 4,753,130 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,982,163 - 5,003,157 (+)NCBIHuRef
CHM1_11424,866,568 - 24,887,067 (+)NCBICHM1_1
T2T-CHM13v2.01418,597,752 - 18,618,021 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NYNRINHumanBrain-Lung-Thyroid Syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
NYNRINHumanhepatoblastoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: HepatoblastomaClinVar 
NYNRINHumanlysinuric protein intolerance  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Lysinuric protein intoleranceClinVarPMID:28492532
NYNRINHumanPerlman syndrome  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Predisposition to Wilms tumorClinVarPMID:28492532
NYNRINHumanPerlman syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Predisposition to Wilms tumorClinVar 
NYNRINHumanSpecific Granule Deficiency  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Specific granule deficiencyClinVarPMID:28492532

1 to 20 of 49 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NYNRINHuman17alpha-ethynylestradiol increases expressionISONynrin (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of NYNRIN mRNACTDPMID:29097150
NYNRINHuman17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of NYNRIN mRNACTDPMID:31614463
NYNRINHuman2,3,7,8-tetrachlorodibenzodioxine increases expressionISONynrin (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of NYNRIN mRNACTDPMID:32109520
NYNRINHuman2,3,7,8-tetrachlorodibenzodioxine decreases expressionISONynrin (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of NYNRIN mRNACTDPMID:33387578
NYNRINHuman2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISONynrin (Mus musculus)6480464[Tetrachlorodibenzodioxin affects the methylation of NYNRIN intron] which results in decreased expression of NYNRIN mRNACTDPMID:33017471
NYNRINHuman4,4'-sulfonyldiphenol affects methylationISONynrin (Mus musculus)6480464bisphenol S affects the methylation of NYNRIN geneCTDPMID:31683443
NYNRINHuman5-aza-2'-deoxycytidine affects expressionEXP 6480464Decitabine affects the expression of NYNRIN mRNACTDPMID:23300844
NYNRINHumanacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of NYNRIN mRNACTDPMID:32763439
NYNRINHumanaflatoxin B1 decreases expressionEXP 6480464Aflatoxin B1 results in decreased expression of NYNRIN mRNACTDPMID:27153756
NYNRINHumanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of NYNRIN exon and Aflatoxin B1 results in decreased methylation of NYNRIN geneCTDPMID:27153756 and PMID:30157460
NYNRINHumanAflatoxin B2 alpha decreases methylationEXP 6480464aflatoxin B2 results in decreased methylation of NYNRIN exonCTDPMID:30157460
NYNRINHumanamphetamine decreases expressionISONynrin (Rattus norvegicus)6480464Amphetamine results in decreased expression of NYNRIN mRNACTDPMID:30779732
NYNRINHumanantirheumatic drug increases expressionEXP 6480464Antirheumatic Agents results in increased expression of NYNRIN mRNACTDPMID:24449571
NYNRINHumanarsane multiple interactionsEXP 6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of NYNRIN mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NYNRIN mRNACTDPMID:39836092
NYNRINHumanarsenic atom multiple interactionsEXP 6480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased abundance of Manganese]] results in decreased expression of NYNRIN mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NYNRIN mRNACTDPMID:39836092
NYNRINHumanbenzo[a]pyrene decreases methylationEXP 6480464Benzo(a)pyrene results in decreased methylation of NYNRIN promoterCTDPMID:27901495
NYNRINHumanbenzo[e]pyrene decreases methylationEXP 6480464benzo(e)pyrene results in decreased methylation of NYNRIN exonCTDPMID:30157460
NYNRINHumanbis(2-ethylhexyl) phthalate decreases expressionISONynrin (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of NYNRIN mRNACTDPMID:33754040
NYNRINHumanbisphenol A increases expressionISONynrin (Rattus norvegicus)6480464bisphenol A results in increased expression of NYNRIN mRNACTDPMID:30816183
NYNRINHumanbisphenol A increases expressionISONynrin (Mus musculus)6480464bisphenol A results in increased expression of NYNRIN mRNACTDPMID:32156529

1 to 20 of 49 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NYNRINHumanbiological_process involved_inND 150520179 BHF-UCLGO_REF:0000015
NYNRINHumanDNA integration involved_inIEAInterPro:IPR001584150520179 InterProGO_REF:0000002
NYNRINHumanDNA synthesis involved in DNA repair involved_inIEAARBA:ARBA00027472150520179 UniProtGO_REF:0000117
NYNRINHumanDNA-templated DNA replication involved_inIEAARBA:ARBA00028857150520179 UniProtGO_REF:0000117

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NYNRINHumancellular_component is_active_inND 150520179 BHF-UCLGO_REF:0000015
NYNRINHumancytoplasmic ribonucleoprotein granule is_active_inIBAPANTHER:PTN001767779 more ...150520179 GO_CentralGO_REF:0000033
NYNRINHumanmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
NYNRINHumanmembrane located_inIEAUniProtKB-SubCell:SL-0162150520179 UniProtGO_REF:0000044
NYNRINHumannucleus is_active_inIBAMGI:2136825 more ...150520179 GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NYNRINHumanmolecular_function enablesND 150520179 BHF-UCLGO_REF:0000015
NYNRINHumanmRNA binding enablesIBAMGI:2385891 more ...150520179 GO_CentralGO_REF:0000033
NYNRINHumannucleic acid binding enablesIEAInterPro:IPR002156 and InterPro:IPR036397150520179 InterProGO_REF:0000002
NYNRINHumanRNA endonuclease activity enablesIBAMGI:2385891 more ...150520179 GO_CentralGO_REF:0000033
NYNRINHumanRNA-DNA hybrid ribonuclease activity enablesIEAInterPro:IPR002156150520179 InterProGO_REF:0000002

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
NYNRINHumanHepatoblastoma  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: HepatoblastomaClinVar 

#
Reference Title
Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10718198   PMID:12477932   PMID:14702039   PMID:16713569   PMID:17114934   PMID:19561090   PMID:20686565   PMID:21873635   PMID:24097068   PMID:24255178   PMID:25416956   PMID:26186194  
PMID:28514442   PMID:29395067   PMID:33277362   PMID:33961781   PMID:34079125   PMID:34349018   PMID:35271311   PMID:36897256   PMID:37689310   PMID:37704626   PMID:38334954   PMID:39098523  



NYNRIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,399,003 - 24,419,283 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,399,003 - 24,419,283 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,868,209 - 24,888,489 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,937,832 - 23,958,334 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,946,953 - 23,958,328NCBI
Celera144,732,635 - 4,753,130 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,982,163 - 5,003,157 (+)NCBIHuRef
CHM1_11424,866,568 - 24,887,067 (+)NCBICHM1_1
T2T-CHM13v2.01418,597,752 - 18,618,021 (+)NCBIT2T-CHM13v2.0
Nynrin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,091,572 - 56,112,193 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,091,467 - 56,112,193 (+)EnsemblGRCm39 Ensembl
GRCm381455,854,115 - 55,874,736 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,854,010 - 55,874,736 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,472,952 - 56,493,573 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,808,087 - 54,828,812 (+)NCBIMGSCv36mm8
Celera1453,656,002 - 53,676,413 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nynrin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,302,778 - 33,325,120 (+)NCBIGRCr8
mRatBN7.21529,332,873 - 29,355,215 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,332,869 - 29,355,215 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01534,520,040 - 34,541,671 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,520,142 - 34,539,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,408,544 - 38,429,969 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1528,907,311 - 28,928,945 (+)NCBICelera
Cytogenetic Map15p13NCBI
Nynrin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,889,773 - 35,910,771 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,890,158 - 35,910,859 (-)NCBIChiLan1.0ChiLan1.0
NYNRIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,753,394 - 25,774,318 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,969,975 - 24,991,457 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,174,889 - 5,195,706 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,298,139 - 23,318,905 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,298,139 - 23,318,905 (+)Ensemblpanpan1.1panPan2
NYNRIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,368,702 - 4,389,565 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,368,560 - 4,387,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,290,642 - 4,311,331 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,480,427 - 4,501,112 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,480,470 - 4,501,112 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,169,884 - 4,190,658 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,232,603 - 4,253,276 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,494,843 - 4,515,537 (+)NCBIUU_Cfam_GSD_1.0
Nynrin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,233,896 - 36,254,730 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722134,190 - 155,115 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722134,221 - 155,020 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NYNRIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,879,260 - 74,898,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,877,910 - 74,898,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,148,821 - 80,169,569 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NYNRIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,380,864 - 1,401,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,381,483 - 1,401,750 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,067,287 - 13,087,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nynrin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,094,908 - 8,118,679 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,093,119 - 8,114,465 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in NYNRIN
224 total Variants

1 to 10 of 378 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 14q11.2-12(chr14:20151149-27723796)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051484]|See cases [RCV000051484] Chr14:20151149..27723796 [GRCh38]
Chr14:20619308..28193002 [GRCh37]
Chr14:19689148..27262842 [NCBI36]
Chr14:14q11.2-12		 pathogenic
GRCh38/hg38 14q11.2-21.2(chr14:20196945-45284802)x1 copy number loss See cases [RCV000051485] Chr14:20196945..45284802 [GRCh38]
Chr14:20665104..45754005 [GRCh37]
Chr14:19734944..44823755 [NCBI36]
Chr14:14q11.2-21.2		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:23548960-41983402)x1 copy number loss See cases [RCV000051490] Chr14:23548960..41983402 [GRCh38]
Chr14:24018169..42452605 [GRCh37]
Chr14:23088009..41522355 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3 copy number gain See cases [RCV000053803] Chr14:20000611..38984415 [GRCh38]
Chr14:20468770..39453619 [GRCh37]
Chr14:19538610..38523370 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
GRCh38/hg38 14q11.2-21.1(chr14:20150949-39746154)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053806]|See cases [RCV000053806] Chr14:20150949..39746154 [GRCh38]
Chr14:20619108..40215358 [GRCh37]
Chr14:19688948..39285109 [NCBI36]
Chr14:14q11.2-21.1		 pathogenic
NM_025081.2(NYNRIN):c.1672C>T (p.Pro558Ser) single nucleotide variant Malignant melanoma [RCV000070517] Chr14:24409466 [GRCh38]
Chr14:24878672 [GRCh37]
Chr14:23948512 [NCBI36]
Chr14:14q12		 not provided
NM_025081.3(NYNRIN):c.2269C>T (p.Arg757Cys) single nucleotide variant not provided [RCV005107651]|not specified [RCV004835709] Chr14:24410063 [GRCh38]
Chr14:24879269 [GRCh37]
Chr14:23949109 [NCBI36]
Chr14:14q12		 uncertain significance|not provided
NM_025081.2(NYNRIN):c.4269C>T (p.Ser1423=) single nucleotide variant Malignant melanoma [RCV000070519] Chr14:24416018 [GRCh38]
Chr14:24885224 [GRCh37]
Chr14:23955064 [NCBI36]
Chr14:14q12		 not provided
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-12(chr14:20412587-25018120)x3 copy number gain See cases [RCV000137725] Chr14:20412587..25018120 [GRCh38]
Chr14:20880746..25487326 [GRCh37]
Chr14:19950586..24557166 [NCBI36]
Chr14:14q11.2-12		 likely pathogenic
1 to 10 of 378 rows

Predicted Target Of
Summary Value
Count of predictions:1370
Count of miRNA genes:800
Interacting mature miRNAs:944
Transcripts:ENST00000382554, ENST00000554505
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 157 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597289371GWAS1385445_Htotal cholesterol measurement, high density lipoprotein cholesterol measurement QTL GWAS1385445 (human)6e-10total cholesterol measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)142440662624406627Human
597099668GWAS1195742_Hsex hormone-binding globulin measurement QTL GWAS1195742 (human)1e-25sex hormone-binding globulin measurement142440272024402721Human
597191323GWAS1287397_Hsex hormone-binding globulin measurement QTL GWAS1287397 (human)3e-68sex hormone-binding globulin measurement142440272024402721Human
597272988GWAS1369062_Htotal cholesterol measurement QTL GWAS1369062 (human)1e-37total cholesterol measurementblood total cholesterol level (CMO:0000051)142440272024402721Human
597336723GWAS1432797_HC-reactive protein measurement QTL GWAS1432797 (human)3e-12C-reactive protein measurementblood C-reactive protein level (CMO:0003160)142440482024404821Human
597158812GWAS1254886_Hlipid measurement, high density lipoprotein cholesterol measurement QTL GWAS1254886 (human)4e-11lipid measurement, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)142440232424402325Human
597185939GWAS1282013_Hfree cholesterol in small HDL measurement QTL GWAS1282013 (human)7e-10blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)142440232424402325Human
597153180GWAS1249254_Hlow density lipoprotein cholesterol measurement QTL GWAS1249254 (human)7e-10low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)142440482024404821Human
597289108GWAS1385182_Hcholesterol:total lipids ratio, high density lipoprotein cholesterol measurement QTL GWAS1385182 (human)2e-12cholesterol:total lipids ratio, high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)142440662624406627Human
597165975GWAS1262049_Hcholesteryl ester measurement, low density lipoprotein cholesterol measurement QTL GWAS1262049 (human)8e-11blood lipid amount (VT:0003949)blood low density lipoprotein cholesterol level (CMO:0000053)142440272024402721Human

1 to 10 of 157 rows
RH66363  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,888,028 - 24,888,150UniSTSGRCh37
Build 361423,957,868 - 23,957,990RGDNCBI36
Celera144,752,664 - 4,752,786RGD
Cytogenetic Map14q12UniSTS
HuRef145,002,691 - 5,002,813UniSTS
GeneMap99-GB4 RH Map1420.64UniSTS
NCBI RH Map1431.0UniSTS
SHGC-141849  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,888,244 - 24,888,584UniSTSGRCh37
Build 361423,958,084 - 23,958,424RGDNCBI36
Celera144,752,880 - 4,753,220RGD
Cytogenetic Map14q12UniSTS
HuRef145,002,907 - 5,003,247UniSTS
TNG Radiation Hybrid Map142339.0UniSTS
IB2324  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371424,888,128 - 24,888,291UniSTSGRCh37
Build 361423,957,968 - 23,958,131RGDNCBI36
Celera144,752,764 - 4,752,927RGD
Cytogenetic Map14q12UniSTS
HuRef145,002,791 - 5,002,954UniSTS
GeneMap99-GB4 RH Map1420.64UniSTS
Whitehead-RH Map1427.7UniSTS
NCBI RH Map1431.0UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2431 2788 2236 4942 1720 2321 5 619 1679 461 2256 7013 6204 46 3715 831 1735 1592 174 1



Ensembl Acc Id: ENST00000382554   ⟹   ENSP00000371994
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,399,003 - 24,419,283 (+)Ensembl
Ensembl Acc Id: ENST00000554505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1424,412,594 - 24,414,718 (+)Ensembl
RefSeq Acc Id: NM_025081   ⟹   NP_079357
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,399,003 - 24,419,283 (+)NCBI
GRCh371424,867,992 - 24,888,494 (+)RGD
Build 361423,937,832 - 23,958,334 (+)NCBI Archive
Celera144,732,635 - 4,753,130 (+)RGD
HuRef144,982,163 - 5,003,157 (+)RGD
CHM1_11424,866,568 - 24,887,067 (+)NCBI
T2T-CHM13v2.01418,597,752 - 18,618,021 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011537016   ⟹   XP_011535318
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381424,411,457 - 24,419,283 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054376460   ⟹   XP_054232435
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01418,610,195 - 18,618,021 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_079357 (Get FASTA)   NCBI Sequence Viewer  
  XP_011535318 (Get FASTA)   NCBI Sequence Viewer  
  XP_054232435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH08219 (Get FASTA)   NCBI Sequence Viewer  
  AAH65283 (Get FASTA)   NCBI Sequence Viewer  
  BAA92543 (Get FASTA)   NCBI Sequence Viewer  
  BAB13925 (Get FASTA)   NCBI Sequence Viewer  
  CAD66580 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000371994
  ENSP00000371994.3
GenBank Protein Q9P2P1 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_079357   ⟸   NM_025081
- UniProtKB: Q86TR3 (UniProtKB/Swiss-Prot),   Q6P153 (UniProtKB/Swiss-Prot),   Q9HAC4 (UniProtKB/Swiss-Prot),   Q9P2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011535318   ⟸   XM_011537016
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000371994   ⟸   ENST00000382554
RefSeq Acc Id: XP_054232435   ⟸   XM_054376460
- Peptide Label: isoform X1
Integrase catalytic   RNase H type-1   RNase NYN

Name Modeler Protein Id AA Range Protein Structure
AF-Q9P2P1-F1-model_v2 AlphaFold Q9P2P1 1-1898 view protein structure

RGD ID:6791707
Promoter ID:HG_KWN:19112
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000382554,   NM_025081
Position:
Human AssemblyChrPosition (strand)Source
Build 361423,937,926 - 23,938,426 (+)MPROMDB


1 to 40 of 43 rows
Database
Acc Id
Source(s)
COSMIC NYNRIN COSMIC
Ensembl Genes ENSG00000205978 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000382554 ENTREZGENE
  ENST00000382554.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.340.70 UniProtKB/Swiss-Prot
  3.10.20.370 UniProtKB/Swiss-Prot
  3.30.420.10 UniProtKB/Swiss-Prot
  3.30.70.270 UniProtKB/Swiss-Prot
  3.40.50.11980 UniProtKB/Swiss-Prot
GTEx ENSG00000205978 GTEx
HGNC ID HGNC:20165 ENTREZGENE
Human Proteome Map NYNRIN Human Proteome Map
InterPro DNA/RNA_pol_sf UniProtKB/Swiss-Prot
  Integrase_cat-core UniProtKB/Swiss-Prot
  Integrase_H2C2 UniProtKB/Swiss-Prot
  Rev_trsase/Diguanyl_cyclase UniProtKB/Swiss-Prot
  RNase_Zc3h12_NYN UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_domain UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
  RT_RNaseH_2 UniProtKB/Swiss-Prot
  ZC3H12/N4BP1_RNase_Reg UniProtKB/Swiss-Prot
KEGG Report hsa:57523 UniProtKB/Swiss-Prot
NCBI Gene 57523 ENTREZGENE
OMIM 620129 OMIM
PANTHER N4BP1-RELATED UniProtKB/Swiss-Prot
  PROTEIN NYNRIN UniProtKB/Swiss-Prot
Pfam Integrase_H2C2 UniProtKB/Swiss-Prot
  RNase_Zc3h12a UniProtKB/Swiss-Prot
  RT_RNaseH_2 UniProtKB/Swiss-Prot
PharmGKB PA165479228 PharmGKB
PROSITE INTEGRASE UniProtKB/Swiss-Prot
  RNASE_H_1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53098 UniProtKB/Swiss-Prot
  SSF56672 UniProtKB/Swiss-Prot
UniProt NYNRI_HUMAN UniProtKB/Swiss-Prot
  Q6P153 ENTREZGENE
  Q86TR3 ENTREZGENE
  Q9HAC4 ENTREZGENE
  Q9P2P1 ENTREZGENE
1 to 40 of 43 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 NYNRIN  NYN domain and retroviral integrase containing  KIAA1305  KIAA1305  Symbol and/or name change 5135510 APPROVED