Musk (muscle, skeletal, receptor tyrosine kinase) - Rat Genome Database

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Gene: Musk (muscle, skeletal, receptor tyrosine kinase) Mus musculus
Analyze
Symbol: Musk
Name: muscle, skeletal, receptor tyrosine kinase
RGD ID: 11021
MGI Page MGI
Description: Enables PDZ domain binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of protein modification process; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within several processes, including neuromuscular junction development; positive regulation of motor neuron apoptotic process; and regulation of synaptic assembly at neuromuscular junction. Located in neuromuscular junction and postsynaptic membrane. Is expressed in several structures, including decidua; embryo mesenchyme; limb; nervous system; and skeletal musculature. Used to study congenital myasthenic syndrome 9. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Mdk4; MGC117677; Mlk; muscle localized kinase 2; muscle, skeletal receptor tyrosine protein kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine protein kinase receptor; muscle-specific tyrosine-protein kinase receptor; Ns; Nsk1; Nsk2; Nsk3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,285,742 - 58,377,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,285,962 - 58,374,303 (+)EnsemblGRCm39 Ensembl
GRCm38458,285,729 - 58,377,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,285,960 - 58,374,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37458,298,834 - 58,387,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,380,016 - 58,468,357 (+)NCBIMGSCv36mm8
Celera458,198,854 - 58,290,062 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell differentiation  (IEA)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA)
cochlea development  (ISO)
enzyme-linked receptor protein signaling pathway  (IDA,IGI,IMP)
long-term synaptic potentiation  (ISO)
memory  (ISO)
motor neuron apoptotic process  (IMP)
negative regulation of gene expression  (ISO)
neuromuscular junction development  (IGI,ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of motor neuron apoptotic process  (IMP)
positive regulation of neuron projection development  (IBA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IBA)
positive regulation of protein geranylgeranylation  (IMP)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of Rac protein signal transduction  (IDA,IGI,IMP)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (IDA,IGI,IMP)
positive regulation of synaptic assembly at neuromuscular junction  (ISO)
positive regulation of synaptic transmission, cholinergic  (ISO)
protein autophosphorylation  (ISO)
receptor clustering  (IGI,IMP,ISO)
regulation of DNA-templated transcription  (IMP)
regulation of synaptic assembly at neuromuscular junction  (IMP)
response to axon injury  (ISO)
response to electrical stimulus  (ISO)
response to muscle activity  (ISO)
retina development in camera-type eye  (ISO)
skeletal muscle acetylcholine-gated channel clustering  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Long-lasting treatment effect of rituximab in MuSK myasthenia. Díaz-Manera J, etal., Neurology. 2012 Jan 17;78(3):189-93. doi: 10.1212/WNL.0b013e3182407982. Epub 2012 Jan 4.
2. Agrin acts via a MuSK receptor complex. Glass DJ, etal., Cell 1996 May 17;85(4):513-23.
3. Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Herbst R, etal., Development 2002 Dec;129(23):5449-60.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study. Tsonis AI, etal., J Neuroimmunol. 2015 Jul 15;284:10-7. doi: 10.1016/j.jneuroim.2015.04.015. Epub 2015 Apr 27.
13. Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury. Valenzuela DM, etal., Neuron 1995 Sep;15(3):573-84.
14. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
15. Delayed synapsing muscles are more severely affected in an experimental model of MuSK-induced myasthenia gravis. Xu K, etal., Neuroscience. 2006 Dec;143(3):655-9. Epub 2006 Nov 1.
Additional References at PubMed
PMID:7624144   PMID:8535092   PMID:8653786   PMID:8892231   PMID:9136771   PMID:9698449   PMID:10191100   PMID:10320756   PMID:10619845   PMID:10655525   PMID:10934257   PMID:11114734  
PMID:11312299   PMID:11312300   PMID:11323662   PMID:11395002   PMID:11748247   PMID:11829488   PMID:11988168   PMID:12165471   PMID:12441053   PMID:12477932   PMID:12756238   PMID:12832540  
PMID:12885777   PMID:14622576   PMID:14678832   PMID:15062984   PMID:15159418   PMID:15496425   PMID:15737732   PMID:15851520   PMID:15883645   PMID:15964791   PMID:16146674   PMID:16237673  
PMID:16337809   PMID:16407563   PMID:16487930   PMID:16510846   PMID:16557298   PMID:16602821   PMID:16675143   PMID:16794080   PMID:17012237   PMID:17119023   PMID:17452444   PMID:17576800  
PMID:17640526   PMID:17785180   PMID:18084289   PMID:18165682   PMID:18253062   PMID:18272689   PMID:18367600   PMID:18420419   PMID:18434415   PMID:18718936   PMID:18830404   PMID:18848351  
PMID:18957220   PMID:19038220   PMID:19073864   PMID:19244212   PMID:19345204   PMID:20053883   PMID:20371544   PMID:20463225   PMID:20484637   PMID:20498043   PMID:20603078   PMID:20603331  
PMID:21255125   PMID:21267068   PMID:21419809   PMID:21441923   PMID:21750038   PMID:21873635   PMID:21969364   PMID:22142810   PMID:22210232   PMID:22328506   PMID:22396407   PMID:22498925  
PMID:22939980   PMID:23382219   PMID:23440963   PMID:23482493   PMID:23621612   PMID:23986861   PMID:24297891   PMID:24952961   PMID:25042397   PMID:25368159   PMID:25377642   PMID:25810523  
PMID:26025922   PMID:27151977   PMID:27601729   PMID:28069867   PMID:29061639   PMID:29125188   PMID:29323161   PMID:29949772   PMID:30206360   PMID:30385274   PMID:30528255   PMID:31340406  
PMID:32558157   PMID:34090516   PMID:34091985   PMID:34360794   PMID:35340430   PMID:36525997   PMID:38327785  


Genomics

Comparative Map Data
Musk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39458,285,742 - 58,377,848 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl458,285,962 - 58,374,303 (+)EnsemblGRCm39 Ensembl
GRCm38458,285,729 - 58,377,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl458,285,960 - 58,374,303 (+)EnsemblGRCm38mm10GRCm38
MGSCv37458,298,834 - 58,387,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,380,016 - 58,468,357 (+)NCBIMGSCv36mm8
Celera458,198,854 - 58,290,062 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
MUSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389110,668,791 - 110,806,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9110,668,779 - 110,806,558 (+)EnsemblGRCh38hg38GRCh38
GRCh379113,431,071 - 113,568,838 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,470,960 - 112,603,099 (+)NCBINCBI36Build 36hg18NCBI36
Build 349110,510,693 - 110,642,833NCBI
Celera983,932,761 - 84,062,557 (+)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef983,032,852 - 83,161,644 (+)NCBIHuRef
CHM1_19113,577,505 - 113,709,694 (+)NCBICHM1_1
T2T-CHM13v2.09122,838,447 - 122,978,207 (+)NCBIT2T-CHM13v2.0
Musk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8577,853,560 - 77,967,653 (+)NCBIGRCr8
mRatBN7.2573,058,427 - 73,169,696 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl573,058,121 - 73,171,932 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,950,396 - 75,053,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0576,772,006 - 76,875,299 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0576,744,136 - 76,847,436 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0575,392,790 - 75,498,694 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,392,790 - 75,498,694 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,542,952 - 79,649,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4576,273,430 - 76,388,614 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1576,278,542 - 76,393,727 (+)NCBI
Celera571,894,778 - 71,996,416 (+)NCBICelera
Cytogenetic Map5q24NCBI
Musk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541916,387,770 - 16,484,266 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541916,387,770 - 16,484,266 (-)NCBIChiLan1.0ChiLan1.0
MUSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21128,609,032 - 28,747,000 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1928,616,248 - 28,749,362 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0981,814,766 - 81,947,341 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19109,980,748 - 110,107,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,980,748 - 110,107,480 (+)Ensemblpanpan1.1panPan2
MUSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11165,552,320 - 65,642,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1165,551,889 - 65,642,349 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1163,954,775 - 64,044,628 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01166,682,701 - 66,788,272 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1166,682,615 - 66,772,740 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11165,202,004 - 65,291,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01165,223,782 - 65,329,259 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01165,913,828 - 66,003,578 (+)NCBIUU_Cfam_GSD_1.0
Musk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947180,764,116 - 180,884,300 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,387,027 - 2,486,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365592,387,019 - 2,486,685 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MUSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,650,710 - 251,756,608 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,650,151 - 251,758,538 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,535,445 - 282,564,190 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MUSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11228,739,094 - 28,872,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,886,470 - 14,018,232 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Musk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624758733,919 - 829,075 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624758733,380 - 829,192 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Musk
3604 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1403
Count of miRNA genes:202
Interacting mature miRNAs:216
Transcripts:ENSMUST00000081919, ENSMUST00000084578, ENSMUST00000098057, ENSMUST00000098059, ENSMUST00000102893, ENSMUST00000135879, ENSMUST00000177951, ENSMUST00000179951
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142318Lyr2_mlymphoma resistance 2 (mouse)Not determined1401045763283678Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
4141911W6q15_mweight 6 weeks QTL 15 (mouse)Not determined1789261688982216Mouse
39128211Lwq22_mliver weight QTL 22 (mouse)41789261688982216Mouse
1357453Kidq4_mkidney weight QTL 4 (mouse)Not determined41789261688982216Mouse
1300574Im2_mimmunoregulatory 2 (mouse)Not determined42807768262077816Mouse
1301586Stheal3_msoft tissue heal 3 (mouse)Not determined42865844262658566Mouse
1357877Synch1_msynechia 1 (mouse)Not determined42870992562710107Mouse
1301990Arvm1_mautoimmune renal vasculitis 1 (mouse)Not determined42933264663332776Mouse
1301792Hdlq10_mHDL QTL 10 (mouse)Not determined43585970769859853Mouse
1300977Mopkd1_mmodifier of polycystic kidney disease progression 1 (mouse)Not determined43655083970550967Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1302116Bbaa1_mB.burgdorferi-associated arthritis 1 (mouse)Not determined43825093072251078Mouse
10412178Habiir2_mhyperoxic acute lung injury imprinted region 2 (mouse)Not determined43945212663283678Mouse
1301786Bpq3_mblood pressure QTL 3 (mouse)Not determined44240224076402381Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
1301941Mmtg1_mmodifier of mammary tumor growth 1 (mouse)Not determined44565844283099157Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
12879977Bod2_mbone length and organs 2 (mouse)44628353180283678Mouse
10043880Adip23_madiposity 23 (mouse)Not determined44628353180283678Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
10449022Aanq1_maristolochic acid nephrotoxicity QTL 1 (mouse)44660382680603826Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
11532688Mh_mmodifier of hemostasis (mouse)44830477582304775Mouse
25314308Mlh1fc1_mMLH1 foci count 1 (mouse)44850000076918237Mouse
1301995Lprm1_mlymphoproliferation modifier 1 (mouse)Not determined45010026284100408Mouse
1301213Lgth3_mbody length 3 (mouse)Not determined45010026284100408Mouse
13207572Spir2_mStreptococcus pneumoniae infection resistance 2 (mouse)45068279588510637Mouse
1301033Abbp2_mA/J and C57BL/6 blood pressure 2 (mouse)Not determined45355083993763305Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
13524838Hbasrq1a_mhabituation of the acoustic startle response QTL 1a (mouse)45447158988471589Mouse
13524841Hbasrq1_mhabituation of the acoustic startle response QTL 1 (mouse)45447158988471589Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
27095934Ulnl2_mulna length 2, 5 week (mouse)45770000094788237Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001037128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001037129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001037130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001165996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006537661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB691772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL805969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL807748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY114512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY360453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY955296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY955297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY955298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY956403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY956404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000081919   ⟹   ENSMUSP00000080590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,960 - 58,374,302 (+)Ensembl
GRCm38.p6 Ensembl458,285,960 - 58,374,302 (+)Ensembl
RefSeq Acc Id: ENSMUST00000084578   ⟹   ENSMUSP00000081625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,962 - 58,374,303 (+)Ensembl
GRCm38.p6 Ensembl458,285,962 - 58,374,303 (+)Ensembl
RefSeq Acc Id: ENSMUST00000098057   ⟹   ENSMUSP00000095665
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,962 - 58,374,303 (+)Ensembl
GRCm38.p6 Ensembl458,285,962 - 58,374,303 (+)Ensembl
RefSeq Acc Id: ENSMUST00000098059   ⟹   ENSMUSP00000095667
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,962 - 58,374,302 (+)Ensembl
GRCm38.p6 Ensembl458,285,962 - 58,374,302 (+)Ensembl
RefSeq Acc Id: ENSMUST00000102893   ⟹   ENSMUSP00000099957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,962 - 58,374,303 (+)Ensembl
GRCm38.p6 Ensembl458,285,962 - 58,374,303 (+)Ensembl
RefSeq Acc Id: ENSMUST00000135879
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,286,175 - 58,304,324 (+)Ensembl
GRCm38.p6 Ensembl458,286,175 - 58,304,324 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177951   ⟹   ENSMUSP00000136696
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,962 - 58,374,302 (+)Ensembl
GRCm38.p6 Ensembl458,285,962 - 58,374,302 (+)Ensembl
RefSeq Acc Id: ENSMUST00000179951   ⟹   ENSMUSP00000137453
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl458,285,962 - 58,374,302 (+)Ensembl
GRCm38.p6 Ensembl458,285,962 - 58,374,302 (+)Ensembl
RefSeq Acc Id: NM_001037127   ⟹   NP_001032204
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,962 - 58,374,303 (+)NCBI
GRCm38458,285,962 - 58,374,303 (+)NCBI
MGSCv37458,298,834 - 58,387,175 (+)RGD
Celera458,198,854 - 58,290,062 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001037128   ⟹   NP_001032205
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,962 - 58,374,303 (+)NCBI
GRCm38458,285,962 - 58,374,303 (+)NCBI
MGSCv37458,298,834 - 58,387,175 (+)RGD
Celera458,198,854 - 58,290,062 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001037129   ⟹   NP_001032206
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,962 - 58,374,303 (+)NCBI
GRCm38458,285,962 - 58,374,303 (+)NCBI
MGSCv37458,298,834 - 58,387,175 (+)RGD
Celera458,198,854 - 58,290,062 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001037130   ⟹   NP_001032207
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,962 - 58,374,303 (+)NCBI
GRCm38458,285,962 - 58,374,303 (+)NCBI
MGSCv37458,298,834 - 58,387,175 (+)RGD
Celera458,198,854 - 58,290,062 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001165996   ⟹   NP_001159468
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,962 - 58,356,093 (+)NCBI
GRCm38458,285,962 - 58,356,093 (+)NCBI
MGSCv37458,298,834 - 58,387,175 (+)RGD
Celera458,198,854 - 58,290,062 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_010944   ⟹   NP_035074
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,962 - 58,374,303 (+)NCBI
GRCm38458,285,962 - 58,374,303 (+)NCBI
MGSCv37458,298,834 - 58,387,175 (+)RGD
Celera458,198,854 - 58,290,062 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006537659   ⟹   XP_006537722
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,742 - 58,377,848 (+)NCBI
GRCm38458,285,729 - 58,377,848 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006537661   ⟹   XP_006537724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39458,285,743 - 58,377,848 (+)NCBI
GRCm38458,285,730 - 58,377,848 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032204 (Get FASTA)   NCBI Sequence Viewer  
  NP_001032205 (Get FASTA)   NCBI Sequence Viewer  
  NP_001032206 (Get FASTA)   NCBI Sequence Viewer  
  NP_001032207 (Get FASTA)   NCBI Sequence Viewer  
  NP_001159468 (Get FASTA)   NCBI Sequence Viewer  
  NP_035074 (Get FASTA)   NCBI Sequence Viewer  
  XP_006537722 (Get FASTA)   NCBI Sequence Viewer  
  XP_006537724 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79203 (Get FASTA)   NCBI Sequence Viewer  
  AAA79204 (Get FASTA)   NCBI Sequence Viewer  
  AAI00343 (Get FASTA)   NCBI Sequence Viewer  
  AAM66750 (Get FASTA)   NCBI Sequence Viewer  
  AAR12275 (Get FASTA)   NCBI Sequence Viewer  
  AAY40318 (Get FASTA)   NCBI Sequence Viewer  
  AAY40319 (Get FASTA)   NCBI Sequence Viewer  
  AAY40320 (Get FASTA)   NCBI Sequence Viewer  
  AAY40321 (Get FASTA)   NCBI Sequence Viewer  
  AAY40322 (Get FASTA)   NCBI Sequence Viewer  
  BAM29289 (Get FASTA)   NCBI Sequence Viewer  
  CAA60165 (Get FASTA)   NCBI Sequence Viewer  
  CAA60166 (Get FASTA)   NCBI Sequence Viewer  
  EDL02228 (Get FASTA)   NCBI Sequence Viewer  
  EDL02229 (Get FASTA)   NCBI Sequence Viewer  
  EDL02230 (Get FASTA)   NCBI Sequence Viewer  
  EDL02231 (Get FASTA)   NCBI Sequence Viewer  
  EDL02232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000080590.6
  ENSMUSP00000081625
  ENSMUSP00000081625.6
  ENSMUSP00000095665.4
  ENSMUSP00000095667.4
  ENSMUSP00000099957
  ENSMUSP00000099957.4
  ENSMUSP00000136696
  ENSMUSP00000136696.2
  ENSMUSP00000137453.2
GenBank Protein Q61006 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001032205   ⟸   NM_001037128
- Peptide Label: isoform 2
- UniProtKB: Q32SD3 (UniProtKB/TrEMBL),   J3QPS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032206   ⟸   NM_001037129
- Peptide Label: isoform 3
- UniProtKB: Q497X0 (UniProtKB/TrEMBL),   F6WVU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032204   ⟸   NM_001037127
- Peptide Label: isoform 1
- UniProtKB: E9PVV8 (UniProtKB/TrEMBL),   Q32SD4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_035074   ⟸   NM_010944
- Peptide Label: isoform 4
- UniProtKB: Q61987 (UniProtKB/Swiss-Prot),   Q61005 (UniProtKB/Swiss-Prot),   Q61988 (UniProtKB/Swiss-Prot),   Q61006 (UniProtKB/Swiss-Prot),   Q32S50 (UniProtKB/TrEMBL),   K3W4P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032207   ⟸   NM_001037130
- Peptide Label: isoform 5
- UniProtKB: Q32S49 (UniProtKB/TrEMBL),   I7GSQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001159468   ⟸   NM_001165996
- Peptide Label: isoform 6
- UniProtKB: Q1XD56 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006537722   ⟸   XM_006537659
- Peptide Label: isoform X1
- UniProtKB: J3QPS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006537724   ⟸   XM_006537661
- Peptide Label: isoform X2
- UniProtKB: F6WVU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000081625   ⟸   ENSMUST00000084578
RefSeq Acc Id: ENSMUSP00000136696   ⟸   ENSMUST00000177951
RefSeq Acc Id: ENSMUSP00000137453   ⟸   ENSMUST00000179951
RefSeq Acc Id: ENSMUSP00000080590   ⟸   ENSMUST00000081919
RefSeq Acc Id: ENSMUSP00000095667   ⟸   ENSMUST00000098059
RefSeq Acc Id: ENSMUSP00000095665   ⟸   ENSMUST00000098057
RefSeq Acc Id: ENSMUSP00000099957   ⟸   ENSMUST00000102893
Protein Domains
FZ   Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61006-F1-model_v2 AlphaFold Q61006 1-868 view protein structure

Promoters
RGD ID:6835719
Promoter ID:MM_KWN:37791
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   3T3L1_Day3
Transcripts:ENSMUST00000081919,   ENSMUST00000098059,   NM_001037127_MUSK,   NM_001037128,   NM_001037129,   NM_001037130,   NM_001165996,   NM_010944,   OTTMUST00000017195,   OTTMUST00000017196,   OTTMUST00000017197,   UC008SYV.1,   UC008SYW.1,   UC008SYX.1,   UC008SYY.1,   UC008SYZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36458,298,591 - 58,299,091 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103581 AgrOrtholog
Ensembl Genes ENSMUSG00000057280 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081919.12 UniProtKB/TrEMBL
  ENSMUST00000084578 ENTREZGENE
  ENSMUST00000084578.12 UniProtKB/Swiss-Prot
  ENSMUST00000098057.10 UniProtKB/TrEMBL
  ENSMUST00000098059.10 UniProtKB/TrEMBL
  ENSMUST00000102893 ENTREZGENE
  ENSMUST00000102893.10 UniProtKB/Swiss-Prot
  ENSMUST00000177951 ENTREZGENE
  ENSMUST00000177951.8 UniProtKB/TrEMBL
  ENSMUST00000179951.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Frizzled_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18198 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:103581 ENTREZGENE
NCBI Gene 18198 ENTREZGENE
PANTHER CONTACTIN 5 UniProtKB/TrEMBL
  MUSCLE ASSOCIATED RECEPTOR TYROSINE KINASE UniProtKB/TrEMBL
  MUSCLE, SKELETAL RECEPTOR TYROSINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF01392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB MUSK RGD
PhenoGen Musk PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50038 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PVV8 ENTREZGENE, UniProtKB/TrEMBL
  F6WVU1 ENTREZGENE, UniProtKB/TrEMBL
  I7GSQ5 ENTREZGENE, UniProtKB/TrEMBL
  J3QPS3 ENTREZGENE, UniProtKB/TrEMBL
  K3W4P7 ENTREZGENE, UniProtKB/TrEMBL
  MUSK_MOUSE UniProtKB/Swiss-Prot
  Q1XD56 ENTREZGENE, UniProtKB/TrEMBL
  Q32S49 ENTREZGENE, UniProtKB/TrEMBL
  Q32S50 ENTREZGENE, UniProtKB/TrEMBL
  Q32SD3 ENTREZGENE, UniProtKB/TrEMBL
  Q32SD4 ENTREZGENE, UniProtKB/TrEMBL
  Q497X0 ENTREZGENE, UniProtKB/TrEMBL
  Q61005 ENTREZGENE
  Q61006 ENTREZGENE
  Q61987 ENTREZGENE
  Q61988 ENTREZGENE
UniProt Secondary Q61005 UniProtKB/Swiss-Prot
  Q61987 UniProtKB/Swiss-Prot
  Q61988 UniProtKB/Swiss-Prot