RGD Reference Report - Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina. - Rat Genome Database

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Identification of developmentally regulated expression of MuSK in astrocytes of the rodent retina.

Authors: Cheusova, T  Khan, MA  Enz, R  Hashemolhosseini, S 
Citation: Cheusova T, etal., J Neurochem. 2006 Oct;99(2):450-7. Epub 2006 Aug 8.
RGD ID: 2317091
Pubmed: PMID:16899069   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1471-4159.2006.04086.x   (Journal Full-text)

One of the master regulators of postsynaptic neuromuscular synaptogenesis is the muscle-specific receptor tyrosine kinase (MuSK). In mammals prominent MuSK expression is believed to be restricted to skeletal muscle. Upon activation by nerve-derived agrin MuSK-dependent signalling participates in both the induction of genes encoding postsynaptic components and aggregation of nicotinic acetylcholine receptors (AChR) in the subsynaptic muscle membrane. Strikingly, expression of certain isoforms of nerve-derived agrin can also be detected in the CNS. In this study, we examined the expression of MuSK in the brain and eye of rodents. In the retina MuSK was expressed in astrocytes between postnatal days 7 and 14, i.e. at the time when the eyes open. We found that agrin was localized adjacent to MuSK-expressing astrocytes which in turn were detected close to the inner limiting membrane of the rodent retina. In summary, the presence of MuSK on retinal astrocytes suggests a novel role of MuSK signalling pathways in the CNS.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MuskRatretina development in camera-type eye  IEP  RGD 

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MuskRatcell projection  IDA  RGD 


Genes (Rattus norvegicus)
Musk  (muscle associated receptor tyrosine kinase)