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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:retinoic acid signaling pathway
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Accession:PW:0001014 term browser browse the term
Definition:Retinoic acid, a vitamin A-derived metabolite, plays important roles in development and cell differentiation. All-trans retinoic acid (RA) binds to nuclear RA (RARs) and X (RXRs) receptor subtypes that once activated act as transcription factors.
Synonyms:exact_synonym: RA signaling pathway
 related_synonym: Signaling by Retinoic Acid;   retinoic acid receptor signaling pathway
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retinoic acid signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ncoa1 nuclear receptor coactivator 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Ncoa3 nuclear receptor coactivator 3 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:19471584 RGD:6484676 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Pramex1 PRAME like, X-linked 1 ISO RGD PMID:19471584 RGD:6484676 NCBI chr  X:98,567,994...98,574,654
Ensembl chr  X:98,569,415...98,572,096 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 ISO RGD PMID:19471584 RGD:6484676 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135 		JBrowse link
G Rara retinoic acid receptor, alpha ISO RGD PMID:17132850 PMID:19471584 PMID:17320364 RGD:6484674, RGD:6484676, RGD:6484731 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rarb retinoic acid receptor, beta ISO RGD PMID:17132850 PMID:19471584 PMID:17320364 RGD:6484674, RGD:6484676, RGD:6484731 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288 		JBrowse link
G Rarg retinoic acid receptor, gamma ISO RGD PMID:17132850 PMID:19471584 PMID:17320364 RGD:6484674, RGD:6484676, RGD:6484731 NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177 		JBrowse link
G Rxra retinoid X receptor alpha ISO RGD PMID:17132853 PMID:17320364 RGD:6484675, RGD:6484731 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Rxrb retinoid X receptor beta ISO RGD PMID:17132853 PMID:17320364 RGD:6484675, RGD:6484731 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Rxrg retinoid X receptor gamma ISO RGD PMID:17132853 PMID:17320364 RGD:6484675, RGD:6484731 NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167 		JBrowse link
G Trim24 tripartite motif-containing 24 ISO RGD PMID:19471584 RGD:6484676 NCBI chr 4:66,567,342...66,692,029
Ensembl chr 4:66,566,686...66,717,241 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      transcription factor mediated signaling pathway 460
        retinoic acid signaling pathway 15
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        organic chemical homeostasis pathway 438
          vitamin homeostasis 150
            vitamin A homeostasis 150
              retinoic acid signaling pathway 15
paths to the root