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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:genito-urinary system and sex hormones drug pathway
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Accession:PW:0001202 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of compounds used for the treatment of genito-urinary system conditions or as sex hormones derivatives and analogs. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


show annotations for term's descendants           Sort by:
ibuprofen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1, member C1 ISO SMPDB SMP:00086 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00086 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00086 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,526...53,302,993 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00086 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B ISO SMPDB SMP:00086 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,271,583...53,281,123 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00086 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00086 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2C49 cytochrome P450 2C49 ISO SMPDB SMP:00086 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB SMP:00086 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 ISO SMPDB SMP:00086 NCBI chr 8:114,016,915...114,035,905
Ensembl chr 8:114,011,304...114,035,357 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00086 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO SMPDB SMP:00086 NCBI chr14:11,217,125...11,293,018
Ensembl chr14:11,216,978...11,293,410 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00086 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO SMPDB SMP:00086 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00086 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00086 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00086 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G LOC100623255 UDP-glucuronosyltransferase 2B31 ISO SMPDB SMP:00086 NCBI chr 8:65,915,718...65,936,113 JBrowse link
G LOC110255237 cytochrome P450 4F6-like ISO SMPDB SMP:00086 NCBI chr 2:61,893,963...61,917,944
Ensembl chr 2:61,889,495...61,917,929 		JBrowse link
G LOC110256483 carbonyl reductase [NADPH] 1-like ISO SMPDB SMP:00086 NCBI chr13:199,713,741...199,719,535 JBrowse link
G LOC110259329 docosahexaenoic acid omega-hydroxylase CYP4F3-like ISO SMPDB SMP:00086 NCBI chr 2:61,863,378...61,884,717
Ensembl chr 2:61,864,575...61,984,903 		JBrowse link
G LOC110261221 cytochrome P450 2J2-like ISO SMPDB SMP:00086 NCBI chr 6:152,321,816...152,358,179
Ensembl chr 6:152,321,848...152,648,979 		JBrowse link
G LTA4H leukotriene A4 hydrolase ISO SMPDB SMP:00086 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515 		JBrowse link
G LTC4S leukotriene C4 synthase ISO SMPDB SMP:00086 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285 		JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00086 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00086 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00086 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PLA2G4B phospholipase A2 group IVB ISO SMPDB SMP:00086 NCBI chr 1:129,514,801...129,524,365
Ensembl chr 1:129,514,346...129,524,313 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00086 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G PRXL2B peroxiredoxin like 2B ISO SMPDB SMP:00086 NCBI chr 6:64,432,187...64,435,328
Ensembl chr 6:64,432,148...64,435,320 		JBrowse link
G PTGDS prostaglandin D2 synthase ISO SMPDB SMP:00086
G PTGES prostaglandin E synthase ISO SMPDB SMP:00086 NCBI chr 1:269,911,785...269,924,481
Ensembl chr 1:269,911,789...269,924,462 		JBrowse link
G PTGIS prostaglandin I2 synthase ISO SMPDB SMP:00086 NCBI chr17:51,153,151...51,200,515
Ensembl chr17:51,153,154...51,200,300 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00086 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00086 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00086 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 ISO SMPDB SMP:00086 NCBI chr 2:8,809,547...8,817,124
Ensembl chr 2:8,802,349...8,817,337 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 ISO SMPDB SMP:00086 NCBI chr 2:8,782,030...8,800,998
Ensembl chr 2:8,782,060...8,800,997 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO SMPDB SMP:00086 NCBI chr18:9,717,291...9,886,699
Ensembl chr18:9,717,294...9,886,681 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 ISO SMPDB SMP:00086 NCBI chr15:133,968,693...134,049,029 JBrowse link
ibuprofen pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 ISO SMPDB SMP:00590 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00590 NCBI chr13:124,387,921...124,409,967
Ensembl chr13:124,390,970...124,413,200 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00590 NCBI chr14:39,687,028...39,695,748
Ensembl chr14:39,687,000...39,695,752 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00590 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00590 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00590 NCBI chr 9:46,264,929...46,277,056
Ensembl chr 9:46,264,933...46,276,995 		JBrowse link
G LOC100623255 UDP-glucuronosyltransferase 2B31 ISO SMPDB SMP:00590 NCBI chr 8:65,915,718...65,936,113 JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00590 NCBI chr 3:41,394,267...41,397,547
Ensembl chr 3:41,394,058...41,397,687 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00590 NCBI chr 9:109,260,850...109,280,256
Ensembl chr 9:109,252,011...109,280,247 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00590 NCBI chr 3:125,752,079...125,774,225
Ensembl chr 3:125,751,978...125,776,077 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00590 NCBI chr 1:107,886,663...107,893,155
Ensembl chr 1:107,886,658...107,893,253 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00590 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00590 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00590 NCBI chr14:50,249,607...50,251,636
Ensembl chr14:50,246,710...50,251,642 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 ISO SMPDB SMP:00590 NCBI chr 2:8,809,547...8,817,124
Ensembl chr 2:8,802,349...8,817,337 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 ISO SMPDB SMP:00590 NCBI chr 2:8,782,030...8,800,998
Ensembl chr 2:8,782,060...8,800,997 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 ISO SMPDB SMP:00590 NCBI chr15:133,968,693...134,049,029 JBrowse link
naproxen pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C1 aldo-keto reductase family 1, member C1 ISO SMPDB SMP:00120 NCBI chr10:65,580,297...65,594,998
Ensembl chr10:65,576,464...65,678,248 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00120 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00120 NCBI chr12:53,292,530...53,302,850
Ensembl chr12:53,292,526...53,302,993 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00120 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871 		JBrowse link
G ALOX15B arachidonate 15-lipoxygenase type B ISO SMPDB SMP:00120 NCBI chr12:53,259,867...53,281,127
Ensembl chr12:53,271,583...53,281,123 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00120 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090 		JBrowse link
G CYP2B6B cytochrome P450 family 2 subfamily B member 6B ISO SMPDB SMP:00120 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB SMP:00120 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 ISO SMPDB SMP:00120 NCBI chr 8:114,016,915...114,035,905
Ensembl chr 8:114,011,304...114,035,357 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO SMPDB SMP:00120 NCBI chr14:11,217,125...11,293,018
Ensembl chr14:11,216,978...11,293,410 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO SMPDB SMP:00120 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G LOC110255237 cytochrome P450 4F6-like ISO SMPDB SMP:00120 NCBI chr 2:61,893,963...61,917,944
Ensembl chr 2:61,889,495...61,917,929 		JBrowse link
G LOC110256483 carbonyl reductase [NADPH] 1-like ISO SMPDB SMP:00120 NCBI chr13:199,713,741...199,719,535 JBrowse link
G LOC110259329 docosahexaenoic acid omega-hydroxylase CYP4F3-like ISO SMPDB SMP:00120 NCBI chr 2:61,863,378...61,884,717
Ensembl chr 2:61,864,575...61,984,903 		JBrowse link
G LOC110261221 cytochrome P450 2J2-like ISO SMPDB SMP:00120 NCBI chr 6:152,321,816...152,358,179
Ensembl chr 6:152,321,848...152,648,979 		JBrowse link
G LTA4H leukotriene A4 hydrolase ISO SMPDB SMP:00120 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515 		JBrowse link
G LTC4S leukotriene C4 synthase ISO SMPDB SMP:00120 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285 		JBrowse link
G PLA2G4B phospholipase A2 group IVB ISO SMPDB SMP:00120 NCBI chr 1:129,514,801...129,524,365
Ensembl chr 1:129,514,346...129,524,313 		JBrowse link
G PRXL2B peroxiredoxin like 2B ISO SMPDB SMP:00120 NCBI chr 6:64,432,187...64,435,328
Ensembl chr 6:64,432,148...64,435,320 		JBrowse link
G PTGDS prostaglandin D2 synthase ISO SMPDB SMP:00120
G PTGES prostaglandin E synthase ISO SMPDB SMP:00120 NCBI chr 1:269,911,785...269,924,481
Ensembl chr 1:269,911,789...269,924,462 		JBrowse link
G PTGIS prostaglandin I2 synthase ISO SMPDB SMP:00120 NCBI chr17:51,153,151...51,200,515
Ensembl chr17:51,153,154...51,200,300 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB SMP:00120 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB SMP:00120 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO SMPDB SMP:00120 NCBI chr18:9,717,291...9,886,699
Ensembl chr18:9,717,294...9,886,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4044
    drug pathway 384
      genito-urinary system and sex hormones drug pathway 40
        amphotericin B drug pathway + 0
        ibuprofen drug pathway + 40
        naproxen drug pathway + 25
        nystatin drug pathway + 0
paths to the root