LTC4S (leukotriene C4 synthase) - Rat Genome Database

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Gene: LTC4S (leukotriene C4 synthase) Sus scrofa
Analyze
Symbol: LTC4S
Name: leukotriene C4 synthase
RGD ID: 14078944
Description: ENCODES a protein that exhibits glutathione binding (ortholog); leukotriene-C4 synthase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to vitamin A (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); acute promyelocytic leukemia (ortholog); aspirin-induced respiratory disease (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred); INTERACTS WITH aristolochic acid A; deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,799,449 - 78,802,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,799,446 - 78,802,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,365,497 - 80,368,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LTC4S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl278,799,449 - 78,802,285 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1278,799,446 - 78,802,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2280,365,497 - 80,368,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LTC4S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385179,793,986 - 179,796,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5179,793,980 - 179,796,647 (+)EnsemblGRCh38hg38GRCh38
GRCh375179,220,987 - 179,223,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,153,592 - 179,156,119 (+)NCBINCBI36Build 36hg18NCBI36
Build 345179,153,591 - 179,156,119NCBI
Celera5174,846,142 - 174,848,669 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,947,161 - 173,949,688 (+)NCBIHuRef
CHM1_15178,653,394 - 178,655,921 (+)NCBICHM1_1
T2T-CHM13v2.05180,349,182 - 180,351,843 (+)NCBIT2T-CHM13v2.0
Ltc4s
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,127,288 - 50,129,378 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,127,288 - 50,129,443 (-)EnsemblGRCm39 Ensembl
GRCm381150,236,461 - 50,238,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,236,461 - 50,238,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,049,974 - 50,051,973 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,079,895 - 50,081,894 (-)NCBIMGSCv36mm8
Celera1154,797,050 - 54,799,049 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1130.4NCBI
Ltc4s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,060,002 - 35,066,466 (-)NCBIGRCr8
mRatBN7.21034,560,476 - 34,562,790 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1034,560,360 - 34,562,651 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,235,902 - 39,237,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0107,775,154 - 7,777,109 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,229,574 - 34,231,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01035,736,486 - 35,743,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1035,737,664 - 35,739,625 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01035,498,195 - 35,506,088 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41035,786,877 - 35,788,838 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11035,787,925 - 35,789,881 (-)NCBI
Celera1033,909,805 - 33,911,766 (-)NCBICelera
Cytogenetic Map10q22NCBI
Ltc4s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955408788,856 - 791,505 (-)NCBIChiLan1.0ChiLan1.0
LTC4S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24174,735,060 - 174,739,519 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15172,874,599 - 172,879,058 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,946,346 - 174,950,805 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15182,256,113 - 182,261,003 (+)NCBIpanpan1.1PanPan1.1panPan2
LTC4S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1111,893,927 - 1,897,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl111,894,380 - 1,897,752 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha112,012,534 - 2,020,224 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0111,863,608 - 1,871,298 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl111,867,307 - 1,871,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1111,835,205 - 1,842,895 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0111,914,372 - 1,922,062 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0112,154,596 - 2,162,286 (-)NCBIUU_Cfam_GSD_1.0
Ltc4s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213119,765,712 - 119,768,688 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936739975,493 - 978,482 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936739975,494 - 978,426 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTC4S
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12381,523,784 - 81,526,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2381,523,775 - 81,526,179 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607512,900,551 - 12,903,368 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ltc4s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473342,670,632 - 42,672,846 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473342,668,963 - 42,673,385 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LTC4S
27 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 7 1 1 19 1 2
Below cutoff 2 1 1 2 2 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000024428   ⟹   ENSSSCP00000022469
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,799,449 - 78,802,256 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000079472   ⟹   ENSSSCP00000072631
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,799,449 - 78,802,285 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084930   ⟹   ENSSSCP00000065374
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl278,799,449 - 78,801,197 (-)Ensembl
RefSeq Acc Id: XM_003123645   ⟹   XP_003123693
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1278,799,446 - 78,802,281 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003123693   ⟸   XM_003123645
- UniProtKB: I3LEI1 (UniProtKB/TrEMBL),   A0A4X1VVE8 (UniProtKB/TrEMBL),   A0A4X1VW52 (UniProtKB/TrEMBL),   A0A8D1M8I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000022469   ⟸   ENSSSCT00000024428
RefSeq Acc Id: ENSSSCP00000065374   ⟸   ENSSSCT00000084930
RefSeq Acc Id: ENSSSCP00000072631   ⟸   ENSSSCT00000079472


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000028488 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005007799 UniProtKB/TrEMBL
  ENSSSCG00015068087 UniProtKB/TrEMBL
  ENSSSCG00025058748 UniProtKB/TrEMBL
  ENSSSCG00030022357 UniProtKB/TrEMBL
  ENSSSCG00035017778 UniProtKB/TrEMBL
  ENSSSCG00040038208 UniProtKB/TrEMBL
  ENSSSCG00045034250 UniProtKB/TrEMBL
  ENSSSCG00050035483 UniProtKB/TrEMBL
  ENSSSCG00055014248 UniProtKB/TrEMBL
  ENSSSCG00060059541 UniProtKB/TrEMBL
  ENSSSCG00065031253 UniProtKB/TrEMBL
  ENSSSCG00070026968 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000024428 ENTREZGENE
  ENSSSCT00000024428.2 UniProtKB/TrEMBL
  ENSSSCT00000079472.2 UniProtKB/TrEMBL
  ENSSSCT00000084930.1 UniProtKB/TrEMBL
  ENSSSCT00005011813.1 UniProtKB/TrEMBL
  ENSSSCT00005011842.1 UniProtKB/TrEMBL
  ENSSSCT00005011869.1 UniProtKB/TrEMBL
  ENSSSCT00015091530.1 UniProtKB/TrEMBL
  ENSSSCT00015091683.1 UniProtKB/TrEMBL
  ENSSSCT00015091792.1 UniProtKB/TrEMBL
  ENSSSCT00025080469.1 UniProtKB/TrEMBL
  ENSSSCT00025080595.1 UniProtKB/TrEMBL
  ENSSSCT00025080684.1 UniProtKB/TrEMBL
  ENSSSCT00030031086.1 UniProtKB/TrEMBL
  ENSSSCT00030031102.1 UniProtKB/TrEMBL
  ENSSSCT00030031113.1 UniProtKB/TrEMBL
  ENSSSCT00035022887.1 UniProtKB/TrEMBL
  ENSSSCT00035022893.1 UniProtKB/TrEMBL
  ENSSSCT00035022897.1 UniProtKB/TrEMBL
  ENSSSCT00040051137.1 UniProtKB/TrEMBL
  ENSSSCT00040051296.1 UniProtKB/TrEMBL
  ENSSSCT00040051347.1 UniProtKB/TrEMBL
  ENSSSCT00045058745.1 UniProtKB/TrEMBL
  ENSSSCT00045058777.1 UniProtKB/TrEMBL
  ENSSSCT00045058811.1 UniProtKB/TrEMBL
  ENSSSCT00050047685.1 UniProtKB/TrEMBL
  ENSSSCT00050047690.1 UniProtKB/TrEMBL
  ENSSSCT00050047694.1 UniProtKB/TrEMBL
  ENSSSCT00055028144.1 UniProtKB/TrEMBL
  ENSSSCT00055028244.1 UniProtKB/TrEMBL
  ENSSSCT00055028292.1 UniProtKB/TrEMBL
  ENSSSCT00060081205.1 UniProtKB/TrEMBL
  ENSSSCT00060081226.1 UniProtKB/TrEMBL
  ENSSSCT00060081234.1 UniProtKB/TrEMBL
  ENSSSCT00065042261.1 UniProtKB/TrEMBL
  ENSSSCT00065042267.1 UniProtKB/TrEMBL
  ENSSSCT00065042273.1 UniProtKB/TrEMBL
  ENSSSCT00070054086.1 UniProtKB/TrEMBL
  ENSSSCT00070054087.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.550 UniProtKB/TrEMBL
InterPro 5_LipOase_AP UniProtKB/TrEMBL
  FLAP/GST2/LTC4S_CS UniProtKB/TrEMBL
  MAPEG-like_dom_sf UniProtKB/TrEMBL
  Membr-assoc_MAPEG UniProtKB/TrEMBL
KEGG Report ssc:100520063 UniProtKB/TrEMBL
NCBI Gene LTC4S ENTREZGENE
PANTHER LEUKOTRIENE C4 SYNTHASE UniProtKB/TrEMBL
  MICROSOMAL GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
Pfam MAPEG UniProtKB/TrEMBL
PRINTS 5LPOXGNASEAP UniProtKB/TrEMBL
PROSITE FLAP_GST2_LTC4S UniProtKB/TrEMBL
Superfamily-SCOP SSF161084 UniProtKB/TrEMBL
UniProt A0A4X1VVE8 ENTREZGENE
  A0A4X1VW52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0T222_PIG UniProtKB/TrEMBL
  A0A8D1J5W9_PIG UniProtKB/TrEMBL
  A0A8D1M8I1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1U2P5_PIG UniProtKB/TrEMBL
  A0A8D2C4H0_PIG UniProtKB/TrEMBL
  I3LEI1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1VVE8 UniProtKB/TrEMBL
  A0A5G2QKL4 UniProtKB/TrEMBL
  A0A5G2R5W6 UniProtKB/TrEMBL
VGNC ID VGNC:89890 ENTREZGENE