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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:G1/S transition pathway
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Accession:PW:0000088 term browser browse the term
Definition:The series of events underlying the transition from G1 into S phase and under the control of Cyclin E/A - Cdk2 and cyclin D-Cdk4/Cdk6 complexes and their regulators. Genetic alterations of this important transition point are frequent in human cancers.
Synonyms:related_synonym: G1/S Transition;   G1/S transition of mitotic cell cycle


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G1/S transition pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNA1 cyclin A1 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr25:4,189,457...4,198,170
Ensembl chr25:4,189,457...4,198,373 		JBrowse link
G CCNA2 cyclin A2 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr19:18,317,866...18,324,592
Ensembl chr19:18,318,004...18,323,691 		JBrowse link
G CCND1 cyclin D1 ISO RGD PMID:10919634 RGD:8694143 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005 		JBrowse link
G CCND2 cyclin D2 ISO RGD PMID:10919634 RGD:8694143 NCBI chr27:40,563,306...40,593,362
Ensembl chr27:40,564,921...40,594,255 		JBrowse link
G CCND3 cyclin D3 ISO RGD PMID:10919634 RGD:8694143 NCBI chr12:10,593,786...10,688,304
Ensembl chr12:10,594,712...10,600,891 		JBrowse link
G CCNE1 cyclin E1 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr 1:121,688,622...121,697,533
Ensembl chr 1:121,688,796...121,697,649 		JBrowse link
G CCNE2 cyclin E2 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr29:39,534,872...39,551,141
Ensembl chr29:39,534,968...39,546,566 		JBrowse link
G CDK2 cyclin dependent kinase 2 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr10:300,863...306,546
Ensembl chr10:300,903...305,438 		JBrowse link
G CDK4 cyclin dependent kinase 4 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr10:1,812,864...1,815,815
Ensembl chr10:1,812,886...1,815,789 		JBrowse link
G CDK6 cyclin dependent kinase 6 ISO RGD PMID:10919634 PMID:16236519 RGD:8694143 RGD:8694150 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO RGD PMID:10919634 RGD:8694143 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B ISO RGD PMID:10919634 RGD:8694143 NCBI chr27:33,609,154...33,613,558
Ensembl chr27:33,611,760...33,612,906 		JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C ISO RGD PMID:10919634 RGD:8694143 NCBI chr18:46,860,636...46,861,697 JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO RGD PMID:10919634 RGD:8694143 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO RGD PMID:10919634 RGD:8694143 NCBI chr11:41,259,627...41,264,832 JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C ISO RGD PMID:10919634 RGD:8694143 NCBI chr15:10,219,974...10,224,944
Ensembl chr15:10,220,185...10,224,390 		JBrowse link
G CDKN2D cyclin dependent kinase inhibitor 2D ISO RGD PMID:10919634 RGD:8694143 NCBI chr20:50,607,382...50,609,929
Ensembl chr20:50,607,674...50,609,482 		JBrowse link
G RB1 RB transcriptional corepressor 1 ISO RGD PMID:16236519 RGD:8694150 NCBI chr22:3,061,621...3,204,625
Ensembl chr22:3,063,239...3,257,726 		JBrowse link
G RBL1 RB transcriptional corepressor like 1 ISO RGD PMID:16236519 RGD:8694150 NCBI chr24:25,698,313...25,757,358
Ensembl chr24:25,699,638...25,757,229 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 ISO RGD PMID:16236519 RGD:8694150 NCBI chr 2:62,263,974...62,315,371
Ensembl chr 2:62,265,293...62,315,425 		JBrowse link
altered G1/S transition pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A ISO RGD PMID:18772397 RGD:5490966 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4045
    regulatory pathway 2499
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1332
        cell cycle pathway 97
          cell cycle pathway, mitotic 20
            G1/S transition pathway 20
              altered G1/S transition pathway 1
paths to the root