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ONTOLOGY REPORT - ANNOTATIONS

Term:protein tyrosine/serine/threonine phosphatase activity
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Accession:GO:0008138 term browser browse the term
Definition:Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Comment:Note that this term applies only to free amino acids. Consider 'protein serine/threonine phosphatase activity' or 'protein tyrosine/serine/threonine phosphatase activity' if you want to annotate a protein phosphatase.
Synonyms:broad_synonym: dual-specificity protein phosphatase
 xref: Reactome:R-HSA-9652816 "Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs";   reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs";   reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs"


show annotations for term's descendants           Sort by:
protein tyrosine/serine/threonine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP1 dual specificity phosphatase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086 		JBrowse link
G DUSP12 dual specificity phosphatase 12 enables IEA
IBA		 Ensembl
TreeGrafter
GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:88,811,565...88,818,513
Ensembl chr 4:88,809,565...88,818,411 		JBrowse link
G DUSP13A dual specificity phosphatase 13A enables IEA UniProt
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118
G DUSP13B dual specificity phosphatase 13B enables IEA
IBA		 UniProt
InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000118 NCBI chr14:77,660,124...77,677,713 JBrowse link
G DUSP15 dual specificity phosphatase 15 enables IEA Ensembl GO_REF:0000107 NCBI chr17:35,540,615...35,550,493
Ensembl chr17:35,539,971...35,550,432 		JBrowse link
G DUSP18 dual specificity phosphatase 18 enables IEA Ensembl GO_REF:0000107 NCBI chr14:47,534,152...47,550,953
Ensembl chr14:47,536,202...47,550,495 		JBrowse link
G DUSP19 dual specificity phosphatase 19 enables IEA Ensembl GO_REF:0000107 NCBI chr15:88,549,250...88,574,978
Ensembl chr15:88,549,275...88,571,883 		JBrowse link
G DUSP22 dual specificity phosphatase 22 enables ISO (PMID:38225265) UniProt PMID:38225265 NCBI chr 7:43,437...96,270
Ensembl chr 7:43,487...96,267 		JBrowse link
G DUSP23 dual specificity phosphatase 23 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:90,720,655...90,722,675
Ensembl chr 4:90,720,696...90,721,946 		JBrowse link
G DUSP26 dual specificity phosphatase 26 enables IEA
IBA		 Ensembl
InterPro
GO_Central
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118
G DUSP29 dual specificity phosphatase 29 enables ISS
IEA
IBA		 UniProt
InterPro
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr14:77,602,871...77,643,109
Ensembl chr14:77,602,871...77,643,114 		JBrowse link
G DUSP3 dual specificity phosphatase 3 enables IEA
IBA		 Ensembl
InterPro
TreeGrafter
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr12:19,336,308...19,349,739
Ensembl chr12:19,336,354...19,349,734 		JBrowse link
G DUSP5 dual specificity phosphatase 5 enables IEA Ensembl GO_REF:0000107 NCBI chr14:120,906,340...120,919,398
Ensembl chr14:120,906,343...120,919,384 		JBrowse link
G DUSP6 dual specificity phosphatase 6 ISO RGD PMID:8631996 RGD:70726 NCBI chr 5:93,303,058...93,307,510
Ensembl chr 5:93,302,975...93,307,504 		JBrowse link
G EYA3 EYA transcriptional coactivator and phosphatase 3 enables ISO (PMID:14628042) MGI PMID:14628042 NCBI chr 6:85,095,409...85,185,856
Ensembl chr 6:85,095,409...85,185,799 		JBrowse link
G MTMR3 myotubularin related protein 3 enables IEA Ensembl GO_REF:0000107 NCBI chr14:46,874,977...47,022,581
Ensembl chr14:46,875,050...47,023,487 		JBrowse link
G PPM1F protein phosphatase, Mg2+/Mn2+ dependent 1F enables IEA Ensembl GO_REF:0000107 NCBI chr14:50,040,612...50,083,047
Ensembl chr14:50,040,663...50,063,325 		JBrowse link
G RNGTT RNA guanylyltransferase and 5'-phosphatase enables IEA UniProt GO_REF:0000104 NCBI chr 1:56,852,864...57,061,985
Ensembl chr 1:56,852,866...57,061,972 		JBrowse link
G STYXL2 serine/threonine/tyrosine interacting like 2 enables IBA
IEA		 GO_Central
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 4:83,871,434...83,902,313
Ensembl chr 4:83,871,436...83,902,292 		JBrowse link
JUN kinase phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP19 dual specificity phosphatase 19 enables IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr15:88,549,250...88,574,978
Ensembl chr15:88,549,275...88,571,883 		JBrowse link
MAP kinase tyrosine/serine/threonine phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DUSP1 dual specificity phosphatase 1 enables IEA
IBA		 Ensembl
InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086 		JBrowse link
G DUSP10 dual specificity phosphatase 10 enables IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr10:10,866,446...10,905,852
Ensembl chr10:10,866,448...10,905,857 		JBrowse link
G DUSP14 dual specificity phosphatase 14 enables IEA InterPro GO_REF:0000002 NCBI chr12:38,941,052...38,978,568
Ensembl chr12:38,941,124...38,975,000 		JBrowse link
G DUSP16 dual specificity phosphatase 16 enables IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:59,869,902...59,961,839
Ensembl chr 5:59,915,197...59,961,829 		JBrowse link
G DUSP18 dual specificity phosphatase 18 enables IEA InterPro GO_REF:0000002 NCBI chr14:47,534,152...47,550,953
Ensembl chr14:47,536,202...47,550,495 		JBrowse link
G DUSP2 dual specificity phosphatase 2 enables IEA
IBA		 InterPro
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:47,052,443...47,054,816
Ensembl chr 3:47,052,458...47,054,810 		JBrowse link
G DUSP21 dual specificity phosphatase 21 enables IEA InterPro GO_REF:0000002 NCBI chr  X:39,929,707...39,930,539 JBrowse link
G DUSP4 dual specificity phosphatase 4 enables ISO
IEA		 RGD
InterPro
TreeGrafter		 PMID:7782322 GO_REF:0000002 GO_REF:0000118 RGD:633293 NCBI chr15:55,491,084...55,508,460
Ensembl chr15:55,491,087...55,508,455 		JBrowse link
G DUSP5 dual specificity phosphatase 5 enables ISO
IEA
IBA		 RGD
InterPro
GO_Central
TreeGrafter		 PMID:9699150 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 RGD:68228 NCBI chr14:120,906,340...120,919,398
Ensembl chr14:120,906,343...120,919,384 		JBrowse link
G DUSP6 dual specificity phosphatase 6 enables IEA
IBA		 InterPro
Ensembl
GO_Central
TreeGrafter		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:93,303,058...93,307,510
Ensembl chr 5:93,302,975...93,307,504 		JBrowse link
G DUSP7 dual specificity phosphatase 7 enables IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr13:34,199,404...34,210,621
Ensembl chr13:34,199,409...34,206,649 		JBrowse link
G DUSP8 dual specificity phosphatase 8 enables IEA
IBA		 InterPro
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000118 NCBI chr 2:1,006,589...1,022,444
Ensembl chr 2:1,008,761...1,022,460 		JBrowse link
G DUSP9 dual specificity phosphatase 9 enables IEA
IBA		 InterPro
Ensembl
TreeGrafter
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:124,404,852...124,414,246
Ensembl chr  X:124,409,289...124,414,212 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18691
    catalytic activity 5667
      catalytic activity, acting on a protein 2329
        phosphoprotein phosphatase activity 172
          protein tyrosine/serine/threonine phosphatase activity 28
            JUN kinase phosphatase activity 1
            MAP kinase tyrosine/serine/threonine phosphatase activity 13
Path 2
Term Annotations click to browse term
  molecular_function 18691
    catalytic activity 5667
      hydrolase activity 2403
        hydrolase activity, acting on ester bonds 778
          phosphoric ester hydrolase activity 381
            phosphatase activity 289
              phosphoprotein phosphatase activity 172
                protein tyrosine/serine/threonine phosphatase activity 28
                  JUN kinase phosphatase activity 1
                  MAP kinase tyrosine/serine/threonine phosphatase activity 13
paths to the root