DUSP8 (dual specificity phosphatase 8) - Rat Genome Database

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Gene: DUSP8 (dual specificity phosphatase 8) Sus scrofa
Analyze
Symbol: DUSP8
Name: dual specificity phosphatase 8
RGD ID: 14094682
Description: ENCODES a protein that exhibits MAP kinase tyrosine phosphatase activity (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); myosin phosphatase activity (inferred); INVOLVED IN negative regulation of MAPK cascade (inferred); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ASSOCIATED WITH delta beta-thalassemia (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity protein phosphatase 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,008,761 - 1,022,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,006,589 - 1,022,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DUSP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl21,008,761 - 1,022,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.121,006,589 - 1,022,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DUSP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,554,051 - 1,572,848 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,554,051 - 1,572,271 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,575,281 - 1,593,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,531,857 - 1,549,726 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,533,958 - 1,549,726NCBI
Celera111,612,536 - 1,630,385 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,368,228 - 1,380,274 (-)NCBIHuRef
CHM1_1111,574,204 - 1,586,091 (-)NCBICHM1_1
T2T-CHM13v2.0111,635,383 - 1,654,159 (-)NCBIT2T-CHM13v2.0
Dusp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,633,224 - 141,649,799 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,633,227 - 141,649,580 (-)EnsemblGRCm39 Ensembl
GRCm387142,079,487 - 142,095,907 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,079,490 - 142,095,843 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,267,401 - 149,276,175 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,890,886 - 141,899,660 (-)NCBIMGSCv36mm8
Celera7141,835,850 - 141,844,624 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.59NCBI
Dusp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,596,912 - 206,613,728 (-)NCBIGRCr8
mRatBN7.21197,167,392 - 197,184,285 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1197,169,422 - 197,182,921 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,512,040 - 205,525,546 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,630,408 - 212,643,923 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,304,565 - 205,318,081 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01215,030,429 - 215,043,111 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1215,030,429 - 215,033,460 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,943,575 - 221,955,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,215,086 - 202,229,746 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,374,803 - 202,377,833 (-)NCBI
Celera1194,795,319 - 194,808,824 (-)NCBICelera
Cytogenetic Map1q41NCBI
Dusp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,813,336 - 10,826,801 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,816,647 - 10,826,787 (+)NCBIChiLan1.0ChiLan1.0
DUSP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,976,367 - 3,995,198 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1113,187,393 - 3,206,228 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0111,592,858 - 1,611,740 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1111,620,076 - 1,637,071 (-)NCBIpanpan1.1PanPan1.1panPan2
DUSP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,791,878 - 45,809,996 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,794,330 - 45,809,996 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,402,494 - 44,420,592 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,473,116 - 46,491,220 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11845,920,950 - 45,939,027 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,501,453 - 45,519,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,246,738 - 46,264,877 (-)NCBIUU_Cfam_GSD_1.0
Dusp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049471,160,492 - 1,179,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816414,478 - 433,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816414,506 - 430,491 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,361,228 - 1,372,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,358,643 - 1,372,266 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603898,527,211 - 98,546,395 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,205,991 - 21,216,222 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,203,180 - 21,215,919 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUSP8
107 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 2 1 2 21 1
Below cutoff 6 1 2 4 2 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000056757   ⟹   ENSSSCP00000037721
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl21,008,761 - 1,022,460 (-)Ensembl
RefSeq Acc Id: XM_021082598   ⟹   XP_020938257
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.121,006,589 - 1,022,444 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020938257   ⟸   XM_021082598
- UniProtKB: A0A4X1UF29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000037721   ⟸   ENSSSCT00000056757
Protein Domains
Rhodanese   Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025044091 UniProtKB/TrEMBL
  ENSSSCG00040018813 UniProtKB/TrEMBL
  ENSSSCG00045022780 UniProtKB/TrEMBL
  ENSSSCG00055020319 UniProtKB/TrEMBL
  ENSSSCG00060028606 UniProtKB/TrEMBL
  ENSSSCG00065057595 UniProtKB/TrEMBL
  ENSSSCG00070016196 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000056757 ENTREZGENE
  ENSSSCT00000056757.3 UniProtKB/TrEMBL
  ENSSSCT00025059848.1 UniProtKB/TrEMBL
  ENSSSCT00040025392.1 UniProtKB/TrEMBL
  ENSSSCT00045038887.1 UniProtKB/TrEMBL
  ENSSSCT00055039804.1 UniProtKB/TrEMBL
  ENSSSCT00060038672.1 UniProtKB/TrEMBL
  ENSSSCT00065078807.1 UniProtKB/TrEMBL
  ENSSSCT00070031802.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/TrEMBL
  DUSP8_DSP UniProtKB/TrEMBL
  MKP UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Rhodanese-like_dom UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/TrEMBL
NCBI Gene DUSP8 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 8 UniProtKB/TrEMBL
Pfam DSPc UniProtKB/TrEMBL
  Rhodanese UniProtKB/TrEMBL
PRINTS MAPKPHPHTASE UniProtKB/TrEMBL
PROSITE RHODANESE_3 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_DUAL UniProtKB/TrEMBL
SMART DSPc UniProtKB/TrEMBL
  RHOD UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
  SSF52821 UniProtKB/TrEMBL
UniProt A0A287A1C0_PIG UniProtKB/TrEMBL
  A0A4X1UF29 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1UZG4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87489 ENTREZGENE