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ONTOLOGY REPORT - ANNOTATIONS

Term:MAP kinase kinase activity
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Accession:GO:0004708 term browser browse the term
Definition:Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
Synonyms:exact_synonym: ERK activator kinase activity;   MAPK activator activity;   MAPKK activity
 narrow_synonym: MAP kinase kinase 4 activity;   MAP kinase kinase 7 activity
 broad_synonym: MEK activity
 related_synonym: ATP:protein phosphotransferase (MAPKKK-activated) activity;   MAP kinase or ERK kinase activity;   MAP2K;   MAPKK;   MAPKK1;   MEK1;   MEK2;   MKK;   MKK2;   MKK4;   MKK6;   MKK7;   STK27;   mitogen-activated protein kinase kinase activity
 xref: EC:2.7.12.2;   MetaCyc:2.7.12.2-RXN;   Reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5";   Reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3";   Reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR";   reactome:R-HSA-1247960 "Activation of p38 MAPK";   reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK"


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MAP kinase kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf Braf transforming gene enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:39,580,171...39,702,592
Ensembl chr 6:39,580,171...39,702,397 		JBrowse link
G Map2k1 mitogen-activated protein kinase kinase 1 enables ISO
IDA
IBA
IMP		 (PMID:1411546)
(PMID:11841548)		 MGI
GO_Central
RGD		 PMID:1411546 PMID:7611406 PMID:7624324 PMID:7935430 PMID:8393135 More... GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:1582177 RGD:2293305 RGD:2298674 RGD:61657 NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 enables ISO
IDA
IBA		 (PMID:8297798) MGI
RGD
GO_Central		 PMID:7611406 PMID:8297798 PMID:8393135 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:2298674 RGD:61657 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 enables ISO
IBA
IDA
IMP		 (PMID:10202148), (PMID:8900184)
(PMID:10097111)		 MGI
GO_Central		 PMID:8900184 PMID:10097111 PMID:10202148 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr11:60,822,880...60,843,637
Ensembl chr11:60,822,859...60,843,637 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 enables ISO MGI
RGD		 PMID:7768885 GO_REF:0000096 MGI:4417868 RGD:2293351 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Map2k5 mitogen-activated protein kinase kinase 5 enables IBA
IDA		 (PMID:19654213) GO_Central
MGI		 PMID:19654213 GO_REF:0000033 NCBI chr 9:63,071,050...63,288,964
Ensembl chr 9:63,071,050...63,285,184 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 enables ISO
IBA
IMP
TAS		 (PMID:20551513) MGI
GO_Central
Reactome
RGD		 PMID:20550965 PMID:20551513 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:7243113 Reactome:R-MMU-448961 NCBI chr11:110,289,928...110,416,348
Ensembl chr11:110,289,948...110,416,348 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 enables ISO MGI
RGD		 PMID:20550965 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:7243113 NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 enables EXP (MGI:5767077|PMID:9065412), (MGI:5767078|PMID:9078260) Reactome PMID:9065412 PMID:9078260 MGI:5767077 MGI:5767078 NCBI chr13:111,882,962...111,954,803
Ensembl chr13:111,882,962...111,945,527 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 enables IDA (PMID:12464436) MGI PMID:12464436 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Mir140 microRNA 140 ISO RGD PMID:28922712 RGD:329347824 NCBI chr 8:108,277,876...108,277,945
Ensembl chr 8:108,277,876...108,277,945 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr  X:142,301,370...142,580,792
Ensembl chr  X:142,301,587...142,580,792 		JBrowse link
G Pbk PDZ binding kinase enables IEA UniProt GO_REF:0000003 MGI:2152096 NCBI chr14:66,043,337...66,055,271
Ensembl chr14:66,043,286...66,055,271 		JBrowse link
G Sbk2 SH3-binding domain kinase family, member 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 7:4,959,133...4,967,405
Ensembl chr 7:4,943,511...4,967,405 		JBrowse link
JUN kinase kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k4 mitogen-activated protein kinase kinase 4 enables ISO
IBA		 MGI
RGD
GO_Central		 PMID:7768885 PMID:17064355 GO_REF:0000033 GO_REF:0000096 MGI:4417868 RGD:2293351 RGD:2298577 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 enables ISO
IDA
IBA		 (MGI:1101248|PMID:9405446), (MGI:2182169|PMID:11959862) MGI
RGD
BHF-UCL
GO_Central		 PMID:9405446 PMID:10051439 PMID:11849756 PMID:11959862 PMID:17064355 GO_REF:0000033 GO_REF:0000096 MGI:1101248 MGI:2182169 MGI:4417868 RGD:2298561 RGD:2298565 RGD:2298577 NCBI chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897
Ensembl chr 8:4,288,740...4,297,897 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      catalytic activity, acting on a protein 2360
        protein kinase activity 604
          protein serine/threonine/tyrosine kinase activity 41
            MAP kinase kinase activity 14
              JUN kinase kinase activity 2
Path 2
Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      transferase activity 2294
        transferase activity, transferring phosphorus-containing groups 922
          kinase activity 758
            protein kinase activity 604
              protein serine/threonine/tyrosine kinase activity 41
                MAP kinase kinase activity 14
                  JUN kinase kinase activity 2
paths to the root