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Gene: Map2k6 (mitogen-activated protein kinase kinase 6) Mus musculus
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Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Description: Predicted to have identical protein binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including activation of MAPK activity; cardiac muscle contraction; and negative regulation of cold-induced thermogenesis. Predicted to localize to the cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6); PARTICIPATES IN cardiomyopathy pathway; adenosine signaling pathway; FasL mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen activated protein kinase kinase 6; MKK6; Prkmk6; protein kinase, mitogen activated, kinase 6; SAPKK3
Orthologs:
Homo sapiens (human) : MAP2K6 (mitogen-activated protein kinase kinase 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Map2k6 (mitogen-activated protein kinase kinase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k6 (mitogen-activated protein kinase kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Canis lupus familiaris (dog) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Sus scrofa (pig) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Chlorocebus sabaeus (green monkey) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Heterocephalus glaber (naked mole-rat) : Map2k6 (mitogen-activated protein kinase kinase 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11110,399,122 - 110,525,522 (+)Ensembl
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBImm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11 E1-E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Map2k6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552419
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.