Map2k6 (mitogen-activated protein kinase kinase 6) - Rat Genome Database

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Gene: Map2k6 (mitogen-activated protein kinase kinase 6) Mus musculus
Analyze
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
RGD ID: 1552419
MGI Page MGI
Description: Enables MAP kinase kinase activity. Involved in bone development; negative regulation of cold-induced thermogenesis; and osteoblast differentiation. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAP kinase activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen activated protein kinase kinase 6; MKK6; Prkm; Prkmk6; protein kinase, mitogen activated, kinase 6; SAP; SAPKK3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,289,928 - 110,416,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,289,948 - 110,416,348 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11110,399,122 - 110,525,522 (+)Ensemblmm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBIMGSCv36mm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11E1- E2NCBI
cM Map1173.6NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-alpha-phellandrene  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-nitrofluorene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amino acid  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucan  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
bortezomib  (ISO)
bromoacetate  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (EXP)
dichromium trioxide  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
Didecyldimethylammonium  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
filipin III  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
iron(2+) sulfate (anhydrous)  (ISO)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
maneb  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methimazole  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mevinphos  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
ouabain  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
perfluorohexanesulfonic acid  (EXP)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
ritodrine  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
Securinine  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulfates  (ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (ISO)
tanespimycin  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thiram  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimethyltin  (EXP)
Triptolide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)
cytosol  (IEA,ISO,TAS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development. Adams RH, etal., Mol Cell 2000 Jul;6(1):109-16.
2. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. Braz JC, etal., J Clin Invest. 2003 May;111(10):1475-86. doi: 10.1172/JCI17295.
3. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. Chang AY J Biomed Sci. 2012 Nov 17;19:96. doi: 10.1186/1423-0127-19-96.
4. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
5. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Demidov ON, etal., Oncogene. 2007 Apr 12;26(17):2502-6. Epub 2006 Oct 2.
6. Active kinase proteome screening reveals novel signal complexity in cardiomyopathy. Fernando P, etal., Mol Cell Proteomics. 2005 May;4(5):673-82. Epub 2005 Feb 18.
7. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Hartzler AW, etal., Neurobiol Aging. 2002 Sep-Oct;23(5):855-9.
8. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Hickson JA, etal., Cancer Res. 2006 Feb 15;66(4):2264-70.
9. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. Kaiser RA, etal., J Biol Chem. 2004 Apr 9;279(15):15524-30. Epub 2004 Jan 28.
10. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kang SW, etal., Kidney Int. 2001 Aug;60(2):543-52.
11. p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Kumar V, etal., Cancer Res. 2010 Dec 15;70(24):10381-91. doi: 10.1158/0008-5472.CAN-10-1470. Epub 2010 Oct 27.
12. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
13. Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. Lotan TL, etal., J Pathol. 2007 Aug;212(4):386-94.
14. Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. Martindale JJ, etal., J Biol Chem. 2005 Jan 7;280(1):669-76. Epub 2004 Oct 18.
15. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. MGD IEA MGD IEA
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Vander Griend DJ, etal., Cancer Res. 2005 Dec 1;65(23):10984-91.
Additional References at PubMed
PMID:8621675   PMID:8861944   PMID:8889548   PMID:9768359   PMID:10097111   PMID:10349636   PMID:10834841   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12151339  
PMID:12213961   PMID:12477932   PMID:12482988   PMID:12520002   PMID:12556533   PMID:12824301   PMID:12893778   PMID:14610273   PMID:14681479   PMID:14744933   PMID:15142957   PMID:15489334  
PMID:15644321   PMID:15767678   PMID:16141072   PMID:16141073   PMID:16199873   PMID:16387856   PMID:16498455   PMID:16602821   PMID:16766635   PMID:17214902   PMID:17588539   PMID:17854274  
PMID:17964260   PMID:17983595   PMID:18287559   PMID:18501927   PMID:18757346   PMID:18799693   PMID:19427893   PMID:19561096   PMID:19564926   PMID:20004242   PMID:20551513   PMID:21078955  
PMID:21368234   PMID:21606198   PMID:21610252   PMID:21642586   PMID:21873635   PMID:23202732   PMID:23431145   PMID:24400116   PMID:24596247   PMID:25100655   PMID:25359213   PMID:25406311  
PMID:27009039   PMID:27012769   PMID:27748998   PMID:28378742   PMID:29021624   PMID:29688375   PMID:30418981   PMID:31698040   PMID:32325033   PMID:32371393   PMID:33128541   PMID:33417276  
PMID:33994863   PMID:34321999   PMID:34948353   PMID:35471456   PMID:35592906   PMID:35971771   PMID:38730210  


Genomics

Comparative Map Data
Map2k6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,289,928 - 110,416,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,289,948 - 110,416,348 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11110,399,122 - 110,525,522 (+)Ensemblmm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBIMGSCv36mm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11E1- E2NCBI
cM Map1173.6NCBI
MAP2K6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,414,697 - 69,553,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,414,697 - 69,553,865 (+)Ensemblhg38GRCh38
GRCh371767,410,838 - 67,550,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,922,433 - 65,050,065 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341765,010,164 - 65,051,067NCBI
Celera1763,982,421 - 64,110,030 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1762,796,464 - 62,924,594 (+)NCBIHuRef
CHM1_11767,475,265 - 67,603,400 (+)NCBICHM1_1
T2T-CHM13v2.01770,291,653 - 70,430,810 (+)NCBIT2T-CHM13v2.0
Map2k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,872,747 - 95,987,747 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1095,872,546 - 95,987,721 (+)EnsemblGRCr8
mRatBN7.21095,373,304 - 95,490,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1095,373,204 - 95,488,293 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10100,429,713 - 100,544,144 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,892,740 - 100,007,172 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01095,301,015 - 95,415,445 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01098,707,160 - 98,823,054 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1098,706,960 - 98,823,287 (+)Ensemblrn6Rnor6.0
Rnor_5.01098,413,927 - 98,527,709 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41099,859,684 - 99,974,446 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1094,024,106 - 94,137,678 (+)NCBICelera
RGSC_v3.11099,873,953 - 99,989,003 (+)NCBI
Cytogenetic Map10q32.1NCBI
Map2k6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554783,331,607 - 3,448,842 (-)Ensembl
ChiLan1.0NW_0049554783,331,607 - 3,448,840 (-)NCBIChiLan1.0ChiLan1.0
MAP2K6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21985,434,352 - 85,573,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11790,255,171 - 90,400,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01763,342,720 - 63,483,926 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11768,730,011 - 68,870,713 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1768,730,011 - 68,870,454 (+)EnsemblpanPan2panpan1.1
MAP2K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,840,714 - 15,962,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,840,983 - 15,952,026 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha916,731,937 - 16,853,765 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0917,501,891 - 17,623,440 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl917,501,897 - 17,614,738 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1916,445,924 - 16,567,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0910,966,413 - 11,088,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0910,965,262 - 11,086,973 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
MAP2K6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1210,894,966 - 11,018,641 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11210,891,445 - 11,018,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,145,143 - 11,264,150 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11652,045,398 - 52,188,416 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1652,057,784 - 52,187,997 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607722,937,949 - 23,081,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248704,287,835 - 4,416,559 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248704,224,108 - 4,420,217 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Map2k6
4990 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:791
Count of miRNA genes:537
Interacting mature miRNAs:610
Transcripts:ENSMUST00000020949, ENSMUST00000100260, ENSMUST00000133920, ENSMUST00000146084, ENSMUST00000146540
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
4141702Hmtb6_mhemostasis and thrombosis rebleeding time 6 (mouse)Not determined107616344110519830Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse

Markers in Region
D11Mit300  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811110,493,228 - 110,493,308UniSTSGRCm38
MGSCv3711110,354,542 - 110,354,622UniSTSGRCm37
Cytogenetic Map11E1UniSTS
cM Map1168.0UniSTS
Whitehead Genetic1171.0UniSTS
Whitehead_YAC11 UniSTS
Map2k6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3711110,374,685 - 110,374,817UniSTSGRCm37
Celera11122,252,867 - 122,252,999UniSTS
Cytogenetic Map11E1UniSTS
cM Map11 UniSTS
cM MapUN UniSTS
UniSTS:224328  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811110,513,007 - 110,513,200UniSTSGRCm38
MGSCv3711110,374,321 - 110,374,514UniSTSGRCm37
Celera11122,252,504 - 122,252,697UniSTS
Cytogenetic Map11E1UniSTS
Map2k6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811110,513,371 - 110,513,503UniSTSGRCm38
MGSCv3711110,374,685 - 110,374,817UniSTSGRCm37
Celera11122,252,867 - 122,252,999UniSTS
Cytogenetic Map11E1UniSTS
cM MapUN UniSTS
cM Map11 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001356345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001356353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011249035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA389344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI429449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK043482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL603826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL691461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB202796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE859531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU695367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY280286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY284275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X98067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000020949   ⟹   ENSMUSP00000020949
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11110,289,948 - 110,404,467 (+)Ensembl
GRCm38.p6 Ensembl11110,399,122 - 110,513,641 (+)Ensembl
Ensembl Acc Id: ENSMUST00000100260   ⟹   ENSMUSP00000097831
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11110,289,948 - 110,416,348 (+)Ensembl
GRCm38.p6 Ensembl11110,399,122 - 110,525,522 (+)Ensembl
Ensembl Acc Id: ENSMUST00000133920
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11110,369,865 - 110,388,752 (+)Ensembl
GRCm38.p6 Ensembl11110,479,039 - 110,497,926 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146084
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11110,290,085 - 110,404,467 (+)Ensembl
GRCm38.p6 Ensembl11110,399,259 - 110,513,641 (+)Ensembl
Ensembl Acc Id: ENSMUST00000146540
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11110,368,203 - 110,390,348 (+)Ensembl
GRCm38.p6 Ensembl11110,477,377 - 110,499,522 (+)Ensembl
RefSeq Acc Id: NM_001356345   ⟹   NP_001343274
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,289,928 - 110,416,348 (+)NCBI
GRCm3811110,399,102 - 110,525,522 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356346   ⟹   NP_001343275
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,370,166 - 110,404,467 (+)NCBI
GRCm3811110,479,340 - 110,513,641 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356347   ⟹   NP_001343276
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,369,341 - 110,404,467 (+)NCBI
GRCm3811110,478,515 - 110,513,641 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356352   ⟹   NP_001343281
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,289,928 - 110,404,467 (+)NCBI
GRCm3811110,399,102 - 110,513,641 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001356353   ⟹   NP_001343282
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,289,928 - 110,404,467 (+)NCBI
GRCm3811110,399,102 - 110,513,641 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011943   ⟹   NP_036073
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,289,928 - 110,404,467 (+)NCBI
GRCm3811110,399,102 - 110,513,641 (+)NCBI
MGSCv3711110,260,436 - 110,374,951 (+)RGD
Celera11122,139,172 - 122,253,133 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011249034   ⟹   XP_011247336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,290,487 - 110,413,834 (+)NCBI
GRCm3811110,399,103 - 110,523,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011249035   ⟹   XP_011247337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,368,208 - 110,413,834 (+)NCBI
GRCm3811110,477,382 - 110,523,008 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156708   ⟹   XP_036012601
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,291,320 - 110,413,834 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036156709   ⟹   XP_036012602
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911110,370,250 - 110,413,834 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036073   ⟸   NM_011943
- Peptide Label: isoform 1
- UniProtKB: P70236 (UniProtKB/Swiss-Prot),   Q543Z5 (UniProtKB/TrEMBL),   Q8BP44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011247336   ⟸   XM_011249034
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011247337   ⟸   XM_011249035
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001343274   ⟸   NM_001356345
- Peptide Label: isoform 2
- UniProtKB: A2AGS2 (UniProtKB/TrEMBL),   Q8C371 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001343281   ⟸   NM_001356352
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001343282   ⟸   NM_001356353
- Peptide Label: isoform 4
- UniProtKB: Q60521 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001343276   ⟸   NM_001356347
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001343275   ⟸   NM_001356346
- Peptide Label: isoform 3
Ensembl Acc Id: ENSMUSP00000020949   ⟸   ENSMUST00000020949
Ensembl Acc Id: ENSMUSP00000097831   ⟸   ENSMUST00000100260
RefSeq Acc Id: XP_036012601   ⟸   XM_036156708
- Peptide Label: isoform X2
- UniProtKB: Q8BP44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036012602   ⟸   XM_036156709
- Peptide Label: isoform X1
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70236-F1-model_v2 AlphaFold P70236 1-334 view protein structure

Promoters
RGD ID:6821220
Promoter ID:MM_KWN:10407
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Lung
Transcripts:ENSMUST00000100260,   OTTMUST00000006983,   OTTMUST00000006984
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611110,260,179 - 110,260,679 (+)MPROMDB
RGD ID:6821222
Promoter ID:MM_KWN:10409
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000006987
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611110,337,826 - 110,338,326 (+)MPROMDB
RGD ID:6821223
Promoter ID:MM_KWN:10410
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:UC007MDT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611110,340,291 - 110,340,791 (+)MPROMDB
RGD ID:8677216
Promoter ID:EPDNEW_M16637
Type:initiation region
Name:Map2k6_1
Description:Mus musculus mitogen-activated protein kinase kinase 6 , transcriptvariant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16638  EPDNEW_M16639  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811110,399,122 - 110,399,182EPDNEW
RGD ID:8677214
Promoter ID:EPDNEW_M16638
Type:single initiation site
Name:Map2k6_2
Description:Mus musculus mitogen-activated protein kinase kinase 6 , transcriptvariant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16637  EPDNEW_M16639  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811110,414,758 - 110,414,818EPDNEW
RGD ID:8677218
Promoter ID:EPDNEW_M16639
Type:initiation region
Name:Map2k6_3
Description:Mus musculus mitogen-activated protein kinase kinase 6 , transcriptvariant 6, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M16638  EPDNEW_M16637  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811110,479,325 - 110,479,385EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346870 AgrOrtholog
Ensembl Genes ENSMUSG00000020623 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000020949 ENTREZGENE
  ENSMUST00000020949.12 UniProtKB/Swiss-Prot
  ENSMUST00000100260 ENTREZGENE
  ENSMUST00000146084 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report mmu:26399 UniProtKB/Swiss-Prot
MGD MGI:1346870 ENTREZGENE
NCBI Gene 26399 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/Swiss-Prot
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Map2k6 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A2AGS2 ENTREZGENE, UniProtKB/TrEMBL
  MP2K6_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P70273_MOUSE UniProtKB/TrEMBL
  Q3UU57_MOUSE UniProtKB/TrEMBL
  Q543Z5 ENTREZGENE, UniProtKB/TrEMBL
  Q60521 ENTREZGENE, UniProtKB/TrEMBL
  Q8BP44 ENTREZGENE, UniProtKB/TrEMBL
  Q8C371 ENTREZGENE, UniProtKB/TrEMBL