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Gene: Map2k6 (mitogen-activated protein kinase kinase 6) Mus musculus
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Description: Predicted to have identical protein binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including activation of MAPK activity; cardiac muscle contraction; and negative regulation of cold-induced thermogenesis. Predicted to localize to the cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6); PARTICIPATES IN cardiomyopathy pathway; adenosine signaling pathway; FasL mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; mitogen activated protein kinase kinase 6; MKK6; Prkmk6; protein kinase, mitogen activated, kinase 6; SAPKK3
Homo sapiens (human) : MAP2K6 (mitogen-activated protein kinase kinase 6)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Map2k6 (mitogen-activated protein kinase kinase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k6 (mitogen-activated protein kinase kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Canis lupus familiaris (dog) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Sus scrofa (pig) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Chlorocebus sabaeus (green monkey) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Heterocephalus glaber (naked mole-rat) : Map2k6 (mitogen-activated protein kinase kinase 6)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11110,399,122 - 110,525,522 (+)Ensembl
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBImm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11 E1-E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Map2k6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1552419
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.