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ONTOLOGY REPORT - ANNOTATIONS

Term:poly(A)-specific ribonuclease activity
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Accession:GO:0004535 term browser browse the term
Definition:Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
Synonyms:exact_synonym: poly(A)-specific RNase activity
 related_synonym: 2',3'-exoribonuclease activity;   3'-exoribonuclease activity
 xref: EC:3.1.13.4;   MetaCyc:3.1.13.4-RXN;   Reactome:R-HSA-9822311 "CCR4-NOT deadenylates mRNA in CCR4-NOT:BTG4:PABPN1L:mRNP";   Reactome:R-HSA-9822335 "CCR4-NOT(CNOT6L) deadenylates mRNA in CCR4-NOT(CNOT6L):ZFP36L2:mRNA";   reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA";   reactome:R-HSA-429992 "PARN deadenylates mRNA";   reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA"


show annotations for term's descendants           Sort by:
poly(A)-specific ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNOT1 CCR4-NOT transcription complex subunit 1 contributes_to
enables		 ISO
IEA		 (PMID:21976065) UniProtKB
Ensembl		 PMID:21976065 GO_REF:0000107 NCBI chr16:38,793,212...38,902,686
Ensembl chr16:57,919,283...58,027,472 		JBrowse link
G CNOT2 CCR4-NOT transcription complex subunit 2 contributes_to
enables		 ISO
IEA		 (PMID:21299754) UniProtKB
Ensembl		 PMID:21299754 GO_REF:0000107 NCBI chr12:67,753,703...67,865,375
Ensembl chr12:70,520,722...70,633,149 		JBrowse link
G CNOT6 CCR4-NOT transcription complex subunit 6 enables IEA UniProt
TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:175,695,802...175,780,534
Ensembl chr 5:183,007,081...183,089,997 		JBrowse link
G CNOT6L CCR4-NOT transcription complex subunit 6 like enables IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000118 NCBI chr 4:46,374,255...46,482,552
Ensembl chr 4:52,263,010...52,320,307 		JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 enables IEA Ensembl
TreeGrafter
InterPro
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 8:16,439,014...16,459,636
Ensembl chr 8:13,387,288...13,404,445 		JBrowse link
G CNOT8 CCR4-NOT transcription complex subunit 8 enables IEA Ensembl
TreeGrafter
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 5:150,262,907...150,280,215
Ensembl chr 5:156,256,448...156,274,293 		JBrowse link
G NOCT nocturnin enables IEA InterPro GO_REF:0000002 NCBI chr 4:131,378,656...131,409,711
Ensembl chr 4:142,691,169...142,719,514 		JBrowse link
G PAN2 poly(A) specific ribonuclease subunit PAN2 enables IEA InterPro
TreeGrafter
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr12:32,581,728...32,598,445
Ensembl chr12:32,835,235...32,853,645 		JBrowse link
G PAN3 poly(A) specific ribonuclease subunit PAN3 contributes_to
enables		 ISO
IEA		 (PMID:14583602) UniProtKB
Ensembl		 PMID:14583602 GO_REF:0000107 NCBI chr13:9,420,405...9,579,859
Ensembl chr13:27,798,607...27,921,266 		JBrowse link
G PARN poly(A)-specific ribonuclease enables IEA InterPro
Ensembl
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr16:13,363,879...13,556,054
Ensembl chr16:14,787,881...14,977,786 		JBrowse link
G PDE12 phosphodiesterase 12 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:57,489,602...57,502,240
Ensembl chr 3:58,696,083...58,699,719 		JBrowse link
G PNLDC1 PARN like ribonuclease domain containing exonuclease 1 enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000003 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 NCBI chr 6:157,682,286...157,707,632
Ensembl chr 6:162,694,724...162,716,700 		JBrowse link
G TOE1 target of EGR1, exonuclease enables IEA Ensembl
UniProt		 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:44,642,812...44,646,808
Ensembl chr 1:46,000,713...46,005,279 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      catalytic activity, acting on a nucleic acid 593
        catalytic activity, acting on RNA 366
          RNA nuclease activity 118
            RNA exonuclease activity 44
              RNA exonuclease activity, producing 5'-phosphomonoesters 34
                3'-5'-RNA exonuclease activity 31
                  poly(A)-specific ribonuclease activity 13
Path 2
Term Annotations click to browse term
  molecular_function 17493
    catalytic activity 5389
      hydrolase activity 2314
        hydrolase activity, acting on ester bonds 742
          nuclease activity 199
            RNA nuclease activity 118
              RNA exonuclease activity 44
                RNA exonuclease activity, producing 5'-phosphomonoesters 34
                  3'-5'-RNA exonuclease activity 31
                    poly(A)-specific ribonuclease activity 13
paths to the root