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ONTOLOGY REPORT - ANNOTATIONS

Term:RNA exonuclease activity
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Accession:GO:0004532 term browser browse the term
Definition:Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
Synonyms:exact_synonym: exoribonuclease activity
 xref: reactome:R-HSA-429961 "DCPS scavenges the 7-methylguanosine cap of mRNA"


show annotations for term's descendants           Sort by:
RNA exonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnot6 CCR4-NOT transcription complex, subunit 6 enables ISO
ISS		 (PMID:11889047)
GO_REF:0000024		 RGD
UniProt		 PMID:11889047 GO_REF:0000024 NCBI chr10:33,978,785...34,031,025
Ensembl chr10:33,980,831...34,031,025 		JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 enables ISO (PMID:19276069) RGD PMID:19276069 NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576 		JBrowse link
G Exosc1 exosome component 1 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 1:240,734,777...240,745,431
Ensembl chr 1:240,734,773...240,745,438 		JBrowse link
G Exosc10 exosome component 10 enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940 		JBrowse link
G Exosc2 exosome component 2 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575 		JBrowse link
G Exosc3 exosome component 3 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 5:59,573,849...59,579,065
Ensembl chr 5:59,573,886...59,579,060 		JBrowse link
G Exosc4 exosome component 4 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 7:108,047,831...108,050,573
Ensembl chr 7:108,047,831...108,050,573 		JBrowse link
G Exosc5 exosome component 5 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 1:81,168,128...81,177,266
Ensembl chr 1:81,166,023...81,177,265 		JBrowse link
G Exosc6 exosome component 6 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr19:39,022,171...39,023,585
Ensembl chr19:39,022,183...39,023,515 		JBrowse link
G Exosc7 exosome component 7 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270 		JBrowse link
G Exosc8 exosome component 8 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928 		JBrowse link
G Exosc9 exosome component 9 NOT|enables ISO (PMID:17174896) RGD PMID:17174896 NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051 		JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A enables ISS
ISO		 GO_REF:0000024
(PMID:19322177)
(MGI:3842851|PMID:19322177)		 UniProt
RGD		 PMID:19322177 GO_REF:0000024 MGI:3842851 NCBI chr 5:137,376,562...137,385,351
Ensembl chr 5:137,376,564...137,385,351 		JBrowse link
3'-5'-RNA exonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angel1 angel homolog 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:106,349,125...106,386,202
Ensembl chr 6:106,349,126...106,386,209 		JBrowse link
G Angel2 angel homolog 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:102,509,111...102,529,501
Ensembl chr13:102,510,589...102,529,493 		JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 enables ISO (PMID:15769875) RGD PMID:15769875 NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576 		JBrowse link
G Cnot8 CCR4-NOT transcription complex, subunit 8 enables ISO (PMID:15769875) RGD PMID:15769875 NCBI chr10:42,281,614...42,294,740
Ensembl chr10:42,281,722...42,294,730 		JBrowse link
G Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease enables ISO
IBA		 (PMID:20531386)
GO_REF:0000033		 RGD
GO_Central		 PMID:20531386 GO_REF:0000033 NCBI chr15:75,820,040...75,850,450
Ensembl chr15:75,823,436...75,850,642 		JBrowse link
G Dis3l DIS3-like exosome 3'-5' exoribonuclease enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:20531386), (PMID:20531389)		 UniProt
GO_Central
RGD		 PMID:20531386 PMID:20531389 GO_REF:0000024 GO_REF:0000033 NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165 		JBrowse link
G Dis3l2 DIS3-like 3'-5' exoribonuclease 2 enables ISO
IBA		 (PMID:23756462), (PMID:24141620)
GO_REF:0000033
(MGI:5494337|PMID:23594738), (MGI:5603455|PMID:25119025)		 RGD
GO_Central		 PMID:23594738 PMID:23756462 PMID:24141620 PMID:25119025 GO_REF:0000033 MGI:5494337 MGI:5603455 NCBI chr 9:87,355,409...87,736,616
Ensembl chr 9:87,356,457...87,736,616 		JBrowse link
G Eri1 exoribonuclease 1 enables IEA
IBA		 GO_REF:0000002
GO_REF:0000033		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr16:56,724,101...56,744,228
Ensembl chr16:56,724,115...56,744,226 		JBrowse link
G Eri2 ERI1 exoribonuclease family member 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:174,140,831...174,168,757
Ensembl chr 1:174,141,993...174,168,665 		JBrowse link
G Eri3 ERI1 exoribonuclease family member 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:131,016,146...131,143,347
Ensembl chr 5:131,016,126...131,143,329 		JBrowse link
G Exd2 exonuclease 3'-5' domain containing 2 enables ISO (PMID:31127291) RGD PMID:31127291 NCBI chr 6:100,116,867...100,150,452
Ensembl chr 6:100,116,867...100,150,442 		JBrowse link
G Exosc10 exosome component 10 enables ISO
IBA
IEA		 (PMID:26950371)
GO_REF:0000033
GO_REF:0000002		 RGD
GO_Central
InterPro		 PMID:26950371 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:158,995,313...159,018,940
Ensembl chr 5:158,995,313...159,018,940 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 enables ISO (PMID:11401564) RGD PMID:11401564 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027 		JBrowse link
G Isg20l1 interferon stimulated exonuclease gene 20 like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:93,692,674...93,701,377
Ensembl chr 1:93,693,837...93,694,943 		JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:173,396,780...173,407,102
Ensembl chr 2:173,396,780...173,406,614 		JBrowse link
G Isg20l3 interferon stimulated exonuclease gene 20 like 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:86,932,181...86,933,542
Ensembl chr  X:86,932,382...86,933,455 		JBrowse link
G Noct nocturnin enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400 		JBrowse link
G Pan2 poly(A) specific ribonuclease subunit PAN2 enables ISO
ISS		 (PMID:14583602)
GO_REF:0000024		 RGD
UniProt		 PMID:14583602 GO_REF:0000024 NCBI chr 7:729,146...747,744
Ensembl chr 7:729,562...747,744 		JBrowse link
G Parn poly(A)-specific ribonuclease enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:1,410,636...1,548,573
Ensembl chr10:1,410,642...1,548,560 		JBrowse link
G Pde12 phosphodiesterase 12 enables ISO
IBA		 (PMID:21245038), (PMID:21666256)
GO_REF:0000033		 RGD
GO_Central		 PMID:21245038 PMID:21666256 GO_REF:0000033 NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887 		JBrowse link
G Pnldc1 PARN like ribonuclease domain containing exonuclease 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:47,843,224...47,861,675
Ensembl chr 1:47,843,224...47,861,674 		JBrowse link
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 enables ISO
IBA		 (PMID:19509288)
GO_REF:0000033		 RGD
GO_Central		 PMID:19509288 GO_REF:0000033 NCBI chr14:102,877,553...102,908,696
Ensembl chr14:102,877,553...102,908,696 		JBrowse link
G Polrmt RNA polymerase mitochondrial enables ISO (PMID:35449456) RGD PMID:35449456 NCBI chr 7:9,959,532...9,969,791
Ensembl chr 7:9,959,576...9,969,791 		JBrowse link
G Rexo2 RNA exonuclease 2 enables ISO
IBA
IEA		 (PMID:30926754), (PMID:31588022), (PMID:32365187)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107		 RGD
GO_Central
InterPro
Ensembl		 PMID:30926754 PMID:31588022 PMID:32365187 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:48,811,900...48,823,622
Ensembl chr 8:48,811,900...48,823,622 		JBrowse link
G Toe1 target of EGR1, exonuclease enables ISO
IBA		 (PMID:17178830)
GO_REF:0000033		 RGD
GO_Central		 PMID:17178830 GO_REF:0000033 NCBI chr 5:130,270,484...130,274,050
Ensembl chr 5:130,262,319...130,274,050 		JBrowse link
G Usb1 U6 snRNA biogenesis phosphodiesterase 1 enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:23190533), (PMID:30215753)		 UniProt
GO_Central
RGD		 PMID:23190533 PMID:30215753 GO_REF:0000024 GO_REF:0000033 NCBI chr19:9,689,313...9,702,306
Ensembl chr19:9,689,316...9,702,302 		JBrowse link
G Xrn2 5'-3' exoribonuclease 2 enables ISO (PMID:23482395) RGD PMID:23482395 NCBI chr 3:134,436,916...134,509,308
Ensembl chr 3:134,437,109...134,509,306 		JBrowse link
5'-3' RNA exonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpsf3 cleavage and polyadenylation specific factor 3 enables ISO
IBA		 (MGI:4418605|PMID:18955505)
(PMID:18955505)
GO_REF:0000033		 RGD
GO_Central		 PMID:18955505 GO_REF:0000033 MGI:4418605 NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128 		JBrowse link
G Dcp2 decapping mRNA 2 enables ISO (PMID:26950371) RGD PMID:26950371 NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557 		JBrowse link
G Xrn1 5'-3' exoribonuclease 1 enables ISO
IBA		 (PMID:26950371)
(PMID:9049243)
GO_REF:0000033
(MGI:86601|PMID:9049243)		 RGD
GO_Central		 PMID:9049243 PMID:26950371 GO_REF:0000033 MGI:86601 NCBI chr 8:96,527,871...96,637,385
Ensembl chr 8:96,528,195...96,632,739 		JBrowse link
G Xrn2 5'-3' exoribonuclease 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:134,436,916...134,509,308
Ensembl chr 3:134,437,109...134,509,306 		JBrowse link
exoribonuclease II activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dis3l DIS3-like exosome 3'-5' exoribonuclease enables ISS
ISO		 GO_REF:0000024
(PMID:37602378)		 UniProt
RGD		 PMID:37602378 GO_REF:0000024 NCBI chr 8:64,803,925...64,840,306
Ensembl chr 8:64,803,927...64,840,165 		JBrowse link
G Helz2 helicase with zinc finger 2 enables ISO (PMID:37602378) RGD PMID:37602378 NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159 		JBrowse link
poly(A)-specific ribonuclease activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnot1 CCR4-NOT transcription complex, subunit 1 contributes_to ISO (PMID:21976065) RGD PMID:21976065 NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574 		JBrowse link
G Cnot2 CCR4-NOT transcription complex, subunit 2 contributes_to ISO (PMID:21299754) RGD PMID:21299754 NCBI chr 7:52,130,445...52,222,338
Ensembl chr 7:52,130,441...52,223,575 		JBrowse link
G Cnot6 CCR4-NOT transcription complex, subunit 6 enables IEA
IBA
ISS
ISO		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000024
(PMID:11889047), (PMID:18377426)		 UniProt
GO_Central
RGD		 PMID:11889047 PMID:18377426 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 NCBI chr10:33,978,785...34,031,025
Ensembl chr10:33,980,831...34,031,025 		JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like enables IBA
ISO		 GO_REF:0000033
(PMID:17452450)		 GO_Central
RGD		 PMID:17452450 GO_REF:0000033 NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203 		JBrowse link
G Cnot7 CCR4-NOT transcription complex, subunit 7 enables ISO
IBA		 (PMID:15769875), (PMID:19276069), (PMID:21336257), (PMID:31439799)
(PMID:18625844)
GO_REF:0000033		 RGD
GO_Central		 PMID:15769875 PMID:18625844 PMID:19276069 PMID:21336257 PMID:31439799 GO_REF:0000033 NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576 		JBrowse link
G Cnot8 CCR4-NOT transcription complex, subunit 8 enables ISO
IBA		 (PMID:15769875)
GO_REF:0000033		 RGD
GO_Central		 PMID:15769875 GO_REF:0000033 NCBI chr10:42,281,614...42,294,740
Ensembl chr10:42,281,722...42,294,730 		JBrowse link
G ENSRNOG00000068058 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr16:17,898,135...17,898,773 JBrowse link
G Noct nocturnin enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:17400819), (PMID:22073225)
GO_REF:0000002
(MGI:5308514|PMID:22073225), (MGI:5567912|PMID:17400819)		 UniProt
RGD
InterPro		 PMID:17400819 PMID:22073225 GO_REF:0000002 GO_REF:0000024 MGI:5308514 MGI:5567912 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400 		JBrowse link
G Pan2 poly(A) specific ribonuclease subunit PAN2 enables
contributes_to		 IEA
ISO
ISS
IBA		 GO_REF:0000003
(PMID:14583602)
GO_REF:0000024
GO_REF:0000104
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:14583602 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr 7:729,146...747,744
Ensembl chr 7:729,562...747,744 		JBrowse link
G Pan3 poly(A) specific ribonuclease subunit PAN3 contributes_to ISO (PMID:14583602) RGD PMID:14583602 NCBI chr12:7,476,707...7,595,384
Ensembl chr12:7,476,697...7,599,204 		JBrowse link
G Parn poly(A)-specific ribonuclease enables ISO (PMID:25049417), (PMID:26482878), (PMID:26950371) RGD PMID:25049417 PMID:26482878 PMID:26950371 NCBI chr10:1,410,636...1,548,573
Ensembl chr10:1,410,642...1,548,560 		JBrowse link
G Pde12 phosphodiesterase 12 enables IEA
ISO		 GO_REF:0000107
(PMID:15231837)		 Ensembl
RGD		 PMID:15231837 GO_REF:0000107 NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887 		JBrowse link
G Pnldc1 PARN like ribonuclease domain containing exonuclease 1 enables ISO (PMID:27515512)
(MGI:5825409|PMID:27515512)		 RGD PMID:27515512 MGI:5825409 NCBI chr 1:47,843,224...47,861,675
Ensembl chr 1:47,843,224...47,861,674 		JBrowse link
G Toe1 target of EGR1, exonuclease enables ISO (PMID:17178830) RGD PMID:17178830 NCBI chr 5:130,270,484...130,274,050
Ensembl chr 5:130,262,319...130,274,050 		JBrowse link
poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Usb1 U6 snRNA biogenesis phosphodiesterase 1 enables ISO
ISS		 (PMID:23022480), (PMID:23190533), (PMID:26213367), (PMID:28887445), (PMID:31832688)
GO_REF:0000024		 RGD
UniProt		 PMID:23022480 PMID:23190533 PMID:26213367 PMID:28887445 PMID:31832688 GO_REF:0000024 NCBI chr19:9,689,313...9,702,306
Ensembl chr19:9,689,316...9,702,302 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      catalytic activity, acting on a nucleic acid 633
        catalytic activity, acting on RNA 398
          RNA nuclease activity 138
            RNA exonuclease activity 47
              RNA exonuclease activity, producing 5'-phosphomonoesters + 37
Path 2
Term Annotations click to browse term
  molecular_function 20736
    catalytic activity 6109
      hydrolase activity 2583
        hydrolase activity, acting on ester bonds 813
          nuclease activity 229
            exonuclease activity 94
              RNA exonuclease activity 47
                RNA exonuclease activity, producing 5'-phosphomonoesters + 37
paths to the root