PAN3 (poly(A) specific ribonuclease subunit PAN3) - Rat Genome Database

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Gene: PAN3 (poly(A) specific ribonuclease subunit PAN3) Pan paniscus
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Symbol: PAN3
Name: poly(A) specific ribonuclease subunit PAN3
RGD ID: 11707837
Description: ENCODES a protein that exhibits poly(A)-specific ribonuclease activity (ortholog); INVOLVED IN deadenylation-dependent decapping of nuclear-transcribed mRNA (ortholog); positive regulation of cytoplasmic mRNA processing body assembly (ortholog); protein targeting (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (inferred); P-body (inferred); PAN complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: PAB-dependent poly(A)-specific ribonuclease subunit PAN3; PAN2-PAN3 deadenylation complex subunit PAN3; PAN3 poly(A) specific ribonuclease subunit; PAN3 poly(A) specific ribonuclease subunit homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,723,636 - 27,886,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,827,987 - 18,990,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,420,405 - 9,579,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,797,325 - 27,921,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1327,798,607 - 27,921,266 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
P-body  (IEA)
PAN complex  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PAN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,723,636 - 27,886,390 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,827,987 - 18,990,992 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,420,405 - 9,579,859 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,797,325 - 27,921,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1327,798,607 - 27,921,266 (+)Ensemblpanpan1.1panPan2
PAN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381328,138,193 - 28,295,335 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1328,138,506 - 28,295,335 (+)EnsemblGRCh38hg38GRCh38
GRCh371328,712,682 - 28,869,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,646,417 - 27,767,472 (+)NCBINCBI36Build 36hg18NCBI36
Celera139,787,744 - 9,944,258 (+)NCBICelera
Cytogenetic Map13q12.2NCBI
HuRef139,533,856 - 9,690,407 (+)NCBIHuRef
CHM1_11328,681,211 - 28,837,730 (+)NCBICHM1_1
T2T-CHM13v2.01327,361,098 - 27,517,568 (+)NCBIT2T-CHM13v2.0
Pan3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,363,018 - 147,485,310 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,366,971 - 147,485,312 (+)EnsemblGRCm39 Ensembl
GRCm385147,426,208 - 147,548,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,430,161 - 147,548,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv375148,242,156 - 148,360,077 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,741,238 - 147,858,845 (+)NCBIMGSCv36mm8
Celera5145,424,005 - 145,541,898 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map586.93NCBI
Pan3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,512,835 - 12,637,066 (-)NCBIGRCr8
mRatBN7.2127,476,707 - 7,595,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,476,697 - 7,599,204 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0129,214,116 - 9,331,901 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,216,536 - 9,331,195 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01211,333,266 - 11,449,831 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4128,046,162 - 8,165,081 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera129,218,136 - 9,336,110 (-)NCBICelera
Cytogenetic Map12p11NCBI
Pan3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,500,748 - 7,647,255 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,500,478 - 7,646,541 (+)NCBIChiLan1.0ChiLan1.0
PAN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,416,321 - 11,550,830 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,417,657 - 11,550,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,479,225 - 11,613,731 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,544,373 - 11,678,148 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2511,545,635 - 11,678,130 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12511,440,197 - 11,574,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,432,789 - 11,566,165 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,474,666 - 11,609,590 (-)NCBIUU_Cfam_GSD_1.0
Pan3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,518,051 - 172,654,798 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647223,297,847 - 23,431,982 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647223,297,679 - 23,434,107 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,487,138 - 5,614,452 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,487,019 - 5,614,458 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,173,907 - 5,301,062 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,249,596 - 7,405,770 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl37,249,298 - 7,405,910 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605736,983,767 - 37,141,534 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pan3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,227,308 - 10,364,522 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,224,772 - 10,364,816 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000031856   ⟹   ENSPPAP00000009216
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1327,798,607 - 27,921,266 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000031858   ⟹   ENSPPAP00000009218
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1327,798,607 - 27,921,266 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000031860   ⟹   ENSPPAP00000009220
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1327,798,623 - 27,918,465 (+)Ensembl
RefSeq Acc Id: XM_034936497   ⟹   XP_034792388
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,723,659 - 27,886,390 (+)NCBI
NHGRI_mPanPan11318,829,526 - 18,990,992 (+)NCBI
Mhudiblu_PPA_v0139,421,346 - 9,579,859 (+)NCBI
RefSeq Acc Id: XM_034936498   ⟹   XP_034792389
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,723,658 - 27,886,390 (+)NCBI
NHGRI_mPanPan11318,829,525 - 18,990,992 (+)NCBI
Mhudiblu_PPA_v0139,420,405 - 9,579,859 (+)NCBI
RefSeq Acc Id: XM_034936499   ⟹   XP_034792390
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,723,658 - 27,886,390 (+)NCBI
NHGRI_mPanPan11318,829,525 - 18,990,992 (+)NCBI
Mhudiblu_PPA_v0139,420,405 - 9,579,859 (+)NCBI
RefSeq Acc Id: XM_034936500   ⟹   XP_034792391
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,723,661 - 27,886,390 (+)NCBI
NHGRI_mPanPan11318,829,527 - 18,990,992 (+)NCBI
Mhudiblu_PPA_v0139,421,495 - 9,577,737 (+)NCBI
RefSeq Acc Id: XM_034936501   ⟹   XP_034792392
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,728,009 - 27,886,390 (+)NCBI
NHGRI_mPanPan11318,832,701 - 18,990,992 (+)NCBI
Mhudiblu_PPA_v0139,421,565 - 9,577,737 (+)NCBI
RefSeq Acc Id: XM_034936502   ⟹   XP_034792393
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,723,636 - 27,871,497 (+)NCBI
NHGRI_mPanPan11318,827,987 - 18,976,092 (+)NCBI
Mhudiblu_PPA_v0139,421,346 - 9,564,084 (+)NCBI
RefSeq Acc Id: XM_063595692   ⟹   XP_063451762
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,723,660 - 27,886,390 (+)NCBI
RefSeq Acc Id: XP_034792389   ⟸   XM_034936498
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034792390   ⟸   XM_034936499
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034792388   ⟸   XM_034936497
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034792393   ⟸   XM_034936502
- Peptide Label: isoform X7
RefSeq Acc Id: XP_034792391   ⟸   XM_034936500
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034792392   ⟸   XM_034936501
- Peptide Label: isoform X6
- UniProtKB: A0A2R8ZXC7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000009220   ⟸   ENSPPAT00000031860
RefSeq Acc Id: ENSPPAP00000009218   ⟸   ENSPPAT00000031858
RefSeq Acc Id: ENSPPAP00000009216   ⟸   ENSPPAT00000031856
RefSeq Acc Id: XP_063451762   ⟸   XM_063595692
- Peptide Label: isoform X5
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027826 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000031856.1 UniProtKB/TrEMBL
  ENSPPAT00000031858.1 UniProtKB/TrEMBL
  ENSPPAT00000031860.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.3700 UniProtKB/TrEMBL
  1.20.5.5160 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PAN3 UniProtKB/TrEMBL
  Pan3_PK UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
NCBI Gene PAN3 ENTREZGENE
PANTHER PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3 UniProtKB/TrEMBL
  PTHR12272 UniProtKB/TrEMBL
Pfam Pan3_PK UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R8ZW87_PANPA UniProtKB/TrEMBL
  A0A2R8ZXC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A1T8_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 PAN3  poly(A) specific ribonuclease subunit PAN3    PAN3 poly(A) specific ribonuclease subunit  Symbol and/or name change 5135510 APPROVED