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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of spindle checkpoint
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Accession:GO:0090231 term browser browse the term
Definition:Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) UniProt PMID:19010891 NCBI chr 3:1,236,066...1,559,346
Ensembl chr 3:1,236,076...1,559,041 		JBrowse link
G MAD2L1BP MAD2L1 binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,613,349...38,623,845
Ensembl chr 7:38,613,440...38,623,832 		JBrowse link
G PRAP1 proline rich acidic protein 1 involved_in ISO (PMID:24374861) UniProt PMID:24374861 NCBI chr14:141,325,965...141,329,955 JBrowse link
negative regulation of mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SKA1 spindle and kinetochore associated complex subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:99,976,354...99,993,492
Ensembl chr 1:99,976,485...99,993,462 		JBrowse link
G SKA3 spindle and kinetochore associated complex subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:1,302,880...1,321,132
Ensembl chr11:1,302,886...1,320,981 		JBrowse link
positive regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNL1 kinetochore scaffold 1 involved_in ISO (PMID:35167144) UniProt PMID:35167144 NCBI chr 1:130,652,493...130,728,989 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:18,507,710...18,558,057
Ensembl chr13:18,506,194...18,558,007 		JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:120,067,792...120,097,305
Ensembl chr 3:120,065,973...120,097,056 		JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:1,236,066...1,559,346
Ensembl chr 3:1,236,076...1,559,041 		JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:103,927,358...103,936,669
Ensembl chr 8:103,927,353...103,936,664 		JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:104,000,794...104,055,785
Ensembl chr 6:103,999,034...104,055,760 		JBrowse link
G PCID2 PCI domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,541,278...78,556,784
Ensembl chr11:78,541,318...78,556,733 		JBrowse link
G TPR translocated promoter region, nuclear basket protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:127,481,678...127,540,393
Ensembl chr 9:127,481,684...127,540,398 		JBrowse link
G XRCC3 X-ray repair cross complementing 3 involved_in IEA Ensembl GO_REF:0000107
regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZWINT ZW10 interacting kinetochore protein involved_in ISO (PMID:26486467) UniProt PMID:26486467 NCBI chr14:94,094,781...94,109,447
Ensembl chr14:94,094,894...94,102,060 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 involved_in IEA
IBA		 InterPro
Ensembl
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:6,685,934...6,689,913
Ensembl chr 9:6,685,939...6,689,256 		JBrowse link
G CCNB1 cyclin B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377 		JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:260,465,809...260,648,070
Ensembl chr 1:260,466,942...260,648,161 		JBrowse link
G KNL1 kinetochore scaffold 1 involved_in ISO (PMID:19893618) UniProt PMID:19893618 NCBI chr 1:130,652,493...130,728,989 JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:17724024) MGI
GO_Central		 PMID:17724024 GO_REF:0000033 NCBI chr 3:21,548,349...21,593,667 JBrowse link
G LOC100520426 leucine carboxyl methyltransferase 1 involved_in IBA GO_Central GO_REF:0000033
G LOC100625764 leucine carboxyl methyltransferase 1-like involved_in IBA GO_Central GO_REF:0000033
G LOC100626661 leucine carboxyl methyltransferase 1 involved_in IBA GO_Central GO_REF:0000033
G LOC110255302 leucine carboxyl methyltransferase 1-like involved_in IBA GO_Central GO_REF:0000033
G LOC110258596 leucine carboxyl methyltransferase 1-like involved_in IBA GO_Central GO_REF:0000033
G PRP4K pre-mRNA processing factor kinase PRP4K involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:2,382,498...2,417,085
Ensembl chr 7:2,382,495...2,412,908 		JBrowse link
G USP44 ubiquitin specific peptidase 44 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:87,864,410...87,890,913
Ensembl chr 5:87,875,851...87,889,680 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17876
    cellular process 17418
      signal transduction 6990
        intracellular signal transduction 3030
          cell cycle checkpoint signaling 178
            spindle checkpoint signaling 49
              regulation of spindle checkpoint 25
                negative regulation of spindle checkpoint + 5
                positive regulation of spindle checkpoint + 9
                regulation of meiosis I spindle assembly checkpoint + 2
                regulation of mitotic spindle checkpoint + 24
Path 2
Term Annotations click to browse term
  biological_process 17876
    biological regulation 12990
      regulation of biological process 12608
        regulation of cellular process 12270
          regulation of cell cycle 1053
            regulation of cell cycle process 744
              negative regulation of cell cycle process 309
                negative regulation of cell cycle phase transition 259
                  cell cycle checkpoint signaling 178
                    spindle checkpoint signaling 49
                      regulation of spindle checkpoint 25
                        negative regulation of spindle checkpoint + 5
                        positive regulation of spindle checkpoint + 9
                        regulation of meiosis I spindle assembly checkpoint + 2
                        regulation of mitotic spindle checkpoint + 24
paths to the root