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ONTOLOGY REPORT - ANNOTATIONS

Term:protein K48-linked deubiquitination
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Accession:GO:0071108 term browser browse the term
Definition:A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.


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protein K48-linked deubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC004691.2 novel protein, MINDY4 and AQP1 readthrough involved_in IEA InterPro GO_REF:0000002 Ensembl chr 7:30,852,273...30,923,812 JBrowse link
G ATXN3 ataxin 3 involved_in IDA (PMID:22970133) ParkinsonsUK-UCL PMID:22970133 NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621 		JBrowse link
G BAP1 BRCA1 associated protein 1 involved_in IMP (PMID:19188440) UniProt PMID:19188440 NCBI chr 3:52,401,008...52,410,008
Ensembl chr 3:52,401,008...52,410,008 		JBrowse link
G MINDY1 MINDY lysine 48 deubiquitinase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:150,996,536...151,008,393
Ensembl chr 1:150,996,549...151,008,376 		JBrowse link
G MINDY2 MINDY lysine 48 deubiquitinase 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr15:58,771,302...58,861,900
Ensembl chr15:58,771,192...58,861,900 		JBrowse link
G MINDY3 MINDY lysine 48 deubiquitinase 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr10:15,778,174...15,860,507
Ensembl chr10:15,778,170...15,860,507 		JBrowse link
G MINDY4 MINDY lysine 48 deubiquitinase 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:30,771,417...30,892,387
Ensembl chr 7:30,771,417...30,892,387 		JBrowse link
G MINDY4B MINDY family member 4B involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:150,870,376...150,905,439
Ensembl chr 3:150,870,376...150,905,439 		JBrowse link
G OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 involved_in IDA
IEA
IBA		 (PMID:18954305), (PMID:19211026), (PMID:23827681) UniProt
TreeGrafter
GO_Central		 PMID:18954305 PMID:19211026 PMID:23827681 GO_REF:0000033 GO_REF:0000118 NCBI chr11:63,986,438...63,998,412
Ensembl chr11:63,985,853...64,001,811 		JBrowse link
G OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 involved_in IDA
IBA		 (PMID:18954305), (PMID:23827681) UniProt
GO_Central		 PMID:18954305 PMID:23827681 GO_REF:0000033 NCBI chr14:94,026,340...94,048,930
Ensembl chr14:94,026,340...94,048,930 		JBrowse link
G OTUD3 OTU deubiquitinase 3 acts_upstream_of_or_within
involved_in		 IDA
IBA		 (PMID:26280536)
(PMID:35675826)		 MGI
UniProt
GO_Central		 PMID:26280536 PMID:35675826 GO_REF:0000033 NCBI chr 1:19,882,395...19,912,945
Ensembl chr 1:19,882,395...19,912,945 		JBrowse link
G OTUD4 OTU deubiquitinase 4 involved_in IDA (PMID:23827681) UniProt PMID:23827681 NCBI chr 4:145,133,650...145,180,589
Ensembl chr 4:145,110,838...145,180,589 		JBrowse link
G OTUD5 OTU deubiquitinase 5 involved_in IMP
IDA		 (PMID:33523931)
(PMID:22245969), (PMID:23827681)		 UniProt PMID:22245969 PMID:23827681 PMID:33523931 NCBI chr  X:48,922,024...48,958,381
Ensembl chr  X:48,922,024...48,958,386 		JBrowse link
G OTUD7A OTU deubiquitinase 7A involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:31,475,398...31,870,673
Ensembl chr15:31,475,398...31,870,789 		JBrowse link
G OTUD7B OTU deubiquitinase 7B involved_in IDA
IBA
ISS		 (PMID:21097510) ParkinsonsUK-UCL
GO_Central
UniProt		 PMID:21097510 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:149,937,812...150,067,653
Ensembl chr 1:149,937,812...150,010,726 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IDA (PMID:23827681) UniProt PMID:23827681 NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314 		JBrowse link
G USP14 ubiquitin specific peptidase 14 involved_in IMP (PMID:18162577) UniProt PMID:18162577 NCBI chr18:158,557...214,629
Ensembl chr18:158,383...214,629 		JBrowse link
G USP17L2 ubiquitin specific peptidase 17 like family member 2 involved_in IMP (PMID:19188362), (PMID:20368735) UniProt PMID:19188362 PMID:20368735 NCBI chr 8:12,136,435...12,138,849
Ensembl chr 8:12,136,435...12,138,849 		JBrowse link
G USP19 ubiquitin specific peptidase 19 involved_in ISO (MGI:5614537|PMID:25088257) ParkinsonsUK-UCL PMID:25088257 MGI:5614537 NCBI chr 3:49,108,050...49,120,823
Ensembl chr 3:49,108,046...49,120,938 		JBrowse link
G USP20 ubiquitin specific peptidase 20 involved_in IDA (PMID:19424180) UniProt PMID:19424180 NCBI chr 9:129,835,458...129,881,828
Ensembl chr 9:129,834,698...129,881,828 		JBrowse link
G USP25 ubiquitin specific peptidase 25 involved_in IMP (PMID:18538659) UniProt PMID:18538659 NCBI chr21:15,729,982...15,880,064
Ensembl chr21:15,729,982...15,880,064 		JBrowse link
G USP27X ubiquitin specific peptidase 27 X-linked involved_in ISS
IDA		 (PMID:31534008) UniProt PMID:31534008 GO_REF:0000024 NCBI chr  X:49,879,484...49,882,558
Ensembl chr  X:49,879,484...49,882,558 		JBrowse link
G USP29 ubiquitin specific peptidase 29 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:57,119,087...57,131,926
Ensembl chr19:57,119,138...57,131,926 		JBrowse link
G USP33 ubiquitin specific peptidase 33 involved_in IDA (PMID:19363159) UniProt PMID:19363159 NCBI chr 1:77,695,987...77,759,852
Ensembl chr 1:77,695,987...77,759,852 		JBrowse link
G USP34 ubiquitin specific peptidase 34 involved_in IDA (PMID:21383061) UniProt PMID:21383061 NCBI chr 2:61,187,463...61,471,087
Ensembl chr 2:61,187,463...61,471,087 		JBrowse link
G USP37 ubiquitin specific peptidase 37 involved_in IDA (PMID:21596315) UniProt PMID:21596315 NCBI chr 2:218,450,251...218,568,351
Ensembl chr 2:218,450,251...218,568,351 		JBrowse link
G USP5 ubiquitin specific peptidase 5 involved_in IMP (PMID:19098288) UniProt PMID:19098288 NCBI chr12:6,852,150...6,866,632
Ensembl chr12:6,852,148...6,866,632 		JBrowse link
G USP50 ubiquitin specific peptidase 50 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:50,493,025...50,546,666
Ensembl chr15:50,494,018...50,546,708 		JBrowse link
G USP8 ubiquitin specific peptidase 8 involved_in IDA
IBA
IEA		 (PMID:16520378) UniProt
GO_Central
TreeGrafter		 PMID:16520378 GO_REF:0000033 GO_REF:0000118 NCBI chr15:50,424,405...50,514,421
Ensembl chr15:50,424,380...50,514,421 		JBrowse link
G VCPIP1 valosin containing protein interacting protein 1 involved_in IDA
IBA		 (PMID:23827681) UniProt
GO_Central		 PMID:23827681 GO_REF:0000033 NCBI chr 8:66,628,487...66,667,231
Ensembl chr 8:66,628,487...66,667,231 		JBrowse link
G YOD1 YOD1 deubiquitinase involved_in IDA
IMP		 (PMID:19818707), (PMID:21376232)
(PMID:24068323), (PMID:27753622)		 ParkinsonsUK-UCL
UniProt		 PMID:19818707 PMID:21376232 PMID:24068323 PMID:27753622 NCBI chr 1:207,043,849...207,053,116
Ensembl chr 1:207,043,849...207,052,980 		JBrowse link
negative regulation of protein K48-linked deubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IDA (PMID:21097510) ParkinsonsUK-UCL PMID:21097510 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505 		JBrowse link
G UBXN1 UBX domain protein 1 involved_in IDA
IBA		 (PMID:21135095) ParkinsonsUK-UCL
GO_Central		 PMID:21135095 GO_REF:0000033 NCBI chr11:62,676,500...62,679,073
Ensembl chr11:62,676,498...62,679,117 		JBrowse link
regulation of protein K48-linked deubiquitination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OTUD4 OTU deubiquitinase 4 involved_in IDA
IBA		 (PMID:25944111) UniProt
GO_Central		 PMID:25944111 GO_REF:0000033 NCBI chr 4:145,133,650...145,180,589
Ensembl chr 4:145,110,838...145,180,589 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 19654
    metabolic process 12453
      macromolecule metabolic process 10235
        protein metabolic process 4401
          protein modification process 2226
            post-translational protein modification 1047
              protein modification by small protein conjugation or removal 1006
                protein modification by small protein removal 154
                  protein deubiquitination 135
                    protein K48-linked deubiquitination 33
                      negative regulation of protein K48-linked deubiquitination 2
                      regulation of protein K48-linked deubiquitination + 3
paths to the root