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Gene: USP8 (ubiquitin specific peptidase 8) Homo sapiens

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Symbol:

USP8

Name:

ubiquitin specific peptidase 8

RGD ID:

1312730

HGNC Page

HGNC:12631

Description:

Enables K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; protein deubiquitination; and regulation of protein metabolic process. Acts upstream of or within mitotic cytokinesis and protein deubiquitination. Located in early endosome and midbody. Is active in cytosol. Implicated in ACTH-secreting pituitary adenoma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

deubiquitinating enzyme 8; FLJ34456; hUBPy; HumORF8; KIAA0055; MGC129718; PITA4; SPG59; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; ubiquitin specific protease 8; ubiquitin thioesterase 8; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; UBPY

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Usp8 (ubiquitin specific peptidase 8)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Usp8 (ubiquitin specific peptidase 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Usp8 (ubiquitin specific peptidase 8)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	USP8 (ubiquitin specific peptidase 8)	NCBI	Ortholog
Canis lupus familiaris (dog):	USP8 (ubiquitin specific peptidase 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Usp8 (ubiquitin specific peptidase 8)	NCBI	Ortholog
Sus scrofa (pig):	USP8 (ubiquitin specific peptidase 8)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	USP8 (ubiquitin specific peptidase 8)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Usp8 (ubiquitin specific peptidase 8)	NCBI	Ortholog
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Usp8 (ubiquitin specific peptidase 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Usp8 (ubiquitin specific peptidase 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	usp8 (ubiquitin specific peptidase 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	DOA4	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	usp-50	Alliance	DIOPT (OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	UBP5	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Usp8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus laevis (African clawed frog):	usp8.S	Alliance	DIOPT (Xenbase)
Xenopus tropicalis (tropical clawed frog):	usp8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus laevis (African clawed frog):	usp8.L	Alliance	DIOPT (Xenbase)

Related Pseudogenes:

USP8P1 USP8P2

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	50,424,405 - 50,514,421 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	50,424,380 - 50,514,421 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	50,716,602 - 50,806,618 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	48,503,871 - 48,579,265 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	48,503,870 - 48,579,263	NCBI
Celera	15	27,609,144 - 27,685,855 (+)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	27,547,372 - 27,623,683 (+)	NCBI		HuRef
CHM1_1	15	50,834,671 - 50,911,286 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	48,232,513 - 48,322,500 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	ACTH-secreting pituitary adenoma		IAGP	(Homo sapiens) and (Homo sapiens)	8554872	ClinVar Annotator: match by term: USP8-related condition	ClinVar	PMID:25741868 and PMID:28492532
USP8	Human	ACTH-secreting pituitary adenoma		IAGP	(Homo sapiens) more ...	8554872	ClinVar Annotator: match by term: USP8-related condition	ClinVar	PMID:28492532
USP8	Human	Bloom syndrome		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Bloom syndrome	ClinVar	PMID:28492532
USP8	Human	colorectal cancer		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Familial colorectal cancer	ClinVar	PMID:28492532
USP8	Human	hereditary spastic paraplegia		IAGP	(Homo sapiens) and (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hereditary spastic paraplegia	ClinVar	PMID:17576681 more ...
USP8	Human	hereditary spastic paraplegia		IAGP	(Homo sapiens) more ...	8554872	ClinVar more ...	ClinVar	PMID:28492532
USP8	Human	hereditary spastic paraplegia		IAGP	(Homo sapiens) more ...	8554872	ClinVar Annotator: match by term: Hereditary spastic paraplegia	ClinVar	PMID:25741868 and PMID:28492532
USP8	Human	hereditary spastic paraplegia 59		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Autosomal recessive spastic paraplegia type 59	ClinVar	PMID:25741868 and PMID:28492532
USP8	Human	pituitary-dependent Cushing's disease		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Pituitary dependent hypercortisolism	ClinVar
USP8	Human	pituitary-dependent Cushing's disease		IAGP	(Homo sapiens) and (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pituitary dependent hypercortisolism	ClinVar	PMID:25675982 and PMID:25942478
USP8	Human	pituitary-dependent Cushing's disease		IAGP	(Homo sapiens)	8554872	ClinVar Annotator: match by term: Pituitary dependent hypercortisolism	ClinVar	PMID:25741868 and PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	ACTH-secreting pituitary adenoma		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25485838
USP8	Human	esophagus squamous cell carcinoma		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:35022897
USP8	Human	pituitary-dependent Cushing's disease		EXP		11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:25485838

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	ACTH-secreting pituitary adenoma		IAGP		7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	(+)-schisandrin B	multiple interactions	ISO	Usp8 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of USP8 mRNA]	CTD	PMID:31150632
USP8	Human	1,2-dimethylhydrazine	decreases expression	ISO	Usp8 (Mus musculus)	6480464	1 and 2-Dimethylhydrazine results in decreased expression of USP8 mRNA	CTD	PMID:22206623
USP8	Human	17alpha-ethynylestradiol	affects expression	ISO	Usp8 (Mus musculus)	6480464	Ethinyl Estradiol affects the expression of USP8 mRNA	CTD	PMID:17555576
USP8	Human	17beta-estradiol	decreases expression	ISO	Usp8 (Mus musculus)	6480464	Estradiol results in decreased expression of USP8 mRNA	CTD	PMID:39298647
USP8	Human	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	Usp8 (Mus musculus)	6480464	Tetrachlorodibenzodioxin affects the expression of USP8 mRNA	CTD	PMID:21570461
USP8	Human	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	Usp8 (Rattus norvegicus)	6480464	Tetrachlorodibenzodioxin results in increased expression of USP8 mRNA	CTD	PMID:34747641
USP8	Human	2,4,6-trinitrobenzenesulfonic acid	decreases expression	ISO	Usp8 (Rattus norvegicus)	6480464	Trinitrobenzenesulfonic Acid results in decreased expression of USP8 mRNA	CTD	PMID:23537331
USP8	Human	2-hydroxypropanoic acid	decreases expression	EXP		6480464	Lactic Acid results in decreased expression of USP8 mRNA	CTD	PMID:30851411
USP8	Human	3-chloropropane-1,2-diol	increases expression	ISO	Usp8 (Rattus norvegicus)	6480464	alpha-Chlorohydrin results in increased expression of USP8 protein	CTD	PMID:34915118
USP8	Human	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	EXP		6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP8 mRNA	CTD	PMID:28628672
USP8	Human	Aroclor 1254	decreases expression	ISO	Usp8 (Mus musculus)	6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of USP8 mRNA	CTD	PMID:23650126
USP8	Human	bafilomycin A1	multiple interactions	EXP		6480464	[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein] and bafilomycin A1 promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]	CTD	PMID:35022897
USP8	Human	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of USP8 mRNA	CTD	PMID:17879257
USP8	Human	bis(2-ethylhexyl) phthalate	decreases expression	ISO	Usp8 (Mus musculus)	6480464	Diethylhexyl Phthalate results in decreased expression of USP8 mRNA	CTD	PMID:33754040
USP8	Human	bisphenol A	increases expression	ISO	Usp8 (Rattus norvegicus)	6480464	bisphenol A results in increased expression of USP8 mRNA	CTD	PMID:25181051 more ...
USP8	Human	bisphenol A	decreases expression	ISO	Usp8 (Mus musculus)	6480464	bisphenol A results in decreased expression of USP8 mRNA	CTD	PMID:33221593
USP8	Human	bisphenol A	affects methylation	ISO	Usp8 (Mus musculus)	6480464	bisphenol A affects the methylation of USP8 promoter	CTD	PMID:27334623
USP8	Human	bisphenol F	multiple interactions	EXP		6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP8 mRNA	CTD	PMID:28628672
USP8	Human	caffeine	decreases phosphorylation	EXP		6480464	Caffeine results in decreased phosphorylation of USP8 protein	CTD	PMID:35688186
USP8	Human	chloroquine	multiple interactions	EXP		6480464	[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein] and Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]	CTD	PMID:35022897
USP8	Human	choline	multiple interactions	ISO	Usp8 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP8 gene	CTD	PMID:20938992
USP8	Human	coumarin	increases phosphorylation	EXP		6480464	coumarin results in increased phosphorylation of USP8 protein	CTD	PMID:35688186
USP8	Human	dexamethasone	multiple interactions	EXP		6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP8 mRNA	CTD	PMID:28628672
USP8	Human	Dibutyl phosphate	affects expression	EXP		6480464	di-n-butylphosphoric acid affects the expression of USP8 mRNA	CTD	PMID:37042841
USP8	Human	dicrotophos	decreases expression	EXP		6480464	dicrotophos results in decreased expression of USP8 mRNA	CTD	PMID:28302478
USP8	Human	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of USP8 mRNA	CTD	PMID:29803840
USP8	Human	ethanol	affects splicing	ISO	Usp8 (Mus musculus)	6480464	Ethanol affects the splicing of USP8 mRNA	CTD	PMID:30319688
USP8	Human	folic acid	multiple interactions	ISO	Usp8 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP8 gene	CTD	PMID:20938992
USP8	Human	FR900359	affects phosphorylation	EXP		6480464	FR900359 affects the phosphorylation of USP8 protein	CTD	PMID:37730182
USP8	Human	indometacin	multiple interactions	EXP		6480464	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of USP8 mRNA	CTD	PMID:28628672
USP8	Human	L-methionine	multiple interactions	ISO	Usp8 (Mus musculus)	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of USP8 gene	CTD	PMID:20938992
USP8	Human	methapyrilene	decreases expression	ISO	Usp8 (Rattus norvegicus)	6480464	Methapyrilene results in decreased expression of USP8 mRNA	CTD	PMID:30467583
USP8	Human	methyl methanesulfonate	increases expression	EXP		6480464	Methyl Methanesulfonate results in increased expression of USP8 mRNA	CTD	PMID:23649840
USP8	Human	nonanoic acid	increases expression	ISO	Usp8 (Mus musculus)	6480464	pelargonic acid results in increased expression of USP8 mRNA	CTD	PMID:11379042
USP8	Human	paracetamol	affects expression	ISO	Usp8 (Mus musculus)	6480464	Acetaminophen affects the expression of USP8 mRNA	CTD	PMID:17562736
USP8	Human	paracetamol	increases expression	ISO	Usp8 (Rattus norvegicus)	6480464	Acetaminophen results in increased expression of USP8 mRNA	CTD	PMID:33387578
USP8	Human	pifithrin-alpha hydrobromide	multiple interactions	EXP		6480464	pifithrin inhibits the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein] more ...	CTD	PMID:35022897
USP8	Human	rac-lactic acid	decreases expression	EXP		6480464	Lactic Acid results in decreased expression of USP8 mRNA	CTD	PMID:30851411
USP8	Human	raloxifene	decreases expression	ISO	Usp8 (Mus musculus)	6480464	Raloxifene Hydrochloride results in decreased expression of USP8 mRNA	CTD	PMID:33269387
USP8	Human	resveratrol	multiple interactions	EXP		6480464	[Plant Extracts co-treated with Resveratrol] results in increased expression of USP8 mRNA	CTD	PMID:23557933
USP8	Human	sodium arsenate	decreases expression	ISO	Usp8 (Mus musculus)	6480464	sodium arsenate results in decreased expression of USP8 mRNA	CTD	PMID:21795629
USP8	Human	sodium arsenate	increases expression	ISO	Usp8 (Mus musculus)	6480464	sodium arsenate results in increased expression of USP8 mRNA	CTD	PMID:21795629
USP8	Human	sodium arsenite	increases expression	EXP		6480464	sodium arsenite results in increased expression of USP8 mRNA	CTD	PMID:12016162 and PMID:38568856
USP8	Human	tamoxifen	affects expression	ISO	Usp8 (Mus musculus)	6480464	Tamoxifen affects the expression of USP8 mRNA	CTD	PMID:17555576
USP8	Human	tetrachloromethane	multiple interactions	ISO	Usp8 (Rattus norvegicus)	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of USP8 mRNA]	CTD	PMID:31150632
USP8	Human	tetrachloromethane	decreases expression	ISO	Usp8 (Rattus norvegicus)	6480464	Carbon Tetrachloride results in decreased expression of USP8 mRNA	CTD	PMID:31150632
USP8	Human	titanium dioxide	decreases methylation	ISO	Usp8 (Mus musculus)	6480464	titanium dioxide results in decreased methylation of USP8 gene	CTD	PMID:35295148
USP8	Human	toluene 2,4-diisocyanate	decreases expression	ISO	Usp8 (Mus musculus)	6480464	Toluene 2 and 4-Diisocyanate results in decreased expression of USP8 mRNA	CTD	PMID:11379042
USP8	Human	triptonide	decreases expression	ISO	Usp8 (Mus musculus)	6480464	triptonide results in decreased expression of USP8 mRNA	CTD	PMID:33045310
USP8	Human	tungsten	decreases expression	ISO	Usp8 (Mus musculus)	6480464	Tungsten results in decreased expression of USP8 mRNA	CTD	PMID:30912803
USP8	Human	valproic acid	affects expression	EXP		6480464	Valproic Acid affects the expression of USP8 mRNA	CTD	PMID:25979313

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	cellular response to dexamethasone stimulus		ISO	Usp8 (Rattus norvegicus)	9068941		RGD	PMID:19527720 and REF_RGD_ID:13208949
USP8	Human	cellular response to dexamethasone stimulus	involved_in	IEA	UniProtKB:A6HPZ0 more ...	150520179		Ensembl	GO_REF:0000107
USP8	Human	cellular response to nerve growth factor stimulus	involved_in	IEA	UniProtKB:A6HPZ0 more ...	150520179		Ensembl	GO_REF:0000107
USP8	Human	cellular response to nerve growth factor stimulus		ISO	Usp8 (Rattus norvegicus)	9068941		RGD	PMID:25662281 and REF_RGD_ID:11053004
USP8	Human	endosome organization	involved_in	IBA	MGI:1934029 and PANTHER:PTN008578257	150520179		GO_Central	GO_REF:0000033
USP8	Human	endosome organization	involved_in	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	mitotic cytokinesis	acts_upstream_of_or_within	IMP		150520179	PMID:18388320	MGI	PMID:18388320
USP8	Human	negative regulation of lysosomal protein catabolic process	involved_in	IMP		150520179	PMID:27444016	FlyBase	PMID:27444016
USP8	Human	positive regulation of amyloid fibril formation	involved_in	IMP		150520179	PMID:27444016	FlyBase	PMID:27444016
USP8	Human	positive regulation of canonical Wnt signaling pathway	involved_in	IMP		150520179	PMID:20495530	FlyBase	PMID:20495530
USP8	Human	protein deubiquitination	involved_in	IMP		150520179	PMID:27302062	UniProt	PMID:27302062
USP8	Human	protein deubiquitination	involved_in	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	protein deubiquitination	involved_in	IEA	ARBA:ARBA00027879	150520179		UniProt	GO_REF:0000117
USP8	Human	protein deubiquitination	involved_in	IEA	InterPro:IPR001394	150520179		InterPro	GO_REF:0000002
USP8	Human	protein deubiquitination	acts_upstream_of_or_within	IMP		150520179	PMID:18388320	MGI	PMID:18388320
USP8	Human	protein K48-linked deubiquitination	involved_in	IDA		150520179	PMID:16520378	UniProt	PMID:16520378
USP8	Human	protein K63-linked deubiquitination	involved_in	IDA		150520179	PMID:16520378	UniProt	PMID:16520378
USP8	Human	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
USP8	Human	Ras protein signal transduction	involved_in	IBA	MGI:1934029 and PANTHER:PTN008578257	150520179		GO_Central	GO_REF:0000033
USP8	Human	Ras protein signal transduction	acts_upstream_of_or_within	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	involved_in	IEA	UniProtKB:A6HPZ0 more ...	150520179		Ensembl	GO_REF:0000107
USP8	Human	regulation of protein localization	involved_in	IMP		150520179	PMID:27302062	UniProt	PMID:27302062
USP8	Human	regulation of protein stability	involved_in	IMP		150520179	PMID:27302062	UniProt	PMID:27302062

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	acrosomal membrane	located_in	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	cytoplasm	located_in	IDA		150520179	PMID:18388320	MGI	PMID:18388320
USP8	Human	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
USP8	Human	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
USP8	Human	cytosol	is_active_in	IDA		150520179	PMID:16520378	UniProt	PMID:16520378
USP8	Human	cytosol	located_in	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	cytosol	is_active_in	IBA	MGI:1934029 more ...	150520179		GO_Central	GO_REF:0000033
USP8	Human	cytosol	located_in	TAS		150520179		Reactome	Reactome:R-HSA-1358791 more ...
USP8	Human	cytosol	located_in	IDA		150520179	PMID:27444016	FlyBase	PMID:27444016
USP8	Human	early endosome	located_in	IEA	UniProtKB:A6HPZ0 more ...	150520179		Ensembl	GO_REF:0000107
USP8	Human	early endosome	located_in	IDA		150520179	PMID:16520378	UniProt	PMID:16520378
USP8	Human	endosome	located_in	IEA	UniProtKB-KW:KW-0967	150520179		UniProt	GO_REF:0000043
USP8	Human	endosome membrane	located_in	IEA	UniProtKB-SubCell:SL-0100	150520179		UniProt	GO_REF:0000044
USP8	Human	endosome membrane	located_in	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	glutamatergic synapse	is_active_in	IEA	UniProtKB:A6HPZ0 more ...	150520179		Ensembl	GO_REF:0000107
USP8	Human	membrane	located_in	IEA	UniProtKB-KW:KW-0472	150520179		UniProt	GO_REF:0000043
USP8	Human	midbody	located_in	IDA		150520179	PMID:18388320	MGI	PMID:18388320
USP8	Human	midbody	located_in	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	midbody	is_active_in	IBA	MGI:1934029 more ...	150520179		GO_Central	GO_REF:0000033
USP8	Human	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
USP8	Human	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043
USP8	Human	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	150520179		UniProt	GO_REF:0000044
USP8	Human	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043
USP8	Human	postsynaptic density	is_active_in	IEA	UniProtKB:A6HPZ0 more ...	150520179		Ensembl	GO_REF:0000107
USP8	Human	postsynaptic density	is_active_in	IBA	PANTHER:PTN008371010 and Usp8 (Rattus norvegicus)	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	cadherin binding	enables	HDA		150520179	PMID:25468996	BHF-UCL	PMID:25468996
USP8	Human	cysteine-type deubiquitinase activity	enables	IEA	InterPro:IPR001394 and InterPro:IPR018200	150520179		InterPro	GO_REF:0000002
USP8	Human	cysteine-type deubiquitinase activity	enables	IEA	UniProtKB:Q80U87 and ensembl:ENSMUSP00000028841	150520179		Ensembl	GO_REF:0000107
USP8	Human	cysteine-type deubiquitinase activity	enables	IBA	MGI:1934029 more ...	150520179		GO_Central	GO_REF:0000033
USP8	Human	cysteine-type deubiquitinase activity	enables	IDA		150520179	PMID:16520378 more ...	MGI	PMID:16520378 more ...
USP8	Human	cysteine-type deubiquitinase activity	enables	TAS		150520179	PMID:9628861	Reactome	PMID:9628861 more ...
USP8	Human	cysteine-type deubiquitinase activity	enables	IEA	EC:3.4.19.12	150520179		UniProt	GO_REF:0000003
USP8	Human	cysteine-type endopeptidase activity	enables	TAS		150520179	PMID:9827704	PINC	PMID:9827704
USP8	Human	cysteine-type peptidase activity	enables	IEA	UniProtKB-KW:KW-0788	150520179		UniProt	GO_REF:0000043
USP8	Human	cysteine-type peptidase activity	enables	IEA	ARBA:ARBA00027409	150520179		UniProt	GO_REF:0000117
USP8	Human	deubiquitinase activity	enables	IEA	ARBA:ARBA00026566	150520179		UniProt	GO_REF:0000117
USP8	Human	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
USP8	Human	K48-linked deubiquitinase activity	enables	IDA		150520179	PMID:16520378	UniProt	PMID:16520378
USP8	Human	K63-linked deubiquitinase activity	enables	IDA		150520179	PMID:16520378	UniProt	PMID:16520378
USP8	Human	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
USP8	Human	protein binding	enables	IPI	UniProtKB:P63104	150520179	PMID:15161933 more ...	IntAct	PMID:15161933 more ...
USP8	Human	protein binding	enables	IPI	UniProtKB:P31947	150520179	PMID:15778465	IntAct	PMID:15778465
USP8	Human	protein binding	enables	IPI	UniProtKB:P31947 more ...	150520179	PMID:36931259	IntAct	PMID:36931259
USP8	Human	protein binding	enables	IPI	UniProtKB:Q7LBR1 more ...	150520179	PMID:17711858 and PMID:19302785	IntAct	PMID:17711858 and PMID:19302785
USP8	Human	protein binding	enables	IPI	UniProtKB:Q14596	150520179	PMID:19427866	IntAct	PMID:19427866
USP8	Human	protein binding	enables	IPI	UniProtKB:Q16665 and UniProtKB:Q99814	150520179	PMID:24378640	IntAct	PMID:24378640
USP8	Human	protein binding	enables	IPI	UniProtKB:Q9NR09	150520179	PMID:18329369	UniProt	PMID:18329369
USP8	Human	protein binding	enables	IPI	UniProtKB:P62258 and UniProtKB:P63104	150520179	PMID:35271311	IntAct	PMID:35271311
USP8	Human	SH3 domain binding	enables	IEA	UniProtKB-KW:KW-0729	150520179		UniProt	GO_REF:0000043

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	mitochondrial autophagy pathway		TAS		10401790		RGD

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	endocytosis pathway		IEA		6907045		KEGG	hsa:04144

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
USP8	Human	Abdominal obesity		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Abdominal obesity		IAGP		8699517		HPO	MIM:219090
USP8	Human	Abnormal cerebellum morphology		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Abnormal cerebral white matter morphology		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Abnormal fear-induced behavior		IAGP		8699517		HPO	MIM:219090
USP8	Human	Abnormal libido		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Abnormality of the cardiovascular system		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Abnormality of the respiratory system		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Acne		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Adrenal hyperplasia		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Alkalosis		IAGP		8699517		HPO	MIM:219090
USP8	Human	Amenorrhea		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Atypical behavior		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Autosomal dominant inheritance		IAGP		8699517		HPO	MIM:219090
USP8	Human	Autosomal recessive inheritance		IAGP		8699517		HPO	MIM:219090
USP8	Human	Avascular necrosis		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Biconcave vertebral bodies		IAGP		8699517		HPO	MIM:219090
USP8	Human	Bruising susceptibility		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Bruising susceptibility		IAGP		8699517		HPO	MIM:219090
USP8	Human	Capillary fragility		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Clonus		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Decreased eosinophil count		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Dementia		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Depression		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Diabetes mellitus		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Dorsocervical fat pad		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Ecchymosis		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Ecchymosis		IAGP		8699517		HPO	MIM:219090
USP8	Human	Edema		IAGP		8699517		HPO	MIM:219090
USP8	Human	Emotional lability		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Emotional lability		IAGP		8699517		HPO	MIM:219090
USP8	Human	Facial erythema		IAGP		8699517		HPO	MIM:219090
USP8	Human	Fatiguable weakness of proximal limb muscles		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Flushing		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Glucose intolerance		IAGP		8699517		HPO	MIM:219090
USP8	Human	Headache		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Hirsutism		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Hirsutism		IAGP		8699517		HPO	MIM:219090
USP8	Human	Hyperpigmentation of the skin		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Hypertension		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Hypertension		IAGP		8699517		HPO	MIM:219090
USP8	Human	Hypokalemia		IAGP		8699517		HPO	MIM:219090
USP8	Human	Immunodeficiency		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Impaired glucose tolerance		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Impaired glucose tolerance		IAGP		8699517		HPO	MIM:219090
USP8	Human	Increased body weight		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Increased circulating ACTH level		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Increased circulating ACTH level		IAGP		8699517		HPO	MIM:219090
USP8	Human	Increased circulating cortisol level		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Increased urinary cortisol level		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Intellectual disability		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Intra-oral hyperpigmentation		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Kyphosis		IAGP		8699517		HPO	MIM:219090
USP8	Human	Large sella turcica		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Leukocytosis		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Limb hypertonia		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Livedo reticularis		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Lower limb hyperreflexia		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Lower limb spasticity		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Lymphopenia		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Memory impairment		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Moon facies		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Muscle weakness		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Myocardial infarction		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Nephrolithiasis		IAGP		8699517		HPO	MIM:219090
USP8	Human	Nystagmus		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Obesity		IAGP		8699517		HPO	MIM:219090
USP8	Human	Oligomenorrhea		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Oligomenorrhea		IAGP		8699517		HPO	MIM:219090
USP8	Human	Optic nerve compression		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Osteoporosis		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Osteoporosis		IAGP		8699517		HPO	MIM:219090
USP8	Human	Panic attack		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Paradoxical increased cortisol secretion on dexamethasone suppression test		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Paranoia		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Pedal edema		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Pituitary adenoma		IAGP		8699517		HPO	MIM:219090
USP8	Human	Pituitary corticotropic cell adenoma		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Plethora		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Poor wound healing		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Poor wound healing		IAGP		8699517		HPO	MIM:219090
USP8	Human	Proximal amyotrophy		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Psychosis		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Psychotic episodes		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Psychotic mentation		IAGP		8699517		HPO	MIM:219090
USP8	Human	Purpura		IAGP		8699517		HPO	MIM:219090
USP8	Human	Purpura		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Recurrent cutaneous fungal infections		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Secondary amenorrhea		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Skeletal muscle atrophy		IAGP		8699517		HPO	MIM:219090
USP8	Human	Skin ulcer		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Sparse scalp hair		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Spastic gait		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Spastic paraplegia		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Striae distensae		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Striae distensae		IAGP		8699517		HPO	MIM:219090
USP8	Human	Stroke		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Suicidal ideation		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Talipes equinovarus		IAGP		8699517		HPO	ORPHA:401795
USP8	Human	Thin skin		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Thin skin		IAGP		8699517		HPO	MIM:219090
USP8	Human	Truncal obesity		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Vertebral compression fracture		IAGP		8699517		HPO	ORPHA:96253
USP8	Human	Vertebral compression fracture		IAGP		8699517		HPO	MIM:219090
USP8	Human	Visual field defect		IAGP		8699517		HPO	ORPHA:96253

#	Reference Title	Reference Citation
1.	The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.	Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
2.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	RGD HPO Phenotype Annotation Pipeline	RGD automated import pipeline for human HPO-to-gene-to-disease annotations

PMID:7584044	PMID:8889548	PMID:9582025	PMID:9628861	PMID:9827704	PMID:10982817	PMID:11500497	PMID:12176364	PMID:12477932	PMID:12773374	PMID:12838346	PMID:13129930
PMID:14661020	PMID:14702039	PMID:15161933	PMID:15314180	PMID:15324660	PMID:15342353	PMID:15489334	PMID:15778465	PMID:16120644	PMID:16341674	PMID:16344560	PMID:16520378
PMID:16771824	PMID:17035239	PMID:17121848	PMID:17210635	PMID:17353931	PMID:17711858	PMID:17720156	PMID:17979178	PMID:18029348	PMID:18329369	PMID:18388320	PMID:18728397
PMID:19302785	PMID:19427866	PMID:19523899	PMID:19608861	PMID:19615732	PMID:19684015	PMID:20301682	PMID:20495530	PMID:20736164	PMID:20876529	PMID:21448666	PMID:21828287
PMID:21873635	PMID:22118674	PMID:22195557	PMID:22253573	PMID:22626734	PMID:22779921	PMID:22841719	PMID:22863883	PMID:22939629	PMID:23153581	PMID:23287719	PMID:23297398
PMID:23333852	PMID:23472066	PMID:23477725	PMID:23748694	PMID:23750007	PMID:24255178	PMID:24270891	PMID:24344018	PMID:24378640	PMID:24482476	PMID:24825905	PMID:24828152
PMID:24894536	PMID:25170077	PMID:25216678	PMID:25468996	PMID:25485838	PMID:25527291	PMID:25675982	PMID:25700639	PMID:25733871	PMID:25853104	PMID:25863102	PMID:25921289
PMID:25930709	PMID:25942478	PMID:26186194	PMID:26214742	PMID:26285834	PMID:26344197	PMID:26459808	PMID:26472760	PMID:26496610	PMID:26507658	PMID:26571504	PMID:26578638
PMID:26683461	PMID:26701869	PMID:27173435	PMID:27302062	PMID:27321185	PMID:27444016	PMID:27501351	PMID:28505279	PMID:28514442	PMID:28515276	PMID:28544031	PMID:28710116
PMID:28850717	PMID:28973533	PMID:28982703	PMID:29180353	PMID:29472535	PMID:29473952	PMID:29507755	PMID:29560723	PMID:29568061	PMID:29576527	PMID:29604273	PMID:29626091
PMID:29735556	PMID:29880877	PMID:30010158	PMID:30021884	PMID:30132974	PMID:30221684	PMID:30759391	PMID:30844069	PMID:30931944	PMID:31182584	PMID:31199479	PMID:31241013
PMID:31243344	PMID:31273566	PMID:31280266	PMID:31443721	PMID:31511647	PMID:31527799	PMID:31581124	PMID:32053843	PMID:32120844	PMID:32818533	PMID:32924931	PMID:33080340
PMID:33141564	PMID:33221858	PMID:33288548	PMID:33600786	PMID:33845483	PMID:33916271	PMID:33961781	PMID:34079090	PMID:34079125	PMID:34081623	PMID:34129829	PMID:34373451
PMID:34535262	PMID:34630422	PMID:34664215	PMID:34672954	PMID:34709727	PMID:34750505	PMID:34839365	PMID:35256949	PMID:35271311	PMID:35361778	PMID:35384245	PMID:35451730
PMID:35559673	PMID:35575683	PMID:35636624	PMID:35658874	PMID:35686696	PMID:35786929	PMID:35811497	PMID:35831314	PMID:35906200	PMID:35914814	PMID:35981231	PMID:35995394
PMID:36114006	PMID:36215168	PMID:36539510	PMID:36724073	PMID:36822331	PMID:36931259	PMID:36976175	PMID:37190052	PMID:37205094	PMID:37311739	PMID:37332045	PMID:37639742
PMID:37704159	PMID:37741774	PMID:37827155	PMID:37925320	PMID:37981592	PMID:38180476	PMID:38334954	PMID:38691659	PMID:38803224	PMID:39214302

USP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	50,424,405 - 50,514,421 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	50,424,380 - 50,514,421 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	50,716,602 - 50,806,618 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	48,503,871 - 48,579,265 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	48,503,870 - 48,579,263	NCBI
Celera	15	27,609,144 - 27,685,855 (+)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	27,547,372 - 27,623,683 (+)	NCBI		HuRef
CHM1_1	15	50,834,671 - 50,911,286 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	48,232,513 - 48,322,500 (+)	NCBI		T2T-CHM13v2.0

Usp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	126,549,280 - 126,601,234 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	126,549,248 - 126,601,217 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	126,707,201 - 126,759,314 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	126,707,328 - 126,759,297 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	126,533,099 - 126,585,033 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	126,398,804 - 126,450,738 (+)	NCBI		MGSCv36	mm8
Celera	2	127,946,958 - 127,999,152 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.76	NCBI

Usp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	134,413,832 - 134,463,040 (+)	NCBI		GRCr8
mRatBN7.2	3	113,962,136 - 114,009,683 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,962,164 - 114,009,666 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	117,845,850 - 117,893,311 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	126,441,377 - 126,488,837 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	124,101,758 - 124,149,218 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	119,173,818 - 119,222,499 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,173,818 - 119,222,484 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	125,699,400 - 125,747,055 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	114,237,065 - 114,284,543 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	114,103,490 - 114,189,451 (+)	NCBI
Celera	3	112,804,623 - 112,852,132 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Usp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	3,840,007 - 3,891,284 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	3,839,308 - 3,903,595 (-)	NCBI	ChiLan1.0	ChiLan1.0

USP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	39,669,333 - 39,746,278 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	43,850,502 - 43,939,848 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	29,374,945 - 29,451,235 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	47,699,282 - 47,790,624 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	47,713,997 - 47,790,624 (+)	Ensembl	panpan1.1		panPan2

USP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	16,341,970 - 16,408,246 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	16,342,009 - 16,408,012 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	16,268,046 - 16,334,339 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	16,485,884 - 16,552,179 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	16,485,928 - 16,552,172 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	16,408,382 - 16,474,666 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	16,525,850 - 16,592,342 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	16,632,281 - 16,698,545 (+)	NCBI		UU_Cfam_GSD_1.0

Usp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	94,615,145 - 94,673,337 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	12,463,120 - 12,520,674 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	12,463,189 - 12,524,148 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	121,306,032 - 121,413,223 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	121,306,031 - 121,376,154 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	134,747,956 - 134,815,830 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	32,829,627 - 32,906,493 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	32,829,523 - 32,866,073 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	108,247,584 - 108,324,662 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	9,613,227 - 9,679,404 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	9,615,963 - 9,678,969 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in USP8
167 total Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_005154.5(USP8):c.1328A>G (p.Asp443Gly)	single nucleotide variant	Hereditary spastic paraplegia [RCV000542854]\|not provided [RCV004715256]	Chr15:50481590 [GRCh38] Chr15:50481590..50481591 [GRCh38] Chr15:50773787 [GRCh37] Chr15:50773787..50773788 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2658+5_2658+8dup	duplication	Hereditary spastic paraplegia [RCV000550889]\|not provided [RCV001356127]	Chr15:50494282..50494283 [GRCh38] Chr15:50786479..50786480 [GRCh37] Chr15:15q21.2	likely benign\|uncertain significance
NM_005154.5(USP8):c.928C>A (p.Gln310Lys)	single nucleotide variant	not provided [RCV000087331]	Chr15:50476927 [GRCh38] Chr15:50769124 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh38/hg38 15q21.1-21.3(chr15:46042302-54195828)x1	copy number loss	See cases [RCV000051619]	Chr15:46042302..54195828 [GRCh38] Chr15:46334500..54488025 [GRCh37] Chr15:44121792..52275317 [NCBI36] Chr15:15q21.1-21.3	pathogenic
GRCh38/hg38 15q21.1-21.3(chr15:48695331-53923002)x1	copy number loss	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]\|See cases [RCV000051620]	Chr15:48695331..53923002 [GRCh38] Chr15:48987528..54215199 [GRCh37] Chr15:46774820..52002491 [NCBI36] Chr15:15q21.1-21.3	pathogenic
NM_001128610.2(USP8):c.687-1732G>T	single nucleotide variant	Lung cancer [RCV000099539]	Chr15:50469901 [GRCh38] Chr15:50762098 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3292T>G (p.Ser1098Ala)	single nucleotide variant	Hereditary spastic paraplegia [RCV001348238]	Chr15:50499023 [GRCh38] Chr15:50791220 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2152TCC[1] (p.Ser719del)	microsatellite	Pituitary dependent hypercortisolism [RCV000149416]	Chr15:50490442..50490444 [GRCh38] Chr15:50782639..50782641 [GRCh37] Chr15:15q21.2	pathogenic
NM_005154.5(USP8):c.2152T>C (p.Ser718Pro)	single nucleotide variant	Pituitary dependent hypercortisolism [RCV000149417]	Chr15:50490443 [GRCh38] Chr15:50782640 [GRCh37] Chr15:15q21.2	pathogenic
NM_005154.5(USP8):c.2153C>G (p.Ser718Cys)	single nucleotide variant	Pituitary dependent hypercortisolism [RCV000149418]	Chr15:50490444 [GRCh38] Chr15:50782641 [GRCh37] Chr15:15q21.2	pathogenic
NM_005154.5(USP8):c.2159C>G (p.Pro720Arg)	single nucleotide variant	Pituitary dependent hypercortisolism [RCV000149420]	Chr15:50490450 [GRCh38] Chr15:50782647 [GRCh37] Chr15:15q21.2	pathogenic
GRCh38/hg38 15q21.1-21.2(chr15:47460844-52494222)x1	copy number loss	See cases [RCV000135639]	Chr15:47460844..52494222 [GRCh38] Chr15:47753041..52786419 [GRCh37] Chr15:45540333..50573711 [NCBI36] Chr15:15q21.1-21.2	pathogenic
NM_005154.5(USP8):c.1084A>G (p.Ile362Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV000532955]	Chr15:50477365 [GRCh38] Chr15:50769562 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2971C>T (p.Arg991Ter)	single nucleotide variant	not provided [RCV001169927]	Chr15:50497164 [GRCh38] Chr15:50789361 [GRCh37] Chr15:15q21.2	pathogenic
NM_005154.5(USP8):c.1448G>A (p.Arg483Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV000557543]\|USP8-related disorder [RCV003915496]\|not provided [RCV004716522]	Chr15:50481710 [GRCh38] Chr15:50773907 [GRCh37] Chr15:15q21.2	benign
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4	copy number gain	See cases [RCV000447123]	Chr15:41745084..102354798 [GRCh37] Chr15:15q15.1-26.3	pathogenic
GRCh37/hg19 15q21.1-21.2(chr15:48940736-51309941)x1	copy number loss	See cases [RCV000447625]	Chr15:48940736..51309941 [GRCh37] Chr15:15q21.1-21.2	uncertain significance
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3	copy number gain	See cases [RCV000510717]	Chr15:22770422..102429112 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4	copy number gain	See cases [RCV000447765]	Chr15:20733395..102511616 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q15.1-21.2(chr15:41689327-52446981)x1	copy number loss	See cases [RCV000448968]	Chr15:41689327..52446981 [GRCh37] Chr15:15q15.1-21.2	pathogenic
NM_005154.5(USP8):c.3130C>G (p.Pro1044Ala)	single nucleotide variant	not provided [RCV000509313]	Chr15:50498687 [GRCh38] Chr15:50790884 [GRCh37] Chr15:15q21.2	not provided
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)	copy number gain	See cases [RCV000512019]	Chr15:22770422..102429112 [GRCh37] Chr15:15q11.2-26.3	pathogenic
GRCh37/hg19 15q21.2(chr15:50718893-51246087)x3	copy number gain	See cases [RCV000510872]	Chr15:50718893..51246087 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.397C>T (p.Arg133Trp)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633121]\|not provided [RCV004691965]	Chr15:50459061 [GRCh38] Chr15:50751258 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.802T>A (p.Leu268Ile)	single nucleotide variant	Hereditary spastic paraplegia [RCV000535635]\|not provided [RCV004715257]	Chr15:50471748 [GRCh38] Chr15:50763945 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1857T>C (p.Phe619=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000536150]\|not provided [RCV004716523]	Chr15:50484328 [GRCh38] Chr15:50776525 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.823C>T (p.Arg275Trp)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633119]	Chr15:50471769 [GRCh38] Chr15:50763966 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2443A>G (p.Asn815Asp)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633120]	Chr15:50492909 [GRCh38] Chr15:50785106 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2511G>A (p.Leu837=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633123]\|not provided [RCV004716595]	Chr15:50494133 [GRCh38] Chr15:50786330 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1296A>G (p.Gln432=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633124]	Chr15:50481558 [GRCh38] Chr15:50773755 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1162A>G (p.Lys388Glu)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633125]\|not provided [RCV004716596]	Chr15:50477443 [GRCh38] Chr15:50769640 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1042G>A (p.Ala348Thr)	single nucleotide variant	Hereditary spastic paraplegia [RCV000559198]\|not provided [RCV004715255]	Chr15:50477323 [GRCh38] Chr15:50769520 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.3033G>A (p.Leu1011=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000557319]\|not provided [RCV004716524]	Chr15:50497226 [GRCh38] Chr15:50789423 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.583A>G (p.Lys195Glu)	single nucleotide variant	Hereditary spastic paraplegia [RCV000633122]	Chr15:50465088 [GRCh38] Chr15:50757285 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2320C>G (p.Pro774Ala)	single nucleotide variant	Hereditary spastic paraplegia [RCV000700781]	Chr15:50492786 [GRCh38] Chr15:50784983 [GRCh37] Chr15:15q21.2	uncertain significance
Single allele	duplication	not provided [RCV000677926]	Chr15:31115047..102354857 [GRCh37] Chr15:15q13.2-26.3	pathogenic
GRCh37/hg19 15q15.3-21.3(chr15:43759773-53252240)x1	copy number loss	not provided [RCV000683686]	Chr15:43759773..53252240 [GRCh37] Chr15:15q15.3-21.3	pathogenic
GRCh37/hg19 15q21.2-21.3(chr15:50727285-57603305)x3	copy number gain	not provided [RCV000683691]	Chr15:50727285..57603305 [GRCh37] Chr15:15q21.2-21.3	pathogenic
NM_005154.5(USP8):c.335+7A>G	single nucleotide variant	Hereditary spastic paraplegia [RCV000689968]	Chr15:50449492 [GRCh38] Chr15:50741689 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.865G>A (p.Val289Ile)	single nucleotide variant	Hereditary spastic paraplegia [RCV000691735]	Chr15:50476864 [GRCh38] Chr15:50769061 [GRCh37] Chr15:15q21.2	uncertain significance
NC_000015.9:g.(?_50789266)_(50791305_?)dup	duplication	Hereditary spastic paraplegia [RCV000708299]	Chr15:50497069..50499108 [GRCh38] Chr15:50789266..50791305 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3	copy number gain	not provided [RCV000751156]	Chr15:20071673..102461162 [GRCh37] Chr15:15q11.1-26.3	pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3	copy number gain	not provided [RCV000751155]	Chr15:20016811..102493540 [GRCh37] Chr15:15q11.1-26.3	pathogenic
NM_005154.5(USP8):c.1675C>T (p.His559Tyr)	single nucleotide variant	Hereditary spastic paraplegia [RCV000875024]\|USP8-related disorder [RCV003908313]\|not provided [RCV004715345]	Chr15:50481937 [GRCh38] Chr15:50774134 [GRCh37] Chr15:15q21.2	benign\|likely benign
NM_005154.5(USP8):c.564A>G (p.Leu188=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000897089]	Chr15:50465069 [GRCh38] Chr15:50757266 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1219-5T>C	single nucleotide variant	not provided [RCV000929557]	Chr15:50481476 [GRCh38] Chr15:50773673 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.36C>T (p.Tyr12=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000972040]	Chr15:50439109 [GRCh38] Chr15:50731306 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2895+3_2895+7dup	duplication	not provided [RCV000877553]	Chr15:50496085..50496086 [GRCh38] Chr15:50788282..50788283 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.541+9G>A	single nucleotide variant	Hereditary spastic paraplegia [RCV000876245]	Chr15:50462331 [GRCh38] Chr15:50754528 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1148C>T (p.Pro383Leu)	single nucleotide variant	Hereditary spastic paraplegia [RCV001431368]	Chr15:50477429 [GRCh38] Chr15:50769626 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2754T>C (p.Asn918=)	single nucleotide variant	not provided [RCV000918075]	Chr15:50495943 [GRCh38] Chr15:50788140 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1516A>C (p.Lys506Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV000872191]\|not provided [RCV003456447]	Chr15:50481778 [GRCh38] Chr15:50773975 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.297C>A (p.Val99=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000875327]	Chr15:50449447 [GRCh38] Chr15:50741644 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2383C>T (p.Leu795=)	single nucleotide variant	Hereditary spastic paraplegia [RCV001454764]	Chr15:50492849 [GRCh38] Chr15:50785046 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2331T>C (p.Thr777=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000874042]	Chr15:50492797 [GRCh38] Chr15:50784994 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.24T>C (p.Pro8=)	single nucleotide variant	not provided [RCV000918841]	Chr15:50439097 [GRCh38] Chr15:50731294 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.400C>T (p.Leu134=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000874746]\|not provided [RCV004715344]	Chr15:50459064 [GRCh38] Chr15:50751261 [GRCh37] Chr15:15q21.2	benign
NM_203494.5(USP50):c.962G>C (p.Gly321Ala)	single nucleotide variant	not provided [RCV000948956]	Chr15:50500812 [GRCh38] Chr15:50793009 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2391C>T (p.Asn797=)	single nucleotide variant	Hereditary spastic paraplegia [RCV005092648]\|not provided [RCV000894705]	Chr15:50492857 [GRCh38] Chr15:50785054 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1531G>C (p.Glu511Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV000807610]	Chr15:50481793 [GRCh38] Chr15:50773990 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2246A>G (p.Tyr749Cys)	single nucleotide variant	Hereditary spastic paraplegia [RCV000815035]	Chr15:50492712 [GRCh38] Chr15:50784909 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.2-21.3(chr15:50083229-53439931)x1	copy number loss	not provided [RCV000848123]	Chr15:50083229..53439931 [GRCh37] Chr15:15q21.2-21.3	uncertain significance
NM_005154.5(USP8):c.1460A>G (p.Gln487Arg)	single nucleotide variant	Hereditary spastic paraplegia [RCV000798738]	Chr15:50481722 [GRCh38] Chr15:50773919 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1872C>T (p.Asp624=)	single nucleotide variant	Hereditary spastic paraplegia [RCV000871151]\|not provided [RCV004704237]	Chr15:50484343 [GRCh38] Chr15:50776540 [GRCh37] Chr15:15q21.2	likely benign
GRCh37/hg19 15q21.1-21.3(chr15:49031132-56740397)x3	copy number gain	not provided [RCV000849275]	Chr15:49031132..56740397 [GRCh37] Chr15:15q21.1-21.3	pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3	copy number gain	not provided [RCV000845891]	Chr15:48000433..60747551 [GRCh37] Chr15:15q21.1-22.2	pathogenic
NM_005154.5(USP8):c.1922G>A (p.Ser641Asn)	single nucleotide variant	Hereditary spastic paraplegia [RCV001226138]	Chr15:50489832 [GRCh38] Chr15:50782029 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.2(chr15:50727191-51138573)x3	copy number gain	not provided [RCV000846770]	Chr15:50727191..51138573 [GRCh37] Chr15:15q21.2	uncertain significance
NC_000015.9:g.(?_50731271)_(54025330_?)dup	duplication	not provided [RCV003105626]	Chr15:50731271..54025330 [GRCh37] Chr15:15q21.2-21.3	uncertain significance
NM_005154.5(USP8):c.1330C>T (p.Arg444Cys)	single nucleotide variant	Autosomal recessive spastic paraplegia type 59 [RCV004765340]\|Hereditary spastic paraplegia [RCV002064746]	Chr15:50481592 [GRCh38] Chr15:50773789 [GRCh37] Chr15:15q21.2	likely benign\|uncertain significance
NM_005154.5(USP8):c.2896-9T>C	single nucleotide variant	Hereditary spastic paraplegia [RCV000874525]	Chr15:50497080 [GRCh38] Chr15:50789277 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.250-8A>C	single nucleotide variant	Hereditary spastic paraplegia [RCV005092919]\|not provided [RCV000963316]	Chr15:50449392 [GRCh38] Chr15:50741589 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2634T>C (p.Asp878=)	single nucleotide variant	not provided [RCV000903868]	Chr15:50494256 [GRCh38] Chr15:50786453 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.762G>A (p.Glu254=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002548235]\|USP8-related disorder [RCV003942989]\|not provided [RCV003392704]	Chr15:50471708 [GRCh38] Chr15:50763905 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1015T>C (p.Leu339=)	single nucleotide variant	not provided [RCV000932087]	Chr15:50477296 [GRCh38] Chr15:50769493 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.634G>A (p.Asp212Asn)	single nucleotide variant	Hereditary spastic paraplegia [RCV000876098]\|USP8-related disorder [RCV003955736]	Chr15:50465139 [GRCh38] Chr15:50757336 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1464G>A (p.Glu488=)	single nucleotide variant	Hereditary spastic paraplegia [RCV001517106]	Chr15:50481726 [GRCh38] Chr15:50773923 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2842G>C (p.Ala948Pro)	single nucleotide variant	Hereditary spastic paraplegia [RCV001207175]	Chr15:50496031 [GRCh38] Chr15:50788228 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3105T>G (p.Leu1035=)	single nucleotide variant	not provided [RCV000890074]	Chr15:50498662 [GRCh38] Chr15:50790859 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2235-9C>T	single nucleotide variant	Hereditary spastic paraplegia [RCV002548265]	Chr15:50492692 [GRCh38] Chr15:50784889 [GRCh37] Chr15:15q21.2	likely benign
GRCh37/hg19 15q21.1-21.2(chr15:47192561-50819726)x1	copy number loss	not provided [RCV001006685]	Chr15:47192561..50819726 [GRCh37] Chr15:15q21.1-21.2	pathogenic
NM_005154.5(USP8):c.-58G>C	single nucleotide variant	not provided [RCV001723043]	Chr15:50439016 [GRCh38] Chr15:50731213 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1129A>G (p.Ile377Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV001069592]	Chr15:50477410 [GRCh38] Chr15:50769607 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.254A>C (p.Tyr85Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV001215011]	Chr15:50449404 [GRCh38] Chr15:50741601 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.886G>A (p.Val296Ile)	single nucleotide variant	Hereditary spastic paraplegia [RCV001246142]	Chr15:50476885 [GRCh38] Chr15:50769082 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2297A>G (p.Asn766Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV001205749]	Chr15:50492763 [GRCh38] Chr15:50784960 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3334C>T (p.Arg1112Ter)	single nucleotide variant	Hereditary spastic paraplegia [RCV001213502]\|not provided [RCV004695185]\|not specified [RCV002249800]	Chr15:50499065 [GRCh38] Chr15:50791262 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.748A>C (p.Arg250=)	single nucleotide variant	not provided [RCV001257173]	Chr15:50471694 [GRCh38] Chr15:50763891 [GRCh37] Chr15:15q21.2	likely benign
NC_000015.9:g.(?_32964879)_(91358519_?)dup	duplication	Bloom syndrome [RCV001343104]\|Familial colorectal cancer [RCV001325176]	Chr15:32964879..91358519 [GRCh37] Chr15:15q13.3-26.1	uncertain significance
NM_005154.5(USP8):c.2291A>G (p.Asn764Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV001294286]	Chr15:50492757 [GRCh38] Chr15:50784954 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.1-21.3(chr15:48744917-53851050)x1	copy number loss	not provided [RCV001270659]	Chr15:48744917..53851050 [GRCh37] Chr15:15q21.1-21.3	pathogenic
NM_005154.5(USP8):c.1120C>A (p.Pro374Thr)	single nucleotide variant	Hereditary spastic paraplegia [RCV001370618]	Chr15:50477401 [GRCh38] Chr15:50769598 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2307T>C (p.Phe769=)	single nucleotide variant	Hereditary spastic paraplegia [RCV001415033]	Chr15:50492773 [GRCh38] Chr15:50784970 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1053G>A (p.Thr351=)	single nucleotide variant	Hereditary spastic paraplegia [RCV001421989]	Chr15:50477334 [GRCh38] Chr15:50769531 [GRCh37] Chr15:15q21.2	likely benign
NC_000015.9:g.(?_50731261)_(50791295_?)dup	duplication	Hereditary spastic paraplegia [RCV001362835]	Chr15:50731261..50791295 [GRCh37] Chr15:15q21.2	uncertain significance
NC_000015.9:g.(?_50789266)_(50791305_?)dup	duplication	Hereditary spastic paraplegia [RCV001304847]	Chr15:50789266..50791305 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1050G>T (p.Gln350His)	single nucleotide variant	Hereditary spastic paraplegia [RCV001341214]	Chr15:50477331 [GRCh38] Chr15:50769528 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1296= (p.Gln432=)	variation	Hereditary spastic paraplegia [RCV001515377]\|not provided [RCV004715446]	Chr15:50481558 [GRCh38] Chr15:50773755 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1840C>T (p.Leu614=)	single nucleotide variant	Hereditary spastic paraplegia [RCV001497087]	Chr15:50484311 [GRCh38] Chr15:50776508 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2215A>G (p.Thr739Ala)	single nucleotide variant	Hereditary spastic paraplegia [RCV001522628]\|not provided [RCV004715473]	Chr15:50490506 [GRCh38] Chr15:50782703 [GRCh37] Chr15:15q21.2	benign
GRCh37/hg19 15q21.2(chr15:50550911-50902848)	copy number loss	Neurodevelopmental delay [RCV002280698]	Chr15:50550911..50902848 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1540A>G (p.Ile514Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV001889072]	Chr15:50481802 [GRCh38] Chr15:50773999 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.775C>A (p.Leu259Ile)	single nucleotide variant	Hereditary spastic paraplegia [RCV001874863]	Chr15:50471721 [GRCh38] Chr15:50763918 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.1-21.2(chr15:48940736-51309941)	copy number loss	not specified [RCV002052474]	Chr15:48940736..51309941 [GRCh37] Chr15:15q21.1-21.2	uncertain significance
GRCh37/hg19 15q21.2(chr15:50733977-51138579)x3	copy number gain	not provided [RCV001832906]	Chr15:50733977..51138579 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1726C>T (p.Pro576Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV002003200]	Chr15:50481988 [GRCh38] Chr15:50774185 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1597G>A (p.Ala533Thr)	single nucleotide variant	Hereditary spastic paraplegia [RCV001926892]	Chr15:50481859 [GRCh38] Chr15:50774056 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1310G>A (p.Ser437Asn)	single nucleotide variant	Hereditary spastic paraplegia [RCV002004595]	Chr15:50481572 [GRCh38] Chr15:50773769 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.1-21.3(chr15:47635238-56509908)	copy number loss	not specified [RCV002052472]	Chr15:47635238..56509908 [GRCh37] Chr15:15q21.1-21.3	pathogenic
NM_005154.5(USP8):c.2972G>A (p.Arg991Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV001894769]	Chr15:50497165 [GRCh38] Chr15:50789362 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2108C>A (p.Pro703His)	single nucleotide variant	Hereditary spastic paraplegia [RCV001883586]\|Pituitary dependent hypercortisolism [RCV002490098]	Chr15:50490399 [GRCh38] Chr15:50782596 [GRCh37] Chr15:15q21.2	uncertain significance
NC_000015.9:g.(?_50789266)_(50791285_?)dup	duplication	Hereditary spastic paraplegia [RCV001920576]	Chr15:50789266..50791285 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1925A>C (p.Glu642Ala)	single nucleotide variant	Hereditary spastic paraplegia [RCV001993947]	Chr15:50489835 [GRCh38] Chr15:50782032 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2624T>C (p.Phe875Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV002027187]	Chr15:50494246 [GRCh38] Chr15:50786443 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.317C>G (p.Ser106Cys)	single nucleotide variant	Hereditary spastic paraplegia [RCV001934338]	Chr15:50449467 [GRCh38] Chr15:50741664 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1553A>C (p.Gln518Pro)	single nucleotide variant	Hereditary spastic paraplegia [RCV001875523]	Chr15:50481815 [GRCh38] Chr15:50774012 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.587A>C (p.Asn196Thr)	single nucleotide variant	Hereditary spastic paraplegia [RCV001981784]	Chr15:50465092 [GRCh38] Chr15:50757289 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1775C>T (p.Ser592Phe)	single nucleotide variant	Hereditary spastic paraplegia [RCV001880873]	Chr15:50482037 [GRCh38] Chr15:50774234 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1674A>T (p.Glu558Asp)	single nucleotide variant	Hereditary spastic paraplegia [RCV001978612]	Chr15:50481936 [GRCh38] Chr15:50774133 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.659G>A (p.Ser220Asn)	single nucleotide variant	Hereditary spastic paraplegia [RCV002013869]	Chr15:50465164 [GRCh38] Chr15:50757361 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2532T>C (p.Tyr844=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002105103]	Chr15:50494154 [GRCh38] Chr15:50786351 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1692C>G (p.Ala564=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002071817]	Chr15:50481954 [GRCh38] Chr15:50774151 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.3180C>T (p.Tyr1060=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002131003]\|not provided [RCV004809789]	Chr15:50498911 [GRCh38] Chr15:50791108 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.3038+16T>G	single nucleotide variant	Hereditary spastic paraplegia [RCV002132239]\|not provided [RCV004716873]	Chr15:50497247 [GRCh38] Chr15:50789444 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2121T>C (p.Asp707=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002135181]	Chr15:50490412 [GRCh38] Chr15:50782609 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1090T>C (p.Leu364=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002117175]	Chr15:50477371 [GRCh38] Chr15:50769568 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.104+16C>T	single nucleotide variant	Hereditary spastic paraplegia [RCV002132490]\|not provided [RCV004716874]	Chr15:50439193 [GRCh38] Chr15:50731390 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.2287C>T (p.Arg763Trp)	single nucleotide variant	Hereditary spastic paraplegia [RCV002132358]\|not provided [RCV004715604]	Chr15:50492753 [GRCh38] Chr15:50784950 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1365C>T (p.Leu455=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002108514]	Chr15:50481627 [GRCh38] Chr15:50773824 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2292C>A (p.Asn764Lys)	single nucleotide variant	Hereditary spastic paraplegia [RCV002139107]\|not provided [RCV004715621]	Chr15:50492758 [GRCh38] Chr15:50784955 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1773A>C (p.Thr591=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002218779]	Chr15:50482035 [GRCh38] Chr15:50774232 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.249+21_249+23del	deletion	Hereditary spastic paraplegia [RCV002160279]	Chr15:50441512..50441514 [GRCh38] Chr15:50733709..50733711 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.250-15T>C	single nucleotide variant	Hereditary spastic paraplegia [RCV002118626]	Chr15:50449385 [GRCh38] Chr15:50741582 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.3172-16_3172-13dup	duplication	Hereditary spastic paraplegia [RCV002136910]	Chr15:50498883..50498884 [GRCh38] Chr15:50791080..50791081 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.1434A>G (p.Gln478=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002124007]	Chr15:50481696 [GRCh38] Chr15:50773893 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2523G>A (p.Gln841=)	single nucleotide variant	Hereditary spastic paraplegia [RCV002122260]	Chr15:50494145 [GRCh38] Chr15:50786342 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1052C>T (p.Thr351Met)	single nucleotide variant	Hereditary spastic paraplegia [RCV003122069]	Chr15:50477333 [GRCh38] Chr15:50769530 [GRCh37] Chr15:15q21.2	benign
GRCh37/hg19 15q21.1-22.2(chr15:48589845-63543438)x3	copy number gain	not provided [RCV002472512]	Chr15:48589845..63543438 [GRCh37] Chr15:15q21.1-22.2	pathogenic
GRCh37/hg19 15q21.2(chr15:50705605-50770917)x1	copy number loss	not provided [RCV002475780]	Chr15:50705605..50770917 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1873G>A (p.Asp625Asn)	single nucleotide variant	Hereditary spastic paraplegia [RCV002971231]	Chr15:50484344 [GRCh38] Chr15:50776541 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2519G>A (p.Gly840Glu)	single nucleotide variant	Hereditary spastic paraplegia [RCV002843701]	Chr15:50494141 [GRCh38] Chr15:50786338 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.952_955dup (p.Pro319fs)	duplication	Hereditary spastic paraplegia [RCV002867115]	Chr15:50476948..50476949 [GRCh38] Chr15:50769145..50769146 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3018G>A (p.Val1006=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003081208]	Chr15:50497211 [GRCh38] Chr15:50789408 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1213C>T (p.Pro405Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV002926647]	Chr15:50477494 [GRCh38] Chr15:50769691 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.268C>T (p.Leu90Phe)	single nucleotide variant	Hereditary spastic paraplegia [RCV002640037]	Chr15:50449418 [GRCh38] Chr15:50741615 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1891-17T>A	single nucleotide variant	Hereditary spastic paraplegia [RCV002927408]	Chr15:50489784 [GRCh38] Chr15:50781981 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.479C>G (p.Ser160Cys)	single nucleotide variant	Hereditary spastic paraplegia [RCV002952985]	Chr15:50459143 [GRCh38] Chr15:50751340 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2983C>G (p.Leu995Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV003040732]	Chr15:50497176 [GRCh38] Chr15:50789373 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1022A>G (p.Glu341Gly)	single nucleotide variant	Hereditary spastic paraplegia [RCV002742011]	Chr15:50477303 [GRCh38] Chr15:50769500 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.802T>G (p.Leu268Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV003057405]	Chr15:50471748 [GRCh38] Chr15:50763945 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.335+4C>G	single nucleotide variant	Hereditary spastic paraplegia [RCV002791222]	Chr15:50449489 [GRCh38] Chr15:50741686 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2235-20G>T	single nucleotide variant	Hereditary spastic paraplegia [RCV002581951]	Chr15:50492681 [GRCh38] Chr15:50784878 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.499-13T>C	single nucleotide variant	Hereditary spastic paraplegia [RCV002933918]	Chr15:50462267 [GRCh38] Chr15:50754464 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.3119A>G (p.Tyr1040Cys)	single nucleotide variant	Hereditary spastic paraplegia [RCV003063636]	Chr15:50498676 [GRCh38] Chr15:50790873 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.515A>G (p.Asn172Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV002632108]	Chr15:50462296 [GRCh38] Chr15:50754493 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3335G>A (p.Arg1112Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV003067338]	Chr15:50499066 [GRCh38] Chr15:50791263 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3326T>C (p.Leu1109Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV002725829]	Chr15:50499057 [GRCh38] Chr15:50791254 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1218+17A>T	single nucleotide variant	Hereditary spastic paraplegia [RCV002944106]	Chr15:50477516 [GRCh38] Chr15:50769713 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1972-20T>G	single nucleotide variant	Hereditary spastic paraplegia [RCV002587949]	Chr15:50490243 [GRCh38] Chr15:50782440 [GRCh37] Chr15:15q21.2	likely benign
GRCh37/hg19 15q21.2(chr15:49775348-51221365)x1	copy number loss	not provided [RCV003326927]	Chr15:49775348..51221365 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.1-21.3(chr15:49390592-56800964)x1	copy number loss	not provided [RCV003483230]	Chr15:49390592..56800964 [GRCh37] Chr15:15q21.1-21.3	pathogenic
Single allele	deletion	not provided [RCV003448697]	Chr15:41321409..51718601 [GRCh37] Chr15:15q15.1-21.2	pathogenic
GRCh37/hg19 15q21.2(chr15:50582422-51322910)x1	copy number loss	not provided [RCV003483233]	Chr15:50582422..51322910 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.2(chr15:50595262-51210478)x3	copy number gain	not provided [RCV003485065]	Chr15:50595262..51210478 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.2(chr15:50749119-51455096)x3	copy number gain	not provided [RCV003485066]	Chr15:50749119..51455096 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.964C>T (p.Arg322Ter)	single nucleotide variant	USP8-related disorder [RCV003399819]	Chr15:50476963 [GRCh38] Chr15:50769160 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1551G>A (p.Lys517=)	single nucleotide variant	not provided [RCV003394838]	Chr15:50481813 [GRCh38] Chr15:50774010 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.824G>A (p.Arg275Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646447]	Chr15:50471770 [GRCh38] Chr15:50763967 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1299A>G (p.Gln433=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646013]	Chr15:50481561 [GRCh38] Chr15:50773758 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.104+17G>A	single nucleotide variant	Hereditary spastic paraplegia [RCV003646122]	Chr15:50439194 [GRCh38] Chr15:50731391 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1151T>A (p.Val384Asp)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646789]	Chr15:50477432 [GRCh38] Chr15:50769629 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3290A>T (p.Lys1097Ile)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646279]	Chr15:50499021 [GRCh38] Chr15:50791218 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1878C>T (p.Thr626=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646830]	Chr15:50484349 [GRCh38] Chr15:50776546 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.2746C>A (p.Gln916Lys)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646845]	Chr15:50495935 [GRCh38] Chr15:50788132 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1947A>G (p.Pro649=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646943]	Chr15:50489857 [GRCh38] Chr15:50782054 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.542-19T>C	single nucleotide variant	Hereditary spastic paraplegia [RCV003646438]	Chr15:50465028 [GRCh38] Chr15:50757225 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1148C>A (p.Pro383Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV003876093]	Chr15:50477429 [GRCh38] Chr15:50769626 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1896A>G (p.Gln632=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003647084]	Chr15:50489806 [GRCh38] Chr15:50782003 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.104+20A>G	single nucleotide variant	Hereditary spastic paraplegia [RCV003646428]	Chr15:50439197 [GRCh38] Chr15:50731394 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.104+5G>C	single nucleotide variant	Hereditary spastic paraplegia [RCV003647101]	Chr15:50439182 [GRCh38] Chr15:50731379 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.965G>A (p.Arg322Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646604]\|USP8-related disorder [RCV003901267]	Chr15:50476964 [GRCh38] Chr15:50769161 [GRCh37] Chr15:15q21.2	likely benign\|uncertain significance
NM_005154.5(USP8):c.578C>T (p.Thr193Met)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646635]	Chr15:50465083 [GRCh38] Chr15:50757280 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.494A>T (p.Gln165Leu)	single nucleotide variant	Hereditary spastic paraplegia [RCV003646031]	Chr15:50459158 [GRCh38] Chr15:50751355 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1859G>A (p.Arg620Lys)	single nucleotide variant	Hereditary spastic paraplegia [RCV003645993]	Chr15:50484330 [GRCh38] Chr15:50776527 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.513G>C (p.Lys171Asn)	single nucleotide variant	Hereditary spastic paraplegia [RCV003534288]	Chr15:50462294 [GRCh38] Chr15:50754491 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.530C>G (p.Thr177Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV003534228]	Chr15:50462311 [GRCh38] Chr15:50754508 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.297C>T (p.Val99=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003534142]	Chr15:50449447 [GRCh38] Chr15:50741644 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1219-20C>G	single nucleotide variant	Hereditary spastic paraplegia [RCV003534178]	Chr15:50481461 [GRCh38] Chr15:50773658 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.808A>G (p.Ile270Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV003534235]	Chr15:50471754 [GRCh38] Chr15:50763951 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3079T>A (p.Ser1027Thr)	single nucleotide variant	Hereditary spastic paraplegia [RCV003534202]	Chr15:50498636 [GRCh38] Chr15:50790833 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1620C>T (p.Thr540=)	single nucleotide variant	Hereditary spastic paraplegia [RCV003531532]	Chr15:50481882 [GRCh38] Chr15:50774079 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.3038+22_3038+24del	microsatellite	Hereditary spastic paraplegia [RCV003842531]	Chr15:50497249..50497251 [GRCh38] Chr15:50789446..50789448 [GRCh37] Chr15:15q21.2	likely benign
NM_005154.5(USP8):c.1573A>T (p.Met525Leu)	single nucleotide variant	Hereditary spastic paraplegia [RCV003824106]	Chr15:50481835 [GRCh38] Chr15:50774032 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2835A>T (p.Thr945=)	single nucleotide variant	not provided [RCV003886967]	Chr15:50496024 [GRCh38] Chr15:50788221 [GRCh37] Chr15:15q21.2	likely benign
NM_203494.5(USP50):c.1000G>C (p.Ala334Pro)	single nucleotide variant	not specified [RCV004477585]	Chr15:50500774 [GRCh38] Chr15:50792971 [GRCh37] Chr15:15q21.2	uncertain significance
NC_000015.9:g.(?_50731271)_(51634264_?)dup	duplication	not provided [RCV004583141]	Chr15:50731271..51634264 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.673G>A (p.Ala225Thr)	single nucleotide variant	USP8-related disorder [RCV004752441]	Chr15:50465178 [GRCh38] Chr15:50757375 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2861T>C (p.Leu954Pro)	single nucleotide variant	not provided [RCV004810068]	Chr15:50496050 [GRCh38] Chr15:50788247 [GRCh37] Chr15:15q21.2	uncertain significance
GRCh37/hg19 15q21.2(chr15:50512187-50905780)x1	copy number loss	not provided [RCV004819872]	Chr15:50512187..50905780 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1301CTC[1] (p.Pro435del)	microsatellite	Hereditary spastic paraplegia [RCV005195354]	Chr15:50481563..50481565 [GRCh38] Chr15:50773760..50773762 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2879_2895+12dup	duplication	Hereditary spastic paraplegia [RCV005171066]	Chr15:50496066..50496067 [GRCh38] Chr15:50788263..50788264 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2320C>T (p.Pro774Ser)	single nucleotide variant	Hereditary spastic paraplegia [RCV005179592]	Chr15:50492786 [GRCh38] Chr15:50784983 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.286A>C (p.Lys96Gln)	single nucleotide variant	Hereditary spastic paraplegia [RCV005206648]	Chr15:50449436 [GRCh38] Chr15:50741633 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.3353C>A (p.Thr1118Lys)	single nucleotide variant	Hereditary spastic paraplegia [RCV005190452]	Chr15:50499084 [GRCh38] Chr15:50791281 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2896-8dup	duplication	Hereditary spastic paraplegia [RCV005144297]	Chr15:50497074..50497075 [GRCh38] Chr15:50789271..50789272 [GRCh37] Chr15:15q21.2	benign
NM_005154.5(USP8):c.407A>C (p.Gln136Pro)	single nucleotide variant	Hereditary spastic paraplegia [RCV005168989]	Chr15:50459071 [GRCh38] Chr15:50751268 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.930G>T (p.Gln310His)	single nucleotide variant	Hereditary spastic paraplegia [RCV005138806]	Chr15:50476929 [GRCh38] Chr15:50769126 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1637A>G (p.Lys546Arg)	single nucleotide variant	Hereditary spastic paraplegia [RCV005137116]	Chr15:50481899 [GRCh38] Chr15:50774096 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.988A>G (p.Ile330Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV005083594]	Chr15:50476987 [GRCh38] Chr15:50769184 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.2809C>T (p.Leu937Phe)	single nucleotide variant	Hereditary spastic paraplegia [RCV005180067]	Chr15:50495998 [GRCh38] Chr15:50788195 [GRCh37] Chr15:15q21.2	uncertain significance
NM_005154.5(USP8):c.1793G>T (p.Gly598Val)	single nucleotide variant	Hereditary spastic paraplegia [RCV005111543]	Chr15:50482055 [GRCh38] Chr15:50774252 [GRCh37] Chr15:15q21.2	uncertain significance

Predicted Target Of

	Summary Value
Count of predictions:	3547
Count of miRNA genes:	952
Interacting mature miRNAs:	1157
Transcripts:	ENST00000307179, ENST00000396444, ENST00000419830, ENST00000425032, ENST00000433963, ENST00000558091, ENST00000558892, ENST00000559242, ENST00000559329, ENST00000560297, ENST00000560379, ENST00000560527, ENST00000560730, ENST00000560885, ENST00000560954, ENST00000560982, ENST00000561206, ENST00000561211, ENST00000561330
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
597610390	GWAS1667250_H	monocyte count QTL GWAS1667250 (human)		4e-11	monocyte quantity (VT:0000223)	blood monocyte count (CMO:0000032)	15	50478057	50478058	Human
597341843	GWAS1437917_H	osteoarthritis QTL GWAS1437917 (human)		6e-08	osteoarthritis		15	50487362	50487363	Human
597027358	GWAS1123432_H	systolic blood pressure QTL GWAS1123432 (human)		2e-08	systolic blood pressure	systolic blood pressure (CMO:0000004)	15	50468713	50468714	Human
597460625	GWAS1556699_H	osteoarthritis, knee QTL GWAS1556699 (human)		0.000005	osteoarthritis, hip, osteoarthritis, knee		15	50495228	50495229	Human
1643273	BW330_H	Body Weight QTL 330 (human)	1.05	0.014	Body weight	body mass index	15	26866719	52866719	Human
597339914	GWAS1435988_H	osteoarthritis QTL GWAS1435988 (human)		1e-10	osteoarthritis		15	50487362	50487363	Human
597360777	GWAS1456851_H	neutrophil count, eosinophil count QTL GWAS1456851 (human)		6e-12	eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	15	50507898	50507899	Human
597176843	GWAS1272917_H	protein measurement QTL GWAS1272917 (human)		1e-16	protein measurement		15	50492819	50492820	Human
2299958	PRSTS330_H	Prostate tumor susceptibility QTL 330 (human)	1.02	0.0151	Prostate tumor susceptibility		15	34790230	60790230	Human
597361282	GWAS1457356_H	granulocyte count QTL GWAS1457356 (human)		2e-11	granulocyte count		15	50507898	50507899	Human
597493383	GWAS1589457_H	osteoarthritis QTL GWAS1589457 (human)		0.000001	osteoarthritis		15	50495359	50495360	Human
597125557	GWAS1221631_H	osteoarthritis, knee QTL GWAS1221631 (human)		9e-10	osteoarthritis, knee		15	50467231	50467232	Human
597026225	GWAS1122299_H	hypertension QTL GWAS1122299 (human)		8e-10	hypertension		15	50464426	50464427	Human
1559354	LDLPS4_H	Low density lipoprotein particle size QTL 4 (human)	2.2	0.019	LDL particle size		15	34790230	60790230	Human
597256361	GWAS1352435_H	total cholesterol measurement QTL GWAS1352435 (human)		1e-18	total cholesterol measurement	blood total cholesterol level (CMO:0000051)	15	50492793	50492794	Human
597248424	GWAS1344498_H	blood phosphate measurement QTL GWAS1344498 (human)		7e-11	blood phosphate amount (VT:0001565)	blood phosphate level (CMO:0000504)	15	50433405	50433406	Human
597255714	GWAS1351788_H	triglyceride measurement QTL GWAS1351788 (human)		1e-15	triglyceride measurement	blood triglyceride level (CMO:0000118)	15	50492793	50492794	Human
597169956	GWAS1266030_H	cyclic AMP-responsive element-binding protein 3-like protein 4 measurement QTL GWAS1266030 (human)		5e-112	cyclic AMP-responsive element-binding protein 3-like protein 4 measurement		15	50492793	50492794	Human
597245735	GWAS1341809_H	blood protein measurement QTL GWAS1341809 (human)		2e-13	blood protein amount (VT:0005416)	blood protein measurement (CMO:0000028)	15	50492793	50492794	Human
597172697	GWAS1268771_H	rac GTPase-activating protein 1 measurement QTL GWAS1268771 (human)		2e-23	rac GTPase-activating protein 1 measurement		15	50492793	50492794	Human
597182683	GWAS1278757_H	ubiquitin carboxyl-terminal hydrolase 25 measurement QTL GWAS1278757 (human)		2e-17	ubiquitin carboxyl-terminal hydrolase 25 measurement		15	50492819	50492820	Human
597182684	GWAS1278758_H	ubiquitin carboxyl-terminal hydrolase 8 measurement QTL GWAS1278758 (human)		2e-16	ubiquitin carboxyl-terminal hydrolase 8 measurement		15	50438934	50438935	Human
597035218	GWAS1131292_H	heel bone mineral density QTL GWAS1131292 (human)		1e-17	heel bone mineral density	bone mineral density (CMO:0001226)	15	50468713	50468714	Human
597358428	GWAS1454502_H	granulocyte percentage of myeloid white cells QTL GWAS1454502 (human)		8e-09	granulocyte quantity (VT:0000334)		15	50505794	50505795	Human
597208150	GWAS1304224_H	electrocardiography QTL GWAS1304224 (human)		2e-08	electrocardiography		15	50483365	50483366	Human
597208151	GWAS1304225_H	electrocardiography QTL GWAS1304225 (human)		3e-08	electrocardiography		15	50483365	50483366	Human
597183050	GWAS1279124_H	E3 ISG15--protein ligase HERC5 measurement QTL GWAS1279124 (human)		8e-14	E3 ISG15--protein ligase HERC5 measurement		15	50492793	50492794	Human
597178314	GWAS1274388_H	protein measurement QTL GWAS1274388 (human)		4e-14	protein measurement		15	50492819	50492820	Human
597060549	GWAS1156623_H	FEV/FVC ratio QTL GWAS1156623 (human)		3e-13	FEV/FVC ratio	forced expiratory volume to forced vital capacity ratio (CMO:0000241)	15	50426364	50426365	Human
597026118	GWAS1122192_H	mean arterial pressure QTL GWAS1122192 (human)		3e-09	mean arterial pressure	mean arterial blood pressure (CMO:0000009)	15	50453226	50453227	Human
597178315	GWAS1274389_H	protein measurement QTL GWAS1274389 (human)		5e-18	protein measurement		15	50492793	50492794	Human
597254466	GWAS1350540_H	aspartate aminotransferase to alanine aminotransferase ratio QTL GWAS1350540 (human)		3e-14	aspartate aminotransferase to alanine aminotransferase ratio	serum aspartate aminotransferase activity level to alanine aminotransferase activity level ratio (CMO:0002245)	15	50492819	50492820	Human
597602627	GWAS1659487_H	monocyte count QTL GWAS1659487 (human)		9e-12	monocyte quantity (VT:0000223)	blood monocyte count (CMO:0000032)	15	50478057	50478058	Human
597442754	GWAS1538828_H	Alzheimer disease, educational attainment QTL GWAS1538828 (human)		0.000004	Alzheimer disease, educational attainment		15	50507898	50507899	Human
597090889	GWAS1186963_H	mean reticulocyte volume QTL GWAS1186963 (human)		7e-10	reticulocyte morphology trait (VT:0002424)	mean corpuscular volume (CMO:0000038)	15	50442099	50442100	Human
597177337	GWAS1273411_H	protein measurement QTL GWAS1273411 (human)		4e-20	protein measurement		15	50492819	50492820	Human
597255163	GWAS1351237_H	total cholesterol measurement QTL GWAS1351237 (human)		1e-11	total cholesterol measurement	blood total cholesterol level (CMO:0000051)	15	50492819	50492820	Human
1559411	SCL107_H	Serum cholesterol level QTL 107 (human)	3.88		Lipid level	triglyceride	15	26543552	52543552	Human
597170301	GWAS1266375_H	protein measurement QTL GWAS1266375 (human)		8e-35	protein measurement		15	50492819	50492820	Human
597183216	GWAS1279290_H	MHC class I polypeptide-related sequence A measurement QTL GWAS1279290 (human)		1e-66	MHC class I polypeptide-related sequence A measurement		15	50492793	50492794	Human
597183217	GWAS1279291_H	MHC class I polypeptide-related sequence A measurement QTL GWAS1279291 (human)		2e-19	MHC class I polypeptide-related sequence A measurement		15	50492819	50492820	Human
597183218	GWAS1279292_H	MHC class I polypeptide-related sequence B measurement QTL GWAS1279292 (human)		2e-79	MHC class I polypeptide-related sequence B measurement		15	50492819	50492820	Human
597516535	GWAS1612609_H	Parkinson disease QTL GWAS1612609 (human)		3e-08	Parkinson disease		15	50495212	50495213	Human
597245044	GWAS1341118_H	low density lipoprotein cholesterol measurement QTL GWAS1341118 (human)		8e-18	low density lipoprotein cholesterol measurement	blood aspartate aminotransferase activity level (CMO:0000580)	15	50492793	50492794	Human
597177448	GWAS1273522_H	complement C4 measurement QTL GWAS1273522 (human)		5e-40	complement C4 measurement		15	50492819	50492820	Human
597110246	GWAS1206320_H	ankylosing spondylitis QTL GWAS1206320 (human)		1e-13	ankylosing spondylitis		15	50492819	50492820	Human
597112800	GWAS1208874_H	osteoarthritis, knee QTL GWAS1208874 (human)		2e-08	osteoarthritis, knee		15	50438934	50438935	Human
597254382	GWAS1350456_H	apolipoprotein B measurement QTL GWAS1350456 (human)		2e-15	apolipoprotein B measurement	blood apoliprotein B level (CMO:0000522)	15	50492793	50492794	Human
597090797	GWAS1186871_H	monocyte percentage of leukocytes QTL GWAS1186871 (human)		3e-14	monocyte quantity (VT:0000223)	blood monocyte count to total leukocyte count ratio (CMO:0000374)	15	50481590	50481591	Human
597492320	GWAS1588394_H	osteoarthritis QTL GWAS1588394 (human)		0.0000001	osteoarthritis		15	50495359	50495360	Human

D15S1200

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	50,791,702 - 50,791,951	UniSTS	GRCh37
Build 36	15	48,578,994 - 48,579,243	RGD	NCBI36
Celera	15	27,684,281 - 27,684,529	RGD
Cytogenetic Map	15	q21.2	UniSTS
HuRef	15	27,622,109 - 27,622,357	UniSTS
GeneMap99-GB4 RH Map	15	177.97	UniSTS
Whitehead-RH Map	15	141.9	UniSTS
Whitehead-YAC Contig Map	15		UniSTS
NCBI RH Map	15	218.3	UniSTS

D15S712E

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	50,791,747 - 50,791,845	UniSTS	GRCh37
Build 36	15	48,579,039 - 48,579,137	RGD	NCBI36
Celera	15	27,684,326 - 27,684,423	RGD
Cytogenetic Map	15	q21.2	UniSTS
HuRef	15	27,622,154 - 27,622,251	UniSTS
GeneMap99-GB4 RH Map	15	177.42	UniSTS

RH104427

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	50,786,316 - 50,786,469	UniSTS	GRCh37
GRCh37	6	31,245,679 - 31,245,829	UniSTS	GRCh37
Build 36	6	31,353,658 - 31,353,808	RGD	NCBI36
Celera	6	32,844,349 - 32,844,499	RGD
Celera	15	27,678,896 - 27,679,049	UniSTS
Cytogenetic Map	15	q21.2	UniSTS
Cytogenetic Map	6	p21.33	UniSTS
HuRef	15	27,616,782 - 27,616,935	UniSTS
HuRef	6	31,046,299 - 31,046,449	UniSTS
GeneMap99-GB4 RH Map	15	178.53	UniSTS

G07414

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	50,791,499 - 50,791,839	UniSTS	GRCh37
GRCh37	6	31,246,745 - 31,247,082	UniSTS	GRCh37
Build 36	6	31,354,724 - 31,355,061	RGD	NCBI36
Celera	15	27,684,079 - 27,684,417	UniSTS
Celera	6	32,845,415 - 32,845,752	RGD
Cytogenetic Map	6	p21.3	UniSTS
Cytogenetic Map	15	q21.2	UniSTS
HuRef	15	27,621,907 - 27,622,245	UniSTS
HuRef	6	31,047,365 - 31,047,695	UniSTS

RH25289

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	31,245,553 - 31,245,676	UniSTS	GRCh37
GRCh37	15	50,785,035 - 50,786,313	UniSTS	GRCh37
Build 36	6	31,353,532 - 31,353,655	RGD	NCBI36
Celera	15	27,677,615 - 27,678,893	UniSTS
Celera	6	32,844,223 - 32,844,346	RGD
Cytogenetic Map	6	p21.33	UniSTS
Cytogenetic Map	15	q21.2	UniSTS
HuRef	6	31,046,173 - 31,046,296	UniSTS
HuRef	15	27,615,501 - 27,616,779	UniSTS
GeneMap99-GB4 RH Map	6	117.96	UniSTS
NCBI RH Map	6	428.4	UniSTS

RH45725

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	15	50,793,098 - 50,793,247	UniSTS	GRCh37
Build 36	15	48,580,390 - 48,580,539	RGD	NCBI36
Celera	15	27,685,676 - 27,685,825	RGD
Cytogenetic Map	15	q21.1	UniSTS
Cytogenetic Map	15	q21.2	UniSTS
HuRef	15	27,623,504 - 27,623,653	UniSTS
GeneMap99-GB4 RH Map	15	179.43	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	pharyngeal arch	renal system	reproductive system	respiratory system	sensory system	visual system
1204	2439	2788	2253	4973	1726	2351	6	624	1951	465	2269	7306	6472	53	3734	1	852	1744	1617	175	1


RefSeq Transcripts	NG_047101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001128610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001283049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_005154	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006720761	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006720762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011522193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017022718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017022719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017022720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017022721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017022722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_024450098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA399951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AA399952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AA773713	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC012170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AI276208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK091775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK292400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK296480	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK300590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC015545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC026954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC038801	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC051345	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC092443	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC110590	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM751645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX537420	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA312140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D29956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA112964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KF459553	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	OP328166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000307179 ⟹ ENSP00000302239

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,405 - 50,514,421 (+)	Ensembl

Ensembl Acc Id:

ENST00000396444 ⟹ ENSP00000379721

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,382 - 50,514,419 (+)	Ensembl

Ensembl Acc Id:

ENST00000419830

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,493,185 - 50,499,695 (+)	Ensembl

Ensembl Acc Id:

ENST00000425032 ⟹ ENSP00000412682

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,387 - 50,499,415 (+)	Ensembl

Ensembl Acc Id:

ENST00000558091 ⟹ ENSP00000454059

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,426,894 - 50,459,070 (+)	Ensembl

Ensembl Acc Id:

ENST00000558892

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,399 - 50,444,616 (+)	Ensembl

Ensembl Acc Id:

ENST00000559242 ⟹ ENSP00000453320

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,439,026 - 50,462,310 (+)	Ensembl

Ensembl Acc Id:

ENST00000559329 ⟹ ENSP00000454003

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,405 - 50,481,702 (+)	Ensembl

Ensembl Acc Id:

ENST00000560297 ⟹ ENSP00000453206

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,380 - 50,449,440 (+)	Ensembl

Ensembl Acc Id:

ENST00000560379

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,498,497 - 50,499,407 (+)	Ensembl

Ensembl Acc Id:

ENST00000560527

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,458,503 - 50,471,735 (+)	Ensembl

Ensembl Acc Id:

ENST00000560730 ⟹ ENSP00000452950

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,415 - 50,481,705 (+)	Ensembl

Ensembl Acc Id:

ENST00000560885

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,405 - 50,462,305 (+)	Ensembl

Ensembl Acc Id:

ENST00000560954

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,382 - 50,459,134 (+)	Ensembl

Ensembl Acc Id:

ENST00000560982 ⟹ ENSP00000453427

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,448 - 50,441,463 (+)	Ensembl

Ensembl Acc Id:

ENST00000561206

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,489,494 - 50,490,430 (+)	Ensembl

Ensembl Acc Id:

ENST00000561211 ⟹ ENSP00000457345

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,494 - 50,465,173 (+)	Ensembl

Ensembl Acc Id:

ENST00000561330 ⟹ ENSP00000453460

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,439,043 - 50,481,705 (+)	Ensembl

Ensembl Acc Id:

ENST00000625664 ⟹ ENSP00000485810

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	15	50,424,427 - 50,481,682 (+)	Ensembl

RefSeq Acc Id:

NM_001128610 ⟹ NP_001122082

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	50,424,405 - 50,514,421 (+)	NCBI
GRCh37	15	50,716,579 - 50,793,280 (+)	NCBI
HuRef	15	27,547,367 - 27,623,686 (+)	NCBI
CHM1_1	15	50,834,666 - 50,911,289 (+)	NCBI
T2T-CHM13v2.0	15	48,232,513 - 48,322,500 (+)	NCBI

Sequence:

show sequence

GAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGGCATTTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGTGAGTGCGGGTCTTGGG
CCCTAGCACCTGTTCTCTGGGAAGTCGTCCGCTGTGAACGATGAACGCCTTTCCTTCCACCAGCTGCTGGTTACCCCGGAGACAAGCTCTGTCCGCGGAGAGGAGTGGGACAACTCCTAAAGGAAAGA
AGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTCAGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAG
ACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGCACAGTGCCCTGAAGATCTTTAAGACAGCAGAAGAATGCAGATTAGATCGTGATGAGGAAAGGGCCTATGTACTATATATGAAATA
CGTGACTGTTTATAATCTTATCAAAAAAAGACCTGATTTCAAGCAACAGCAGGATTATTTCCATTCAATACTTGGACCTGGAAACATCAAAAAAGCTGTCGAAGAAGCTGAAAGACTCTCTGAAAGCC
TTAAATTAAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCGGCTACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAA
GGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAACCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGGA
TAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAG
CACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGGAGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGAT
GCACTTTTCAAGTGGGAAAGTAAAACTGTCCTGCGCAATGAGCCTTTGGTTTTAGAGGGAGGCTATGAAAACTGGCTCCTTTGTTATCCCCAGTATACAACAAATGCTAAGGTCACTCCACCCCCACG
ACGCCAGAATGAAGAGGTGTCTATCTCATTGGATTTTACTTATCCCTCATTGGAAGAATCAATTCCTTCTAAACCTGCTGCCCAGACGCCACCTGCATCTATAGAAGTAGATGAAAATATAGAATTGA
TAAGTGGTCAAAATGAGAGAATGGGACCACTGAATATATCAACTCCAGTTGAACCAGTTGCTGCTTCTAAATCTGATGTTTCACCCATAATTCAGCCAGTGCCTAGTATAAAGAATGTTCCACAGATT
GATCGTACTAAAAAACCAGCAGTCAAATTGCCTGAAGAGCATAGAATAAAATCTGAAAGTACAAACCATGAGCAACAATCTCCTCAGAGTGGAAAAGTTATTCCTGATCGTTCCACCAAGCCAGTAGT
TTTTTCTCCAACTCTCATGTTAACAGATGAAGAAAAGGCTCGTATTCATGCAGAAACTGCTCTTCTAATGGAAAAAAACAAACAAGAAAAAGAACTTCGGGAAAGGCAGCAAGAGGAACAGAAAGAGA
AACTGAGGAAGGAAGAACAAGAACAAAAAGCCAAAAAGAAACAAGAAGCTGAAGAAAATGAAATTACAGAGAAGCAACAAAAAGCAAAAGAAGAAATGGAGAAGAAAGAAAGTGAACAGGCCAAGAAA
GAAGATAAAGAAACCTCAGCAAAGAGGGGCAAAGAAATAACAGGAGTAAAAAGACAAAGTAAAAGTGAACATGAAACTTCTGATGCCAAGAAATCTGTAGAAGATAGGGGGAAAAGGTGTCCAACCCC
AGAAATACAGAAAAAGTCAACAGGAGATGTGCCCCATACATCTGTGACAGGGGATTCAGGTTCAGGCAAGCCATTTAAGATTAAAGGACAACCAGAAAGTGGAATTCTAAGGACAGGAACTTTTAGAG
AGGATACAGACGATACCGAAAGAAATAAAGCTCAACGAGAACCTTTGACAAGAGCACGAAGTGAAGAAATGGGGAGGATCGTACCAGGACTGCCTTCAGGCTGGGCCAAGTTTCTTGACCCAATCACT
GGAACCTTTCGTTATTATCATTCACCCACCAACACTGTTCATATGTACCCACCGGAAATGGCTCCTTCATCTGCACCTCCTTCCACCCCTCCAACTCATAAAGCCAAGCCACAGATTCCTGCTGAGCG
GGATAGGGAACCTTCCAAACTGAAGCGCTCCTACTCCTCCCCAGATATAACCCAGGCTATTCAAGAGGAAGAGAAGAGGAAGCCAACAGTAACTCCAACAGTTAATCGGGAAAACAAGCCAACATGTT
ATCCTAAAGCTGAGATCTCAAGGCTTTCTGCTTCTCAGATTCGGAACCTCAATCCTGTTTTTGGAGGTTCTGGACCAGCTCTTACTGGACTTCGTAACTTAGGAAATACTTGTTATATGAACTCAATA
TTGCAGTGCCTATGTAACGCTCCACATTTGGCTGATTATTTCAACCGAAACTGTTATCAGGATGATATTAACAGGTCAAATTTGTTGGGGCATAAAGGTGAAGTGGCAGAAGAATTTGGTATAATCAT
GAAAGCCCTGTGGACAGGACAGTATAGATATATCAGTCCAAAGGACTTTAAAATCACCATTGGGAAGATCAATGACCAGTTTGCAGGATACAGTCAGCAAGATTCACAAGAATTGCTTCTGTTCCTAA
TGGATGGTCTCCATGAAGATCTAAATAAAGCTGATAATCGGAAGAGATATAAAGAAGAAAATAATGATCATCTCGATGACTTTAAAGCTGCAGAACATGCCTGGCAGAAACACAAGCAGCTCAATGAG
TCTATTATTGTTGCACTTTTTCAGGGTCAATTCAAATCTACAGTACAGTGCCTCACATGTCACAAAAAGTCTAGGACATTTGAGGCCTTCATGTATTTGTCTCTACCACTAGCATCCACAAGTAAATG
TACATTACAGGATTGCCTTAGATTATTTTCCAAAGAAGAAAAACTCACAGATAACAACAGATTTTACTGCAGTCATTGCAGAGCTCGACGGGATTCTCTAAAAAAGATAGAAATCTGGAAGTTACCAC
CTGTGCTTTTAGTGCATCTGAAACGTTTTTCCTACGATGGCAGGTGGAAACAAAAATTACAGACATCTGTGGACTTCCCGTTAGAAAATCTTGACTTGTCACAGTATGTTATTGGTCCAAAGAACAAT
TTGAAGAAATATAATTTGTTTTCTGTTTCAAATCACTACGGTGGGCTGGATGGAGGCCACTACACAGCCTATTGTAAAAATGCAGCAAGACAACGGTGGTTTAAGTTTGATGATCATGAAGTTTCTGA
TATCTCCGTTTCTTCTGTGAAATCTTCAGCAGCTTATATCCTCTTTTATACTTCATTGGGACCACGAGTAACTGATGTAGCCACATAAGGAGACATAGGTTATAAACTAGTTATCTTTTAAAAGGCTC
AGCAACACAACTCTTGAAATGCTTATCAGGATAATGGTAGCTATAGCTGGCCATTTAGAGGAATTCTAGGACAGTGGGAGCTGTGTTACTAGCACTATATAATTCCGGTCAGTGCTGACAAATAACAT
TTAACAAGTATTGCAGTAATCATCACTTACAGGTACCATTTATTTCAAAACAACTTTTTTAGTCTGCTCCAAAGTTAAAATAATTAACTAGCTAAGCATTATTATTCGACTGGTCTAAAAACTATTGT
TATCTTTTTTTTTTCCTTTTCACTGTTATGGCCTTTTCACATTTCTAAATCCCATCTTGATATACTATGAATACTCTAGAATGATGTAAAGCAGATAGGAATGTATGTGTACATATTTATTGCATACT
TGCACATCAAATCGATGTACATAGTTTAACACGTGGTCCTTTTGTGAAACCTAGAACTCAGAGGATTGCTTTTTTTCTTTCAGCCTATTTTGAGTTAACTTCAGTGCTTTCTTAGGGAAATGACAGGG
CAAAGCAATTTTTCTGTTGGCTTTGGGCTGTATTTGTGCACTAAATCTTTATTCTAAAAAAAAAAATGGAAACTTTAATTTTTTTAAAACGAGAATTTCATTTACAGCTACATTAAAATCTTAATGAG
AAAAATAATTTATAACCCTGTGGGTGTTCTGTCTTTAATATTGTATTATCAAATATAGGACAGTAAAACCATAGATTTTATATACACACGTGCTATATAATAACACCCAGAGTCATTCTTTCAAGACT
AGTATTCTCACATATTGAGAATATTCATTCTAAATATTAAAGTAAAAATGCCGGGAGTCAGGCATGATTGCAAAGTGAACTGCATTATAAACTACATCTTTACAGAGTGATGTATTAAGAGGGTTAAA
GGAGCTTATAATTTATTTAACCGAGGGACTCAGTTGCTATATATATAGTCAGTAAAACACTCCATATAAAAATAAGATTCTAAAAGTGCTTCAGAAAGAGACCACCATTAGCAGGCTCTCAGGGAGAA
GATGAAAGGATGGGGTTCAAATTGTGAAGCTGACAACTTTTCATGTTTTACAATTAGTCTAAGAGACCACTTCTTGGCTAAATTATTATATCAAATATATTCAAATCATATTCTTAAACTCATCGAGC
CATTTGAACAAAAATTATTTTTGTTTAGCTTCATGAGTATCTTTGGAAAATAATTTGTTGAATATATATGATTATGAGATATTTTCTGATAAACACTGAATTTTGAAACCTGAACTCACTATATAATT
GCAGTGTTTTGAAGGCCTGCATCCATTAGCATTGCATTATATTCACACTGCCTTTTTTAGTGAACCAAGACCCATCTTCTGGACGACAGATTTATCTTAAGATGAAAGGTTGTATAACATGCCCACAA
GGCATAAAAATGTTAATGATGCAAGTAAGTTCTAAGAGTTTAATGACCAAGCAAAACTCTACCACCAGATGCTGACTGCTTGTTTTGCAGTGTTCAGGAAACACCATTTTCCTGGCTCTTAACGCTTT
TGTATTGGTATGGAAAAGGGCTGGCAGCTATAGAACAGGAGATCCATAGCATTTTGAACAGAAGTATCTGGAATCTCACTGACTCGTGTGTTATCAAAGCTATATCAGGCCTGGGTGACTGAATTCTT
GCAGAAAGCAGTGTAGTGGCCACCATCCAAATCACCAAAATGGTTCTATGGGAGAAAGGAATGTCAAACTTAGTATTCACATATGAACACTAACTACTGGAACAGAAATGATAGGGCCAAGAGATGCT
TTTTAAATTGTCCCTTATTCTAAATTAAAAGGAAGTGATAATTTTGTTGTTAAATCATGCATATAGCCTGACTGCTATATTGCTTCTCATTTCATTGTAACTACTTATATGTTGTGCCCATTGACTAT
CATCTGTGAATAAAGAAAGACAATATTTAGCAGCATCTGATTAATGTTTATCAGTGAACATTTAGTTAGCACTTAATATACATCAACTATTAAGCATTAAAGGAAATTTTACAATAAGAAGATAATTC
AGGCCGGGCACAGTGGCTCACACCTGTAATCCCAACACTCTGGGAGGCTGAGGCAGGTGGATTGCTTGAGTCCAGGAGTTCAAGACCAGCCTGGGCAAAATAGCGAGACTCCATATCTTTTAAAGGAA
AAAAAAAAAAAAAAAAAAGATGAGCTAGGCATAGTGGTGCACACCTGTAGTCCCAGCTACTTGGGAAGTTGGGGTGGGAGGATCTCTCGAGCCTGAGAGGTCGAGGCTGCAATGAGCCGTGATTGTAC
CACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTTAAAATTGTAAGTTCATTTACGTAAGATGGCTTCTTTTTTTTTTTTTTAAAGTTAGGATAAGCCACAGAAGAGACATTTAACATTAGA
ATAAGGATCTTAACTGCATATTGCTACAGCACAAATTGAGGGGGCTATGTAGCAACAACCCCTCAATCCCCCATAGGGTACAAAAAATAATGTATCTCATTTTCCTTTTTCCATGTCTTTCCTAACCC
AGTATTGTTTGGAACAAAGGCATTAGAGAGGTGTACTTCCAAGGAGGTGTTATGGTGTATGATAAGGGTCAGCAAACCACGGCCCGTGGGTCAACTCCAGGCTGTTTTTGTAAGACCCATGCATTAGC
AACGGGTTTTAAATTTTTATATGGTTGGGGAAAAGATCCAAGTAATAATAGTATTGTTATATGTGAAAATTTTATGAAATTCAAATGTCAATGTCCTTAAAGTTTTATGGGAACACAGTCATGCTCAT
TTGTTTACACTTTTCAGTGGCTGCTTTAATGATACAACAGTAAAACTGAATAGTTGCAGCCAATACCATATGGCTTATGAGGCCTAAAATATTTACTGTTTGGCCTTTAACAGAATAAGTTTGCTGAC
CTCTGCTGTAGAGGAAGAAAATTGATTATTTGTTAACTTATTTTTAATTTTTTGAGATGGAGTCTCTCTCTGTTGCCCAGGCTGGAATGCAGTGGCACGATCTCGGCTCACTGCAACCTCCGCCTCCC
AGGTTCAAGCAATTCTTCTGCCTCAGCCTTCCAAGTAGCTGGGAGACTACAGGTGCCTGCCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTC
TCGATCTCGACCTCGGGATCCTCCCACTTCGGCCTCCCAAAGTTATTTATTTTTATTTGAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGACGTGATCTCAGCTCACCACAACCTCTGC
TTCCTGGGTTAAAGCTCTTCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTACAGGCACGCACCACCACACCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGCCAGGCTG
GTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCCACCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCAGCCTATTTATTTTTAGAAGCAGTTTCTTGCTATGTTGCCCAGGCTG
TACATGAATTCCTAGGCACAAGCAGTCCTCTCACTTCAGGCCCCCAAATAGCTGGGACTACAGGCATACACCACCATGTCCAGAATGAAAATGGATCTGACTAGTTAATTCCAACGTGAATTCGGGTG
TAATAGTACATTGTGACCTTAGCGAAATTATTTGACCTTTCTGAGCTTTAATTTCTCATCTATTAACATGGCTTGTTTTGTATAGCTGTTATCAAATATCTCATGTATTGAGGGCTAGTACACAGGAG
TTATTTATTCAATATTCCCTTCAACCTTCGTCTTCCCCACCTCTCTCCTTACAGGTAATAGAAATATCTGAAATTCACATTTAAAAGATCAAGGTTCCGCCAGGCCTGGTGGCTCACGCCTGTAATCC
CAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGAGGTCAGGAGTTTGAGACTAGCCTGGCCAACATGGTGAAAATCCATCTCTTCTAAAAATATAAAAATTAGCTGGGCATGGTGGCGCATGCCG
GTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATCATTTGAACCTGGGAGATGGAGGTTGCAGTGAGCTGAGATCATGCCATTGCATTCCAGCCTGGGCGGAGCCCTAAACAGGAAATTTAACAACAG
TATGGTGTGTGGTTTATGCTTTGTGACTGCCTGGGCGTAAAGACAGTCCCTAGTTTCTGTAACCAGTATGCTCGGGTTTTAAAGGTCACGCAAGGACACTCGAGGTAAAGTCTTAGGCCCCCCTACAA
GGTGAGAAGTTGGATTGAGATCCACATACAAAGCCAGGACCTTTAAAGACATTCACCCTCAATGGAAGGATTAAAAAACAAAATCCACCCTCTAGTGCTTGTGTTAGCTTGGACTCATGGTACAGAGA
ATAAAAGTCATTCCTGGGAATTTGTCACCATAGACCTACCTTTTCACCAGTTTGGGATTCAAATTTATACTACCTGTGTGGTCTGCGAATCCTGTGAACTTAATATGAAAAGTATTTCTAGGGCAGTT
GCCAGAAGGAAACAGAATTTCTAGATTGTTGCATGTTAACTCAGACCTAACAGGATATCCACATATGAAACCCCAATGAAGTTGAGATCACAATTCAAAATAATAGAACATGCAAGGAAACAATTTAT
CATAAGAGTCAGAAGGCAATAAGATTTAAACCCCCAAGGACTTTAGATAATAGAATTATTAAGCAGAGGCTACAAATAAAGTATATTTAAATATATTTAGAAGAAGGAAACAAACTTTAGAAACTAAA
TAGAATTTTCAGAAATGAGAAATACAACATAGTTGGCCGTCCATATTTACGGGCTCTGCATCTTCAGAATCAACTAATGTGATGGGAAAGATTTGAAAAAATAATACAACAATAAAAATATACATATT
TTAAAATACAGTGTAACAACTATTTACATAGTATTTATATTGTATTAGATATTATAAGTAATCCAGAGATGACTTAAAGTATATGGGAGGATGTGCATAGGTTACATGCAAATACTACTCCAGGCCTG
GCATGGTGGCTCACACGTGTAATCCCAACGTTTTTGGGGGATGGAGGTGGGCAGACTGCTTGAGCCCAGGAGTTGTAGACCAGCCTGGGCAACATGGCAAAACCCTGTCTACACAAAATACAAAAATT
GACCAGGCATAGTGGCACGTGCCTATAGTCCCAGCTACTTGGTAGGTTGAGGTGGGAGAATCACCTGAGCCCAGGAGGTCGAGGCTACAGTGAGCTGTGACTGAGCCACTGCTCTCCAGCCTGGCAAC
AGAATGAGACCTTGTCTCAAAAAACAAAAACAAAAAACACCAGAAAAGACACCATTTTATATAGGGCCCTTGAGCATCTGTGGATTTTGATAGTCAAAGGGATCCTGGAACCAACTCCCTGCAGATAC
TGAGGTACAACTGTACTGGAAATTAACTTAATGAAGATATTAGGACACAGAAAATGAATAAACCGGACTGGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGTGGACCA
TGAGGTCAGGAGTTCAAGACCAACCTGGTACACATGGTGAAACCCTGTCTCTATTAAAAAAAACAAAAAAAATTAGCTGGGCCTGGTGGCGTGCACCTGTAATCCCAGCTACTTGAGAGGCTGAAGCA
GGAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCATTGCACTCCAGTGTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAGAATAAACTATAAAATGAA
GTTGGGGAAATTAGCAAGAATGGAGTAGTGATGGAGAATACGTGTTAAGAGGCATGAAAAATTGAATGAGAATATTCAGCGTATGTCCTGTAGAAGTTCTAGGAGGAGAGAATCGAGTAGGGGAGCAA
GGCAATATTAAAAGTGATAATGGCTGAAAATGATTAATGAGACATGAATCTTCACATTTAGGAAATGCAGCGAGCCAGGGATAAATAAAAATAATACTGCAGAACAACAGAGACAAAGAGAAAAAGCT
TAAAAGCAACCAGAAAGAAAAAGAGAGTTTACCCACAAGAATCTAACCTGCTGGTAGAAGTTCTCCATAGCAGCCATAGAAATCAGAGACAATACAGTAGCTTCAAAATAATAGAGAAAAATAACTGT
CAATCTGGAATTTGATTTCTAGTTATCATCCAAGAATGAAAGTGAATTAAAGACTTCTCAAAGACTGAGAGACTTCAGGATAACAGACCCTCACTGAAAAGCCTACTGAAATATATGCCACATGAATT
TTAAAAACTCAATGAAGGAAGAAGTGATACATAATAGACAGTGATTAACAAAAAAGACTGATGAAGATCCGGGCAAATATAACCCAATATGAACAGTAGAAAACCATGATAATGTCTCCTTTGGAGGC
ATATTAAAAAATTAAAAACCGGCTGGGCATGGTGGTTCACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCAGGAGGATCGTTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGAC
CTGGTCTCTAAAAAAAATAAAAAAGTTGGCCATGCACAGTAGCATGCCTGTAGTCCCAGCTACTTGGCAGGCAGAGGCAGGAGGATCCCTTAAGCCCAGAGTTCAAAACTGTAGTGAGCTATGATTCA
TTGCACTAGTGCACTCCAGTCTGGGCAACAGAGTGAGACCCTGTCTCAAAAACAAAAGATGCTGAAAACAGTAGTTCAGTGATCAGAATTACAGTGTTCTAAGAGCTTTCCATTTCTTTGGGAGCAGA
GTATAAAGATCTTGATTAACTTTAGGCTTTAAGTATGAAAGCTGTCGTTTTTTAGCATAATTACTAAAGAATCAAAATGTGTAACTTCCAAAGTTGTAGAGGGAAAATAAAGAAAGCTTTATCAGTTT
AGTAGCAGCAAGAACAACAGGGGAAAACAACACAGCAGAGGTCCCCAACCCCCCCAGGCTGCCTGTCCCTGACCTGTTCAGGACCTGGCTGCACAGCAGGAAGCGAGCGGCAAACCTACCCTGAGCAC
CGCCTCCTGTCAGATCAGCTGCTGCATTAGATTCTCACAGCAGCACAAACTCTATTGTGAACTGCGCATGTGAGGGATCTAGGTTGCGTGCTCCTTATGAGAATCTACTGCCTGATTTTCTGAGGTGG
AACAGTTTAATCCCAAAACCATGCCCGCCCCGGCCCCCATCCATGGGAAAAAAACCGCATCAGTGGAAAAATTGTCTTCCACAAAAATCAGTCCCTGGTGCCAACAAGGTTGGGGACTGCCGAATTAG
AAAAATAAGGCTAACATAAACACAAAAGAAGATGACGACAAGTAAATCCGAATTTATTACTAGTTGAAATATATGGGATGTAGTAAATTTACCAAATATTTACTGGATTTTAAATATCCAGTTCTAGC
CAGGCGCGATGGCTCACGTCTATAATCTCAGCACTTGGGGAGGCCGAGGGGGGCGGATCACGAGGTCAGGAGATCAAGACTATCCTGGCCAACACGGTGAAACCTCATCTCTACAAAAATACAAAAAA
TTAGCCGGGCATGGTGGCAGGCGCCTATAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGTGAAGCTTGCAGTGAGCCGAGATCGTGCCACTGCATTCCAGCCTGGGC
GACAGAGCGAGACTTCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGTTTTAGGCCAAGTGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGCGGATCAC
CTGAGATCAGGAGTTCCAGACCACCCTGGCCAACATGGCAAAACCCGGTCTCTACTAAAAATACAAAAATTAGCTGGGTCTGGTGGCACATGCCAGTAATCCCAACTACTTGGGAAGCTGAGGCAGGA
GAGTTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGGCACAGAGTGAGACTCTGTCTCTAAAACAAAACAACAACAACAACAAATCCAGTTCTATG
CACTATATAACATTTAGAACTCAGAAAAGGTGTATTTCCCTTGAGCATCATGTTGGTGCTTAAAATGTTTCAGATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACTTGTCGTAGGTAGA
TATGACCAAGAGAAAGCTGAAGTAGCTATACATCAGCTAAAATGGTCCCTAAGATAGAATGCATTGTAAATGAGTCACTTTATAATGAAAAAAGGTTTAAATCACCCAAATTGTATAATTTGAAACTG
CTACCTACCTAACAAAACAGACTTGTTAAAAACAAATGACAGAACTATAGGGAAGTTTTGACAAGTCTACCATCATAATGGAAGATTTCAACTATTGATCAAGCAGACAAAAATATTAGTATAGATAC
AGCTTTTACAATATATACTTAGATGAGTATCTGACTCCTGAAATAGAAGTGCACTGTCTCAACAAATGTAAAAGAGTTAGTTTAGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGA
GGCCAAGGCAGGCGAATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCATGGTGTCGGCTGCCTGTAATCCCAGCTAC
TGAGGAGGCTGAAGCAGGAAAATCGCTTGAAACTGGGCGGCGGAGGTTGCAGTGAGCCGAGATGGTGCCAGTGCACTCTAGCCCGGGCGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAA
AAAAAAGATTAGTTTAATTTAGACCCTAGTCTTTGAACACAATACAATTAGCAGTCAATACAAAATGATACCCCCACAAAAAATCAATACTTTTGGAAATTAAAAAAACACTTCTAAGTAACTTTATA
AATAAATTATAAAAGTAAAACACTTAGAAGTAAATAGTAATGAAAATACTATATCAAAACATGGGATGCACTGATGTCTGAGAATGTCTTAAAAATAATACGATGCCAAGAAGAGAGTGGGTCAGTAT
TAAGATGAATTGATCATTTATTTTATATTCAAATATCTTGCTTCAGCAAGCTAGTTGATGGATGCATGGCGGTTTGTTATGCTGTCCAATTTTGTATATGTTTGAAATATTCTATAATAAAAAAAGGC
AGAGAAAGTGGGAGATAGACATTTGTAGTTTTAAATACTTATATCTTAAAGGATAGACTGAGTGTTAATACACTGGACACTCAGTTTAAAACATTAAAACATAACAGAATAAACCCTAAAAGAGTAGA
GGGAAGAGATAACACTGTAAGAGGAATAACCCATAAAGCAGAAAACAAAGATGTAATACAGAAGATTTAAAAAAAGGTAAAAGTTGGTGTTTTAAGACAAAATAATTTGGATGTTAGCCTGCCACAGT
GGTTCATGCCTATAATCCCTGCACTTTGGGAGGCCAAGGCAGATGGATCGCCTGAGTCCAGGAGTTTGAAACCAGCTTGGGCAACATGGCAAAACCCCGTCTCTATAAAAAAAAAAAGAGTACAGGCC
AGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTATTAAAAATACAAAAAA
TTACCTGGGCACGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGGTCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGTGCTCCAGCCTGGGCG
ACAGAGCGAGACTCCGTCACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACAAAATTAGCTGGACATGGTGTTGTGCCTGTAGTTCCATCTACTTGGGAGGCTGAGGTGGGAGGATGGCTCGAGCC
TGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCCTGGGAGACAGAGTGAGACCCTCTCTCAAAAATAGTAACTTGGACGTCAATAGTAAGATTTAGAGAATAAGAGACAAGG
CGGCCGGGCGCGGTGGCTCATGTAATCCCAGCACTTTGGAAGGCTGAGGCAGGCGGATCACCAGGTCAGGAAATTGAGACTATCCTGGCTAACACGGTGAAACACCGTCTCTACTAAAAATACAAAAA
ATTAGCCGGGCATGGTGGCGGGCGCCTGTAGTCCCAAGCTACTCAGGAGGCTGAGACAGGAGAATGACTTGAACCCGGGAGGCGGAGCTTGCCGTGAGCTGAGATCGTGCCATTGCACTCCAGCCTGG
GCGACAGAGCGAGACTGCGTCTCAAAAAATAAAATAAAATAAAATAAAATAAAAAAGAGACAAGTCAACGATAAAATTAAAAATGAAAAAACATGTAATAGCTACAGATCCTGAATAAATTTATTGTT
AATACCCTAAAAACTTTATGCCAGCCAACTGAGACCTTAGATGAAATAGACAAATATCTGGAGAATAAGTTACCAAAATGACTGAAGAGAAATACATGGCTCACACCTATATTTTTTACAGAAATTGA
CAAGGGCCAGGAATAATCGAAATACTACTGAAAAATAAGAATAAAGTTGTGATGGTAATGACTTAGGGAATAATGATGGTTCTTGCTCTGCCAGATATCAATGTTTATTTCAAAGCTATAGCTATAAT
TAATATTCATAAGCTAAATTAAGAATTAATTCAATATTAATTTAATAAATTTAATATTTTATAGCTATAATTAATACAGTACGGAATTAGCCCAAATGTGAACAAATTGACCAACAGACACACACAGC
ATAGGAAAACCAGCATTATATGTTACTGAGGAAAAGAAGAGGCTGAGACATTTGGTTATTCATATGCAGAAAAATGAAATTGAATCCCTAATTTATACTACATTTTTGTCAGAAGTGCAAAACAATTT
AAATGTTTGGAAGATATGTAGGTAAATATCTTTGTAATTCCAGGGTTGGAAAGGATTTCTTAAATGAGACACAGAAAAGGACTAACTAGAAAAGATTGATGTTCCAACCAAATTAAAACTTGATTGTC
AGCAATTACAATAAGATACAACAACCAAATGCAGTTTGTGAATTTTGGATGGATTCTGGTCTTTGAAAAAAAATGCTACTAAAAAAAAAAACCTTGTGACAATTGATATTTGAATATGAATCTATGAA
TATGAGTGATGGAATTTTAAATTTTCTTACATATAATTCTGCTATTGTGGGTATGTAGAAGAATGTGGTTAAGGGATTATTTTGATCTATGAAGTGTCACGATACAAGATTTAAATCAGCAAAAAGTT
AGATATACGTGTGTATAGATGTGCACATATATATGTATAGAGAGTGAAAGTAATAAAAGTGTATACACTGCTAAATGTTAATAACTGAATCTAGCTGAAATGTACACCAATGTACACCAATGTTTTGT
TTTTTGGTTTTTTTTTTAGAGATGGAGTCTCGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAG
TAGCTGGGACTACAGGCGCCCGCCACCATGCCCGGCTAATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGCCTTGGC
CTCCCAAAGTGCTGGGATTACAGGCGTCAGCCACCGTGCCCGGCCGATGTACACCAATGTTCTCTGTACAATTCTTTCAGATTTTCTGAATGTTTGCAAAGTTTTATTTTAAAAACTGGAGAGAGAGC
ACTTGAAAAGATGCTCAACATCATTAGTCATTAGGAAAATGCAACTCAAAACCATGACATACCAGTTCATACCTACTTTGTATGGGATAGAATAAAAAATGAGAGGCAGTAACAAGTTCGGTTGAGGA
TGTGGGGAAACTGGAACCTTAGTTCCAGTTGCTGGTGGGAACGTAAAATGCTGCTGCCACTTTGGAAAACAATTTGGCAGTTCCTCAAAAAATTAACCAGAGTTACCATATGACCCAGAAATTTCACA
CTTAGGTATATACCCAACAGAAATGAAAACATGTTTACAGAAAATCCTGTACATAAATGTTCATAGCAGCATTACTGATGACAGCCAAAAGTGGAAACAAGCCAAATGTCCATCACTGGATGGATTAA
GGAAATGTGGTATATCCTATACAATGGAATATTATTTGGCAATAAAAAGGAATGAAGTACAGATACATGCTATGACATGAATGAAACTTGAAAACATTATGCTGAATAAAAGAAAATAAAAACAGAAG
GTCATATATTCTATGATTCTGTTTATTAAAATACCCAGAATAGGCCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACCTGGGGGAGCCGAGGCAGGTGGATCACTTGACGTCTGGAGTTTGAGACC
AGCCTGGGCAATATAGCAAAACCCCATCTCAACCAAAATACACAAAAATTATTGGGGCATGGTGGTGCACACCTGTGGTCCCAGCTACTCGAGGGAGGGAGGAGGGAAGATCACTTGAGCCAGGGAGG
TTGAGGCTGCAGTGAGCTGAGATTGCACCATTGCACTCCAGCCTGAGCAAGAGTGAGATATTGTCTCAAAAAATAAAATAAATAAAATTTTAAAAATACGCAGAATAGGCACATCTATAGAAATATAT
AAAGTAGAGGCCAGGAGAAGTGGTTCATGCCTGTAATCCGAGCACTTTGGGAGGCCAAGGTGGGTGCGCCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGTCAACATGGTGAAACCCCACCTCTACT
AAAAATACAAAAATACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGTTACGAGAATCCCTTGAACCTGGGAGGCGGAAGTTGCAGTGAGCTGAAATCATGCCACTGCACTCCAGCCTGGGCAACAGA
GCAAGACTCTGTTAAAAAAAAAAAAAATAGCGAGAGATCGAGAGAGAGTGCACGTGAGAAGACTAGTAGTTGCTATGGACTGGGGGAGAAGGAACGGGTTACAGGGTTTCTTTTGGGGATAACGAAAA
TGTTCTAAAACTGGACTGTGGTGATAACTGCACAACTCTGTGAATGTACTAAAAACTACTGAACTGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCCTGAGATGGGCAGAT
CACTTGAGGTCAGGAGTTCCAGACCAGTCTGGCCAACATGGTGAAACCACATCTCTACTAAAAATATTTTTAAAAATTAGCCAGGCATGGTGGTGCACCTGTAATCCCAGCTACTTGGGAGGCTGGGG
CATGAGAATCATTTGAAACCAGGGGGTGGAGGTTGCAGTGAGCCGAGATCACACCACCGCACTCCAGCCTGGGCGACAGAGCCAGACTCTGTCTCAAAAACAAACAAAACAAAAACAACAAAAAACAC
AACTGAACACATTTAAGGTGAATTCTGTGGTATGTGAACTATCTCTAAGAACTTCTTTTTATTTAAGTTGGGAAACAAAAAGATCATGTACAACAAACCAAAAACAAAAAAGTTATTTCTAACCCATG
TAACATATAACAAGGATCTAGAACATGTAAATGACTCTTTCCAATCAATAAGAAGAAAAATAACCCAGTTTGTAAAAAATGTGCAAAAGACAAATATTTCATACAATAGGAAAAACTAAAATGAGATA
ATTTTGTATCCATTAGATGGCAAAAATTAAGAAGTCTGATGATCCTGGTAGGGGTATGTATTGGTATAATCACTTGTAGAAAGTTAAATATGCACATACTTTATGATCTAAGTGACCTCACTCCTAAG
TATATACATGAGAGAAACTCTTATGCACATATATATGCAGGAATGTCTGCATAATGTTGTTCATGCCAGCAAAAATTTGGAAACAATGAAATATCAATAGGAAAATGGATAATTTATGATATATTCAC
ACAATATACATCATAGGCTAGTGAAATTATAACCACATGCAACAATATGGATATATCTTTAAAATATTTAATGAAAAAGTATGCTTGGCGCGGTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGA
TGAGGGAGGTGGATCACCTGAGGTCATGAGTTCGAGACAAGAGCGAAACTGTCTAAAAAAAAAAAAAAAAAAAAGAGTGAAGAATCAAGCCACAGAAGGTAATTTAAAAATGTACACTCAAGATTTAA
AAAGAACTACAATTCCATAAGAAAAAGGCAGGCCACAGAATAGGAAAAAGAATAAAAGACTTGTTTAGGCATTTCACAAAAGAAAGTATACAAATTTAAGTAGTTATTTAAACCACAATGCCATTCTA
CTATATGGGCAACCAGAAGGGCCAAAACAAAACGAACAAAAGACTACCAAGTGTTAACAAGGATTTAAGGCAACTGAAACTTCCAGTCATTGCTGGTGGGGGTATGAATTGGTACAGTCGCTTTGGAA
AGCTACTGAGCAGTATGTACTAAAGCCAGACATATGCGTATTTCTGAACCAGGAGTTTCACTCCTAGGTATGTACTCAAAAGAACTGTGTACACTATGTTCACCAAAAAACAAGAATGTTTATAGCAA
CCCTCTTTGCATTAGTCAAAAGCTAGTAATTACCCAAAAGTTCCTGAATGGTAGAATGAATTACTAAATTGTAGTATTTTCATACAATGGAATACTATACAGCAATGAGAATGAATAAATTACAATAT
AAACAACAATATGGATGAACATTACATAATTTTGAATGAAAGGAGCCAGACACAAAAAAAGGATATACTGTACAATTCCATTTATACGAAGCATAAAATCAGGCAAAAATCTATAAATCTGTCCTGCC
AGAAGTCAGTGGTTTTCCAGACTCGAAGGCAGGTACAAGCACAGTTAGGGTGCTGGTAACATTCTGTTTAAACTCTGTTCTGCTGGTTACATGGGTATGTTCACTTGAAAATCCATCAAGTTTTATCC
TCATGGTTTGTGTACTTTTCTGTATATATGTTTCACTTCAATAAAGTTTATTTTTGGTCAA

hide sequence

RefSeq Acc Id:

NM_001283049 ⟹ NP_001269978

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	50,424,405 - 50,514,421 (+)	NCBI
HuRef	15	27,547,367 - 27,623,686 (+)	NCBI
CHM1_1	15	50,834,666 - 50,911,289 (+)	NCBI
T2T-CHM13v2.0	15	48,232,513 - 48,322,500 (+)	NCBI

Sequence:

show sequence

GAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGG
CATTTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTC
AGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAG
ACAGGCAGGAGGAAGCACAGCGGCTACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAACCCAAAAGAGCAAT
GGTGAAAAGAATGAAAAATGTGAGACCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGGATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCA
GGATTCCTGTATTTTACATTCTCTCAGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGG
AGTATGTGGTACTTCTTGACTGGTTTAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAAGTGGGAAAGTAAAACTGTCCTGCGCAATGAGCCTTTGGTT
TTAGAGGGAGGCTATGAAAACTGGCTCCTTTGTTATCCCCAGTATACAACAAATGCTAAGGTCACTCCACCCCCACGACGCCAGAATGAAGAGGTGTCTATCTCATTGGATTTTACTTATCCCTCATT
GGAAGAATCAATTCCTTCTAAACCTGCTGCCCAGACGCCACCTGCATCTATAGAAGTAGATGAAAATATAGAATTGATAAGTGGTCAAAATGAGAGAATGGGACCACTGAATATATCAACTCCAGTTG
AACCAGTTGCTGCTTCTAAATCTGATGTTTCACCCATAATTCAGCCAGTGCCTAGTATAAAGAATGTTCCACAGATTGATCGTACTAAAAAACCAGCAGTCAAATTGCCTGAAGAGCATAGAATAAAA
TCTGAAAGTACAAACCATGAGCAACAATCTCCTCAGAGTGGAAAAGTTATTCCTGATCGTTCCACCAAGCCAGTAGTTTTTTCTCCAACTCTCATGTTAACAGATGAAGAAAAGGCTCGTATTCATGC
AGAAACTGCTCTTCTAATGGAAAAAAACAAACAAGAAAAAGAACTTCGGGAAAGGCAGCAAGAGGAACAGAAAGAGAAACTGAGGAAGGAAGAACAAGAACAAAAAGCCAAAAAGAAACAAGAAGCTG
AAGAAAATGAAATTACAGAGAAGCAACAAAAAGCAAAAGAAGAAATGGAGAAGAAAGAAAGTGAACAGGCCAAGAAAGAAGATAAAGAAACCTCAGCAAAGAGGGGCAAAGAAATAACAGGAGTAAAA
AGACAAAGTAAAAGTGAACATGAAACTTCTGATGCCAAGAAATCTGTAGAAGATAGGGGGAAAAGGTGTCCAACCCCAGAAATACAGAAAAAGTCAACAGGAGATGTGCCCCATACATCTGTGACAGG
GGATTCAGGTTCAGGCAAGGCTCAACGAGAACCTTTGACAAGAGCACGAAGTGAAGAAATGGGGAGGATCGTACCAGGACTGCCTTCAGGCTGGGCCAAGTTTCTTGACCCAATCACTGGAACCTTTC
GTTATTATCATTCACCCACCAACACTGTTCATATGTACCCACCGGAAATGGCTCCTTCATCTGCACCTCCTTCCACCCCTCCAACTCATAAAGCCAAGCCACAGATTCCTGCTGAGCGGGATAGGGAA
CCTTCCAAACTGAAGCGCTCCTACTCCTCCCCAGATATAACCCAGGCTATTCAAGAGGAAGAGAAGAGGAAGCCAACAGTAACTCCAACAGTTAATCGGGAAAACAAGCCAACATGTTATCCTAAAGC
TGAGATCTCAAGGCTTTCTGCTTCTCAGATTCGGAACCTCAATCCTGTTTTTGGAGGTTCTGGACCAGCTCTTACTGGACTTCGTAACTTAGGAAATACTTGTTATATGAACTCAATATTGCAGTGCC
TATGTAACGCTCCACATTTGGCTGATTATTTCAACCGAAACTGTTATCAGGATGATATTAACAGGTCAAATTTGTTGGGGCATAAAGGTGAAGTGGCAGAAGAATTTGGTATAATCATGAAAGCCCTG
TGGACAGGACAGTATAGATATATCAGTCCAAAGGACTTTAAAATCACCATTGGGAAGATCAATGACCAGTTTGCAGGATACAGTCAGCAAGATTCACAAGAATTGCTTCTGTTCCTAATGGATGGTCT
CCATGAAGATCTAAATAAAGCTGATAATCGGAAGAGATATAAAGAAGAAAATAATGATCATCTCGATGACTTTAAAGCTGCAGAACATGCCTGGCAGAAACACAAGCAGCTCAATGAGTCTATTATTG
TTGCACTTTTTCAGGGTCAATTCAAATCTACAGTACAGTGCCTCACATGTCACAAAAAGTCTAGGACATTTGAGGCCTTCATGTATTTGTCTCTACCACTAGCATCCACAAGTAAATGTACATTACAG
GATTGCCTTAGATTATTTTCCAAAGAAGAAAAACTCACAGATAACAACAGATTTTACTGCAGTCATTGCAGAGCTCGACGGGATTCTCTAAAAAAGATAGAAATCTGGAAGTTACCACCTGTGCTTTT
AGTGCATCTGAAACGTTTTTCCTACGATGGCAGGTGGAAACAAAAATTACAGACATCTGTGGACTTCCCGTTAGAAAATCTTGACTTGTCACAGTATGTTATTGGTCCAAAGAACAATTTGAAGAAAT
ATAATTTGTTTTCTGTTTCAAATCACTACGGTGGGCTGGATGGAGGCCACTACACAGCCTATTGTAAAAATGCAGCAAGACAACGGTGGTTTAAGTTTGATGATCATGAAGTTTCTGATATCTCCGTT
TCTTCTGTGAAATCTTCAGCAGCTTATATCCTCTTTTATACTTCATTGGGACCACGAGTAACTGATGTAGCCACATAAGGAGACATAGGTTATAAACTAGTTATCTTTTAAAAGGCTCAGCAACACAA
CTCTTGAAATGCTTATCAGGATAATGGTAGCTATAGCTGGCCATTTAGAGGAATTCTAGGACAGTGGGAGCTGTGTTACTAGCACTATATAATTCCGGTCAGTGCTGACAAATAACATTTAACAAGTA
TTGCAGTAATCATCACTTACAGGTACCATTTATTTCAAAACAACTTTTTTAGTCTGCTCCAAAGTTAAAATAATTAACTAGCTAAGCATTATTATTCGACTGGTCTAAAAACTATTGTTATCTTTTTT
TTTTCCTTTTCACTGTTATGGCCTTTTCACATTTCTAAATCCCATCTTGATATACTATGAATACTCTAGAATGATGTAAAGCAGATAGGAATGTATGTGTACATATTTATTGCATACTTGCACATCAA
ATCGATGTACATAGTTTAACACGTGGTCCTTTTGTGAAACCTAGAACTCAGAGGATTGCTTTTTTTCTTTCAGCCTATTTTGAGTTAACTTCAGTGCTTTCTTAGGGAAATGACAGGGCAAAGCAATT
TTTCTGTTGGCTTTGGGCTGTATTTGTGCACTAAATCTTTATTCTAAAAAAAAAAATGGAAACTTTAATTTTTTTAAAACGAGAATTTCATTTACAGCTACATTAAAATCTTAATGAGAAAAATAATT
TATAACCCTGTGGGTGTTCTGTCTTTAATATTGTATTATCAAATATAGGACAGTAAAACCATAGATTTTATATACACACGTGCTATATAATAACACCCAGAGTCATTCTTTCAAGACTAGTATTCTCA
CATATTGAGAATATTCATTCTAAATATTAAAGTAAAAATGCCGGGAGTCAGGCATGATTGCAAAGTGAACTGCATTATAAACTACATCTTTACAGAGTGATGTATTAAGAGGGTTAAAGGAGCTTATA
ATTTATTTAACCGAGGGACTCAGTTGCTATATATATAGTCAGTAAAACACTCCATATAAAAATAAGATTCTAAAAGTGCTTCAGAAAGAGACCACCATTAGCAGGCTCTCAGGGAGAAGATGAAAGGA
TGGGGTTCAAATTGTGAAGCTGACAACTTTTCATGTTTTACAATTAGTCTAAGAGACCACTTCTTGGCTAAATTATTATATCAAATATATTCAAATCATATTCTTAAACTCATCGAGCCATTTGAACA
AAAATTATTTTTGTTTAGCTTCATGAGTATCTTTGGAAAATAATTTGTTGAATATATATGATTATGAGATATTTTCTGATAAACACTGAATTTTGAAACCTGAACTCACTATATAATTGCAGTGTTTT
GAAGGCCTGCATCCATTAGCATTGCATTATATTCACACTGCCTTTTTTAGTGAACCAAGACCCATCTTCTGGACGACAGATTTATCTTAAGATGAAAGGTTGTATAACATGCCCACAAGGCATAAAAA
TGTTAATGATGCAAGTAAGTTCTAAGAGTTTAATGACCAAGCAAAACTCTACCACCAGATGCTGACTGCTTGTTTTGCAGTGTTCAGGAAACACCATTTTCCTGGCTCTTAACGCTTTTGTATTGGTA
TGGAAAAGGGCTGGCAGCTATAGAACAGGAGATCCATAGCATTTTGAACAGAAGTATCTGGAATCTCACTGACTCGTGTGTTATCAAAGCTATATCAGGCCTGGGTGACTGAATTCTTGCAGAAAGCA
GTGTAGTGGCCACCATCCAAATCACCAAAATGGTTCTATGGGAGAAAGGAATGTCAAACTTAGTATTCACATATGAACACTAACTACTGGAACAGAAATGATAGGGCCAAGAGATGCTTTTTAAATTG
TCCCTTATTCTAAATTAAAAGGAAGTGATAATTTTGTTGTTAAATCATGCATATAGCCTGACTGCTATATTGCTTCTCATTTCATTGTAACTACTTATATGTTGTGCCCATTGACTATCATCTGTGAA
TAAAGAAAGACAATATTTAGCAGCATCTGATTAATGTTTATCAGTGAACATTTAGTTAGCACTTAATATACATCAACTATTAAGCATTAAAGGAAATTTTACAATAAGAAGATAATTCAGGCCGGGCA
CAGTGGCTCACACCTGTAATCCCAACACTCTGGGAGGCTGAGGCAGGTGGATTGCTTGAGTCCAGGAGTTCAAGACCAGCCTGGGCAAAATAGCGAGACTCCATATCTTTTAAAGGAAAAAAAAAAAA
AAAAAAAAGATGAGCTAGGCATAGTGGTGCACACCTGTAGTCCCAGCTACTTGGGAAGTTGGGGTGGGAGGATCTCTCGAGCCTGAGAGGTCGAGGCTGCAATGAGCCGTGATTGTACCACTGCACTC
CAGCCTGGGTGACAGAGTGAGACCCTGTCTTAAAATTGTAAGTTCATTTACGTAAGATGGCTTCTTTTTTTTTTTTTTAAAGTTAGGATAAGCCACAGAAGAGACATTTAACATTAGAATAAGGATCT
TAACTGCATATTGCTACAGCACAAATTGAGGGGGCTATGTAGCAACAACCCCTCAATCCCCCATAGGGTACAAAAAATAATGTATCTCATTTTCCTTTTTCCATGTCTTTCCTAACCCAGTATTGTTT
GGAACAAAGGCATTAGAGAGGTGTACTTCCAAGGAGGTGTTATGGTGTATGATAAGGGTCAGCAAACCACGGCCCGTGGGTCAACTCCAGGCTGTTTTTGTAAGACCCATGCATTAGCAACGGGTTTT
AAATTTTTATATGGTTGGGGAAAAGATCCAAGTAATAATAGTATTGTTATATGTGAAAATTTTATGAAATTCAAATGTCAATGTCCTTAAAGTTTTATGGGAACACAGTCATGCTCATTTGTTTACAC
TTTTCAGTGGCTGCTTTAATGATACAACAGTAAAACTGAATAGTTGCAGCCAATACCATATGGCTTATGAGGCCTAAAATATTTACTGTTTGGCCTTTAACAGAATAAGTTTGCTGACCTCTGCTGTA
GAGGAAGAAAATTGATTATTTGTTAACTTATTTTTAATTTTTTGAGATGGAGTCTCTCTCTGTTGCCCAGGCTGGAATGCAGTGGCACGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGC
AATTCTTCTGCCTCAGCCTTCCAAGTAGCTGGGAGACTACAGGTGCCTGCCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCGA
CCTCGGGATCCTCCCACTTCGGCCTCCCAAAGTTATTTATTTTTATTTGAGACAGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGACGTGATCTCAGCTCACCACAACCTCTGCTTCCTGGGTT
AAAGCTCTTCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTACAGGCACGCACCACCACACCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGCCAGGCTGGTCTTGAACT
CCTGACCTCAAGTGATCCACCTGCCTCCACCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCACCCAGCCTATTTATTTTTAGAAGCAGTTTCTTGCTATGTTGCCCAGGCTGTACATGAATT
CCTAGGCACAAGCAGTCCTCTCACTTCAGGCCCCCAAATAGCTGGGACTACAGGCATACACCACCATGTCCAGAATGAAAATGGATCTGACTAGTTAATTCCAACGTGAATTCGGGTGTAATAGTACA
TTGTGACCTTAGCGAAATTATTTGACCTTTCTGAGCTTTAATTTCTCATCTATTAACATGGCTTGTTTTGTATAGCTGTTATCAAATATCTCATGTATTGAGGGCTAGTACACAGGAGTTATTTATTC
AATATTCCCTTCAACCTTCGTCTTCCCCACCTCTCTCCTTACAGGTAATAGAAATATCTGAAATTCACATTTAAAAGATCAAGGTTCCGCCAGGCCTGGTGGCTCACGCCTGTAATCCCAGCACTTTG
GGAGGCTGAGGCAGGCGGATCACTTGAGGTCAGGAGTTTGAGACTAGCCTGGCCAACATGGTGAAAATCCATCTCTTCTAAAAATATAAAAATTAGCTGGGCATGGTGGCGCATGCCGGTAATCCCAG
CTACTTGGGAGGCTGAGGCAGAATCATTTGAACCTGGGAGATGGAGGTTGCAGTGAGCTGAGATCATGCCATTGCATTCCAGCCTGGGCGGAGCCCTAAACAGGAAATTTAACAACAGTATGGTGTGT
GGTTTATGCTTTGTGACTGCCTGGGCGTAAAGACAGTCCCTAGTTTCTGTAACCAGTATGCTCGGGTTTTAAAGGTCACGCAAGGACACTCGAGGTAAAGTCTTAGGCCCCCCTACAAGGTGAGAAGT
TGGATTGAGATCCACATACAAAGCCAGGACCTTTAAAGACATTCACCCTCAATGGAAGGATTAAAAAACAAAATCCACCCTCTAGTGCTTGTGTTAGCTTGGACTCATGGTACAGAGAATAAAAGTCA
TTCCTGGGAATTTGTCACCATAGACCTACCTTTTCACCAGTTTGGGATTCAAATTTATACTACCTGTGTGGTCTGCGAATCCTGTGAACTTAATATGAAAAGTATTTCTAGGGCAGTTGCCAGAAGGA
AACAGAATTTCTAGATTGTTGCATGTTAACTCAGACCTAACAGGATATCCACATATGAAACCCCAATGAAGTTGAGATCACAATTCAAAATAATAGAACATGCAAGGAAACAATTTATCATAAGAGTC
AGAAGGCAATAAGATTTAAACCCCCAAGGACTTTAGATAATAGAATTATTAAGCAGAGGCTACAAATAAAGTATATTTAAATATATTTAGAAGAAGGAAACAAACTTTAGAAACTAAATAGAATTTTC
AGAAATGAGAAATACAACATAGTTGGCCGTCCATATTTACGGGCTCTGCATCTTCAGAATCAACTAATGTGATGGGAAAGATTTGAAAAAATAATACAACAATAAAAATATACATATTTTAAAATACA
GTGTAACAACTATTTACATAGTATTTATATTGTATTAGATATTATAAGTAATCCAGAGATGACTTAAAGTATATGGGAGGATGTGCATAGGTTACATGCAAATACTACTCCAGGCCTGGCATGGTGGC
TCACACGTGTAATCCCAACGTTTTTGGGGGATGGAGGTGGGCAGACTGCTTGAGCCCAGGAGTTGTAGACCAGCCTGGGCAACATGGCAAAACCCTGTCTACACAAAATACAAAAATTGACCAGGCAT
AGTGGCACGTGCCTATAGTCCCAGCTACTTGGTAGGTTGAGGTGGGAGAATCACCTGAGCCCAGGAGGTCGAGGCTACAGTGAGCTGTGACTGAGCCACTGCTCTCCAGCCTGGCAACAGAATGAGAC
CTTGTCTCAAAAAACAAAAACAAAAAACACCAGAAAAGACACCATTTTATATAGGGCCCTTGAGCATCTGTGGATTTTGATAGTCAAAGGGATCCTGGAACCAACTCCCTGCAGATACTGAGGTACAA
CTGTACTGGAAATTAACTTAATGAAGATATTAGGACACAGAAAATGAATAAACCGGACTGGGCGCGGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGTGGACCATGAGGTCAGG
AGTTCAAGACCAACCTGGTACACATGGTGAAACCCTGTCTCTATTAAAAAAAACAAAAAAAATTAGCTGGGCCTGGTGGCGTGCACCTGTAATCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGC
TTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCATTGCACTCCAGTGTGGGTGACAGAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAGAATAAACTATAAAATGAAGTTGGGGAAA
TTAGCAAGAATGGAGTAGTGATGGAGAATACGTGTTAAGAGGCATGAAAAATTGAATGAGAATATTCAGCGTATGTCCTGTAGAAGTTCTAGGAGGAGAGAATCGAGTAGGGGAGCAAGGCAATATTA
AAAGTGATAATGGCTGAAAATGATTAATGAGACATGAATCTTCACATTTAGGAAATGCAGCGAGCCAGGGATAAATAAAAATAATACTGCAGAACAACAGAGACAAAGAGAAAAAGCTTAAAAGCAAC
CAGAAAGAAAAAGAGAGTTTACCCACAAGAATCTAACCTGCTGGTAGAAGTTCTCCATAGCAGCCATAGAAATCAGAGACAATACAGTAGCTTCAAAATAATAGAGAAAAATAACTGTCAATCTGGAA
TTTGATTTCTAGTTATCATCCAAGAATGAAAGTGAATTAAAGACTTCTCAAAGACTGAGAGACTTCAGGATAACAGACCCTCACTGAAAAGCCTACTGAAATATATGCCACATGAATTTTAAAAACTC
AATGAAGGAAGAAGTGATACATAATAGACAGTGATTAACAAAAAAGACTGATGAAGATCCGGGCAAATATAACCCAATATGAACAGTAGAAAACCATGATAATGTCTCCTTTGGAGGCATATTAAAAA
ATTAAAAACCGGCTGGGCATGGTGGTTCACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCAGGAGGATCGTTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCTGGTCTCTA
AAAAAAATAAAAAAGTTGGCCATGCACAGTAGCATGCCTGTAGTCCCAGCTACTTGGCAGGCAGAGGCAGGAGGATCCCTTAAGCCCAGAGTTCAAAACTGTAGTGAGCTATGATTCATTGCACTAGT
GCACTCCAGTCTGGGCAACAGAGTGAGACCCTGTCTCAAAAACAAAAGATGCTGAAAACAGTAGTTCAGTGATCAGAATTACAGTGTTCTAAGAGCTTTCCATTTCTTTGGGAGCAGAGTATAAAGAT
CTTGATTAACTTTAGGCTTTAAGTATGAAAGCTGTCGTTTTTTAGCATAATTACTAAAGAATCAAAATGTGTAACTTCCAAAGTTGTAGAGGGAAAATAAAGAAAGCTTTATCAGTTTAGTAGCAGCA
AGAACAACAGGGGAAAACAACACAGCAGAGGTCCCCAACCCCCCCAGGCTGCCTGTCCCTGACCTGTTCAGGACCTGGCTGCACAGCAGGAAGCGAGCGGCAAACCTACCCTGAGCACCGCCTCCTGT
CAGATCAGCTGCTGCATTAGATTCTCACAGCAGCACAAACTCTATTGTGAACTGCGCATGTGAGGGATCTAGGTTGCGTGCTCCTTATGAGAATCTACTGCCTGATTTTCTGAGGTGGAACAGTTTAA
TCCCAAAACCATGCCCGCCCCGGCCCCCATCCATGGGAAAAAAACCGCATCAGTGGAAAAATTGTCTTCCACAAAAATCAGTCCCTGGTGCCAACAAGGTTGGGGACTGCCGAATTAGAAAAATAAGG
CTAACATAAACACAAAAGAAGATGACGACAAGTAAATCCGAATTTATTACTAGTTGAAATATATGGGATGTAGTAAATTTACCAAATATTTACTGGATTTTAAATATCCAGTTCTAGCCAGGCGCGAT
GGCTCACGTCTATAATCTCAGCACTTGGGGAGGCCGAGGGGGGCGGATCACGAGGTCAGGAGATCAAGACTATCCTGGCCAACACGGTGAAACCTCATCTCTACAAAAATACAAAAAATTAGCCGGGC
ATGGTGGCAGGCGCCTATAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGTGAAGCTTGCAGTGAGCCGAGATCGTGCCACTGCATTCCAGCCTGGGCGACAGAGCGA
GACTTCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGTTTTAGGCCAAGTGTGGTGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGATCAG
GAGTTCCAGACCACCCTGGCCAACATGGCAAAACCCGGTCTCTACTAAAAATACAAAAATTAGCTGGGTCTGGTGGCACATGCCAGTAATCCCAACTACTTGGGAAGCTGAGGCAGGAGAGTTGCTTG
AACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGGCACAGAGTGAGACTCTGTCTCTAAAACAAAACAACAACAACAACAAATCCAGTTCTATGCACTATATAA
CATTTAGAACTCAGAAAAGGTGTATTTCCCTTGAGCATCATGTTGGTGCTTAAAATGTTTCAGATTTTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACTTGTCGTAGGTAGATATGACCAAG
AGAAAGCTGAAGTAGCTATACATCAGCTAAAATGGTCCCTAAGATAGAATGCATTGTAAATGAGTCACTTTATAATGAAAAAAGGTTTAAATCACCCAAATTGTATAATTTGAAACTGCTACCTACCT
AACAAAACAGACTTGTTAAAAACAAATGACAGAACTATAGGGAAGTTTTGACAAGTCTACCATCATAATGGAAGATTTCAACTATTGATCAAGCAGACAAAAATATTAGTATAGATACAGCTTTTACA
ATATATACTTAGATGAGTATCTGACTCCTGAAATAGAAGTGCACTGTCTCAACAAATGTAAAAGAGTTAGTTTAGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCA
GGCGAATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGCATGGTGTCGGCTGCCTGTAATCCCAGCTACTGAGGAGGCT
GAAGCAGGAAAATCGCTTGAAACTGGGCGGCGGAGGTTGCAGTGAGCCGAGATGGTGCCAGTGCACTCTAGCCCGGGCGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGATT
AGTTTAATTTAGACCCTAGTCTTTGAACACAATACAATTAGCAGTCAATACAAAATGATACCCCCACAAAAAATCAATACTTTTGGAAATTAAAAAAACACTTCTAAGTAACTTTATAAATAAATTAT
AAAAGTAAAACACTTAGAAGTAAATAGTAATGAAAATACTATATCAAAACATGGGATGCACTGATGTCTGAGAATGTCTTAAAAATAATACGATGCCAAGAAGAGAGTGGGTCAGTATTAAGATGAAT
TGATCATTTATTTTATATTCAAATATCTTGCTTCAGCAAGCTAGTTGATGGATGCATGGCGGTTTGTTATGCTGTCCAATTTTGTATATGTTTGAAATATTCTATAATAAAAAAAGGCAGAGAAAGTG
GGAGATAGACATTTGTAGTTTTAAATACTTATATCTTAAAGGATAGACTGAGTGTTAATACACTGGACACTCAGTTTAAAACATTAAAACATAACAGAATAAACCCTAAAAGAGTAGAGGGAAGAGAT
AACACTGTAAGAGGAATAACCCATAAAGCAGAAAACAAAGATGTAATACAGAAGATTTAAAAAAAGGTAAAAGTTGGTGTTTTAAGACAAAATAATTTGGATGTTAGCCTGCCACAGTGGTTCATGCC
TATAATCCCTGCACTTTGGGAGGCCAAGGCAGATGGATCGCCTGAGTCCAGGAGTTTGAAACCAGCTTGGGCAACATGGCAAAACCCCGTCTCTATAAAAAAAAAAAGAGTACAGGCCAGGCGCGGTG
GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTACCTGGGC
ACGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGGTCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGTGCTCCAGCCTGGGCGACAGAGCGAG
ACTCCGTCACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACAAAATTAGCTGGACATGGTGTTGTGCCTGTAGTTCCATCTACTTGGGAGGCTGAGGTGGGAGGATGGCTCGAGCCTGGGAGGCAG
AGGTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCCTGGGAGACAGAGTGAGACCCTCTCTCAAAAATAGTAACTTGGACGTCAATAGTAAGATTTAGAGAATAAGAGACAAGGCGGCCGGGCG
CGGTGGCTCATGTAATCCCAGCACTTTGGAAGGCTGAGGCAGGCGGATCACCAGGTCAGGAAATTGAGACTATCCTGGCTAACACGGTGAAACACCGTCTCTACTAAAAATACAAAAAATTAGCCGGG
CATGGTGGCGGGCGCCTGTAGTCCCAAGCTACTCAGGAGGCTGAGACAGGAGAATGACTTGAACCCGGGAGGCGGAGCTTGCCGTGAGCTGAGATCGTGCCATTGCACTCCAGCCTGGGCGACAGAGC
GAGACTGCGTCTCAAAAAATAAAATAAAATAAAATAAAATAAAAAAGAGACAAGTCAACGATAAAATTAAAAATGAAAAAACATGTAATAGCTACAGATCCTGAATAAATTTATTGTTAATACCCTAA
AAACTTTATGCCAGCCAACTGAGACCTTAGATGAAATAGACAAATATCTGGAGAATAAGTTACCAAAATGACTGAAGAGAAATACATGGCTCACACCTATATTTTTTACAGAAATTGACAAGGGCCAG
GAATAATCGAAATACTACTGAAAAATAAGAATAAAGTTGTGATGGTAATGACTTAGGGAATAATGATGGTTCTTGCTCTGCCAGATATCAATGTTTATTTCAAAGCTATAGCTATAATTAATATTCAT
AAGCTAAATTAAGAATTAATTCAATATTAATTTAATAAATTTAATATTTTATAGCTATAATTAATACAGTACGGAATTAGCCCAAATGTGAACAAATTGACCAACAGACACACACAGCATAGGAAAAC
CAGCATTATATGTTACTGAGGAAAAGAAGAGGCTGAGACATTTGGTTATTCATATGCAGAAAAATGAAATTGAATCCCTAATTTATACTACATTTTTGTCAGAAGTGCAAAACAATTTAAATGTTTGG
AAGATATGTAGGTAAATATCTTTGTAATTCCAGGGTTGGAAAGGATTTCTTAAATGAGACACAGAAAAGGACTAACTAGAAAAGATTGATGTTCCAACCAAATTAAAACTTGATTGTCAGCAATTACA
ATAAGATACAACAACCAAATGCAGTTTGTGAATTTTGGATGGATTCTGGTCTTTGAAAAAAAATGCTACTAAAAAAAAAAACCTTGTGACAATTGATATTTGAATATGAATCTATGAATATGAGTGAT
GGAATTTTAAATTTTCTTACATATAATTCTGCTATTGTGGGTATGTAGAAGAATGTGGTTAAGGGATTATTTTGATCTATGAAGTGTCACGATACAAGATTTAAATCAGCAAAAAGTTAGATATACGT
GTGTATAGATGTGCACATATATATGTATAGAGAGTGAAAGTAATAAAAGTGTATACACTGCTAAATGTTAATAACTGAATCTAGCTGAAATGTACACCAATGTACACCAATGTTTTGTTTTTTGGTTT
TTTTTTTAGAGATGGAGTCTCGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCGCTATCTCGGCTCACTGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAC
TACAGGCGCCCGCCACCATGCCCGGCTAATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGCCTTGGCCTCCCAAAGT
GCTGGGATTACAGGCGTCAGCCACCGTGCCCGGCCGATGTACACCAATGTTCTCTGTACAATTCTTTCAGATTTTCTGAATGTTTGCAAAGTTTTATTTTAAAAACTGGAGAGAGAGCACTTGAAAAG
ATGCTCAACATCATTAGTCATTAGGAAAATGCAACTCAAAACCATGACATACCAGTTCATACCTACTTTGTATGGGATAGAATAAAAAATGAGAGGCAGTAACAAGTTCGGTTGAGGATGTGGGGAAA
CTGGAACCTTAGTTCCAGTTGCTGGTGGGAACGTAAAATGCTGCTGCCACTTTGGAAAACAATTTGGCAGTTCCTCAAAAAATTAACCAGAGTTACCATATGACCCAGAAATTTCACACTTAGGTATA
TACCCAACAGAAATGAAAACATGTTTACAGAAAATCCTGTACATAAATGTTCATAGCAGCATTACTGATGACAGCCAAAAGTGGAAACAAGCCAAATGTCCATCACTGGATGGATTAAGGAAATGTGG
TATATCCTATACAATGGAATATTATTTGGCAATAAAAAGGAATGAAGTACAGATACATGCTATGACATGAATGAAACTTGAAAACATTATGCTGAATAAAAGAAAATAAAAACAGAAGGTCATATATT
CTATGATTCTGTTTATTAAAATACCCAGAATAGGCCAGGCACTGTGGCTCACGCCTGTAATCCCAGCACCTGGGGGAGCCGAGGCAGGTGGATCACTTGACGTCTGGAGTTTGAGACCAGCCTGGGCA
ATATAGCAAAACCCCATCTCAACCAAAATACACAAAAATTATTGGGGCATGGTGGTGCACACCTGTGGTCCCAGCTACTCGAGGGAGGGAGGAGGGAAGATCACTTGAGCCAGGGAGGTTGAGGCTGC
AGTGAGCTGAGATTGCACCATTGCACTCCAGCCTGAGCAAGAGTGAGATATTGTCTCAAAAAATAAAATAAATAAAATTTTAAAAATACGCAGAATAGGCACATCTATAGAAATATATAAAGTAGAGG
CCAGGAGAAGTGGTTCATGCCTGTAATCCGAGCACTTTGGGAGGCCAAGGTGGGTGCGCCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGTCAACATGGTGAAACCCCACCTCTACTAAAAATACAA
AAATACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGTTACGAGAATCCCTTGAACCTGGGAGGCGGAAGTTGCAGTGAGCTGAAATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCT
GTTAAAAAAAAAAAAAATAGCGAGAGATCGAGAGAGAGTGCACGTGAGAAGACTAGTAGTTGCTATGGACTGGGGGAGAAGGAACGGGTTACAGGGTTTCTTTTGGGGATAACGAAAATGTTCTAAAA
CTGGACTGTGGTGATAACTGCACAACTCTGTGAATGTACTAAAAACTACTGAACTGGCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCCTGAGATGGGCAGATCACTTGAGGT
CAGGAGTTCCAGACCAGTCTGGCCAACATGGTGAAACCACATCTCTACTAAAAATATTTTTAAAAATTAGCCAGGCATGGTGGTGCACCTGTAATCCCAGCTACTTGGGAGGCTGGGGCATGAGAATC
ATTTGAAACCAGGGGGTGGAGGTTGCAGTGAGCCGAGATCACACCACCGCACTCCAGCCTGGGCGACAGAGCCAGACTCTGTCTCAAAAACAAACAAAACAAAAACAACAAAAAACACAACTGAACAC
ATTTAAGGTGAATTCTGTGGTATGTGAACTATCTCTAAGAACTTCTTTTTATTTAAGTTGGGAAACAAAAAGATCATGTACAACAAACCAAAAACAAAAAAGTTATTTCTAACCCATGTAACATATAA
CAAGGATCTAGAACATGTAAATGACTCTTTCCAATCAATAAGAAGAAAAATAACCCAGTTTGTAAAAAATGTGCAAAAGACAAATATTTCATACAATAGGAAAAACTAAAATGAGATAATTTTGTATC
CATTAGATGGCAAAAATTAAGAAGTCTGATGATCCTGGTAGGGGTATGTATTGGTATAATCACTTGTAGAAAGTTAAATATGCACATACTTTATGATCTAAGTGACCTCACTCCTAAGTATATACATG
AGAGAAACTCTTATGCACATATATATGCAGGAATGTCTGCATAATGTTGTTCATGCCAGCAAAAATTTGGAAACAATGAAATATCAATAGGAAAATGGATAATTTATGATATATTCACACAATATACA
TCATAGGCTAGTGAAATTATAACCACATGCAACAATATGGATATATCTTTAAAATATTTAATGAAAAAGTATGCTTGGCGCGGTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGATGAGGGAGGT
GGATCACCTGAGGTCATGAGTTCGAGACAAGAGCGAAACTGTCTAAAAAAAAAAAAAAAAAAAAGAGTGAAGAATCAAGCCACAGAAGGTAATTTAAAAATGTACACTCAAGATTTAAAAAGAACTAC
AATTCCATAAGAAAAAGGCAGGCCACAGAATAGGAAAAAGAATAAAAGACTTGTTTAGGCATTTCACAAAAGAAAGTATACAAATTTAAGTAGTTATTTAAACCACAATGCCATTCTACTATATGGGC
AACCAGAAGGGCCAAAACAAAACGAACAAAAGACTACCAAGTGTTAACAAGGATTTAAGGCAACTGAAACTTCCAGTCATTGCTGGTGGGGGTATGAATTGGTACAGTCGCTTTGGAAAGCTACTGAG
CAGTATGTACTAAAGCCAGACATATGCGTATTTCTGAACCAGGAGTTTCACTCCTAGGTATGTACTCAAAAGAACTGTGTACACTATGTTCACCAAAAAACAAGAATGTTTATAGCAACCCTCTTTGC
ATTAGTCAAAAGCTAGTAATTACCCAAAAGTTCCTGAATGGTAGAATGAATTACTAAATTGTAGTATTTTCATACAATGGAATACTATACAGCAATGAGAATGAATAAATTACAATATAAACAACAAT
ATGGATGAACATTACATAATTTTGAATGAAAGGAGCCAGACACAAAAAAAGGATATACTGTACAATTCCATTTATACGAAGCATAAAATCAGGCAAAAATCTATAAATCTGTCCTGCCAGAAGTCAGT
GGTTTTCCAGACTCGAAGGCAGGTACAAGCACAGTTAGGGTGCTGGTAACATTCTGTTTAAACTCTGTTCTGCTGGTTACATGGGTATGTTCACTTGAAAATCCATCAAGTTTTATCCTCATGGTTTG
TGTACTTTTCTGTATATATGTTTCACTTCAATAAAGTTTATTTTTGGTCAA

hide sequence

RefSeq Acc Id:

NM_005154 ⟹ NP_005145

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	50,424,405 - 50,514,421 (+)	NCBI
GRCh37	15	50,716,579 - 50,793,280 (+)	NCBI
Build 36	15	48,503,871 - 48,579,265 (+)	NCBI Archive
HuRef	15	27,547,367 - 27,623,686 (+)	NCBI
CHM1_1	15	50,834,666 - 50,911,289 (+)	NCBI
T2T-CHM13v2.0	15	48,232,513 - 48,322,500 (+)	NCBI

Sequence:

show sequence

GAGCTGGGCTGGCTTCCGTCCTGGTAGCCAAGGCTAATTCTCCCTCGAGTTCTTGGGAGATGGG
CATTTGGCGAGAAGGCTGGCGTTAGTGAAGCGCGCCCGGCGTCACGGAAAGAAGCACTTGTAAGGAAATATAGCATCCATTGTGAAAGTGGAAAAGTAAAGATAATTCATCATGCCTGCTGTGGCTTC
AGTTCCTAAAGAACTCTACCTCAGTTCTTCACTAAAAGACCTTAATAAGAAGACAGAAGTTAAACCAGAGAAAATAAGCACTAAGAGTTATGTGCACAGTGCCCTGAAGATCTTTAAGACAGCAGAAG
AATGCAGATTAGATCGTGATGAGGAAAGGGCCTATGTACTATATATGAAATACGTGACTGTTTATAATCTTATCAAAAAAAGACCTGATTTCAAGCAACAGCAGGATTATTTCCATTCAATACTTGGA
CCTGGAAACATCAAAAAAGCTGTCGAAGAAGCTGAAAGACTCTCTGAAAGCCTTAAATTAAGATATGAAGAAGCTGAAGTCCGGAAAAAACTTGAGGAAAAAGACAGGCAGGAGGAAGCACAGCGGCT
ACAACAAAAAAGGCAGGAAACAGGAAGAGAGGATGGTGGCACATTGGCTAAAGGCTCTTTGGAGAATGTTTTGGATTCCAAAGACAAAACCCAAAAGAGCAATGGTGAAAAGAATGAAAAATGTGAGA
CCAAAGAGAAAGGAGCAATCACAGCAAAGGAACTATACACAATGATGACGGATAAAAACATCAGCTTGATTATAATGGATGCTCGAAGAATGCAGGATTATCAGGATTCCTGTATTTTACATTCTCTC
AGTGTTCCTGAAGAAGCCATCAGTCCAGGAGTCACTGCTAGTTGGATTGAAGCACACCTGCCAGATGATTCTAAAGACACATGGAAGAAGAGGGGGAATGTGGAGTATGTGGTACTTCTTGACTGGTT
TAGTTCTGCCAAAGATTTACAGATTGGAACAACTCTCCGGAGTCTGAAAGATGCACTTTTCAAGTGGGAAAGTAAAACTGTCCTGCGCAATGAGCCTTTGGTTTTAGAGGGAGGCTATGAAAACTGGC
TCCTTTGTTATCCCCAGTATACAACAAATGCTAAGGTCACTCCACCCCCACGACGCCAGAATGAAGAGGTGTCTATCTCATTGGATTTTACTTATCCCTCATTGGAAGAATCAATTCCTTCTAAACCT
GCTGCCCAGACGCCACCTGCATCTATAGAAGTAGATGAAAATATAGAATTGATAAGTGGTCAAAATGAGAGAATGGGACCACTGAATATATCAACTCCAGTTGAACCAGTTGCTGCTTCTAAATCTGA
TGTTTCACCCATAATTCAGCCAGTGCCTAGTATAAAGAATGTTCCACAGATTGATCGTACTAAAAAACCAGCAGTCAAATTGCCTGAAGAGCATAGAATAAAATCTGAAAGTACAAACCATGAGCAAC
AATCTCCTCAGAGTGGAAAAGTTATTCCTGATCGTTCCACCAAGCCAGTAGTTTTTTCTCCAACTCTCATGTTAACAGATGAAGAAAAGGCTCGTATTCATGCAGAAACTGCTCTTCTAATGGAAAAA
AACAAACAAGAAAAAGAACTTCGGGAAAGGCAGCAAGAGGAACAGAAAGAGAAACTGAGGAAGGAAGAACAAGAACAAAAAGCCAAAAAGAAACAAGAAGCTGAAGAAAATGAAATTACAGAGAAGCA
ACAAAAAGCAAAAGAAGAAATGGAGAAGAAAGAAAGTGAACAGGCCAAGAAAGAAGATAAAGAAACCTCAGCAAAGAGGGGCAAAGAAATAACAGGAGTAAAAAGACAAAGTAAAAGTGAACATGAAA
CTTCTGATGCCAAGAAATCTGTAGAAGATAGGGGGAAAAGGTGTCCAACCCCAGAAATACAGAAAAAGTCAACAGGAGATGTGCCCCATACATCTGTGACAGGGGATTCAGGTTCAGGCAAGCCATTT
AAGATTAAAGGACAACCAGAAAGTGGAATTCTAAGGACAGGAACTTTTAGAGAGGATACAGACGATACCGAAAGAAATAAAGCTCAACGAGAACCTTTGACAAGAGCACGAAGTGAAGAAATGGGGAG
GATCGTACCAGGACTGCCTTCAGGCTGGGCCAAGTTTCTTGACCCAATCACTGGAACCTTTCGTTATTATCATTCACCCACCAACACTGTTCATATGTACCCACCGGAAATGGCTCCTTCATCTGCAC
CTCCTTCCACCCCTCCAACTCATAAAGCCAAGCCACAGATTCCTGCTGAGCGGGATAGGGAACCTTCCAAACTGAAGCGCTCCTACTCCTCCCCAGATATAACCCAGGCTATTCAAGAGGAAGAGAAG
AGGAAGCCAACAGTAACTCCAACAGTTAATCGGGAAAACAAGCCAACATGTTATCCTAAAGCTGAGATCTCAAGGCTTTCTGCTTCTCAGATTCGGAACCTCAATCCTGTTTTTGGAGGTTCTGGACC
AGCTCTTACTGGACTTCGTAACTTAGGAAATACTTGTTATATGAACTCAATATTGCAGTGCCTATGTAACGCTCCACATTTGGCTGATTATTTCAACCGAAACTGTTATCAGGATGATATTAACAGGT
CAAATTTGTTGGGGCATAAAGGTGAAGTGGCAGAAGAATTTGGTATAATCATGAAAGCCCTGTGGACAGGACAGTATAGATATATCAGTCCAAAGGACTTTAAAATCACCATTGGGAAGATCAATGAC
CAGTTTGCAGGATACAGTCAGCAAGATTCACAAGAATTGCTTCTGTTCCTAATGGATGGTCTCCATGAAGATCTAAATAAAGCTGATAATCGGAAGAGATATAAAGAAGAAAATAATGATCATCTCGA
TGACTTTAAAGCTGCAGAACATGCCTGGCAGAAACACAAGCAGCTCAATGAGTCTATTATTGTTGCACTTTTTCAGGGTCAATTCAAATCTACAGTACAGTGCCTCACATGTCACAAAAAGTCTAGGA
CATTTGAGGCCTTCATGTATTTGTCTCTACCACTAGCATCCACAAGTAAATGTACATTACAGGATTGCCTTAGATTATTTTCCAAAGAAGAAAAACTCACAGATAACAACAGATTTTACTGCAGTCAT
TGCAGAGCTCGACGGGATTCTCTAAAAAAGATAGAAATCTGGAAGTTACCACCTGTGCTTTTAGTGCATCTGAAACGTTTTTCCTACGATGGCAGGTGGAAACAAAAATTACAGACATCTGTGGACTT
CCCGTTAGAAAATCTTGACTTGTCACAGTATGTTATTGGTCCAAAGAACAATTTGAAGAAATATAATTTGTTTTCTGTTTCAAATCACTACGGTGGGCTGGATGGAGGCCACTACACAGCCTATTGTA
AAAATGCAGCAAGACAACGGTGGTTTAAGTTTGATGATCATGAAGTTTCTGATATCTCCGTTTCTTCTGTGAAATCTTCAGCAGCTTATATCCTCTTTTATACTTCATTGGGACCACGAGTAACTGAT
GTAGCCACATAAGGAGACATAGGTTATAAACTAGTTATCTTTTAAAAGGCTCAGCAACACAACTCTTGAAATGCTTATCAGGATAATGGTAGCTATAGCTGGCCATTTAGAGGAATTCTAGGACAGTG
GGAGCTGTGTTACTAGCACTATATAATTCCGGTCAGTGCTGACAAATAACATTTAACAAGTATTGCAGTAATCATCACTTACAGGTACCATTTATTTCAAAACAACTTTTTTAGTCTGCTCCAAAGTT
AAAATAATTAACTAGCTAAGCATTATTATTCGACTGGTCTAAAAACTATTGTTATCTTTTTTTTTTCCTTTTCACTGTTATGGCCTTTTCACATTTCTAAATCCCATCTTGATATACTATGAATACTC
TAGAATGATGTAAAGCAGATAGGAATGTATGTGTACATATTTATTGCATACTTGCACATCAAATCGATGTACATAGTTTAACACGTGGTCCTTTTGTGAAACCTAGAACTCAGAGGATTGCTTTTTTT
CTTTCAGCCTATTTTGAGTTAACTTCAGTGCTTTCTTAGGGAAATGACAGGGCAAAGCAATTTTTCTGTTGGCTTTGGGCTGTATTTGTGCACTAAATCTTTATTCTAAAAAAAAAAATGGAAACTTT
AATTTTTTTAAAACGAGAATTTCATTTACAGCTACATTAAAATCTTAATGAGAAAAATAATTTATAACCCTGTGGGTGTTCTGTCTTTAATATTGTATTATCAAATATAGGACAGTAAAACCATAGAT
TTTATATACACACGTGCTATATAATAACACCCAGAGTCATTCTTTCAAGACTAGTATTCTCACATATTGAGAATATTCATTCTAAATATTAAAGTAAAAATGCCGGGAGTCAGGCATGATTGCAAAGT
GAACTGCATTATAAACTACATCTTTACAGAGTGATGTATTAAGAGGGTTAAAGGAGCTTATAATTTATTTAACCGAGGGACTCAGTTGCTATATATATAGTCAGTAAAACACTCCATATAAAAATAAG
ATTCTAAAAGTGCTTCAGAAAGAGACCACCATTAGCAGGCTCTCAGGGAGAAGATGAAAGGATGGGGTTCAAATTGTGAAGCTGACAACTTTTCATGTTTTACAATTAGTCTAAGAGACCACTTCTTG
GCTAAATTATTATATCAAATATATTCAAATCATATTCTTAAACTCATCGAGCCATTTGAACAAAAATTATTTTTGTTTAGCTTCATGAGTATCTTTGGAAAATAATTTGTTGAATATATATGATTATG
AGATATTTTCTGATAAACACTGAATTTTGAAACCTGAACTCACTATATAATTGCAGTGTTTTGAAGGCCTGCATCCATTAGCATTGCATTATATTCACACTGCCTTTTTTAGTGAACCAAGACCCATC
TTCTGGACGACAGATTTATCTTAAGATGAAAGGTTGTATAACATGCCCACAAGGCATAAAAATGTTAATGATGCAAGTAAGTTCTAAGAGTTTAATGACCAAGCAAAACTCTACCACCAGATGCTGAC
TGCTTGTTTTGCAGTGTTCAGGAAACACCATTTTCCTGGCTCTTAACGCTTTTGTATTGGTATGGAAAAGGGCTGGCAGCTATAGAACAGGAGATCCATAGCATTTTGAACAGAAGTATCTGGAATCT
CACTGACTCGTGTGTTATCAAAGCTATATCAGGCCTGGGTGACTGAATTCTTGCAGAAAGCAGTGTAGTGGCCACCATCCAAATCACCAAAATGGTTCTATGGGAGAAAGGAATGTCAAACTTAGTAT
TCACATATGAACACTAACTACTGGAACAGAAATGATAGGGCCAAGAGATGCTTTTTAAATTGTCCCTTATTCTAAATTAAAAGGAAGTGATAATTTTGTTGTTAAATCATGCATATAGCCTGACTGCT
ATATTGCTTCTCATTTCATTGTAACTACTTATATGTTGTGCCCATTGACTATCATCTGTGAATAAAGAAAGACAATATTTAGCAGCATCTGATTAATGTTTATCAGTGAACATTTAGTTAGCACTTAA
TATACATCAACTATTAAGCATTAAAGGAAATTTTACAATAAGAAGATAATTCAGGCCGGGCACAGTGGCTCACACCTGTAATCCCAACACTCTGGGAGGCTGAGGCAGGTGGATTGCTTGAGTCCAGG
AGTTCAAGACCAGCCTGGGCAAAATAGCGAGACTCCATATCTTTTAAAGGAAAAAAAAAAAAAAAAAAAAGATGAGCTAGGCATAGTGGTGCACACCTGTAGTCCCAGCTACTTGGGAAGTTGGGGTG
GGAGGATCTCTCGAGCCTGAGAGGTCGAGGCTGCAATGAGCCGTGATTGTACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCTGTCTTAAAATTGTAAGTTCATTTACGTAAGATGGCTTCTT
TTTTTTTTTTTTAAAGTTAGGATAAGCCACAGAAGAGACATTTAACATTAGAATAAGGATCTTAACTGCATATTGCTACAGCACAAATTGAGGGGGCTATGTAGCAACAACCCCTCAATCCCCCATAG
GGTACAAAAAATAATGTATCTCATTTTCCTTTTTCCATGTCTTTCCTAACCCAGTATTGTTTGGAACAAAGGCATTAGAGAGGTGTACTTCCAAGGAGGTGTTATGGTGTATGATAAGGGTCAGCAAA
CCACGGCCCGTGGGTCAACTCCAGGCTGTTTTTGTAAGACCCATGCATTAGCAACGGGTTTTAAATTTTTATATGGTTGGGGAAAAGATCCAAGTAATAATAGTATTGTTATATGTGAAAATTTTATG
AAATTCAAATGTCAATGTCCTTAAAGTTTTATGGGAACACAGTCATGCTCATTTGTTTACACTTTTCAGTGGCTGCTTTAATGATACAACAGTAAAACTGAATAGTTGCAGCCAATACCATATGGCTT
ATGAGGCCTAAAATATTTACTGTTTGGCCTTTAACAGAATAAGTTTGCTGACCTCTGCTGTAGAGGAAGAAAATTGATTATTTGTTAACTTATTTTTAATTTTTTGAGATGGAGTCTCTCTCTGTTGC
CCAGGCTGGAATGCAGTGGCACGATCTCGGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGCAATTCTTCTGCCTCAGCCTTCCAAGTAGCTGGGAGACTACAGGTGCCTGCCACCATGCCCAGCTAA
TTTTTTGTATTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGATGGTCTCGATCTCGACCTCGGGATCCTCCCACTTCGGCCTCCCAAAGTTATTTATTTTTATTTGAGACAGAGTCTTGCTCT
GTTGCCCAGGCTGGAGTGCAGTGACGTGATCTCAGCTCACCACAACCTCTGCTTCCTGGGTTAAAGCTCTTCTCCTGCCTCAGCCTCCCAAGTAACTGGGATTACAGGCACGCACCACCACACCCAGC
TAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCTGCCTCCACCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTG
CACCCAGCCTATTTATTTTTAGAAGCAGTTTCTTGCTATGTTGCCCAGGCTGTACATGAATTCCTAGGCACAAGCAGTCCTCTCACTTCAGGCCCCCAAATAGCTGGGACTACAGGCATACACCACCA
TGTCCAGAATGAAAATGGATCTGACTAGTTAATTCCAACGTGAATTCGGGTGTAATAGTACATTGTGACCTTAGCGAAATTATTTGACCTTTCTGAGCTTTAATTTCTCATCTATTAACATGGCTTGT
TTTGTATAGCTGTTATCAAATATCTCATGTATTGAGGGCTAGTACACAGGAGTTATTTATTCAATATTCCCTTCAACCTTCGTCTTCCCCACCTCTCTCCTTACAGGTAATAGAAATATCTGAAATTC
ACATTTAAAAGATCAAGGTTCCGCCAGGCCTGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGAGGTCAGGAGTTTGAGACTAGCCTGGCCAACATGGTGAAA
ATCCATCTCTTCTAAAAATATAAAAATTAGCTGGGCATGGTGGCGCATGCCGGTAATCCCAGCTACTTGGGAGGCTGAGGCAGAATCATTTGAACCTGGGAGATGGAGGTTGCAGTGAGCTGAGATCA
TGCCATTGCATTCCAGCCTGGGCGGAGCCCTAAACAGGAAATTTAACAACAGTATGGTGTGTGGTTTATGCTTTGTGACTGCCTGGGCGTAAAGACAGTCCCTAGTTTCTGTAACCAGTATGCTCGGG
TTTTAAAGGTCACGCAAGGACACTCGAGGTAAAGTCTTAGGCCCCCCTACAAGGTGAGAAGTTGGATTGAGATCCACATACAAAGCCAGGACCTTTAAAGACATTCACCCTCAATGGAAGGATTAAAA
AACAAAATCCACCCTCTAGTGCTTGTGTTAGCTTGGACTCATGGTACAGAGAATAAAAGTCATTCCTGGGAATTTGTCACCATAGACCTACCTTTTCACCAGTTTGGGATTCAAATTTATACTACCTG
TGTGGTCTGCGAATCCTGTGAACTTAATATGAAAAGTATTTCTAGGGCAGTTGCCAGAAGGAAACAGAATTTCTAGATTGTTGCATGTTAACTCAGACCTAACAGGATATCCACATATGAAACCCCAA
TGAAGTTGAGATCACAATTCAAAATAATAGAACATGCAAGGAAACAATTTATCATAAGAGTCAGAAGGCAATAAGATTTAAACCCCCAAGGACTTTAGATAATAGAATTATTAAGCAGAGGCTACAAA
TAAAGTATATTTAAATATATTTAGAAGAAGGAAACAAACTTTAGAAACTAAATAGAATTTTCAGAAATGAGAAATACAACATAGTTGGCCGTCCATATTTACGGGCTCTGCATCTTCAGAATCAACTA
ATGTGATGGGAAAGATTTGAAAAAATAATACAACAATAAAAATATACATATTTTAAAATACAGTGTAACAACTATTTACATAGTATTTATATTGTATTAGATATTATAAGTAATCCAGAGATGACTTA
AAGTATATGGGAGGATGTGCATAGGTTACATGCAAATACTACTCCAGGCCTGGCATGGTGGCTCACACGTGTAATCCCAACGTTTTTGGGGGATGGAGGTGGGCAGACTGCTTGAGCCCAGGAGTTGT
AGACCAGCCTGGGCAACATGGCAAAACCCTGTCTACACAAAATACAAAAATTGACCAGGCATAGTGGCACGTGCCTATAGTCCCAGCTACTTGGTAGGTTGAGGTGGGAGAATCACCTGAGCCCAGGA
GGTCGAGGCTACAGTGAGCTGTGACTGAGCCACTGCTCTCCAGCCTGGCAACAGAATGAGACCTTGTCTCAAAAAACAAAAACAAAAAACACCAGAAAAGACACCATTTTATATAGGGCCCTTGAGCA
TCTGTGGATTTTGATAGTCAAAGGGATCCTGGAACCAACTCCCTGCAGATACTGAGGTACAACTGTACTGGAAATTAACTTAATGAAGATATTAGGACACAGAAAATGAATAAACCGGACTGGGCGCG
GTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGGCGGGTGGACCATGAGGTCAGGAGTTCAAGACCAACCTGGTACACATGGTGAAACCCTGTCTCTATTAAAAAAAACAAAAAAAATTAG
CTGGGCCTGGTGGCGTGCACCTGTAATCCCAGCTACTTGAGAGGCTGAAGCAGGAGAATCGCTTGAACCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCATTGCACTCCAGTGTGGGTGACA
GAGTGAGACTCCATCTCAAAAAAAAAAAAAAAAGAATAAACTATAAAATGAAGTTGGGGAAATTAGCAAGAATGGAGTAGTGATGGAGAATACGTGTTAAGAGGCATGAAAAATTGAATGAGAATATT
CAGCGTATGTCCTGTAGAAGTTCTAGGAGGAGAGAATCGAGTAGGGGAGCAAGGCAATATTAAAAGTGATAATGGCTGAAAATGATTAATGAGACATGAATCTTCACATTTAGGAAATGCAGCGAGCC
AGGGATAAATAAAAATAATACTGCAGAACAACAGAGACAAAGAGAAAAAGCTTAAAAGCAACCAGAAAGAAAAAGAGAGTTTACCCACAAGAATCTAACCTGCTGGTAGAAGTTCTCCATAGCAGCCA
TAGAAATCAGAGACAATACAGTAGCTTCAAAATAATAGAGAAAAATAACTGTCAATCTGGAATTTGATTTCTAGTTATCATCCAAGAATGAAAGTGAATTAAAGACTTCTCAAAGACTGAGAGACTTC
AGGATAACAGACCCTCACTGAAAAGCCTACTGAAATATATGCCACATGAATTTTAAAAACTCAATGAAGGAAGAAGTGATACATAATAGACAGTGATTAACAAAAAAGACTGATGAAGATCCGGGCAA
ATATAACCCAATATGAACAGTAGAAAACCATGATAATGTCTCCTTTGGAGGCATATTAAAAAATTAAAAACCGGCTGGGCATGGTGGTTCACACCTGTAATCCCAGCACTTTGGAAGGCCAAGGCAGG
AGGATCGTTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGTGAGACCTGGTCTCTAAAAAAAATAAAAAAGTTGGCCATGCACAGTAGCATGCCTGTAGTCCCAGCTACTTGGCAGGCAGAG
GCAGGAGGATCCCTTAAGCCCAGAGTTCAAAACTGTAGTGAGCTATGATTCATTGCACTAGTGCACTCCAGTCTGGGCAACAGAGTGAGACCCTGTCTCAAAAACAAAAGATGCTGAAAACAGTAGTT
CAGTGATCAGAATTACAGTGTTCTAAGAGCTTTCCATTTCTTTGGGAGCAGAGTATAAAGATCTTGATTAACTTTAGGCTTTAAGTATGAAAGCTGTCGTTTTTTAGCATAATTACTAAAGAATCAAA
ATGTGTAACTTCCAAAGTTGTAGAGGGAAAATAAAGAAAGCTTTATCAGTTTAGTAGCAGCAAGAACAACAGGGGAAAACAACACAGCAGAGGTCCCCAACCCCCCCAGGCTGCCTGTCCCTGACCTG
TTCAGGACCTGGCTGCACAGCAGGAAGCGAGCGGCAAACCTACCCTGAGCACCGCCTCCTGTCAGATCAGCTGCTGCATTAGATTCTCACAGCAGCACAAACTCTATTGTGAACTGCGCATGTGAGGG
ATCTAGGTTGCGTGCTCCTTATGAGAATCTACTGCCTGATTTTCTGAGGTGGAACAGTTTAATCCCAAAACCATGCCCGCCCCGGCCCCCATCCATGGGAAAAAAACCGCATCAGTGGAAAAATTGTC
TTCCACAAAAATCAGTCCCTGGTGCCAACAAGGTTGGGGACTGCCGAATTAGAAAAATAAGGCTAACATAAACACAAAAGAAGATGACGACAAGTAAATCCGAATTTATTACTAGTTGAAATATATGG
GATGTAGTAAATTTACCAAATATTTACTGGATTTTAAATATCCAGTTCTAGCCAGGCGCGATGGCTCACGTCTATAATCTCAGCACTTGGGGAGGCCGAGGGGGGCGGATCACGAGGTCAGGAGATCA
AGACTATCCTGGCCAACACGGTGAAACCTCATCTCTACAAAAATACAAAAAATTAGCCGGGCATGGTGGCAGGCGCCTATAGTCCCAGCTACTCCGGAGGCTGAGGCAGGAGAATGGCATGAACCCAG
GAGGTGAAGCTTGCAGTGAGCCGAGATCGTGCCACTGCATTCCAGCCTGGGCGACAGAGCGAGACTTCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGTTTTAGGCCAAGTGTGG
TGGCTCATGCCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGCGGATCACCTGAGATCAGGAGTTCCAGACCACCCTGGCCAACATGGCAAAACCCGGTCTCTACTAAAAATACAAAAATTAGCTG
GGTCTGGTGGCACATGCCAGTAATCCCAACTACTTGGGAAGCTGAGGCAGGAGAGTTGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGGCACAGAG
TGAGACTCTGTCTCTAAAACAAAACAACAACAACAACAAATCCAGTTCTATGCACTATATAACATTTAGAACTCAGAAAAGGTGTATTTCCCTTGAGCATCATGTTGGTGCTTAAAATGTTTCAGATT
TTGGAGCATTTTGGATTTTCAGATTAGGGATGCTCAACTTGTCGTAGGTAGATATGACCAAGAGAAAGCTGAAGTAGCTATACATCAGCTAAAATGGTCCCTAAGATAGAATGCATTGTAAATGAGTC
ACTTTATAATGAAAAAAGGTTTAAATCACCCAAATTGTATAATTTGAAACTGCTACCTACCTAACAAAACAGACTTGTTAAAAACAAATGACAGAACTATAGGGAAGTTTTGACAAGTCTACCATCAT
AATGGAAGATTTCAACTATTGATCAAGCAGACAAAAATATTAGTATAGATACAGCTTTTACAATATATACTTAGATGAGTATCTGACTCCTGAAATAGAAGTGCACTGTCTCAACAAATGTAAAAGAG
TTAGTTTAGGCCAGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGCGAATCACGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGAGAAACCCCGTCTCTACTAA
AAATACAAAAAATTAGCTGGGCATGGTGTCGGCTGCCTGTAATCCCAGCTACTGAGGAGGCTGAAGCAGGAAAATCGCTTGAAACTGGGCGGCGGAGGTTGCAGTGAGCCGAGATGGTGCCAGTGCAC
TCTAGCCCGGGCGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGATTAGTTTAATTTAGACCCTAGTCTTTGAACACAATACAATTAGCAGTCAATACAAAATGATACCCCCA
CAAAAAATCAATACTTTTGGAAATTAAAAAAACACTTCTAAGTAACTTTATAAATAAATTATAAAAGTAAAACACTTAGAAGTAAATAGTAATGAAAATACTATATCAAAACATGGGATGCACTGATG
TCTGAGAATGTCTTAAAAATAATACGATGCCAAGAAGAGAGTGGGTCAGTATTAAGATGAATTGATCATTTATTTTATATTCAAATATCTTGCTTCAGCAAGCTAGTTGATGGATGCATGGCGGTTTG
TTATGCTGTCCAATTTTGTATATGTTTGAAATATTCTATAATAAAAAAAGGCAGAGAAAGTGGGAGATAGACATTTGTAGTTTTAAATACTTATATCTTAAAGGATAGACTGAGTGTTAATACACTGG
ACACTCAGTTTAAAACATTAAAACATAACAGAATAAACCCTAAAAGAGTAGAGGGAAGAGATAACACTGTAAGAGGAATAACCCATAAAGCAGAAAACAAAGATGTAATACAGAAGATTTAAAAAAAG
GTAAAAGTTGGTGTTTTAAGACAAAATAATTTGGATGTTAGCCTGCCACAGTGGTTCATGCCTATAATCCCTGCACTTTGGGAGGCCAAGGCAGATGGATCGCCTGAGTCCAGGAGTTTGAAACCAGC
TTGGGCAACATGGCAAAACCCCGTCTCTATAAAAAAAAAAAGAGTACAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATTGA
GACCATCCTGGCTAACACGGTGAAACCCCATCTCTATTAAAAATACAAAAAATTACCTGGGCACGGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGG
GGTCGGAGCTTGCAGTGAGCCAAGATCGCGCCACTGTGCTCCAGCCTGGGCGACAGAGCGAGACTCCGTCACAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTACAAAATTAGCTGGACATGGTGTTG
TGCCTGTAGTTCCATCTACTTGGGAGGCTGAGGTGGGAGGATGGCTCGAGCCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACTGCACTCCAGCCTGGGAGACAGAGTGAGACCCTCTCTC
AAAAATAGTAACTTGGACGTCAATAGTAAGATTTAGAGAATAAGAGACAAGGCGGCCGGGCGCGGTGGCTCATGTAATCCCAGCACTTTGGAAGGCTGAGGCAGGCGGATCACCAGGTCAGGAAATTG
AGACTATCCTGGCTAACACGGTGAAACACCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCATGGTGGCGGGCGCCTGTAGTCCCAAGCTACTCAGGAGGCTGAGACAGGAGAATGACTTGAACCC
GGGAGGCGGAGCTTGCCGTGAGCTGAGATCGTGCCATTGCACTCCAGCCTGGGCGACAGAGCGAGACTGCGTCTCAAAAAATAAAATAAAATAAAATAAAATAAAAAAGAGACAAGTCAACGATAAAA
TTAAAAATGAAAAAACATGTAATAGCTACAGATCCTGAATAAATTTATTGTTAATACCCTAAAAACTTTATGCCAGCCAACTGAGACCTTAGATGAAATAGACAAATATCTGGAGAATAAGTTACCAA
AATGACTGAAGAGAAATACATGGCTCACACCTATATTTTTTACAGAAATTGACAAGGGCCAGGAATAATCGAAATACTACTGAAAAATAAGAATAAAGTTGTGATGGTAATGACTTAGGGAATAATGA
TGGTTCTTGCTCTGCCAGATATCAATGTTTATTTCAAAGCTATAGCTATAATTAATATTCATAAGCTAAATTAAGAATTAATTCAATATTAATTTAATAAATTTAATATTTTATAGCTATAATTAATA
CAGTACGGAATTAGCCCAAATGTGAACAAATTGACCAACAGACACACACAGCATAGGAAAACCAGCATTATATGTTACTGAGGAAAAGAAGAGGCTGAGACATTTGGTTATTCATATGCAGAAAAATG
AAATTGAATCCCTAATTTATACTACATTTTTGTCAGAAGTGCAAAACAATTTAAATGTTTGGAAGATATGTAGGTAAATATCTTTGTAATTCCAGGGTTGGAAAGGATTTCTTAAATGAGACACAGAA
AAGGACTAACTAGAAAAGATTGATGTTCCAACCAAATTAAAACTTGATTGTCAGCAATTACAATAAGATACAACAACCAAATGCAGTTTGTGAATTTTGGATGGATTCTGGTCTTTGAAAAAAAATGC
TACTAAAAAAAAAAACCTTGTGACAATTGATATTTGAATATGAATCTATGAATATGAGTGATGGAATTTTAAATTTTCTTACATATAATTCTGCTATTGTGGGTATGTAGAAGAATGTGGTTAAGGGA
TTATTTTGATCTATGAAGTGTCACGATACAAGATTTAAATCAGCAAAAAGTTAGATATACGTGTGTATAGATGTGCACATATATATGTATAGAGAGTGAAAGTAATAAAAGTGTATACACTGCTAAAT
GTTAATAACTGAATCTAGCTGAAATGTACACCAATGTACACCAATGTTTTGTTTTTTGGTTTTTTTTTTAGAGATGGAGTCTCGCTCTGTCTCCCAGGCTGGAGTGCAGTGGCGCTATCTCGGCTCAC
TGCAAGCTCCGCCTCCTGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCGCCCGCCACCATGCCCGGCTAATTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCG
TGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTCAGCCACCGTGCCCGGCCGATGTACACCAATGTTCTCTGTACAATTCTT
TCAGATTTTCTGAATGTTTGCAAAGTTTTATTTTAAAAACTGGAGAGAGAGCACTTGAAAAGATGCTCAACATCATTAGTCATTAGGAAAATGCAACTCAAAACCATGACATACCAGTTCATACCTAC
TTTGTATGGGATAGAATAAAAAATGAGAGGCAGTAACAAGTTCGGTTGAGGATGTGGGGAAACTGGAACCTTAGTTCCAGTTGCTGGTGGGAACGTAAAATGCTGCTGCCACTTTGGAAAACAATTTG
GCAGTTCCTCAAAAAATTAACCAGAGTTACCATATGACCCAGAAATTTCACACTTAGGTATATACCCAACAGAAATGAAAACATGTTTACAGAAAATCCTGTACATAAATGTTCATAGCAGCATTACT
GATGACAGCCAAAAGTGGAAACAAGCCAAATGTCCATCACTGGATGGATTAAGGAAATGTGGTATATCCTATACAATGGAATATTATTTGGCAATAAAAAGGAATGAAGTACAGATACATGCTATGAC
ATGAATGAAACTTGAAAACATTATGCTGAATAAAAGAAAATAAAAACAGAAGGTCATATATTCTATGATTCTGTTTATTAAAATACCCAGAATAGGCCAGGCACTGTGGCTCACGCCTGTAATCCCAG
CACCTGGGGGAGCCGAGGCAGGTGGATCACTTGACGTCTGGAGTTTGAGACCAGCCTGGGCAATATAGCAAAACCCCATCTCAACCAAAATACACAAAAATTATTGGGGCATGGTGGTGCACACCTGT
GGTCCCAGCTACTCGAGGGAGGGAGGAGGGAAGATCACTTGAGCCAGGGAGGTTGAGGCTGCAGTGAGCTGAGATTGCACCATTGCACTCCAGCCTGAGCAAGAGTGAGATATTGTCTCAAAAAATAA
AATAAATAAAATTTTAAAAATACGCAGAATAGGCACATCTATAGAAATATATAAAGTAGAGGCCAGGAGAAGTGGTTCATGCCTGTAATCCGAGCACTTTGGGAGGCCAAGGTGGGTGCGCCACTTGA
GGTCAGGAGTTCAAGACCAGCCTGGTCAACATGGTGAAACCCCACCTCTACTAAAAATACAAAAATACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGTTACGAGAATCCCTTGAACCTGGGAGGCG
GAAGTTGCAGTGAGCTGAAATCATGCCACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTTAAAAAAAAAAAAAATAGCGAGAGATCGAGAGAGAGTGCACGTGAGAAGACTAGTAGTTGCTAT
GGACTGGGGGAGAAGGAACGGGTTACAGGGTTTCTTTTGGGGATAACGAAAATGTTCTAAAACTGGACTGTGGTGATAACTGCACAACTCTGTGAATGTACTAAAAACTACTGAACTGGCCAGGCACA
GTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCCTGAGATGGGCAGATCACTTGAGGTCAGGAGTTCCAGACCAGTCTGGCCAACATGGTGAAACCACATCTCTACTAAAAATATTTTTAAAAA
TTAGCCAGGCATGGTGGTGCACCTGTAATCCCAGCTACTTGGGAGGCTGGGGCATGAGAATCATTTGAAACCAGGGGGTGGAGGTTGCAGTGAGCCGAGATCACACCACCGCACTCCAGCCTGGGCGA
CAGAGCCAGACTCTGTCTCAAAAACAAACAAAACAAAAACAACAAAAAACACAACTGAACACATTTAAGGTGAATTCTGTGGTATGTGAACTATCTCTAAGAACTTCTTTTTATTTAAGTTGGGAAAC
AAAAAGATCATGTACAACAAACCAAAAACAAAAAAGTTATTTCTAACCCATGTAACATATAACAAGGATCTAGAACATGTAAATGACTCTTTCCAATCAATAAGAAGAAAAATAACCCAGTTTGTAAA
AAATGTGCAAAAGACAAATATTTCATACAATAGGAAAAACTAAAATGAGATAATTTTGTATCCATTAGATGGCAAAAATTAAGAAGTCTGATGATCCTGGTAGGGGTATGTATTGGTATAATCACTTG
TAGAAAGTTAAATATGCACATACTTTATGATCTAAGTGACCTCACTCCTAAGTATATACATGAGAGAAACTCTTATGCACATATATATGCAGGAATGTCTGCATAATGTTGTTCATGCCAGCAAAAAT
TTGGAAACAATGAAATATCAATAGGAAAATGGATAATTTATGATATATTCACACAATATACATCATAGGCTAGTGAAATTATAACCACATGCAACAATATGGATATATCTTTAAAATATTTAATGAAA
AAGTATGCTTGGCGCGGTAGCTCACACCTGTAATCCCAGCACTTTGGGAGGATGAGGGAGGTGGATCACCTGAGGTCATGAGTTCGAGACAAGAGCGAAACTGTCTAAAAAAAAAAAAAAAAAAAAGA
GTGAAGAATCAAGCCACAGAAGGTAATTTAAAAATGTACACTCAAGATTTAAAAAGAACTACAATTCCATAAGAAAAAGGCAGGCCACAGAATAGGAAAAAGAATAAAAGACTTGTTTAGGCATTTCA
CAAAAGAAAGTATACAAATTTAAGTAGTTATTTAAACCACAATGCCATTCTACTATATGGGCAACCAGAAGGGCCAAAACAAAACGAACAAAAGACTACCAAGTGTTAACAAGGATTTAAGGCAACTG
AAACTTCCAGTCATTGCTGGTGGGGGTATGAATTGGTACAGTCGCTTTGGAAAGCTACTGAGCAGTATGTACTAAAGCCAGACATATGCGTATTTCTGAACCAGGAGTTTCACTCCTAGGTATGTACT
CAAAAGAACTGTGTACACTATGTTCACCAAAAAACAAGAATGTTTATAGCAACCCTCTTTGCATTAGTCAAAAGCTAGTAATTACCCAAAAGTTCCTGAATGGTAGAATGAATTACTAAATTGTAGTA
TTTTCATACAATGGAATACTATACAGCAATGAGAATGAATAAATTACAATATAAACAACAATATGGATGAACATTACATAATTTTGAATGAAAGGAGCCAGACACAAAAAAAGGATATACTGTACAAT
TCCATTTATACGAAGCATAAAATCAGGCAAAAATCTATAAATCTGTCCTGCCAGAAGTCAGTGGTTTTCCAGACTCGAAGGCAGGTACAAGCACAGTTAGGGTGCTGGTAACATTCTGTTTAAACTCT
GTTCTGCTGGTTACATGGGTATGTTCACTTGAAAATCCATCAAGTTTTATCCTCATGGTTTGTGTACTTTTCTGTATATATGTTTCACTTCAATAAAGTTTATTTTTGGTCAA

hide sequence


Protein RefSeqs	NP_001122082	(Get FASTA)	NCBI Sequence Viewer
	NP_001269978	(Get FASTA)	NCBI Sequence Viewer
	NP_005145	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH15545	(Get FASTA)	NCBI Sequence Viewer
	AAH26954	(Get FASTA)	NCBI Sequence Viewer
	AAH38801	(Get FASTA)	NCBI Sequence Viewer
	AAH51345	(Get FASTA)	NCBI Sequence Viewer
	AAI10591	(Get FASTA)	NCBI Sequence Viewer
	BAA06225	(Get FASTA)	NCBI Sequence Viewer
	BAF85089	(Get FASTA)	NCBI Sequence Viewer
	BAG52415	(Get FASTA)	NCBI Sequence Viewer
	BAG59120	(Get FASTA)	NCBI Sequence Viewer
	BAG62288	(Get FASTA)	NCBI Sequence Viewer
	CAD97662	(Get FASTA)	NCBI Sequence Viewer
	EAW77399	(Get FASTA)	NCBI Sequence Viewer
	EAW77400	(Get FASTA)	NCBI Sequence Viewer
	EAW77401	(Get FASTA)	NCBI Sequence Viewer
	EAW77402	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000302239
	ENSP00000302239.4
	ENSP00000379721
	ENSP00000379721.3
	ENSP00000412682
	ENSP00000412682.3
GenBank Protein	P40818	(Get FASTA)	NCBI Sequence Viewer
	WBK39275	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001122082 ⟸ NM_001128610
- Peptide Label:	isoform a
- UniProtKB:	Q86VA0 (UniProtKB/Swiss-Prot), Q7Z3U2 (UniProtKB/Swiss-Prot), Q2TB31 (UniProtKB/Swiss-Prot), B4DKA8 (UniProtKB/Swiss-Prot), Q8IWI7 (UniProtKB/Swiss-Prot), P40818 (UniProtKB/Swiss-Prot), A8K8N5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQ EEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYV VLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPV AASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEEN EITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRAR SEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPV FGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEE NNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKL QTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT hide sequence

RefSeq Acc Id:	NP_005145 ⟸ NM_005154
- Peptide Label:	isoform a
- UniProtKB:	Q86VA0 (UniProtKB/Swiss-Prot), Q7Z3U2 (UniProtKB/Swiss-Prot), Q2TB31 (UniProtKB/Swiss-Prot), B4DKA8 (UniProtKB/Swiss-Prot), Q8IWI7 (UniProtKB/Swiss-Prot), P40818 (UniProtKB/Swiss-Prot), A8K8N5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAYVLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRKKLEEKDRQ EEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYV VLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPV AASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEEN EITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRAR SEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPV FGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEE NNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKL QTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT hide sequence

RefSeq Acc Id:	NP_001269978 ⟸ NM_001283049
- Peptide Label:	isoform b
- UniProtKB:	A8K8N5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKRYEEAEVRKKLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEKGAITAKELYTMMTDKNISLIIMDAR RMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLPDDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGGYENWLLCYPQYTTNAKVTPPPRRQNEEVSISLD FTYPSLEESIPSKPAAQTPPASIEVDENIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEEHRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEE KARIHAETALLMEKNKQEKELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVP HTSVTGDSGSGKAQREPLTRARSEEMGRIVPGLPSGWAKFLDPITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKP TCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLL FLMDGLHEDLNKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWK LPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT hide sequence

Ensembl Acc Id:

ENSP00000412682 ⟸ ENST00000425032

Ensembl Acc Id:

ENSP00000302239 ⟸ ENST00000307179

Protein Domains

MIT Rhodanese USP USP8 dimerisation

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P40818-F1-model_v2	AlphaFold	P40818	1-1118	view protein structure

RGD ID:

6792713

Promoter ID:

HG_KWN:21353

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000396444, NM_001128611, NM_005154, UC001ZYK.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	15	48,503,036 - 48,503,972 (+)	MPROMDB

RGD ID:

7229469

Promoter ID:

EPDNEW_H20480

Type:

initiation region

Name:

USP8_1

Description:

ubiquitin specific peptidase 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	15	50,424,405 - 50,424,465	EPDNEW

Database	Acc Id	Source(s)
COSMIC	USP8	COSMIC
Ensembl Genes	ENSG00000138592	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000307179	ENTREZGENE
	ENST00000307179.9	UniProtKB/Swiss-Prot
	ENST00000396444	ENTREZGENE
	ENST00000396444.7	UniProtKB/Swiss-Prot
	ENST00000425032	ENTREZGENE
	ENST00000425032.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.250.10	UniProtKB/Swiss-Prot
	Cysteine proteinases	UniProtKB/Swiss-Prot
	Phosphotransferase system, lactose/cellobiose-type IIA subunit	UniProtKB/Swiss-Prot
GTEx	ENSG00000138592	GTEx
HGNC ID	HGNC:12631	ENTREZGENE
Human Proteome Map	USP8	Human Proteome Map
InterPro	Papain-like_cys_pep_sf	UniProtKB/Swiss-Prot
	Peptidase_C19_UCH	UniProtKB/Swiss-Prot
	Rhodanese-like_dom	UniProtKB/Swiss-Prot
	Rhodanese-like_dom_sf	UniProtKB/Swiss-Prot
	Ub_carboxyl-term_hydrolase	UniProtKB/Swiss-Prot
	USP8_dimer	UniProtKB/Swiss-Prot
	USP_CS	UniProtKB/Swiss-Prot
	USP_dom	UniProtKB/Swiss-Prot
	WW_USP8	UniProtKB/Swiss-Prot
KEGG Report	hsa:9101	UniProtKB/Swiss-Prot
NCBI Gene	9101	ENTREZGENE
OMIM	603158	OMIM
PANTHER	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	UniProtKB/Swiss-Prot
	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8	UniProtKB/Swiss-Prot
Pfam	Rhodanese	UniProtKB/Swiss-Prot
	UCH	UniProtKB/Swiss-Prot
	USP8_dimer	UniProtKB/Swiss-Prot
	WW_USP8	UniProtKB/Swiss-Prot
PharmGKB	PA37256	PharmGKB
PROSITE	RHODANESE_3	UniProtKB/Swiss-Prot
	USP_1	UniProtKB/Swiss-Prot
	USP_2	UniProtKB/Swiss-Prot
	USP_3	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52821	UniProtKB/Swiss-Prot
	SSF54001	UniProtKB/Swiss-Prot
	USP8 N-terminal domain-like	UniProtKB/Swiss-Prot
UniProt	A0A075B720_HUMAN	UniProtKB/TrEMBL
	A8K8N5	ENTREZGENE, UniProtKB/TrEMBL
	B4DKA8	ENTREZGENE
	H0YKV1_HUMAN	UniProtKB/TrEMBL
	H0YLH2_HUMAN	UniProtKB/TrEMBL
	H0YLS3_HUMAN	UniProtKB/TrEMBL
	H0YM17_HUMAN	UniProtKB/TrEMBL
	H0YM47_HUMAN	UniProtKB/TrEMBL
	H0YNL5_HUMAN	UniProtKB/TrEMBL
	P40818	ENTREZGENE
	Q05CD9_HUMAN	UniProtKB/TrEMBL
	Q05DF5_HUMAN	UniProtKB/TrEMBL
	Q2TB31	ENTREZGENE
	Q7Z3U2	ENTREZGENE
	Q86VA0	ENTREZGENE
	Q8IWI7	ENTREZGENE
	UBP8_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	B4DKA8	UniProtKB/Swiss-Prot
	Q2TB31	UniProtKB/Swiss-Prot
	Q7Z3U2	UniProtKB/Swiss-Prot
	Q86VA0	UniProtKB/Swiss-Prot
	Q8IWI7	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Human Phenotype Annotations - HPO

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Human Phenotype Annotations - HPO