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ONTOLOGY REPORT - ANNOTATIONS

Term:hepatocyte differentiation
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Accession:GO:0070365 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
Synonyms:exact_synonym: liver cell differentiation

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hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 ISO RGD PMID:11668598 RGD:2306909 NCBI chrNW_004955512:5,686,508...5,703,645 JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO RGD PMID:12939595 RGD:4144098 NCBI chrNW_004955457:4,848,116...4,961,384
Ensembl chrNW_004955457:4,844,152...4,961,246 		JBrowse link
G E2f7 E2F transcription factor 7 involved_in ISO (PMID:23064266) UniProt PMID:23064266 NCBI chrNW_004955405:16,148,640...16,187,272
Ensembl chrNW_004955405:16,148,480...16,186,282 		JBrowse link
G E2f8 E2F transcription factor 8 involved_in ISO (PMID:23064264), (PMID:23064266) UniProt PMID:23064264 PMID:23064266 NCBI chrNW_004955476:197,699...215,227
Ensembl chrNW_004955476:197,630...213,441 		JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:22715131 RGD:155791677 NCBI chrNW_004955454:3,094,015...3,096,060
Ensembl chrNW_004955454:3,094,033...3,095,512 		JBrowse link
G Frzb frizzled related protein acts_upstream_of ISO (PMID:19562671) MGI PMID:19562671 NCBI chrNW_004955403:14,598,765...14,627,997
Ensembl chrNW_004955403:14,598,765...14,631,154 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO RGD PMID:10934156 RGD:14701049 NCBI chrNW_004955455:8,082,578...8,099,523 JBrowse link
G Hhex hematopoietically expressed homeobox acts_upstream_of_or_within ISO (PMID:11027604) MGI PMID:11027604 NCBI chrNW_004955425:737,506...742,775
Ensembl chrNW_004955425:735,378...742,775 		JBrowse link
G Hnf1b HNF1 homeobox B ISO RGD PMID:18286537 RGD:2312718 NCBI chrNW_004955451:320,283...371,420
Ensembl chrNW_004955451:320,283...371,420 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:19621519 RGD:12904750 NCBI chrNW_004955445:12,925,248...12,962,501
Ensembl chrNW_004955445:12,924,662...12,984,281 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO RGD PMID:16458388 RGD:2307397 NCBI chrNW_004955446:14,309,516...14,421,991
Ensembl chrNW_004955446:14,309,349...14,422,170 		JBrowse link
G Krt18 keratin 18 ISO RGD PMID:24340101 PMID:28941653 RGD:27226712 RGD:27226713 NCBI chrNW_004955458:227,017...230,752
Ensembl chrNW_004955458:226,805...232,728 		JBrowse link
G LOC102010850 cytochrome P450 1A1 ISO RGD PMID:17574236 RGD:2306655 NCBI chrNW_004955450:3,183,958...3,189,488
Ensembl chrNW_004955450:3,183,750...3,189,488 		JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:15232737) BHF-UCL PMID:15232737 NCBI chrNW_004955406:3,715,140...3,770,019
Ensembl chrNW_004955406:3,719,972...3,770,555 		JBrowse link
G Smarcb1 SWI/SNF related BAF chromatin remodeling complex subunit B1 acts_upstream_of_or_within ISO (PMID:16138077) MGI PMID:16138077 NCBI chrNW_004955455:8,420,263...8,457,105
Ensembl chrNW_004955455:8,415,839...8,457,097 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 acts_upstream_of_or_within ISO (PMID:18722179) MGI PMID:18722179 NCBI chrNW_004955414:22,322,954...22,324,412
Ensembl chrNW_004955414:22,323,031...22,324,367 		JBrowse link
G Wnt1 Wnt family member 1 ISO RGD PMID:20413689 RGD:2326223 NCBI chrNW_004955500:7,797,063...7,811,142
Ensembl chrNW_004955500:7,797,060...7,811,167 		JBrowse link
negative regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Frzb frizzled related protein acts_upstream_of_or_within ISO (PMID:19562671) MGI PMID:19562671 NCBI chrNW_004955403:14,598,765...14,627,997
Ensembl chrNW_004955403:14,598,765...14,631,154 		JBrowse link
positive regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19229878 RGD:8885195 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Foxa3 forkhead box A3 ISO RGD PMID:9878541 RGD:2315086 NCBI chrNW_004955574:293,344...301,955
Ensembl chrNW_004955574:293,344...302,002 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12563
    cellular process 12002
      cellular developmental process 3955
        cell differentiation 3954
          epithelial cell differentiation 701
            hepatocyte differentiation 19
              negative regulation of hepatocyte differentiation 1
              positive regulation of hepatocyte differentiation 2
              regulation of hepatocyte differentiation + 3
Path 2
Term Annotations click to browse term
  biological_process 12563
    developmental process 5951
      anatomical structure development 5628
        multicellular organism development 4604
          system development 4007
            hepaticobiliary system development 257
              liver development 254
                hepatocyte differentiation 19
                  negative regulation of hepatocyte differentiation 1
                  positive regulation of hepatocyte differentiation 2
                  regulation of hepatocyte differentiation + 3
paths to the root