LOC102010850 (cytochrome P450 1A1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: LOC102010850 (cytochrome P450 1A1) Chinchilla lanigera
Analyze
Symbol: LOC102010850 (Ensembl: CYP1A1)
Name: cytochrome P450 1A1
RGD ID: 9056314
Description: ENCODES a protein that exhibits arachidonate monooxygenase activity (ortholog); catalytic activity (ortholog); demethylase activity (ortholog); INVOLVED IN 9-cis-retinoic acid biosynthetic process (ortholog); amine metabolic process (ortholog); camera-type eye development (ortholog); PARTICIPATES IN gefitinib pharmacokinetics pathway; phase I biotransformation pathway via cytochrome P450; tamoxifen pharmacokinetics pathway; ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN mitochondrial inner membrane (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,183,750 - 3,189,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,183,958 - 3,189,488 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
ankylosing spondylitis  (ISO)
Arteritis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
Bardet-Biedl syndrome  (ISO)
Behcet's disease  (ISO)
biliary tract cancer  (ISO)
Birth Weight  (ISO)
Bloom syndrome  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchitis  (ISO)
Brugada syndrome 8  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Bronchitis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clubfoot  (ISO)
colitis  (ISO)
colorectal cancer  (ISO)
contact dermatitis  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
Digestive System Neoplasms  (ISO)
dilated cardiomyopathy  (ISO)
Drug Eruptions  (ISO)
end stage renal disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
esophageal cancer  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Fetal Growth Retardation  (ISO)
gallbladder cancer  (ISO)
Graves' disease  (ISO)
Hamartoma  (ISO)
head and neck cancer  (ISO)
heart disease  (ISO)
Hematuria  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hyperoxia  (ISO)
Hyperoxic Lung Injury  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypospadias  (ISO)
Inflammation  (ISO)
Jaundice  (ISO)
Keshan disease  (ISO)
Kidney Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
long QT syndrome  (ISO)
lung cancer  (ISO)
Lung Injury  (ISO)
male infertility  (ISO)
Metabolic Side Effects of Drugs and Substances  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
multiple myeloma  (ISO)
Nematode Infections  (ISO)
nephritis  (ISO)
Occupational Diseases  (ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
PAPA syndrome  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
periodontitis  (ISO)
peripheral vascular disease  (ISO)
pneumonia  (ISO)
polycystic ovary syndrome  (ISO)
porphyria cutanea tarda  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
reactive arthritis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Sinus Tachycardia  (ISO)
Sjogren's syndrome  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
9-cis-retinoic acid biosynthetic process  (ISO)
amine metabolic process  (ISO)
camera-type eye development  (ISO)
cellular response to copper ion  (ISO)
cellular response to organic cyclic compound  (ISO)
coumarin metabolic process  (ISO)
dibenzo-p-dioxin catabolic process  (ISO)
dibenzo-p-dioxin metabolic process  (ISO)
digestive tract development  (ISO)
estrogen metabolic process  (ISO)
fatty acid metabolic process  (ISO)
flavonoid metabolic process  (ISO)
hepatocyte differentiation  (ISO)
hydrogen peroxide biosynthetic process  (ISO)
insecticide metabolic process  (ISO)
lipid hydroxylation  (ISO)
liver development  (ISO)
long-chain fatty acid metabolic process  (ISO)
maternal process involved in parturition  (ISO)
nitric oxide metabolic process  (ISO)
porphyrin-containing compound metabolic process  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
response to 2,3,7,8-tetrachlorodibenzodioxine  (ISO)
response to 3-methylcholanthrene  (ISO)
response to Aroclor 1254  (ISO)
response to arsenic-containing substance  (ISO)
response to diphenyl ether  (ISO)
response to food  (ISO)
response to genistein  (ISO)
response to herbicide  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to immobilization stress  (ISO)
response to iron(III) ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nematode  (ISO)
response to toxic substance  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
retinol metabolic process  (ISO)
steroid metabolic process  (ISO)
tissue remodeling  (ISO)
toxin metabolic process  (ISO)
xenobiotic metabolic process  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC102010850
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554503,183,750 - 3,189,488 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554503,183,958 - 3,189,488 (+)NCBIChiLan1.0ChiLan1.0
CYP1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381574,719,542 - 74,725,528 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1574,719,542 - 74,725,536 (-)EnsemblGRCh38hg38GRCh38
GRCh371575,011,883 - 75,017,869 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361572,798,943 - 72,804,930 (-)NCBINCBI36Build 36hg18NCBI36
Build 341572,798,942 - 72,804,930NCBI
Celera1551,961,906 - 51,967,900 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1551,809,772 - 51,815,766 (-)NCBIHuRef
CHM1_11575,130,208 - 75,136,202 (-)NCBICHM1_1
T2T-CHM13v2.01572,589,430 - 72,595,416 (-)NCBIT2T-CHM13v2.0
Cyp1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39957,595,211 - 57,611,107 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl957,595,211 - 57,611,107 (+)EnsemblGRCm39 Ensembl
GRCm38957,687,928 - 57,703,824 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl957,687,928 - 57,703,824 (+)EnsemblGRCm38mm10GRCm38
MGSCv37957,535,735 - 57,551,629 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36957,486,065 - 57,501,958 (+)NCBIMGSCv36mm8
Celera985,889,319 - 85,895,530 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.34NCBI
Cyp1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8866,991,940 - 66,998,014 (+)NCBIGRCr8
mRatBN7.2858,096,021 - 58,102,130 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl858,096,077 - 58,102,125 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx863,629,083 - 63,635,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0861,906,655 - 61,912,680 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0859,771,206 - 59,777,229 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0862,472,087 - 62,478,122 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl862,472,095 - 62,478,147 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0862,249,046 - 62,255,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,462,207 - 61,468,237 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1861,481,260 - 61,487,291 (+)NCBI
Celera857,561,801 - 57,567,827 (+)NCBICelera
RH 3.4 Map8671.2RGD
Cytogenetic Map8q24NCBI
CYP1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21663,949,165 - 63,957,527 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11568,112,819 - 68,121,152 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01553,664,968 - 53,672,277 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11573,284,566 - 73,290,636 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1573,284,566 - 73,290,636 (-)Ensemblpanpan1.1panPan2
CYP1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13037,793,277 - 37,799,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3037,793,508 - 37,796,866 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3037,726,194 - 37,732,463 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03037,998,587 - 38,004,872 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3037,998,848 - 38,002,205 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13037,951,106 - 37,957,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03037,976,995 - 37,983,257 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03038,232,580 - 38,238,845 (-)NCBIUU_Cfam_GSD_1.0
LOC101969148
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640115,834,681 - 115,840,894 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647133,682,730 - 33,688,332 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647133,682,730 - 33,688,332 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl758,802,887 - 58,809,775 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1758,802,887 - 58,809,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2763,491,496 - 63,497,751 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7qNCBI
CYP1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1268,753,236 - 8,759,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl268,753,327 - 8,759,384 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048132,870,282 - 132,876,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101707509
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046279887 - 1,323 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSCLAT00000009989   ⟹   ENSCLAP00000009860
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554503,183,750 - 3,189,488 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000009990   ⟹   ENSCLAP00000009861
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554503,185,486 - 3,188,800 (+)Ensembl
RefSeq Acc Id: XM_005393546   ⟹   XP_005393603
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554503,183,958 - 3,189,488 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005393547   ⟹   XP_005393604
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554503,183,958 - 3,189,488 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005393603 (Get FASTA)   NCBI Sequence Viewer  
  XP_005393604 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000009860
  ENSCLAP00000009860.1
  ENSCLAP00000009861
  ENSCLAP00000009861.1
RefSeq Acc Id: XP_005393603   ⟸   XM_005393546
- UniProtKB: A0A8C2V8W5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005393604   ⟸   XM_005393547
- UniProtKB: A0A8C2V8W5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000009861   ⟸   ENSCLAT00000009990
Ensembl Acc Id: ENSCLAP00000009860   ⟸   ENSCLAT00000009989


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006828 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009989 ENTREZGENE
  ENSCLAT00000009989.1 UniProtKB/TrEMBL
  ENSCLAT00000009990 ENTREZGENE
  ENSCLAT00000009990.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP1 UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene LOC102010850 ENTREZGENE
PANTHER CYTOCHROME P450 1A2 UniProtKB/TrEMBL
  STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP1A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8C2V3S6_CHILA UniProtKB/TrEMBL
  A0A8C2V8W5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 LOC102010850  cytochrome P450 1A1    cytochrome P450 1A1-like  Symbol and/or name change 5135510 APPROVED