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ONTOLOGY REPORT - ANNOTATIONS

Term:necroptotic process
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Accession:GO:0070266 term browser browse the term
Definition:A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
Comment:Examples of this are Birc2 and Birc3 (UniProt symbols Q62210 and O08863) in PMID:21052097.
Synonyms:exact_synonym: RIPK1-mediated regulated necrosis
 narrow_synonym: TNF-induced necroptosis;   necroptosis
 broad_synonym: induction of necroptosis;   induction of necroptosis by extracellular signals;   induction of necroptosis of activated-T cells;   programmed necrosis;   programmed necrotic cell death
 related_synonym: PARP-dependent cell death;   activation of necroptosis;   activation of necroptosis by extracellular signals;   activation of necroptosis in response to extracellular signals;   activation of necroptosis of activated-T cells;   establishment of necroptosis;   establishment of necroptosis of activated-T cells;   extracellular signal-induced necroptosis;   parthanatos
 alt_id: GO:0060553;   GO:0060554;   GO:0060555
 xref: Reactome:R-HSA-5213460 "RIPK1-mediated regulated necrosis"


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necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC2 baculoviral IAP repeat containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 involved_in ISO (PMID:21052097) UniProt PMID:21052097 NCBI chr11:97,269,778...97,290,112
Ensembl chr11:100,763,274...100,785,194 		JBrowse link
G CASP8 caspase 8 acts_upstream_of ISO (PMID:21368763)
(PMID:21402742)
(PMID:22037414)		 MGI PMID:21368763 PMID:21402742 PMID:22037414 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator acts_upstream_of ISO (PMID:21368763) MGI PMID:21368763 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052097)
(PMID:27545878)
(PMID:22037414)		 Ensembl
MGI		 PMID:21052097 PMID:22037414 PMID:27545878 GO_REF:0000107 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G FASLG Fas ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281 		JBrowse link
G IPMK inositol polyphosphate multikinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:54,718,987...54,799,264
Ensembl chr10:56,939,012...57,019,101 		JBrowse link
G ITPK1 inositol-tetrakisphosphate 1-kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:73,573,020...73,750,109
Ensembl chr14:92,909,785...93,087,773 		JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:55,237,656...55,266,945
Ensembl chr16:74,591,635...74,620,667 		JBrowse link
G NLRP6 NLR family pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30248149) Ensembl
MGI		 PMID:30248149 GO_REF:0000107 NCBI chr11:274,904...281,590
Ensembl chr11:319,082...325,888 		JBrowse link
G PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase involved_in ISO (PMID:22265414) UniProt PMID:22265414
G PPIF peptidylprolyl isomerase F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22726440) Ensembl
MGI		 PMID:22726440 GO_REF:0000107 NCBI chr10:75,860,197...75,868,098
Ensembl chr10:78,521,642...78,530,202 		JBrowse link
G PYGL glycogen phosphorylase L involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19498109) Ensembl
MGI		 PMID:19498109 GO_REF:0000107 NCBI chr14:31,494,172...31,533,545
Ensembl chr14:49,746,309...49,832,786 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22037414)
(PMID:19498109)
(PMID:21052097)		 Ensembl
MGI		 PMID:19498109 PMID:21052097 PMID:22037414 GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19498109)
(PMID:22675671)
(PMID:22037414)
(PMID:21402742)
(PMID:21368763)		 Ensembl
MGI		 PMID:19498109 PMID:21368763 PMID:21402742 PMID:22037414 PMID:22675671 GO_REF:0000107 NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821 		JBrowse link
G SPATA2 spermatogenesis associated 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:27545878) Ensembl
MGI		 PMID:27545878 GO_REF:0000107 NCBI chr20:46,245,560...46,257,656
Ensembl chr20:47,307,731...47,320,343 		JBrowse link
G TP53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22726440) Ensembl
MGI		 PMID:22726440 GO_REF:0000107 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120 		JBrowse link
G TRPM7 transient receptor potential cation channel subfamily M member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:29,513,220...29,639,506
Ensembl chr15:47,853,187...47,977,451 		JBrowse link
execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLKL mixed lineage kinase domain like pseudokinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:55,237,656...55,266,945
Ensembl chr16:74,591,635...74,620,667 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821 		JBrowse link
necroptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain involved_in ISO (PMID:11101870) BHF-UCL PMID:11101870 NCBI chr11:65,300,889...65,305,020 JBrowse link
G FAS Fas cell surface death receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052097) Ensembl
TreeGrafter
MGI		 PMID:21052097 GO_REF:0000107 GO_REF:0000118 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FASLG Fas ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281 		JBrowse link
G MLKL mixed lineage kinase domain like pseudokinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:55,237,656...55,266,945
Ensembl chr16:74,591,635...74,620,667 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821 		JBrowse link
G TLR3 toll like receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:178,238,352...178,256,264
Ensembl chr 4:190,446,487...190,462,728 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21368763)
(PMID:22037414)
(PMID:21052097)
(PMID:19498109)		 Ensembl
MGI
UniProt		 PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414 GO_REF:0000104 GO_REF:0000107 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
negative regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADPRS ADP-ribosylserine hydrolase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:35,354,721...35,360,029
Ensembl chr 1:36,529,051...36,534,235 		JBrowse link
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) BHF-UCL PMID:22711822 NCBI chr 1:131,282,514...131,326,535
Ensembl chr 1:135,112,040...135,159,299 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052097) Ensembl
TreeGrafter
MGI		 PMID:21052097 GO_REF:0000107 GO_REF:0000118 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:97,269,778...97,290,112
Ensembl chr11:100,763,274...100,785,194 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238 		JBrowse link
G CASP8 caspase 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21368763)
(PMID:22037414)
(PMID:22089168)
(PMID:21402742)		 Ensembl
MGI		 PMID:21368763 PMID:21402742 PMID:22037414 PMID:22089168 GO_REF:0000107 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator acts_upstream_of_or_within ISO (PMID:22089168)
(PMID:22675671)
(PMID:21368763)		 MGI PMID:21368763 PMID:22089168 PMID:22675671 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045 		JBrowse link
G FADD Fas associated via death domain acts_upstream_of_or_within ISO (PMID:22675671)
(PMID:22089168)		 MGI PMID:22089168 PMID:22675671 NCBI chr11:65,300,889...65,305,020 JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in ISO (PMID:21052097) UniProt PMID:21052097 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
G MUTYH mutY DNA glycosylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:44,632,102...44,643,292
Ensembl chr 1:45,990,588...46,002,645 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:64,160,362...64,213,200
Ensembl chr2A:65,284,480...65,336,339 		JBrowse link
G RBCK1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22089168) Ensembl
MGI		 PMID:22089168 GO_REF:0000107 NCBI chr20:615,987...639,366
Ensembl chr20:386,569...409,580 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RNF31 ring finger protein 31 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22089168) Ensembl
MGI		 PMID:22089168 GO_REF:0000107 NCBI chr14:4,923,391...4,936,959
Ensembl chr14:23,047,893...23,061,923 		JBrowse link
G SLC25A4 solute carrier family 25 member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:177,310,982...177,315,016
Ensembl chr 4:189,531,914...189,534,549 		JBrowse link
G YBX3 Y-box binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:10,728,049...10,752,267
Ensembl chr12:10,996,380...11,018,172 		JBrowse link
negative regulation of ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC2 baculoviral IAP repeat containing 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052097) Ensembl
MGI		 PMID:21052097 GO_REF:0000107 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO (PMID:21052097) MGI PMID:21052097 NCBI chr 6:88,398,329...88,470,926
Ensembl chr 6:91,664,263...91,737,468 		JBrowse link
positive regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:119,256,425...119,292,612
Ensembl chr  X:129,550,287...129,586,271 		JBrowse link
G CASP6 caspase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:102,186,215...102,201,992
Ensembl chr 4:112,753,988...112,768,836 		JBrowse link
G GZMB granzyme B ISO RGD PMID:19895873 RGD:2325193 NCBI chr14:5,399,888...5,403,200
Ensembl chr14:23,523,619...23,526,931 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in ISO (PMID:12114629), (PMID:17116882) UniProt PMID:12114629 PMID:17116882 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in IEA
ISO		 Ensembl
RGD		 PMID:22372834 PMID:23386613 GO_REF:0000107 RGD:7777171 RGD:7777172 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
G RIPK3 receptor interacting serine/threonine kinase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:5,112,512...5,116,486
Ensembl chr14:23,235,796...23,239,821 		JBrowse link
G ZBP1 Z-DNA binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:53,944,224...53,961,362
Ensembl chr20:55,222,405...55,239,130 		JBrowse link
regulation of necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC2 baculoviral IAP repeat containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:97,298,736...97,324,966
Ensembl chr11:100,793,036...100,822,421 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:97,269,778...97,290,112
Ensembl chr11:100,763,274...100,785,194 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G FADD Fas associated via death domain ISO RGD PMID:26038570 RGD:11341801 NCBI chr11:65,300,889...65,305,020 JBrowse link
G SPATA2 spermatogenesis associated 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:46,245,560...46,257,656
Ensembl chr20:47,307,731...47,320,343 		JBrowse link
ripoptosome assembly involved in necroptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYLD CYLD lysine 63 deubiquitinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22037414) Ensembl
MGI		 PMID:22037414 GO_REF:0000107 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21052097) Ensembl
MGI		 PMID:21052097 GO_REF:0000107 NCBI chr 6:2,893,802...2,943,162
Ensembl chr 6:2,997,343...3,045,078 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  biological_process 19444
    cellular process 18997
      cell death 1976
        programmed cell death 1976
          programmed necrotic cell death 53
            necroptotic process 38
              execution phase of necroptosis 2
              necroptotic signaling pathway 8
              negative regulation of necroptotic process 17
              positive regulation of necroptotic process 7
              regulation of necroptotic process + 25
              ripoptosome assembly involved in necroptotic process + 4
paths to the root