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ONTOLOGY REPORT - ANNOTATIONS

Term:execution phase of necroptosis
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Accession:GO:0097528 term browser browse the term
Definition:A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.
Synonyms:exact_synonym: execution phase of necroptotic process;   necroptotic execution phase
 broad_synonym: necroptosis


show annotations for term's descendants           Sort by:
execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO
IEA 		(PMID:24316671)
(PMID:27321907), (PMID:32200799), (PMID:32296175)
GO_REF:0000107
GO_REF:0000117 		RGD
Ensembl
UniProt		 PMID:24316671 PMID:27321907 PMID:32200799 PMID:32296175 GO_REF:0000107 GO_REF:0000117 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:56,186,860...56,213,858 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in
acts_upstream_of_or_within 		ISS
ISO 		GO_REF:0000024
(PMID:27746097), (PMID:27917412)
(PMID:24316671) 		UniProt
RGD		 PMID:24316671 PMID:27746097 PMID:27917412 GO_REF:0000024 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:33,253,071...33,262,025 		JBrowse link
G Zbp1 Z-DNA binding protein 1 acts_upstream_of_or_within ISO (PMID:24316671) RGD PMID:24316671 NCBI chr 3:161,993,351...162,009,297
Ensembl chr 3:182,411,665...182,422,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      execution phase of necroptosis 3
Path 2
Term Annotations click to browse term
  biological_process 20668
    cellular process 19605
      cell death 2242
        programmed cell death 2242
          programmed necrotic cell death 59
            necroptotic process 44
              execution phase of necroptosis 3
paths to the root