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Term:execution phase of necroptosis
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Accession:GO:0097528 term browser browse the term
Definition:A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.
Synonyms:exact_synonym: execution phase of necroptotic process;   necroptotic execution phase
 broad_synonym: necroptosis

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execution phase of necroptosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mlkl mixed lineage kinase domain like pseudokinase involved_in ISO (MGI:6434626|PMID:32296175), (MGI:6436412|PMID:32200799), (MGI:6436434|PMID:27321907)
RGD PMID:24316671 PMID:27321907 PMID:32200799 PMID:32296175 MGI:6434626 MGI:6436412 MGI:6436434 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 involved_in ISS
(MGI:6436445|PMID:27746097), (MGI:6442612|PMID:27917412)
PMID:27746097 PMID:27917412 GO_REF:0000024 MGI:6436445 MGI:6442612 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link

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  biological_process 19574
    cellular process 18252
      execution phase of necroptosis 2
Path 2
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  biological_process 19574
    cellular process 18252
      cell death 2113
        programmed cell death 2113
          programmed necrotic cell death 57
            necroptotic process 44
              execution phase of necroptosis 2
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