Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
necroptotic process +   
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
negative regulation of programmed necrotic cell death +   
positive regulation of programmed necrotic cell death +   
programmed necrotic cell death in response to starvation 
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  
regulation of programmed necrotic cell death +   

Synonyms
Exact Synonyms: RIPK1-mediated regulated necrosis
Narrow Synonyms: TNF-induced necroptosis ;   necroptosis
Broad Synonyms: induction of necroptosis ;   induction of necroptosis by extracellular signals ;   induction of necroptosis of activated-T cells ;   programmed necrosis ;   programmed necrotic cell death
Related Synonyms: PARP-dependent cell death ;   activation of necroptosis ;   activation of necroptosis by extracellular signals ;   activation of necroptosis in response to extracellular signals ;   activation of necroptosis of activated-T cells ;   establishment of necroptosis ;   establishment of necroptosis of activated-T cells ;   extracellular signal-induced necroptosis ;   parthanatos
Alternate IDs: GO:0060553 ;   GO:0060554 ;   GO:0060555
Definition Sources: GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153

paths to the root