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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
necroptotic process +   
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former.
negative regulation of programmed necrotic cell death +   
positive regulation of programmed necrotic cell death +   
programmed necrotic cell death in response to starvation 
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  
regulation of programmed necrotic cell death +   

Synonyms
Exact Synonyms: RIPK1-mediated regulated necrosis
Narrow Synonyms: TNF-induced necroptosis ;   necroptosis
Broad Synonyms: induction of necroptosis ;   induction of necroptosis by extracellular signals ;   induction of necroptosis of activated-T cells ;   programmed necrosis ;   programmed necrotic cell death
Related Synonyms: PARP-dependent cell death ;   activation of necroptosis ;   activation of necroptosis by extracellular signals ;   activation of necroptosis in response to extracellular signals ;   activation of necroptosis of activated-T cells ;   establishment of necroptosis ;   establishment of necroptosis of activated-T cells ;   extracellular signal-induced necroptosis ;   parthanatos
Alternate IDs: GO:0060553 ;   GO:0060554 ;   GO:0060555
Definition Sources: GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153

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