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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of B cell activation
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Accession:GO:0050869 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation.
Synonyms:exact_synonym: down regulation of B cell activation;   downregulation of B cell activation;   negative regulation of B lymphocyte activation
 narrow_synonym: inhibition of B cell activation


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negative regulation of B cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BANK1 B cell scaffold protein with ankyrin repeats 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:16546095) Ensembl
MGI
GO_Central		 PMID:16546095 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:118,814,352...119,114,973
Ensembl chr 8:118,814,061...119,157,504 		JBrowse link
G BTK Bruton tyrosine kinase ISO RGD PMID:25545336 RGD:151665128 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G FAS Fas cell surface death receptor acts_upstream_of_or_within ISO (PMID:6610701) MGI PMID:6610701 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FOXJ1 forkhead box J1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,307,370...5,312,117
Ensembl chr12:5,307,374...5,312,106 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10704460) Ensembl
MGI		 PMID:10704460 GO_REF:0000107 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644 		JBrowse link
G LAPTM5 lysosomal protein transmembrane 5 involved_in ISO (PMID:20519653) ARUK-UCL PMID:20519653 NCBI chr 6:87,363,911...87,390,371
Ensembl chr 6:87,363,911...87,390,347 		JBrowse link
G MIR185 microRNA mir-185 acts_upstream_of ISO (PMID:24803541) ARUK-UCL PMID:24803541 NCBI chr14:51,449,903...51,449,978
Ensembl chr14:51,449,903...51,449,978 		JBrowse link
G SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:179,431,494...179,509,359
Ensembl chr13:179,428,779...179,556,447 		JBrowse link
G TBC1D10C TBC1 domain family member 10C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23109291) Ensembl
MGI		 PMID:23109291 GO_REF:0000107 NCBI chr 2:5,112,462...5,118,829
Ensembl chr 2:5,112,467...5,121,061 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:26,474,158...26,489,771
Ensembl chr 1:26,473,938...26,489,822 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (PMID:16618805) MGI PMID:16618805 NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358 		JBrowse link
G HMGB3 high mobility group box 3 acts_upstream_of_or_within ISO (PMID:12714519) MGI PMID:12714519 NCBI chr  X:122,591,413...122,599,496
Ensembl chr  X:122,592,936...122,599,493 		JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (PMID:18523151) MGI PMID:18523151 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,763...127,503,257 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748 		JBrowse link
negative regulation of B cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552 		JBrowse link
G BTK Bruton tyrosine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7680896) Ensembl
MGI		 PMID:7680896 GO_REF:0000107 NCBI chr  X:82,981,512...83,014,475
Ensembl chr  X:82,981,515...83,014,573 		JBrowse link
G BTLA B and T lymphocyte associated acts_upstream_of_or_within ISO (PMID:12796776) MGI PMID:12796776 NCBI chr13:147,348,641...147,376,741 JBrowse link
G CASP3 caspase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12970760) Ensembl
MGI		 PMID:12970760 GO_REF:0000107 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CD300A CD300a molecule involved_in ISO (PMID:21482706) UniProt PMID:21482706 NCBI chr12:6,665,578...6,681,329 JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (PMID:15964995) HGNC-UCL PMID:15964995 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) acts_upstream_of_or_within ISO (PMID:12385742), (PMID:8552190) MGI PMID:8552190 PMID:12385742 NCBI chr 4:88,873,762...88,892,964 JBrowse link
G IL10 interleukin 10 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9184696) MGI
Ensembl		 PMID:9184696 GO_REF:0000107 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10704460) Ensembl
MGI		 PMID:10704460 GO_REF:0000107 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644 		JBrowse link
G LOC100519934 uncharacterized LOC100519934 acts_upstream_of_or_within ISO (PMID:8920854) MGI PMID:8920854 NCBI chr 1:73,119,758...73,124,368 JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G MIR185 microRNA mir-185 acts_upstream_of ISO (PMID:24803541) ARUK-UCL PMID:24803541 NCBI chr14:51,449,903...51,449,978
Ensembl chr14:51,449,903...51,449,978 		JBrowse link
G MNDA myeloid cell nuclear differentiation antigen involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 4:91,416,432...91,433,242 JBrowse link
G PAWR pro-apoptotic WT1 regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12970181) Ensembl
MGI		 PMID:12970181 GO_REF:0000107 NCBI chr 5:101,693,145...101,797,842
Ensembl chr 5:101,693,246...101,797,838 		JBrowse link
G PKN1 protein kinase N1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23223530) Ensembl
MGI		 PMID:23223530 GO_REF:0000107 NCBI chr 2:64,800,718...64,824,952
Ensembl chr 2:64,800,721...64,824,957 		JBrowse link
G PTEN phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:16027169) MGI PMID:16027169 NCBI chr14:99,929,590...100,021,619 JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,208,799...116,292,381 		JBrowse link
G TNFRSF13B TNF receptor superfamily member 13B involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:15240667) GO_Central
MGI		 PMID:15240667 GO_REF:0000033 NCBI chr12:61,245,976...61,270,154
Ensembl chr12:61,246,062...61,270,146 		JBrowse link
G TNFRSF21 TNF receptor superfamily member 21 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:42,020,219...42,091,521
Ensembl chr 7:42,020,227...42,091,448 		JBrowse link
G TSC2 TSC complex subunit 2 acts_upstream_of_or_within ISO (PMID:16027169) MGI PMID:16027169 NCBI chr 3:39,898,924...39,935,579
Ensembl chr 3:39,898,925...39,937,371 		JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,201...45,312,539 		JBrowse link
negative regulation of isotype switching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARP3 poly(ADP-ribose) polymerase family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:34,075,807...34,084,384
Ensembl chr13:34,076,012...34,085,210 		JBrowse link
negative regulation of isotype switching to IgE isotypes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10490661) Ensembl
MGI		 PMID:10490661 GO_REF:0000107 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330 		JBrowse link
G FOXP3 forkhead box P3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16275384) Ensembl
MGI		 PMID:16275384 GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G NDFIP1 Nedd4 family interacting protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17137798) Ensembl
MGI		 PMID:17137798 GO_REF:0000107 NCBI chr 2:143,688,946...143,734,523
Ensembl chr 2:143,629,783...143,734,520 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15240705) Ensembl
MGI		 PMID:15240705 GO_REF:0000107 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 9:68,025,673...68,132,162 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18933
    immune system process 2575
      leukocyte activation 1051
        lymphocyte activation 863
          B cell activation 318
            negative regulation of B cell activation 38
              negative regulation of B cell differentiation + 6
              negative regulation of B cell proliferation 22
              negative regulation of isotype switching + 4
Path 2
Term Annotations click to browse term
  biological_process 18933
    biological regulation 13010
      regulation of biological process 12629
        regulation of multicellular organismal process 3215
          negative regulation of multicellular organismal process 1291
            negative regulation of cell activation 232
              negative regulation of leukocyte activation 212
                negative regulation of lymphocyte activation 182
                  negative regulation of B cell activation 38
                    negative regulation of B cell differentiation + 6
                    negative regulation of B cell proliferation 22
                    negative regulation of isotype switching + 4
paths to the root