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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of regulatory T cell differentiation
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Accession:GO:0045589 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of differentiation of regulatory T cells.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulation of regulatory T lymphocyte differentiation;   regulation of suppressor T cell differentiation;   regulation of suppressor T lymphocyte differentiation
 related_synonym: regulation of regulatory T cell development

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regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 CD28 molecule acts_upstream_of_or_within ISO (PMID:21245484) MGI PMID:21245484 NCBI chrNW_004955457:11,159,769...11,253,099
Ensembl chrNW_004955457:11,162,282...11,192,991 		JBrowse link
G Dicer1 dicer 1, ribonuclease III acts_upstream_of_or_within ISO (PMID:18725527) MGI PMID:18725527 NCBI chrNW_004955438:17,374,899...17,431,599
Ensembl chrNW_004955438:17,382,493...17,431,797 		JBrowse link
G Drosha drosha ribonuclease III acts_upstream_of_or_within ISO (PMID:18725527) MGI PMID:18725527 NCBI chrNW_004955426:17,387,595...17,505,126
Ensembl chrNW_004955426:17,387,534...17,502,294 		JBrowse link
G Fanca FA complementation group A acts_upstream_of_or_within ISO (PMID:24501220) MGI PMID:24501220 NCBI chrNW_004955541:3,272,936...3,320,229
Ensembl chrNW_004955541:3,273,022...3,320,052 		JBrowse link
G Fancd2 FA complementation group D2 acts_upstream_of_or_within ISO (PMID:24501220) MGI PMID:24501220 NCBI chrNW_004955561:1,460,080...1,538,026
Ensembl chrNW_004955561:1,464,869...1,538,045 		JBrowse link
G Kat2a lysine acetyltransferase 2A involved_in ISO (MGI:5926326|PMID:28424240) UniProt PMID:28424240 MGI:5926326 NCBI chrNW_004955451:16,192,228...16,197,103
Ensembl chrNW_004955451:16,191,186...16,197,574 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (PMID:21245484) MGI PMID:21245484 NCBI chrNW_004955452:10,608,317...10,632,310
Ensembl chrNW_004955452:10,608,318...10,632,310 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 ISO RGD PMID:25776069 RGD:13442483 NCBI chrNW_004955482:8,079,905...8,100,791
Ensembl chrNW_004955482:8,096,160...8,097,765 		JBrowse link
G Tgfb1 transforming growth factor beta 1 acts_upstream_of_or_within ISO (PMID:21245484) MGI PMID:21245484 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (IN blood group) involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chrNW_004955422:11,106,061...11,189,951 JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 involved_in ISO (PMID:18641304) BHF-UCL PMID:18641304 NCBI chrNW_004955457:11,028,707...11,034,898
Ensembl chrNW_004955457:11,028,698...11,073,460 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chrNW_004955844:8,094...9,565
Ensembl chrNW_004955844:7,790...10,004 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISO (MGI:3803082|PMID:18641303) UniProt PMID:18641303 MGI:3803082 NCBI chrNW_004955408:3,882,282...3,887,965
Ensembl chrNW_004955408:3,880,155...3,887,973 		JBrowse link
G Lag3 lymphocyte activating 3 involved_in ISO (MGI:3510279|PMID:15485628) UniProt PMID:15485628 MGI:3510279 NCBI chrNW_004955413:4,379,529...4,385,456
Ensembl chrNW_004955413:4,378,972...4,385,909 		JBrowse link
G Mdk midkine involved_in ISO (PMID:22323540) UniProt PMID:22323540 NCBI chrNW_004955422:1,655,351...1,657,026
Ensembl chrNW_004955422:1,655,358...1,657,044 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chrNW_004955406:13,477,077...13,493,309
Ensembl chrNW_004955406:13,477,077...13,493,309 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:16275384)
(PMID:12612578)
(PMID:16301745), (PMID:18573908)		 MGI PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO (PMID:16227984) MGI PMID:16227984 NCBI chrNW_004955475:10,676,592...10,680,565
Ensembl chrNW_004955475:10,676,870...10,680,517 		JBrowse link
G Klhl25 kelch like family member 25 involved_in ISO (PMID:34491895)
(MGI:6765767|PMID:34491895)		 UniProt PMID:34491895 MGI:6765767 NCBI chrNW_004955416:18,965,966...18,991,099 JBrowse link
G LOC102019320 mamu class II histocompatibility antigen, DR alpha chain involved_in ISO (PMID:28467828) UniProt PMID:28467828 NCBI chrNW_004955437:1,109,735...1,114,742
Ensembl chrNW_004955437:1,109,713...1,114,802 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) UniProt PMID:20209097 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 involved_in ISO (PMID:30513302)
(MGI:6284097|PMID:30513302)		 UniProt PMID:30513302 MGI:6284097 NCBI chrNW_004955422:1,455,392...1,644,368
Ensembl chrNW_004955422:1,455,380...1,644,452 		JBrowse link
G Bcl6 BCL6 transcription repressor involved_in ISO (PMID:20935202), (PMID:22387553) BHF-UCL PMID:20935202 PMID:22387553 NCBI chrNW_004955420:19,998,960...20,021,200
Ensembl chrNW_004955420:19,998,742...20,022,259 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO (PMID:23793062) MGI PMID:23793062 NCBI chrNW_004955484:9,025,409...9,037,942
Ensembl chrNW_004955484:9,025,460...9,037,580 		JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) UniProt PMID:12540904 NCBI chrNW_004955406:43,002,817...43,034,555 JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chrNW_004955520:2,338,548...2,371,591
Ensembl chrNW_004955520:2,339,521...2,372,400 		JBrowse link
G Foxo3 forkhead box O3 involved_in ISO (PMID:30513302) UniProt PMID:30513302 NCBI chrNW_004955411:33,655,958...33,770,829
Ensembl chrNW_004955411:33,655,958...33,770,829 		JBrowse link
G Foxp3 forkhead box P3 involved_in
acts_upstream_of_or_within		 ISO (PMID:30513302)
(PMID:12522256), (PMID:15100250), (PMID:16769892), (PMID:17028180)
(PMID:15780990)		 UniProt
MGI		 PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 More... NCBI chrNW_004955543:731,707...742,606
Ensembl chrNW_004955543:731,707...742,606 		JBrowse link
G Il2 interleukin 2 ISO RGD PMID:6233372 RGD:1600097 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:25778793) UniProt PMID:25778793 NCBI chrNW_004955559:1,012,634...1,047,051
Ensembl chrNW_004955559:1,034,917...1,047,034 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO (PMID:24835996)
(MGI:5576410|PMID:24835996)		 UniProt PMID:24835996 MGI:5576410 NCBI chrNW_004955422:19,557,498...19,565,044
Ensembl chrNW_004955422:19,557,498...19,565,036 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chrNW_004955481:5,234,125...5,249,564 JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chrNW_004955442:7,321,337...7,323,109
Ensembl chrNW_004955442:7,321,337...7,323,109 		JBrowse link
G Sox12 SRY-box transcription factor 12 involved_in ISO (MGI:6203502|PMID:30190287) UniProt PMID:30190287 MGI:6203502 NCBI chrNW_004955597:225,796...229,350 JBrowse link
G Tgfb1 transforming growth factor beta 1 involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chrNW_004955555:274,405...288,441
Ensembl chrNW_004955555:270,652...288,441 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) UniProt PMID:24691993 NCBI chrNW_004955437:19,716,466...19,743,428 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    immune system process 1980
      leukocyte activation 888
        lymphocyte activation 720
          lymphocyte differentiation 394
            T cell differentiation 293
              regulatory T cell differentiation 39
                regulation of regulatory T cell differentiation 34
                  negative regulation of regulatory T cell differentiation + 7
                  positive regulation of regulatory T cell differentiation + 19
                  regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 12362
    developmental process 5862
      cellular developmental process 3880
        cell differentiation 3879
          cell development 2838
            hemopoiesis 920
              leukocyte differentiation 592
                mononuclear cell differentiation 483
                  lymphocyte differentiation 394
                    T cell differentiation 293
                      regulatory T cell differentiation 39
                        regulation of regulatory T cell differentiation 34
                          negative regulation of regulatory T cell differentiation + 7
                          positive regulation of regulatory T cell differentiation + 19
                          regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 6
paths to the root