Lag3 (lymphocyte activating 3) - Rat Genome Database

Name: Lag3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Lag3 (lymphocyte activating 3) Chinchilla lanigera

Analyze

Symbol:

Lag3

Name:

lymphocyte activating 3

RGD ID:

8871884

Description:

ENCODES a protein that exhibits MHC class II protein binding (ortholog); transmembrane signaling receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); natural killer cell mediated cytotoxicity (ortholog); negative regulation of interleukin-2 production (ortholog); ASSOCIATED WITH genetic disease (ortholog); Hyperphosphatemic Familial Tumoral Calcinosis 1 (ortholog); lymphoproliferative syndrome 2 (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular region (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

lymphocyte-activation gene 3

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LAG3 (lymphocyte activating 3)	NCBI	Ortholog
Mus musculus (house mouse):	Lag3 (lymphocyte-activation gene 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Lag3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LAG3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LAG3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lag3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LAG3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LAG3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lag3 (lymphocyte activating 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,378,972 - 4,385,909 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	4,379,529 - 4,385,456 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Hyperphosphatemic Familial Tumoral Calcinosis 1 (ISO)

lymphoproliferative syndrome 2 (ISO)

peroxisome biogenesis disorder 2B (ISO)

Temtamy syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway (ISO)

natural killer cell mediated cytotoxicity (ISO)

negative regulation of interleukin-2 production (ISO)

negative regulation of regulatory T cell differentiation (ISO)

negative regulation of T cell activation (ISO)

plasmacytoid dendritic cell activation (ISO)

positive regulation of natural killer cell mediated cytotoxicity (ISO)

regulation of immune response (ISO)

T cell activation (ISO)

Cellular Component

external side of plasma membrane (ISO)

extracellular region (ISO)

Molecular Function

MHC class II protein binding (ISO)

protein binding (ISO)

transmembrane signaling receptor activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Lag3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	4,378,972 - 4,385,909 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	4,379,529 - 4,385,456 (+)	NCBI	ChiLan1.0	ChiLan1.0

LAG3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	6,772,520 - 6,778,455 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	6,772,512 - 6,778,455 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	6,881,686 - 6,887,621 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	6,751,931 - 6,757,880 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	6,751,930 - 6,757,880	NCBI
Celera	12	8,498,967 - 8,504,918 (+)	NCBI		Celera
Cytogenetic Map	12	p13.31	NCBI
HuRef	12	6,735,007 - 6,740,958 (+)	NCBI		HuRef
CHM1_1	12	6,880,658 - 6,886,609 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	6,782,086 - 6,788,021 (+)	NCBI		T2T-CHM13v2.0

Lag3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	124,881,322 - 124,888,668 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	124,881,324 - 124,888,668 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	124,904,359 - 124,912,434 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	124,904,361 - 124,911,705 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	124,854,377 - 124,861,723 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	124,869,980 - 124,877,324 (-)	NCBI		MGSCv36	mm8
Celera	6	126,580,475 - 126,587,853 (-)	NCBI		Celera
Cytogenetic Map	6	F2	NCBI
cM Map	6	59.17	NCBI

Lag3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	159,398,930 - 159,407,001 (-)	NCBI		GRCr8
mRatBN7.2	4	157,712,665 - 157,722,229 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	157,712,667 - 157,720,404 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	163,940,943 - 163,948,668 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	159,723,860 - 159,731,590 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	158,359,232 - 158,367,008 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	157,425,644 - 157,433,700 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	157,425,644 - 157,433,467 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	224,443,422 - 224,451,485 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	161,031,506 - 161,039,255 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	161,276,441 - 161,284,191 (-)	NCBI
Celera	4	146,449,946 - 146,457,685 (-)	NCBI		Celera
Cytogenetic Map	4	q42	NCBI

LAG3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	12,335,059 - 12,341,070 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	12,331,815 - 12,337,845 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	6,903,770 - 6,909,778 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	6,817,143 - 6,823,112 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	6,817,507 - 6,823,047 (+)	Ensembl	panpan1.1		panPan2

LAG3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	38,260,673 - 38,266,771 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	38,260,674 - 38,265,819 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	8,349,842 - 8,355,893 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	38,613,389 - 38,619,438 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	38,613,390 - 38,619,087 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	38,487,367 - 38,493,411 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	38,528,603 - 38,534,658 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	7,829,072 - 7,835,123 (+)	NCBI		UU_Cfam_GSD_1.0

Lag3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	102,374,004 - 102,381,088 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936709	1,041,530 - 1,047,280 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936709	1,041,519 - 1,048,630 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAG3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	63,929,625 - 63,935,410 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	63,929,669 - 63,935,054 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	66,364,099 - 66,369,484 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAG3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	6,809,381 - 6,815,390 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	6,809,584 - 6,815,325 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	1,408,483 - 1,414,491 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lag3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624860	3,456,347 - 3,461,592 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624860	3,454,587 - 3,461,649 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005378825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01013612	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01189509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000021638 ⟹ ENSCLAP00000021435

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955413	4,378,972 - 4,385,909 (+)	Ensembl

RefSeq Acc Id:

XM_005378825 ⟹ XP_005378882

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955413	4,379,529 - 4,385,456 (+)	NCBI

Sequence:

show sequence

GGAGGGGAAGTGGGGAAGGTGGAGGGAGACTTAAGGACCGGGTCAGGGCCCTGGAGCAGCACAG
CAGCATCCAGCTCCTGACAGCCACCTTTCCTCCAGACTGCGCTCTGCCATCGACCAGCCTGGTC
CCCAGGGTGCCCCGGCCCCTGGCCTCCAGCCTCCATCACTGGTCCTCCCCACTCGCTCCGCAGG
CCTCTGAAGGGTTCCCTTTCCGCTAGCTCCCCTCTCTCCATTGCTCTCTGCACAACTTTTCTTG
GTCGCCTCTCCCCTTGCTGAGCTCCCTCTGGAGGTTGAGCCTGGCTCAGCCACAGGGGAGATGG
GGTGGACTCAGTTCCTGGGCTTGGCGCTTCTCCAACTGCTGTGGGTGGCTCCAGTGGAGGCTTC
AGGGCCTGAGAAAGAGGTCACTGTGGTGTGGGCTCAGGAGGGGGCTCCTGCCCAGCTCCCCTGC
AGCCCCACAATCCCCCTCCAAGATTCCAGCCTTCTGCGAAGAGGAGGGGTCACTTGGCAGCATC
AACCAGACAGTGGCCCAGCCGCTCCCGCCCCCGCTCGGCCCTGGAACCTCGGCCCTCGTCCGGA
GGAGGCGCCCACCCCGCAGCGCTACACGGTGCTGAGCGTGGCCCCCGGCGGCCTGCGCAGCGGG
CGGCTCCCCCTGCAACCGCGCGTGCAGCTGGACGAGCGCGGCCTCCAGCGCGGCGACTTCTCGC
TGTGGCTGCGCCCGGCCCTGCGCGCCGACGCCGGCGAGTACCACGCCGCCGTGCGCCTCCTCCG
GGACCGCGCGCTCACCTGCCGGCTCCGTCTGCGCGTGGGCCAGGCCTCGATGACGGCCAGCCCT
GCCGGACCTCTCAGGACCTCTGACTGGGTCATCTTGAACTGCTCCTTCAGCCGTCCAGACCGCC
CGGCCTCTGTCCACTGGTTCCGGGGTCCAGGCCATGTCCCTGTCCAGAAGTCTTCGCACCACCA
CTCAATGGAAAGCTTCCTCTTCCTGCCCCAAGTCAGCCCCTTAGACTCTGGGGTCTGGGGCTGC
ATCCTCACCTACAGAGATGGCTTCAAAGTCCGGATCACACACAACCTCACTGTTCAGGGTCCAG
ACCCCCCAACCCCCTTGATGGTATACACTGGAGCAGGTTCCAGAGCAGAATTACCATGTCACCT
GCCTCCTGGTGTGACAACCCAGTCTTCCCCCATGGCCCTGTGGGCGCCTCCTGGTGGAGGCCCA
GACATCCCCGTGGCTGGAGACAATGGCAACTTCACCCTTCGACTAGAGGCTGTGAGCCTGGCCC
AGGCTGGGACCTACACTTGCCGTATCCATCTACAAGGGCAGCAGCTCAGTGCCATGGTCACTTT
GGCAGTCATCACAGTGACTCCCAAATCTTCTGGGTTACCTGGCTCCCTGGGGAGACTCCTGTGT
GAGGTGACCCCAGCATCTGGATGCGAGCGCTTTGTGTGGAACCCGCTGGACAGGGAGTCCAGAA
GGAGTTTCCCAGGACCCTGGCTGGAGATGCCTGAGGACAAGCTCCTTTCCCAGCCCTGGCAGTG
CCAGGTGCACCAGGAGAAGAGACTTATTGGAGCAGTGATGTATATCCCAGAGTCCAGGCCAGGT
GCTCAGCATGCTGGGAGAGCCCCACATGCCCTCAGAGCAGGCCAGCTCCCTCTCTTTCTCGTCC
TGAGTACCCTTTCATTGCTTCTTTTGGTGACTGGAGCATTTGGCTTTCACCTTTGGAAAACACA
GTGGAGATTGAGAAGATTTTCTGCCTTAGAGCTTGGGATTCGCCCTCCTCAGGCTGAGAGCAAG
ATCGAGGAAGTGGAGCCAGAGCCAGAGCTGGAGCCAGAGCCAGAGCCAGAGACAGAGCTGGGGC
CACAGCCACAGCTGGAGCCACGGCCACAGCTGGATCCTGGGCAGCTCTGACCTGGAGCGGAGGC
AGCAGCAGATCCTCGCAGCTCAGCCCGAATAAACCCCCTGTCAGCAGCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005378882	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000021435
	ENSCLAP00000021435.1

RefSeq Acc Id:

XP_005378882 ⟸ XM_005378825

- UniProtKB:

A0A8C2VVW3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGWTQFLGLALLQLLWVAPVEASGPEKEVTVVWAQEGAPAQLPCSPTIPLQDSSLLRRGGVTWQ
HQPDSGPAAPAPARPWNLGPRPEEAPTPQRYTVLSVAPGGLRSGRLPLQPRVQLDERGLQRGDF
SLWLRPALRADAGEYHAAVRLLRDRALTCRLRLRVGQASMTASPAGPLRTSDWVILNCSFSRPD
RPASVHWFRGPGHVPVQKSSHHHSMESFLFLPQVSPLDSGVWGCILTYRDGFKVRITHNLTVQG
PDPPTPLMVYTGAGSRAELPCHLPPGVTTQSSPMALWAPPGGGPDIPVAGDNGNFTLRLEAVSL
AQAGTYTCRIHLQGQQLSAMVTLAVITVTPKSSGLPGSLGRLLCEVTPASGCERFVWNPLDRES
RRSFPGPWLEMPEDKLLSQPWQCQVHQEKRLIGAVMYIPESRPGAQHAGRAPHALRAGQLPLFL
VLSTLSLLLLVTGAFGFHLWKTQWRLRRFSALELGIRPPQAESKIEEVEPEPELEPEPEPETEL
GPQPQLEPRPQLDPGQL

hide sequence

RefSeq Acc Id:

ENSCLAP00000021435 ⟸ ENSCLAT00000021638

Protein Domains

Ig-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000014680	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000021638	ENTREZGENE
	ENSCLAT00000021638.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
InterPro	Ig-like_dom	UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Ig_sub	UniProtKB/TrEMBL
	IL-1_rcpt_fam	UniProtKB/TrEMBL
NCBI Gene	Lag3	ENTREZGENE
PANTHER	LYMPHOCYTE ACTIVATION GENE 3 PROTEIN	UniProtKB/TrEMBL
	PTHR11890	UniProtKB/TrEMBL
Pfam	Ig_2	UniProtKB/TrEMBL
PROSITE	IG_LIKE	UniProtKB/TrEMBL
SMART	SM00409	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48726	UniProtKB/TrEMBL
UniProt	A0A8C2VVW3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Lag3	lymphocyte activating 3		lymphocyte-activation gene 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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