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ONTOLOGY REPORT - ANNOTATIONS


Term:regulatory T cell differentiation
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Accession:GO:0045066 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulatory T lymphocyte differentiation;   suppressor T cell differentiation;   suppressor T lymphocyte differentiation
 related_synonym: regulatory T cell development



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regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule involved_in ISO (PMID:18641304) RGD PMID:18641304 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of ISO (MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180) RGD PMID:16769892 PMID:17028180 MGI:3693968 MGI:3697020 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:3576270|MGI:3719583 (MGI:3041050|PMID:15100250), (MGI:3718815|PMID:17481928) RGD PMID:15100250 PMID:17481928 MGI:3041050 MGI:3718815 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in
acts_upstream_of
ISO (PMID:22079196)
MGI:1857034|MGI:3696705 (MGI:3695768|PMID:16275384), (MGI:3700459|PMID:16301745), (MGI:3799419|PMID:18573908)
RGD PMID:16275384 PMID:16301745 PMID:18573908 PMID:22079196 MGI:3695768 MGI:3700459 MGI:3799419 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fut7 fucosyltransferase 7 acts_upstream_of_or_within ISO MGI:2387664 (MGI:3799419|PMID:18573908) RGD PMID:18573908 MGI:3799419 NCBI chr 3:8,237,687...8,242,273
Ensembl chr 3:8,239,384...8,242,260
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of ISO MGI:1857455 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within ISO MGI:2677822 (MGI:1926554|PMID:11030619) RGD PMID:11030619 MGI:1926554 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Pla2g2d phospholipase A2, group IID acts_upstream_of_or_within ISO (MGI:3851856|PMID:19564598) RGD PMID:19564598 MGI:3851856 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525
JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:3773459 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in IBA
ISO
PMID:21873635
(PMID:18641304)
RGD PMID:18641304 PMID:21873635 RGD:13792537 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3803082|PMID:18641303)
UniProt
RGD
PMID:18641303 GO_REF:0000024 MGI:3803082 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Lag3 lymphocyte activating 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3510279|PMID:15485628)
UniProt
RGD
PMID:15485628 GO_REF:0000024 MGI:3510279 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404
JBrowse link
G Mdk midkine involved_in ISO
ISS
(PMID:22323540)
GO_REF:0000024
RGD
UniProt
PMID:22323540 GO_REF:0000024 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130
JBrowse link
G Mir21 microRNA 21 involved_in ISO RNAcentral:URS0000338542_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Mir30b microRNA 30b involved_in ISO RNAcentral:URS000039ED8D_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) RGD PMID:18713990 MGI:3806904 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
G Tug1 taurine up-regulated 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034|MGI:2654936|MGI:3696705 (MGI:2653673|PMID:12612578), (MGI:3695768|PMID:16275384), (MGI:3700459|PMID:16301745), (MGI:3799419|PMID:18573908) RGD PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 MGI:2653673 MGI:3695768 MGI:3700459 MGI:3799419 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 involved_in ISO (PMID:30513302)
(MGI:6284097|PMID:30513302)
RGD PMID:30513302 MGI:6284097 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221
JBrowse link
G Bcl6 BCL6, transcription repressor involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618
JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:4462559|MGI:5547539 (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965
JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445
JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO (PMID:22387553) RGD PMID:22387553 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Foxo3 forkhead box O3 involved_in ISO (PMID:30513302) RGD PMID:30513302 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within
involved_in
ISO MGI:2654936 (MGI:2450778|PMID:12522256), (MGI:3041050|PMID:15100250), (MGI:3574163|PMID:15780990), (MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180)
(PMID:30513302)
RGD PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 More... MGI:2450778 MGI:3041050 MGI:3574163 MGI:3693968 MGI:3697020 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Il2 interleukin 2 IDA RGD PMID:6233372 RGD:1600097 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:25778793) RGD PMID:25778793 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562
JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISS
ISO
GO_REF:0000024
(MGI:5576410|PMID:24835996)
(PMID:24835996)
UniProt
RGD
PMID:24835996 GO_REF:0000024 MGI:5576410 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
JBrowse link
G Lgals9 galectin 9 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045
JBrowse link
G Lilrb2 leukocyte immunoglobulin like receptor B2 involved_in ISO (PMID:20448110) RGD PMID:20448110 NCBI chr 1:65,326,832...65,334,683
Ensembl chr 1:65,326,832...65,334,679
JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660
JBrowse link
G Mir214 microRNA 214 IMP RGD PMID:30287503 RGD:38549580 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20448110) RGD PMID:20448110 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO
IEA
(PMID:22387553)
GO_REF:0000107
RGD
Ensembl
PMID:22387553 GO_REF:0000107 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Sox12 SRY-box transcription factor 12 involved_in ISO (MGI:6203502|PMID:30190287) RGD PMID:30190287 MGI:6203502 NCBI chr 3:140,859,499...140,860,518
Ensembl chr 3:140,856,579...140,860,975
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878
JBrowse link
regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:96756|MGI:98725 (MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:4946593 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of_or_within ISO (MGI:3805722|PMID:18725527) RGD PMID:18725527 MGI:3805722 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Drosha drosha ribonuclease III acts_upstream_of_or_within ISO (MGI:3805722|PMID:18725527) RGD PMID:18725527 MGI:3805722 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
JBrowse link
G Fanca FA complementation group A involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2674094 (MGI:5569680|PMID:24501220)
RGD PMID:24501220 PMID:21873635 MGI:5569680, RGD:13792537 NCBI chr19:51,304,021...51,362,586
Ensembl chr19:51,304,021...51,362,527
JBrowse link
G Fancd2 FA complementation group D2 acts_upstream_of_or_within ISO MGI:2673422 (MGI:5569680|PMID:24501220) RGD PMID:24501220 MGI:5569680 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Kat2a lysine acetyltransferase 2A involved_in ISO (MGI:5926326|PMID:28424240) RGD PMID:28424240 MGI:5926326 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:88327 (MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:4946593 NCBI chr 5:141,888,319...141,916,992
Ensembl chr 5:141,888,326...141,903,794
JBrowse link
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616
JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:88327 (MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:4946593 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    immune system process 2730
      leukocyte activation 1025
        lymphocyte activation 840
          lymphocyte differentiation 426
            T cell differentiation 306
              regulatory T cell differentiation 47
                CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 11
                CD8-positive, alpha-beta regulatory T cell differentiation 0
                negative regulation of regulatory T cell differentiation + 10
                positive regulation of regulatory T cell differentiation + 25
                regulation of regulatory T cell differentiation + 43
Path 2
Term Annotations click to browse term
  biological_process 18734
    developmental process 6893
      anatomical structure development 6368
        multicellular organism development 5437
          system development 4939
            immune system development 1129
              hematopoietic or lymphoid organ development 1061
                hemopoiesis 1012
                  leukocyte differentiation 634
                    mononuclear cell differentiation 485
                      lymphocyte differentiation 426
                        T cell differentiation 306
                          regulatory T cell differentiation 47
                            CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 11
                            CD8-positive, alpha-beta regulatory T cell differentiation 0
                            negative regulation of regulatory T cell differentiation + 10
                            positive regulation of regulatory T cell differentiation + 25
                            regulation of regulatory T cell differentiation + 43
paths to the root