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ONTOLOGY REPORT - ANNOTATIONS

Term:regulatory T cell differentiation
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Accession:GO:0045066 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: regulatory T lymphocyte differentiation;   suppressor T cell differentiation;   suppressor T lymphocyte differentiation
 related_synonym: regulatory T cell development


show annotations for term's descendants           Sort by:
regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule involved_in ISO
IEA		 (PMID:18641304)
GO_REF:0000107		 RGD
Ensembl		 PMID:18641304 GO_REF:0000107 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of
involved_in		 ISO (MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180)
(PMID:32644293)		 RGD PMID:16769892 PMID:17028180 PMID:32644293 MGI:3693968 MGI:3697020 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within
involved_in		 ISO MGI:3576270|MGI:3719583 (MGI:3041050|PMID:15100250), (MGI:3718815|PMID:17481928)
(PMID:32644293)		 RGD PMID:15100250 PMID:17481928 PMID:32644293 MGI:3041050 MGI:3718815 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (PMID:32644293) RGD PMID:32644293 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 involved_in
acts_upstream_of		 ISO (PMID:22079196)
MGI:1857034|MGI:3696705 (MGI:3695768|PMID:16275384), (MGI:3700459|PMID:16301745), (MGI:3799419|PMID:18573908)		 RGD PMID:16275384 PMID:16301745 PMID:18573908 PMID:22079196 MGI:3695768 MGI:3700459 MGI:3799419 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Fut7 fucosyltransferase 7 acts_upstream_of_or_within ISO MGI:2387664 (MGI:3799419|PMID:18573908) RGD PMID:18573908 MGI:3799419 NCBI chr 3:8,237,687...8,242,273
Ensembl chr 3:8,239,384...8,242,260 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of ISO MGI:1857455 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within ISO MGI:2677822 (MGI:1926554|PMID:11030619) RGD PMID:11030619 MGI:1926554 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Pla2g2d phospholipase A2, group IID acts_upstream_of_or_within ISO (MGI:3851856|PMID:19564598) RGD PMID:19564598 MGI:3851856 NCBI chr 5:151,016,010...151,022,531
Ensembl chr 5:151,018,870...151,022,525 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) RGD PMID:18195075 MGI:3773459 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 involved_in IBA
ISO		 PMID:21873635
(PMID:18641304)		 RGD PMID:18641304 PMID:21873635 RGD:13792537 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3803082|PMID:18641303)		 UniProt
RGD		 PMID:18641303 GO_REF:0000024 MGI:3803082 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Lag3 lymphocyte activating 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3510279|PMID:15485628)		 UniProt
RGD		 PMID:15485628 GO_REF:0000024 MGI:3510279 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404 		JBrowse link
G Mdk midkine involved_in ISO
IEA
ISS		 (PMID:22323540)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22323540 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mir21 microRNA 21 involved_in ISO RNAcentral:URS0000338542_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir30b microRNA 30b involved_in ISO RNAcentral:URS000039ED8D_9606 (PMID:22387553) RGD PMID:22387553 NCBI chr 7:100,132,589...100,132,675
Ensembl chr 7:100,132,589...100,132,675 		JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) RGD PMID:18713990 MGI:3806904 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788 		JBrowse link
G Tug1 taurine up-regulated 1 IMP RGD PMID:30287503 RGD:38549580 NCBI chr14:78,519,894...78,526,927
Ensembl chr14:78,522,506...78,526,927 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO MGI:1857034|MGI:2654936|MGI:3696705 (MGI:2653673|PMID:12612578), (MGI:3695768|PMID:16275384), (MGI:3700459|PMID:16301745), (MGI:3799419|PMID:18573908) RGD PMID:12612578 PMID:16275384 PMID:16301745 PMID:18573908 MGI:2653673 MGI:3695768 MGI:3700459 MGI:3799419 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Gimap5 GTPase, IMAP family member 5 IMP RGD PMID:15778366 RGD:2303772 NCBI chr 4:77,693,417...77,701,025
Ensembl chr 4:77,687,564...77,703,086 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma acts_upstream_of_or_within ISO MGI:1857455 (MGI:3662823|PMID:16227984) RGD PMID:16227984 MGI:3662823 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Klhl25 kelch-like family member 25 involved_in ISO
ISS		 (PMID:34491895)
(MGI:6765767|PMID:34491895)
GO_REF:0000024		 RGD
UniProt		 PMID:34491895 GO_REF:0000024 MGI:6765767 NCBI chr 1:129,724,894...129,750,142
Ensembl chr 1:129,722,026...129,750,227 		JBrowse link
G RT1-Da RT1 class II, locus Da involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 involved_in ISO (PMID:28467828) RGD PMID:28467828 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:20209097) RGD PMID:20209097 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
positive regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 involved_in ISO (PMID:30513302)
(MGI:6284097|PMID:30513302)		 RGD PMID:30513302 MGI:6284097 NCBI chr 3:77,700,936...77,890,221
Ensembl chr 3:77,700,936...77,890,221 		JBrowse link
G Bcl6 BCL6, transcription repressor involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389 		JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO (MGI:5520006|PMID:23589618) RGD PMID:23589618 MGI:5520006 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO MGI:4462559|MGI:5547539 (MGI:5544872|PMID:23793062) RGD PMID:23793062 MGI:5544872 NCBI chr19:33,571,255...33,586,783
Ensembl chr19:33,574,257...33,586,965 		JBrowse link
G Cd46 CD46 molecule involved_in ISO (PMID:12540904) RGD PMID:12540904 NCBI chr13:106,575,586...106,606,325
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in ISO (PMID:22387553) RGD PMID:22387553 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Foxo3 forkhead box O3 involved_in ISO (PMID:30513302) RGD PMID:30513302 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within
involved_in		 ISO MGI:2654936 (MGI:2450778|PMID:12522256), (MGI:3041050|PMID:15100250), (MGI:3574163|PMID:15780990), (MGI:3693968|PMID:16769892), (MGI:3697020|PMID:17028180)
(PMID:30513302)		 RGD PMID:12522256 PMID:15100250 PMID:15780990 PMID:16769892 PMID:17028180 More... MGI:2450778 MGI:3041050 MGI:3574163 MGI:3693968 MGI:3697020 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Il2 interleukin 2 IDA RGD PMID:6233372 RGD:1600097 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:25778793)
(MGI:5753024|PMID:25778793)		 RGD PMID:25778793 MGI:5753024 NCBI chr 1:95,299,457...95,324,564
Ensembl chr 1:95,295,601...95,324,562 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5576410|PMID:24835996)
(PMID:24835996)		 UniProt
Ensembl
RGD		 PMID:24835996 GO_REF:0000024 GO_REF:0000107 MGI:5576410 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Lilrb4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:20935202), (PMID:22387553) RGD PMID:20935202 PMID:22387553 NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660 		JBrowse link
G Mir214 microRNA 214 IMP RGD PMID:30287503 RGD:38549580 NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:20448110) RGD PMID:20448110 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in ISO
IEA		 (PMID:22387553)
GO_REF:0000107		 RGD
Ensembl		 PMID:22387553 GO_REF:0000107 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Sox12 SRY-box transcription factor 12 involved_in ISO (MGI:6203502|PMID:30190287) RGD PMID:30190287 MGI:6203502 NCBI chr 3:140,859,499...140,860,518
Ensembl chr 3:140,856,579...140,860,975 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISO (MGI:5688819|PMID:25065622) RGD PMID:25065622 MGI:5688819 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Vsir V-set immunoregulatory receptor involved_in ISO (PMID:24691993) RGD PMID:24691993 NCBI chr20:28,281,582...28,307,262
Ensembl chr20:28,281,596...28,303,878 		JBrowse link
regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd28 Cd28 molecule acts_upstream_of_or_within ISO MGI:96756|MGI:98725 (MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:4946593 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of_or_within ISO (MGI:3805722|PMID:18725527) RGD PMID:18725527 MGI:3805722 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G Drosha drosha ribonuclease III acts_upstream_of_or_within ISO (MGI:3805722|PMID:18725527) RGD PMID:18725527 MGI:3805722 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688 		JBrowse link
G Fanca FA complementation group A involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:2674094 (MGI:5569680|PMID:24501220)		 RGD PMID:24501220 PMID:21873635 MGI:5569680, RGD:13792537 NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527 		JBrowse link
G Fancd2 FA complementation group D2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:2673422 (MGI:5569680|PMID:24501220)
GO_REF:0000107		 RGD
Ensembl		 PMID:24501220 GO_REF:0000107 MGI:5569680 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Kat2a lysine acetyltransferase 2A involved_in ISO (MGI:5926326|PMID:28424240) RGD PMID:28424240 MGI:5926326 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO MGI:88327 (MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:4946593 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:34,731,934...34,753,617
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within ISO MGI:88327 (MGI:4946593|PMID:21245484) RGD PMID:21245484 MGI:4946593 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    immune system process 2665
      leukocyte activation 1027
        lymphocyte activation 832
          lymphocyte differentiation 442
            T cell differentiation 318
              regulatory T cell differentiation 48
                CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 12
                CD8-positive, alpha-beta regulatory T cell differentiation 0
                negative regulation of regulatory T cell differentiation + 10
                positive regulation of regulatory T cell differentiation + 25
                regulation of regulatory T cell differentiation + 43
Path 2
Term Annotations click to browse term
  biological_process 19574
    developmental process 6911
      cellular developmental process 4642
        cell differentiation 4641
          cell development 3239
            hemopoiesis 1052
              leukocyte differentiation 666
                mononuclear cell differentiation 499
                  lymphocyte differentiation 442
                    T cell differentiation 318
                      regulatory T cell differentiation 48
                        CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 12
                        CD8-positive, alpha-beta regulatory T cell differentiation 0
                        negative regulation of regulatory T cell differentiation + 10
                        positive regulation of regulatory T cell differentiation + 25
                        regulation of regulatory T cell differentiation + 43
paths to the root