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ONTOLOGY REPORT - ANNOTATIONS

Term:positive T cell selection
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Accession:GO:0043368 term browser browse the term
Definition:The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms:exact_synonym: positive T lymphocyte selection

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positive T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b BCL11 transcription factor B acts_upstream_of_or_within ISO (PMID:17998389) MGI PMID:17998389 NCBI chrNW_004955438:20,562,345...20,637,662
Ensembl chrNW_004955438:20,564,449...20,637,103 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:23334952) MGI PMID:23334952 NCBI chrNW_004955494:2,567,238...2,712,708 JBrowse link
G Themis thymocyte selection associated involved_in ISO (MGI:4352756|PMID:19597499), (MGI:4352757|PMID:19597498), (MGI:4352758|PMID:19597497), (MGI:4361774|PMID:19805304) UniProt PMID:19597497 PMID:19597498 PMID:19597499 PMID:19805304 MGI:4352756 MGI:4352757 MGI:4352758 MGI:4361774 NCBI chrNW_004955436:8,743,835...8,909,040 JBrowse link
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:18228248) MGI PMID:18228248 NCBI chrNW_004955494:2,567,238...2,712,708 JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (PMID:16501569) MGI PMID:16501569 NCBI chrNW_004955433:8,788,867...8,845,925
Ensembl chrNW_004955433:8,788,655...8,845,925 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO (PMID:17227833)
(MGI:3834308|PMID:17227833)		 BHF-UCL PMID:17227833 MGI:3834308 NCBI chrNW_004955491:8,647,133...8,657,381 JBrowse link
CD4-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chrNW_004955444:19,453,789...19,796,419
Ensembl chrNW_004955444:19,453,783...19,795,167 		JBrowse link
CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chrNW_004955444:19,453,789...19,796,419
Ensembl chrNW_004955444:19,453,783...19,795,167 		JBrowse link
CD8-positive, alpha-beta T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator acts_upstream_of_or_within ISO (PMID:8170972) MGI PMID:8170972 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in ISO (MGI:2159528|PMID:11850626), (MGI:3045816|PMID:15078895) UniProt PMID:11850626 PMID:15078895 MGI:2159528 MGI:3045816 NCBI chrNW_004955444:19,453,789...19,796,419
Ensembl chrNW_004955444:19,453,783...19,795,167 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5320871|PMID:22080863) UniProt PMID:22080863 MGI:5320871 NCBI chrNW_004955402:771,410...846,671 JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase like 3 involved_in ISO (MGI:5825383|PMID:28065600)
(PMID:28065600)		 UniProt PMID:28065600 MGI:5825383 NCBI chrNW_004955424:11,236,415...11,255,801
Ensembl chrNW_004955424:11,236,836...11,259,570 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chrNW_004955406:13,391,162...13,402,479 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (PMID:28262505)
(MGI:6106706|PMID:28262505)		 UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004955437:1,584,890...1,592,486
Ensembl chrNW_004955437:1,584,479...1,592,826 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004955495:7,959,033...7,989,216
Ensembl chrNW_004955495:7,957,510...7,988,498 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (MGI:3851279|PMID:19501566) BHF-UCL PMID:19501566 MGI:3851279 NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312 		JBrowse link
positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd3d CD3d molecule involved_in ISO (MGI:87267|PMID:9135151) UniProt PMID:9135151 MGI:87267 NCBI chrNW_004955412:19,481,059...19,484,890
Ensembl chrNW_004955412:19,480,977...19,484,721 		JBrowse link
G Cd74 CD74 molecule acts_upstream_of_or_within ISO (PMID:7679955), (PMID:8598040)
(PMID:9432982)		 MGI PMID:7679955 PMID:8598040 PMID:9432982 NCBI chrNW_004955415:4,129,151...4,138,336
Ensembl chrNW_004955415:4,129,254...4,137,826 		JBrowse link
G Dock2 dedicator of cytokinesis 2 acts_upstream_of_or_within ISO (PMID:12871644) MGI PMID:12871644 NCBI chrNW_004955408:22,630,375...23,059,832
Ensembl chrNW_004955408:22,630,364...23,059,899 		JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B acts_upstream_of_or_within ISO (PMID:15064401) MGI PMID:15064401 NCBI chrNW_004955489:726,641...814,180
Ensembl chrNW_004955489:725,759...814,180 		JBrowse link
G LOC102023843 HLA class II histocompatibility antigen, DM alpha chain acts_upstream_of_or_within ISO (PMID:8598040)
(PMID:8598041), (PMID:9432982)
(PMID:8638109)		 MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chrNW_004955437:1,558,806...1,562,294
Ensembl chrNW_004955437:1,558,911...1,562,162 		JBrowse link
G Nfatc3 nuclear factor of activated T cells 3 involved_in ISO (MGI:3820023|PMID:17579027) UniProt PMID:17579027 MGI:3820023 NCBI chrNW_004955484:8,433,765...8,558,005
Ensembl chrNW_004955484:8,436,330...8,526,680 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:8666928) MGI PMID:8666928 NCBI chrNW_004955406:35,005,577...35,127,395
Ensembl chrNW_004955406:35,005,214...35,129,552 		JBrowse link
G Shh sonic hedgehog signaling molecule involved_in ISO (MGI:3834308|PMID:17227833) BHF-UCL PMID:17227833 MGI:3834308 NCBI chrNW_004955491:8,647,133...8,657,381 JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO (PMID:21098124) MGI PMID:21098124 NCBI chrNW_004955437:9,100,546...9,109,305
Ensembl chrNW_004955437:9,098,968...9,107,057 		JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within ISO (PMID:21487392) MGI PMID:21487392 NCBI chrNW_004955495:6,678,195...6,699,408
Ensembl chrNW_004955495:6,678,195...6,699,058 		JBrowse link
G Zap70 zeta-chain (TCR) associated protein kinase 70kDa acts_upstream_of_or_within ISO (PMID:7630421) MGI PMID:7630421 NCBI chrNW_004955470:4,379,260...4,397,851
Ensembl chrNW_004955470:4,386,311...4,396,419 		JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxn1 forkhead box N1 involved_in ISO (MGI:5554515|PMID:24184560) UniProt PMID:24184560 MGI:5554515 NCBI chrNW_004955481:4,611,246...4,640,606
Ensembl chrNW_004955481:4,611,087...4,627,113 		JBrowse link
G Tox thymocyte selection associated high mobility group box involved_in ISO (MGI:3773459|PMID:18195075) UniProt PMID:18195075 MGI:3773459 NCBI chrNW_004955444:19,453,789...19,796,419
Ensembl chrNW_004955444:19,453,783...19,795,167 		JBrowse link
T-helper 1 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4 interleukin 4 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:26410627) MGI PMID:26410627 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694 		JBrowse link
G Spn sialophorin involved_in ISO (PMID:18036228) UniProt PMID:18036228 NCBI chrNW_004955493:7,256,505...7,258,607 JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO (PMID:20706986) MGI PMID:20706986 NCBI chrNW_004955458:4,833,417...4,847,956
Ensembl chrNW_004955458:4,833,515...4,843,273 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:1354779|PMID:10761931) UniProt PMID:10761931 MGI:1354779 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISO (MGI:3851267|PMID:19578362), (MGI:5448096|PMID:22983707) UniProt PMID:19578362 PMID:22983707 MGI:3851267 MGI:5448096 NCBI chrNW_004955523:42,365...66,103
Ensembl chrNW_004955523:42,218...66,103 		JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:6142555|PMID:27893700)
(MGI:3692468|PMID:16990136)		 UniProt PMID:16990136 PMID:27893700 MGI:3692468 MGI:6142555 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (MGI:6142555|PMID:27893700) UniProt PMID:27893700 MGI:6142555 NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (MGI:5448096|PMID:22983707) UniProt PMID:22983707 MGI:5448096 NCBI chrNW_004955465:12,497,534...12,512,529
Ensembl chrNW_004955465:12,497,462...12,513,106 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004955543:452,172...484,564
Ensembl chrNW_004955543:452,121...484,560 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) UniProt PMID:22184727 NCBI chrNW_004955468:12,233,629...12,264,502 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (MGI:5825383|PMID:28065600) UniProt PMID:28065600 MGI:5825383 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    immune system process 1980
      T cell selection 52
        positive T cell selection 37
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 23
          positive extrathymic T cell selection 0
          positive thymic T cell selection + 14
Path 2
Term Annotations click to browse term
  biological_process 12362
    developmental process 5862
      cellular developmental process 3880
        cell differentiation 3879
          cell development 2838
            hemopoiesis 920
              leukocyte differentiation 592
                mononuclear cell differentiation 483
                  lymphocyte differentiation 394
                    T cell differentiation 293
                      T cell selection 52
                        positive T cell selection 37
                          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment + 23
                          positive extrathymic T cell selection 0
                          positive thymic T cell selection + 14
paths to the root