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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 17 cell lineage commitment
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Accession:GO:0072540 term browser browse the term
Definition:The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Synonyms:exact_synonym: T-helper 17 cell fate commitment;   Th17 cell lineage commitment;   Th17 fate commitment

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T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISO (MGI:3851267|PMID:19578362), (MGI:5448096|PMID:22983707) UniProt PMID:19578362 PMID:22983707 MGI:3851267 MGI:5448096 NCBI chrNW_004955523:42,365...66,103
Ensembl chrNW_004955523:42,218...66,103 		JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:6142555|PMID:27893700)
(MGI:3692468|PMID:16990136)		 UniProt PMID:16990136 PMID:27893700 MGI:3692468 MGI:6142555 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Il6r interleukin 6 receptor involved_in ISO (MGI:6142555|PMID:27893700) UniProt PMID:27893700 MGI:6142555 NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762 		JBrowse link
G Irf4 interferon regulatory factor 4 involved_in ISO (MGI:5448096|PMID:22983707) UniProt PMID:22983707 MGI:5448096 NCBI chrNW_004955465:12,497,534...12,512,529
Ensembl chrNW_004955465:12,497,462...12,513,106 		JBrowse link
G Otud5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chrNW_004955543:452,172...484,564
Ensembl chrNW_004955543:452,121...484,560 		JBrowse link
G Slamf6 SLAM family member 6 involved_in ISO (PMID:22184727) UniProt PMID:22184727 NCBI chrNW_004955468:12,233,629...12,264,502 JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (MGI:5825383|PMID:28065600) UniProt PMID:28065600 MGI:5825383 NCBI chrNW_004955451:16,320,326...16,348,505
Ensembl chrNW_004955451:16,319,904...16,357,687 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase like 3 involved_in ISO (MGI:5825383|PMID:28065600)
(PMID:28065600)		 UniProt PMID:28065600 MGI:5825383 NCBI chrNW_004955424:11,236,415...11,255,801
Ensembl chrNW_004955424:11,236,836...11,259,570 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) UniProt PMID:21151104 MGI:4868293 NCBI chrNW_004955451:13,315,237...13,317,888
Ensembl chrNW_004955451:13,315,859...13,325,937 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chrNW_004955406:13,391,162...13,402,479 JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd2 bromodomain containing 2 involved_in ISO (PMID:28262505)
(MGI:6106706|PMID:28262505)		 UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004955437:1,584,890...1,592,486
Ensembl chrNW_004955437:1,584,479...1,592,826 		JBrowse link
G Brd4 bromodomain containing 4 involved_in ISO (MGI:6106706|PMID:28262505) UniProt PMID:28262505 MGI:6106706 NCBI chrNW_004955495:7,959,033...7,989,216
Ensembl chrNW_004955495:7,957,510...7,988,498 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:28262505) UniProt PMID:28262505 NCBI chrNW_004955413:26,647,553...26,727,875
Ensembl chrNW_004955413:26,648,339...26,727,933 		JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (MGI:3851279|PMID:19501566) BHF-UCL PMID:19501566 MGI:3851279 NCBI chrNW_004955458:3,946,964...3,949,180
Ensembl chrNW_004955458:3,947,803...3,949,312 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12321
    immune system process 1969
      T cell selection 52
        positive T cell selection 37
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 23
            CD4-positive, alpha-beta T cell lineage commitment 19
              T-helper cell lineage commitment 18
                T-helper 17 cell lineage commitment 14
                  negative regulation of T-helper 17 cell lineage commitment 3
                  positive regulation of T-helper 17 cell lineage commitment 4
                  regulation of T-helper 17 cell lineage commitment + 7
Path 2
Term Annotations click to browse term
  biological_process 12321
    cellular process 11505
      cellular developmental process 3877
        cell differentiation 3876
          cell development 2836
            hemopoiesis 919
              leukocyte differentiation 591
                mononuclear cell differentiation 482
                  lymphocyte differentiation 394
                    T cell differentiation 293
                      T cell differentiation involved in immune response 80
                        alpha-beta T cell differentiation involved in immune response 73
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 72
                            T-helper cell differentiation 70
                              T-helper cell lineage commitment 18
                                T-helper 17 cell lineage commitment 14
                                  negative regulation of T-helper 17 cell lineage commitment 3
                                  positive regulation of T-helper 17 cell lineage commitment 4
                                  regulation of T-helper 17 cell lineage commitment + 7
paths to the root