Zap70 (zeta-chain (TCR) associated protein kinase 70kDa) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Zap70 (zeta-chain (TCR) associated protein kinase 70kDa) Chinchilla lanigera
Analyze
Symbol: Zap70
Name: zeta-chain (TCR) associated protein kinase 70kDa (Ensembl:zeta chain of T cell receptor associated protein kinase 70)
RGD ID: 8840460
Description: ENCODES a protein that exhibits ATP binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); phosphotyrosine residue binding (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); beta selection (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH combined immunodeficiency (ortholog); genetic disease (ortholog); immunodeficiency 48 (ortholog); FOUND IN cell-cell junction (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein kinase ZAP-70
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554704,386,311 - 4,396,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554704,379,260 - 4,397,851 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Zap70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554704,386,311 - 4,396,419 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554704,379,260 - 4,397,851 (+)NCBIChiLan1.0ChiLan1.0
ZAP70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38297,713,576 - 97,756,364 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl297,713,576 - 97,744,327 (+)EnsemblGRCh38hg38GRCh38
GRCh37298,330,039 - 98,356,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36297,696,463 - 97,722,755 (+)NCBINCBI36Build 36hg18NCBI36
Build 34297,809,386 - 97,814,841NCBI
Celera292,533,995 - 92,560,286 (+)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef292,095,689 - 92,121,947 (+)NCBIHuRef
CHM1_1298,334,370 - 98,360,661 (+)NCBICHM1_1
T2T-CHM13v2.0298,171,200 - 98,202,543 (+)NCBIT2T-CHM13v2.0
Zap70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39136,800,912 - 36,821,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl136,800,879 - 36,821,899 (+)EnsemblGRCm39 Ensembl
GRCm38136,761,798 - 36,782,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl136,761,798 - 36,782,818 (+)EnsemblGRCm38mm10GRCm38
MGSCv37136,818,706 - 36,839,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36136,706,407 - 36,727,362 (+)NCBIMGSCv36mm8
Celera136,542,193 - 36,563,340 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map115.41NCBI
Zap70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8946,485,605 - 46,507,552 (+)NCBIGRCr8
mRatBN7.2938,989,750 - 39,011,701 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl938,989,750 - 39,011,700 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx947,492,671 - 47,514,535 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0952,608,543 - 52,630,495 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0950,890,437 - 50,912,386 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0943,331,149 - 43,353,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl943,331,155 - 43,353,113 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0942,980,050 - 43,002,015 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4935,693,089 - 35,715,071 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera936,755,106 - 36,777,088 (+)NCBICelera
Cytogenetic Map9q21NCBI
LOC100971372
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21230,715,251 - 30,745,868 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A30,718,013 - 30,748,630 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A101,582,567 - 101,613,175 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A98,613,740 - 98,639,742 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A98,613,740 - 98,639,088 (+)Ensemblpanpan1.1panPan2
ZAP70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11044,887,416 - 44,913,845 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1044,887,433 - 44,900,071 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1044,814,558 - 44,845,740 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01045,763,554 - 45,794,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1045,763,556 - 45,786,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11045,475,442 - 45,506,585 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01045,761,536 - 45,792,714 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01045,944,828 - 45,975,965 (-)NCBIUU_Cfam_GSD_1.0
LOC101971458
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,747,123 - 83,759,795 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367441,000,105 - 1,012,433 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367441,000,105 - 1,012,712 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZAP70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl356,515,449 - 56,541,740 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1356,515,446 - 56,541,806 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2359,135,457 - 59,151,701 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103241092
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1141,403,294 - 1,430,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl141,404,325 - 1,431,015 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041168,846,354 - 168,873,240 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101716577
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,893,601 - 2,901,035 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,893,601 - 2,901,256 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000007387   ⟹   ENSCLAP00000007273
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554704,386,311 - 4,396,419 (+)Ensembl
RefSeq Acc Id: XM_013522842   ⟹   XP_013378296
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554704,379,260 - 4,397,851 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013378296 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000007273
  ENSCLAP00000007273.1
RefSeq Acc Id: XP_013378296   ⟸   XM_013522842
- Sequence:
Ensembl Acc Id: ENSCLAP00000007273   ⟸   ENSCLAT00000007387
Protein Domains
Protein kinase   SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000005113 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000007387 ENTREZGENE
  ENSCLAT00000007387.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_SYK/ZAP-70_inter-SH2_sf UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene Zap70 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE ZAP-70 UniProtKB/TrEMBL
Pfam PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2UYJ8_CHILA UniProtKB/TrEMBL