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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of canonical NF-kappaB signal transduction
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Accession:GO:0043124 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of a canonical NF-kappaB signaling cascade.
Synonyms:exact_synonym: negative regulation of I-kappaB kinase/NF-kappaB signaling
 narrow_synonym: inhibition of I-kappaB kinase/NF-kappaB cascade
 related_synonym: down regulation of I-kappaB kinase/NF-kappaB cascade;   downregulation of I-kappaB kinase/NF-kappaB cascade;   negative regulation of I-kappaB kinase/NF-kappaB cascade

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negative regulation of canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624730:69,941,963...69,959,266
Ensembl chrNW_004624730:69,941,001...69,957,012 		JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:26839314) UniProt PMID:26839314 NCBI chrNW_004624786:8,568,102...8,576,445
Ensembl chrNW_004624786:8,568,198...8,577,914 		JBrowse link
G Azi2 5-azacytidine induced 2 involved_in ISO (PMID:10580148) MGI PMID:10580148 NCBI chrNW_004624788:6,183,405...6,209,941 JBrowse link
G Cactin cactin, spliceosome C complex subunit involved_in ISO (PMID:26363554) UniProt PMID:26363554 NCBI chrNW_004624828:6,313,165...6,322,837
Ensembl chrNW_004624828:6,313,867...6,322,764 		JBrowse link
G Casp8 caspase 8 involved_in ISO (PMID:17047155) UniProt PMID:17047155 NCBI chrNW_004624899:427,064...450,931
Ensembl chrNW_004624899:424,363...451,087 		JBrowse link
G Ccdc22 coiled-coil domain containing 22 involved_in ISO (PMID:23563313) UniProt PMID:23563313 NCBI chrNW_004624893:971,688...1,008,460
Ensembl chrNW_004624893:971,645...998,886 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624768:908,907...1,024,953
Ensembl chrNW_004624768:909,099...1,024,902 		JBrowse link
G Coro1a coronin 1A involved_in ISO (PMID:25093672) AgBase PMID:25093672 NCBI chrNW_004624782:13,106,416...13,111,394
Ensembl chrNW_004624782:13,105,153...13,111,357 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO (PMID:27746020) UniProt PMID:27746020 NCBI chrNW_004624757:5,895,912...5,953,485 JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO (PMID:15310755), (PMID:17389591) BHF-UCL PMID:15310755 PMID:17389591 NCBI chrNW_004624760:13,472,500...13,658,070
Ensembl chrNW_004624760:13,472,672...13,657,930 		JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 involved_in ISO (PMID:11927590) UniProt PMID:11927590 NCBI chrNW_004624824:2,215,337...2,259,696
Ensembl chrNW_004624824:2,214,240...2,259,696 		JBrowse link
G Esr1 estrogen receptor 1 involved_in ISO (PMID:16043358), (PMID:7651415) UniProt PMID:7651415 PMID:16043358 NCBI chrNW_004624785:6,164,507...6,601,302
Ensembl chrNW_004624785:6,164,379...6,601,326 		JBrowse link
G Hdac1 histone deacetylase 1 acts_upstream_of_or_within ISO (PMID:19805123) MGI PMID:19805123 NCBI chrNW_004624764:15,510,655...15,552,020
Ensembl chrNW_004624764:15,510,866...15,552,025 		JBrowse link
G Irak1 interleukin 1 receptor associated kinase 1 involved_in ISO (PMID:10383454) BHF-UCL PMID:10383454 NCBI chrNW_004624946:613,392...618,459
Ensembl chrNW_004624946:613,890...618,445 		JBrowse link
G Irak2 interleukin 1 receptor associated kinase 2 involved_in ISO (PMID:10383454) BHF-UCL PMID:10383454 NCBI chrNW_004624731:5,294,464...5,348,426
Ensembl chrNW_004624731:5,294,431...5,348,481 		JBrowse link
G Irak3 interleukin 1 receptor associated kinase 3 involved_in ISO (PMID:10383454) BHF-UCL PMID:10383454 NCBI chrNW_004624802:2,042,486...2,098,921
Ensembl chrNW_004624802:2,047,409...2,098,545 		JBrowse link
G Irgm immunity related GTPase M involved_in ISO (PMID:36221902) UniProt PMID:36221902 NCBI chrNW_004624733:41,241,488...41,248,162 JBrowse link
G Klf4 KLF transcription factor 4 involved_in ISO (PMID:20551324) BHF-UCL PMID:20551324 NCBI chrNW_004624758:4,047,217...4,052,257
Ensembl chrNW_004624758:4,047,219...4,051,983 		JBrowse link
G Map2k5 mitogen-activated protein kinase kinase 5 involved_in ISO PMID:20551324 BHF-UCL PMID:20551324 RGD:8553940 NCBI chrNW_004624781:5,224,722...5,489,517
Ensembl chrNW_004624781:5,224,724...5,489,488 		JBrowse link
G Mapkbp1 mitogen-activated protein kinase binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624804:8,960,218...9,010,672
Ensembl chrNW_004624804:8,960,952...9,008,753 		JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624838:1,384,337...1,387,602
Ensembl chrNW_004624838:1,384,204...1,390,205 		JBrowse link
G Nfkbid NFKB inhibitor delta acts_upstream_of_or_within ISO (PMID:11931770) MGI PMID:11931770 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Nfkbil1 NFKB inhibitor like 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624754:24,639,757...24,652,059
Ensembl chrNW_004624754:24,639,860...24,649,968 		JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras like 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624788:1,590,441...1,639,059
Ensembl chrNW_004624788:1,608,247...1,639,083 		JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras like 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624795:1,828,046...1,830,880
Ensembl chrNW_004624795:1,828,046...1,830,483 		JBrowse link
G Nlrc3 NLR family CARD domain containing 3 acts_upstream_of_or_within
involved_in		 ISO (PMID:22863753) MGI PMID:22863753 NCBI chrNW_004624824:1,356,587...1,375,403
Ensembl chrNW_004624824:1,357,326...1,375,688 		JBrowse link
G Nlrp6 NLR family pyrin domain containing 6 involved_in
acts_upstream_of_or_within		 ISO (PMID:22763455) CACAO
MGI		 PMID:22763455 NCBI chrNW_004624766:22,143,405...22,150,903 JBrowse link
G Nlrx1 NLR family member X1 acts_upstream_of_or_within ISO (PMID:21703540) MGI PMID:21703540 NCBI chrNW_004624784:14,549,926...14,564,028
Ensembl chrNW_004624784:14,549,834...14,563,398 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1 group D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624795:3,102,424...3,109,497
Ensembl chrNW_004624795:3,102,439...3,109,497 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1 group H member 4 involved_in ISO (PMID:21242261)
(PMID:18972444)		 UniProt PMID:18972444 PMID:21242261 NCBI chrNW_004624750:7,222,306...7,303,809
Ensembl chrNW_004624750:7,219,251...7,303,834 		JBrowse link
G Olfm4 olfactomedin 4 acts_upstream_of_or_within ISO (PMID:20534456) MGI PMID:20534456 NCBI chrNW_004624748:14,394,961...14,515,850
Ensembl chrNW_004624748:14,494,619...14,516,015 		JBrowse link
G Optn optineurin acts_upstream_of_or_within ISO (PMID:17702576) MGI PMID:17702576 NCBI chrNW_004624805:5,683,095...5,717,558
Ensembl chrNW_004624805:5,683,021...5,721,336 		JBrowse link
G Otud7b OTU deubiquitinase 7B involved_in ISO (PMID:11463333)
(PMID:23334419)		 HGNC-UCL
UniProt		 PMID:11463333 PMID:23334419 NCBI chrNW_004624772:17,717,178...17,776,940
Ensembl chrNW_004624772:17,721,218...17,787,299 		JBrowse link
G Per1 period circadian regulator 1 involved_in ISO PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chrNW_004624786:10,706,495...10,722,110
Ensembl chrNW_004624786:10,707,075...10,719,859 		JBrowse link
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624738:25,657,084...25,738,913
Ensembl chrNW_004624738:25,656,755...25,723,236 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:12486103) UniProt PMID:12486103 NCBI chrNW_004624782:14,247,333...14,249,861
Ensembl chrNW_004624782:14,247,864...14,249,000 		JBrowse link
G Rhoa ras homolog family member A ISO RGD PMID:17615156 RGD:1642824 NCBI chrNW_004624730:3,316,122...3,361,820 JBrowse link
G Rhoh ras homolog family member H involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624761:26,717,857...26,721,628
Ensembl chrNW_004624761:26,720,478...26,721,053 		JBrowse link
G Riok3 RIO kinase 3 involved_in ISO (PMID:19557502) UniProt PMID:19557502 NCBI chrNW_004624770:8,675,501...8,696,999
Ensembl chrNW_004624770:8,675,294...8,697,620 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624756:21,806,570...21,837,351
Ensembl chrNW_004624756:21,805,599...21,830,699 		JBrowse link
G Rora RAR related orphan receptor A involved_in ISO (PMID:11252722) UniProt PMID:11252722 NCBI chrNW_004624781:11,014,185...11,688,558
Ensembl chrNW_004624781:11,014,286...11,679,678 		JBrowse link
G Sbno1 strawberry notch homolog 1 involved_in ISO (PMID:39343943) UniProt PMID:39343943 NCBI chrNW_004624747:23,214,619...23,275,928 JBrowse link
G Sirpa signal regulatory protein alpha involved_in ISO (PMID:17954568) ARUK-UCL PMID:17954568 NCBI chrNW_004624741:3,157,734...3,202,018 JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:17680780) UniProt PMID:17680780 NCBI chrNW_004624754:2,304,476...2,332,705
Ensembl chrNW_004624754:2,304,634...2,330,946 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 acts_upstream_of_negative_effect ISO (PMID:23403290) UniProt PMID:23403290 NCBI chrNW_004624830:5,514,595...5,573,250
Ensembl chrNW_004624830:5,514,780...5,574,894 		JBrowse link
G Snip1 Smad nuclear interacting protein 1 involved_in ISO (PMID:11567019) MGI PMID:11567019 NCBI chrNW_004624764:20,280,055...20,292,916 JBrowse link
G Stat1 signal transducer and activator of transcription 1 involved_in ISO (PMID:10848577) UniProt PMID:10848577 NCBI chrNW_004624854:5,067,578...5,106,052
Ensembl chrNW_004624854:5,067,535...5,102,106 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISO (PMID:20706987) UniProt PMID:20706987 NCBI chrNW_004624795:1,648,235...1,680,788
Ensembl chrNW_004624795:1,648,080...1,681,200 		JBrowse link
G Tank TRAF family member associated NFKB activator involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624732:4,221,294...4,325,199
Ensembl chrNW_004624732:4,220,963...4,300,861 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 involved_in ISO (PMID:29130787) BHF-UCL PMID:29130787 NCBI chrNW_004624742:5,871,155...6,080,773 JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor involved_in ISO (PMID:17680780) UniProt PMID:17680780 NCBI chrNW_004624811:9,287,088...9,382,522
Ensembl chrNW_004624811:9,287,088...9,381,660 		JBrowse link
G Tmc8 transmembrane channel like 8 involved_in ISO (PMID:23429285) UniProt PMID:23429285 NCBI chrNW_004624801:7,655,989...7,666,329
Ensembl chrNW_004624801:7,658,209...7,664,830 		JBrowse link
G Tmsb4x thymosin beta 4 X-linked acts_upstream_of_or_within_positive_effect ISO (PMID:21343177) CAFA PMID:21343177 NCBI chrNW_004624882:1,198,099...1,200,237
Ensembl chrNW_004624882:1,198,099...1,200,201 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624733:40,964,020...41,006,381 JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 acts_upstream_of_or_within ISO (PMID:11390377) MGI PMID:11390377 NCBI chrNW_004624755:24,976,375...24,995,150
Ensembl chrNW_004624755:24,976,361...25,001,397 		JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 involved_in ISO (PMID:17088249) UniProt PMID:17088249 NCBI chrNW_004624777:1,124,389...1,222,450
Ensembl chrNW_004624777:1,124,204...1,158,324 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:29663649) ARUK-UCL PMID:29663649 NCBI chrNW_004624754:17,643,397...17,649,255
Ensembl chrNW_004624754:17,643,363...17,648,231 		JBrowse link
G Trim59 tripartite motif containing 59 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:22588174) MGI
TreeGrafter		 PMID:22588174 GO_REF:0000118 NCBI chrNW_004624730:38,178,975...38,192,922
Ensembl chrNW_004624730:38,181,060...38,192,885 		JBrowse link
G Tspan6 tetraspanin 6 involved_in ISO (PMID:22908223) UniProt PMID:22908223 NCBI chrNW_004624902:1,977,700...1,985,004
Ensembl chrNW_004624902:1,978,467...1,986,303 		JBrowse link
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats involved_in ISO (PMID:14961764) MGI PMID:14961764 NCBI chrNW_004624781:3,106,658...3,189,325
Ensembl chrNW_004624781:3,106,608...3,191,870 		JBrowse link
G Usp10 ubiquitin specific peptidase 10 involved_in ISO (PMID:25861989) UniProt PMID:25861989 NCBI chrNW_004624746:1,553,891...1,616,711
Ensembl chrNW_004624746:1,554,023...1,617,308 		JBrowse link
G Usp20 ubiquitin specific peptidase 20 involved_in ISO (PMID:26839314) UniProt PMID:26839314 NCBI chrNW_004624760:5,568,763...5,594,519
Ensembl chrNW_004624760:5,568,761...5,594,510 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
G Zmynd11 zinc finger MYND-type containing 11 involved_in ISO (PMID:20732415) UniProt PMID:20732415 NCBI chrNW_004624775:10,723,145...10,830,856
Ensembl chrNW_004624775:10,723,145...10,830,841 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17660
    negative regulation of biological process 5232
      negative regulation of signaling 1467
        negative regulation of signal transduction 1325
          negative regulation of intracellular signal transduction 686
            negative regulation of canonical NF-kappaB signal transduction 64
Path 2
Term Annotations click to browse term
  biological_process 17660
    biological regulation 11854
      regulation of biological process 11493
        signaling 6597
          signal transduction 6101
            intracellular signal transduction 2840
              intracellular signaling cassette 1828
                canonical NF-kappaB signal transduction 288
                  regulation of canonical NF-kappaB signal transduction 268
                    negative regulation of canonical NF-kappaB signal transduction 64
paths to the root