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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-delta T cell differentiation
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Accession:GO:0042492 term browser browse the term
Definition:The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: gamma-delta T lymphocyte differentiation
 related_synonym: gamma-delta T cell development

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gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jag2 jagged canonical Notch ligand 2 involved_in ISO (MGI:1342169|PMID:10383933) UniProt PMID:10383933 MGI:1342169 NCBI chrNW_004955538:3,421,685...3,433,829
Ensembl chrNW_004955538:3,421,685...3,433,842 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of ISO (PMID:7807014) MGI PMID:7807014 NCBI chrNW_004955452:10,608,317...10,632,310
Ensembl chrNW_004955452:10,608,318...10,632,310 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of ISO (PMID:7807014) MGI PMID:7807014 NCBI chrNW_004955406:35,005,577...35,127,395
Ensembl chrNW_004955406:35,005,214...35,129,552 		JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO (MGI:3695974|PMID:17218525), (MGI:6276541|PMID:30413363) UniProt PMID:17218525 PMID:30413363 MGI:3695974 MGI:6276541 NCBI chrNW_004955406:39,959,458...39,994,214
Ensembl chrNW_004955406:39,966,055...39,994,214 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of ISO (PMID:15294943) MGI PMID:15294943 NCBI chrNW_004955451:16,305,363...16,319,219
Ensembl chrNW_004955451:16,305,363...16,318,534 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of ISO (PMID:15294943) MGI PMID:15294943 NCBI chrNW_004955451:16,253,645...16,295,337
Ensembl chrNW_004955451:16,255,398...16,272,214 		JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of ISO (PMID:7477352)
(PMID:8790395)		 MGI PMID:7477352 PMID:8790395 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581 		JBrowse link
G Tcf7 transcription factor 7 involved_in ISO (MGI:6276541|PMID:30413363) UniProt PMID:30413363 MGI:6276541 NCBI chrNW_004955408:5,362,423...5,388,684
Ensembl chrNW_004955408:5,362,084...5,388,527 		JBrowse link
CD8-positive, gamma-delta intraepithelial T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr9 C-C motif chemokine receptor 9 acts_upstream_of_or_within ISO (PMID:25348153) MGI PMID:25348153 NCBI chrNW_004955420:26,083,445...26,093,740
Ensembl chrNW_004955420:26,083,040...26,093,775 		JBrowse link
G Gpr18 G protein-coupled receptor 18 acts_upstream_of_or_within ISO (PMID:25348153) MGI PMID:25348153 NCBI chrNW_004955404:11,293,897...11,321,072
Ensembl chrNW_004955404:11,293,897...11,321,072 		JBrowse link
positive regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (PMID:7807014) MGI PMID:7807014 NCBI chrNW_004955452:10,608,317...10,632,310
Ensembl chrNW_004955452:10,608,318...10,632,310 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO (MGI:5486619|PMID:23562159) UniProt PMID:23562159 MGI:5486619 NCBI chrNW_004955496:1,728,840...1,827,749
Ensembl chrNW_004955496:1,728,840...1,828,698 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (MGI:3818191|PMID:19015308) UniProt PMID:19015308 MGI:3818191 NCBI chrNW_004955458:1,733,799...1,785,591
Ensembl chrNW_004955458:1,733,883...1,784,182 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:7807014) MGI PMID:7807014 NCBI chrNW_004955406:35,005,577...35,127,395
Ensembl chrNW_004955406:35,005,214...35,129,552 		JBrowse link
G Sox13 SRY-box transcription factor 13 involved_in ISO (MGI:5486619|PMID:23562159) UniProt PMID:23562159 MGI:5486619 NCBI chrNW_004955406:39,959,458...39,994,214
Ensembl chrNW_004955406:39,966,055...39,994,214 		JBrowse link
G Sox4 SRY-box transcription factor 4 involved_in ISO (MGI:5486619|PMID:23562159) UniProt PMID:23562159 MGI:5486619 NCBI chrNW_004955483:5,076,664...5,077,059 JBrowse link
G Stat5a signal transducer and activator of transcription 5A acts_upstream_of_or_within ISO (PMID:15294943) MGI PMID:15294943 NCBI chrNW_004955451:16,305,363...16,319,219
Ensembl chrNW_004955451:16,305,363...16,318,534 		JBrowse link
G Stat5b signal transducer and activator of transcription 5B acts_upstream_of_or_within ISO (PMID:15294943) MGI PMID:15294943 NCBI chrNW_004955451:16,253,645...16,295,337
Ensembl chrNW_004955451:16,255,398...16,272,214 		JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within ISO (PMID:8790395)
(PMID:7477352)		 MGI PMID:7477352 PMID:8790395 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581 		JBrowse link
regulation of gamma-delta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egr3 early growth response 3 acts_upstream_of_or_within ISO (PMID:21737317) MGI PMID:21737317 NCBI chrNW_004955403:46,105,447...46,108,149
Ensembl chrNW_004955403:46,105,447...46,108,149 		JBrowse link
G Rorc RAR related orphan receptor C acts_upstream_of_or_within ISO (PMID:21737317) MGI PMID:21737317 NCBI chrNW_004955589:590,653...616,784
Ensembl chrNW_004955589:590,743...616,694 		JBrowse link
G Sox13 SRY-box transcription factor 13 acts_upstream_of_or_within ISO (PMID:21737317) MGI PMID:21737317 NCBI chrNW_004955406:39,959,458...39,994,214
Ensembl chrNW_004955406:39,966,055...39,994,214 		JBrowse link
G Tcf7 transcription factor 7 involved_in ISO (MGI:5486619|PMID:23562159) UniProt PMID:23562159 MGI:5486619 NCBI chrNW_004955408:5,362,423...5,388,684
Ensembl chrNW_004955408:5,362,084...5,388,527 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12362
    immune system process 1980
      leukocyte activation 888
        lymphocyte activation 720
          T cell activation 507
            T cell differentiation 293
              gamma-delta T cell differentiation 15
                gamma-delta T cell differentiation involved in immune response 0
                gamma-delta T cell lineage commitment 0
                gamma-delta intraepithelial T cell differentiation + 2
                negative regulation of gamma-delta T cell differentiation 0
                positive regulation of gamma-delta T cell differentiation 9
                regulation of gamma-delta T cell differentiation + 12
Path 2
Term Annotations click to browse term
  biological_process 12362
    cellular process 11484
      cellular developmental process 3880
        cell differentiation 3879
          cell development 2838
            hemopoiesis 920
              leukocyte differentiation 592
                mononuclear cell differentiation 483
                  lymphocyte differentiation 394
                    T cell differentiation 293
                      gamma-delta T cell differentiation 15
                        gamma-delta T cell differentiation involved in immune response 0
                        gamma-delta T cell lineage commitment 0
                        gamma-delta intraepithelial T cell differentiation + 2
                        negative regulation of gamma-delta T cell differentiation 0
                        positive regulation of gamma-delta T cell differentiation 9
                        regulation of gamma-delta T cell differentiation + 12
paths to the root