gamma-delta intraepithelial T cell differentiation - Ontology Report

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Term:	gamma-delta intraepithelial T cell differentiation	go back to main search page
Accession:	GO:0002304	browse the term
Definition:	The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.
Comment:	Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:	exact_synonym:	gamma-delta intraepithelial T lymphocyte differentiation
	related_synonym:	gamma-delta intraepithelial T cell development

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Genes (3)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ccr9

C-C motif chemokine receptor 9

acts_upstream_of_or_within

ISO
IEA

MGI:3654108 (PMID:25348153)
GO_REF:0000107

GO_REF:0000107

NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969

G protein-coupled receptor 18

acts_upstream_of_or_within

ISO

MGI:5708707 (PMID:25348153)

NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470

killer cell lectin like receptor C1

involved_in

ISO

(PMID:18064301)

NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425

Term paths to the root

Path 1
Term	Annotations
biological_process	20543
immune system process	3133
leukocyte activation	1084
lymphocyte activation	878
T cell activation	623
T cell differentiation	337
gamma-delta T cell differentiation	17
gamma-delta intraepithelial T cell differentiation	3
CD4-positive gamma-delta intraepithelial T cell differentiation	0
CD8-positive, gamma-delta intraepithelial T cell differentiation	3
Path 2
Term	Annotations
biological_process	20543
cellular process	19534
cellular developmental process	4838
cell differentiation	4837
cell development	3352
hemopoiesis	1084
leukocyte differentiation	690
mononuclear cell differentiation	556
lymphocyte differentiation	455
T cell differentiation	337
gamma-delta T cell differentiation	17
gamma-delta intraepithelial T cell differentiation	3
CD4-positive gamma-delta intraepithelial T cell differentiation	0
CD8-positive, gamma-delta intraepithelial T cell differentiation	3

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