Syk (spleen associated tyrosine kinase) - Rat Genome Database

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Gene: Syk (spleen associated tyrosine kinase) Chinchilla lanigera
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Symbol: Syk
Name: spleen associated tyrosine kinase
RGD ID: 8878794
Description: ENCODES a protein that exhibits ATP binding (ortholog); integrin binding (ortholog); interleukin-15 receptor binding (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); beta selection (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN eicosanoid signaling pathway; FasL mediated signaling pathway; Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH anti-basement membrane glomerulonephritis (ortholog); arthritis (ortholog); colitis (ortholog); FOUND IN B cell receptor complex (ortholog); cytoplasm (ortholog); early phagosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: spleen tyrosine kinase; tyrosine-protein kinase SYK
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555151,328,793 - 1,400,206 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (ISO)
beta selection  (ISO)
blood vessel morphogenesis  (ISO)
cell activation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to lectin  (ISO)
cellular response to lipid  (ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to molecule of fungal origin  (ISO)
collagen-activated tyrosine kinase receptor signaling pathway  (ISO)
defense response to bacterium  (ISO)
enzyme linked receptor protein signaling pathway  (ISO)
innate immune response  (ISO)
integrin-mediated signaling pathway  (ISO)
interleukin-3-mediated signaling pathway  (ISO)
intracellular signal transduction  (ISO)
leukocyte activation involved in immune response  (ISO)
leukocyte cell-cell adhesion  (ISO)
leukotriene biosynthetic process  (ISO)
lymph vessel development  (ISO)
macrophage activation involved in immune response  (ISO)
neutrophil activation involved in immune response  (ISO)
neutrophil chemotaxis  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of alpha-beta T cell differentiation  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-3 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of killing of cells of other organism  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of mast cell degranulation  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (ISO)
protein autophosphorylation  (ISO)
protein import into nucleus  (ISO)
protein phosphorylation  (ISO)
receptor internalization  (ISO)
regulation of arachidonic acid secretion  (ISO)
regulation of DNA-binding transcription factor activity  (ISO)
regulation of ERK1 and ERK2 cascade  (ISO)
regulation of immune response  (ISO)
regulation of neutrophil degranulation  (ISO)
regulation of phagocytosis  (ISO)
regulation of platelet activation  (ISO)
regulation of platelet aggregation  (ISO)
regulation of superoxide anion generation  (ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
serotonin secretion  (ISO)
serotonin secretion by platelet  (ISO)
stimulatory C-type lectin receptor signaling pathway  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Syk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555151,328,793 - 1,400,206 (-)NCBIChiLan1.0ChiLan1.0
SYK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl990,801,787 - 90,898,549 (+)EnsemblGRCh38hg38GRCh38
GRCh38990,801,600 - 90,898,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37993,563,882 - 93,660,831 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36992,603,891 - 92,698,305 (+)NCBINCBI36hg18NCBI36
Build 34990,643,624 - 90,738,036NCBI
Celera963,998,674 - 64,095,487 (+)NCBI
Cytogenetic Map9q22.2NCBI
HuRef963,244,666 - 63,341,118 (+)NCBIHuRef
CHM1_1993,710,484 - 93,807,287 (+)NCBICHM1_1
Syk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391352,736,670 - 52,802,828 (+)NCBIGRCm39mm39
GRCm39 Ensembl1352,737,209 - 52,802,828 (+)Ensembl
GRCm381352,582,610 - 52,648,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1352,583,173 - 52,648,792 (+)EnsemblGRCm38mm10GRCm38
MGSCv371352,692,251 - 52,744,161 (+)NCBIGRCm37mm9NCBIm37
MGSCv361352,609,314 - 52,661,224 (+)NCBImm8
Celera1353,673,505 - 53,725,528 (+)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1327.41NCBI
Syk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21712,604,615 - 12,678,437 (-)NCBI
Rnor_6.0 Ensembl1712,614,311 - 12,669,573 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01712,614,311 - 12,669,568 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01714,703,903 - 14,759,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41718,440,672 - 18,498,001 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11718,440,671 - 18,498,006 (-)NCBI
Celera1712,367,624 - 12,424,213 (-)NCBICelera
RH 3.4 Map17126.2RGD
Cytogenetic Map17p14NCBI
SYK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1989,959,599 - 90,056,101 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl989,959,599 - 90,056,101 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0961,859,767 - 61,956,619 (+)NCBIMhudiblu_PPA_v0panPan3
SYK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1195,903,501 - 95,955,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl195,903,566 - 95,955,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha196,356,719 - 96,440,184 (-)NCBI
ROS_Cfam_1.0196,507,029 - 96,590,534 (-)NCBI
UMICH_Zoey_3.1196,134,620 - 96,217,990 (-)NCBI
UNSW_CanFamBas_1.0195,855,025 - 95,938,496 (-)NCBI
UU_Cfam_GSD_1.0196,615,264 - 96,698,710 (-)NCBI
Syk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494412,408,886 - 12,455,229 (+)NCBI
SpeTri2.0NW_0049367801,553,605 - 1,601,036 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,056,712 - 2,161,172 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,103,706 - 2,160,886 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2142,866,432 - 2,869,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SYK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112101,254,085 - 101,374,724 (+)NCBI
ChlSab1.1 Ensembl12101,260,061 - 101,349,856 (+)Ensembl
Vero_WHO_p1.0NW_02366603889,575,971 - 89,671,205 (+)NCBI
Syk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248681,654,079 - 1,738,648 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000001505   ⟹   ENSCLAP00000001462
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001506   ⟹   ENSCLAP00000001463
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555151,328,630 - 1,380,581 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001507   ⟹   ENSCLAP00000001464
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555151,331,189 - 1,370,431 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000001508   ⟹   ENSCLAP00000001465
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555151,332,658 - 1,370,431 (-)Ensembl
RefSeq Acc Id: XM_005408868   ⟹   XP_005408925
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555151,328,793 - 1,380,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005408869   ⟹   XP_005408926
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555151,331,171 - 1,400,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005408871   ⟹   XP_005408928
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555151,331,171 - 1,380,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506884   ⟹   XP_013362338
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555151,331,171 - 1,376,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013506885   ⟹   XP_013362339
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555151,331,171 - 1,369,718 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005408926   ⟸   XM_005408869
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005408925   ⟸   XM_005408868
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005408928   ⟸   XM_005408871
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013362338   ⟸   XM_013506884
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013362339   ⟸   XM_013506885
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000001464   ⟸   ENSCLAT00000001507
RefSeq Acc Id: ENSCLAP00000001463   ⟸   ENSCLAT00000001506
RefSeq Acc Id: ENSCLAP00000001465   ⟸   ENSCLAT00000001508
RefSeq Acc Id: ENSCLAP00000001462   ⟸   ENSCLAT00000001505


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001101 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000001462 ENTREZGENE
  ENSCLAP00000001463 ENTREZGENE
  ENSCLAP00000001464 ENTREZGENE
Ensembl Transcript ENSCLAT00000001505 ENTREZGENE
  ENSCLAT00000001506 ENTREZGENE
  ENSCLAT00000001507 ENTREZGENE
NCBI Gene Syk ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Syk  spleen associated tyrosine kinase    spleen tyrosine kinase  Symbol and/or name change 5135510 APPROVED