Lef1 (lymphoid enhancer binding factor 1) - Rat Genome Database

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Gene: Lef1 (lymphoid enhancer binding factor 1) Chinchilla lanigera
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Symbol: Lef1
Name: lymphoid enhancer binding factor 1
RGD ID: 9045627
Description: ENCODES a protein that exhibits armadillo repeat domain binding (ortholog); beta-catenin binding (ortholog); C2H2 zinc finger domain binding (ortholog); INVOLVED IN alpha-beta T cell differentiation (ortholog); anatomical structure regression (ortholog); animal organ regeneration (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Animal Disease Models (ortholog); B-Cell Chronic Lymphocytic Leukemia (ortholog); Breast Neoplasms (ortholog); FOUND IN beta-catenin-TCF complex (ortholog); cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: lymphoid enhancer-binding factor 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (ISO)
anatomical structure regression  (ISO)
animal organ regeneration  (ISO)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic process involved in morphogenesis  (ISO)
B cell proliferation  (ISO)
BMP signaling pathway  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
canonical Wnt signaling pathway  (ISO)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell development  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to interleukin-4  (ISO)
chorio-allantoic fusion  (ISO)
dentate gyrus development  (ISO)
embryonic limb morphogenesis  (ISO)
epithelial to mesenchymal transition  (ISO)
face morphogenesis  (ISO)
forebrain neuroblast division  (ISO)
forebrain radial glial cell differentiation  (ISO)
formation of radial glial scaffolds  (ISO)
hippocampus development  (ISO)
histone H3 acetylation  (ISO)
histone H3-K56 acetylation  (ISO)
histone H4 acetylation  (ISO)
kidney development  (ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic process in bone marrow cell  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of interleukin-13 production  (ISO)
negative regulation of interleukin-4 production  (ISO)
negative regulation of interleukin-5 production  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neutrophil differentiation  (ISO)
odontoblast differentiation  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
paraxial mesoderm formation  (ISO)
positive regulation by host of viral transcription  (ISO)
positive regulation of cell cycle process  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell proliferation in bone marrow  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of chondrocyte proliferation  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of granulocyte differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
regulation of cell-cell adhesion  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to lithium ion  (ISO)
response to organic cyclic compound  (ISO)
secondary palate development  (ISO)
sensory perception of taste  (ISO)
skin development  (ISO)
somitogenesis  (ISO)
sprouting angiogenesis  (ISO)
T cell receptor V(D)J recombination  (ISO)
T-helper 1 cell differentiation  (ISO)
tongue development  (ISO)
trachea gland development  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Lef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,828,698 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBIChiLan1.0ChiLan1.0
LEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4108,047,545 - 108,168,956 (-)EnsemblGRCh38hg38GRCh38
GRCh384108,047,548 - 108,168,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374108,968,704 - 109,090,088 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,188,150 - 109,309,027 (-)NCBINCBI36hg18NCBI36
Build 344109,326,304 - 109,447,182NCBI
Celera4106,263,513 - 106,384,975 (-)NCBI
Cytogenetic Map4q25NCBI
HuRef4104,700,344 - 104,821,596 (-)NCBIHuRef
CHM1_14108,945,152 - 109,066,566 (-)NCBICHM1_1
Lef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393130,903,946 - 131,018,006 (+)NCBIGRCm39mm39
GRCm39 Ensembl3130,904,120 - 131,018,005 (+)Ensembl
GRCm383131,110,297 - 131,224,357 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,110,471 - 131,224,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv373130,813,389 - 130,926,252 (+)NCBIGRCm37mm9NCBIm37
MGSCv363131,099,626 - 131,212,489 (+)NCBImm8
Celera3137,630,007 - 137,744,454 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.78NCBI
Lef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22219,666,549 - 219,779,815 (+)NCBI
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
LEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14111,125,312 - 111,245,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,125,312 - 111,245,980 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04100,552,959 - 100,674,156 (-)NCBIMhudiblu_PPA_v0panPan3
LEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,516,002 - 28,633,759 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,517,108 - 28,634,019 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,389,033 - 13,506,807 (+)NCBI
ROS_Cfam_1.03228,744,891 - 28,862,596 (-)NCBI
UMICH_Zoey_3.13228,737,873 - 28,855,560 (-)NCBI
UNSW_CanFamBas_1.03228,482,671 - 28,600,623 (-)NCBI
UU_Cfam_GSD_1.03211,256,345 - 11,374,064 (+)NCBI
Lef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,484,346 - 12,597,999 (+)NCBI
SpeTri2.0NW_004936818453,635 - 569,194 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,824,547 - 113,944,078 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,824,511 - 113,944,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,085,854 - 122,204,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,974,770 - 56,096,214 (-)NCBI
ChlSab1.1 Ensembl755,990,621 - 56,094,110 (-)Ensembl
Vero_WHO_p1.0NW_02366603734,601,310 - 34,723,183 (-)NCBI
Lef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248301,320,034 - 1,422,774 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000004357   ⟹   ENSCLAP00000004275
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554961,728,840 - 1,827,749 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004358   ⟹   ENSCLAP00000004276
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554961,728,848 - 1,828,698 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004359   ⟹   ENSCLAP00000004277
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554961,728,848 - 1,828,698 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004360   ⟹   ENSCLAP00000004278
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554961,729,254 - 1,814,624 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000004361   ⟹   ENSCLAP00000004279
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554961,730,330 - 1,826,635 (+)Ensembl
RefSeq Acc Id: XM_005406198   ⟹   XP_005406255
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005406199   ⟹   XP_005406256
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554961,728,840 - 1,826,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005406200   ⟹   XP_005406257
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554961,728,840 - 1,827,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005406201   ⟹   XP_005406258
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554961,728,840 - 1,826,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005406202   ⟹   XP_005406259
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554961,730,330 - 1,827,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005406203   ⟹   XP_005406260
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554961,730,330 - 1,826,635 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005406256   ⟸   XM_005406199
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005406255   ⟸   XM_005406198
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005406258   ⟸   XM_005406201
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005406257   ⟸   XM_005406200
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005406259   ⟸   XM_005406202
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005406260   ⟸   XM_005406203
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: ENSCLAP00000004276   ⟸   ENSCLAT00000004358
RefSeq Acc Id: ENSCLAP00000004277   ⟸   ENSCLAT00000004359
RefSeq Acc Id: ENSCLAP00000004275   ⟸   ENSCLAT00000004357
RefSeq Acc Id: ENSCLAP00000004279   ⟸   ENSCLAT00000004361
RefSeq Acc Id: ENSCLAP00000004278   ⟸   ENSCLAT00000004360


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003044 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000004275 ENTREZGENE
  ENSCLAP00000004276 ENTREZGENE
  ENSCLAP00000004277 ENTREZGENE
  ENSCLAP00000004279 ENTREZGENE
Ensembl Transcript ENSCLAT00000004357 ENTREZGENE
  ENSCLAT00000004358 ENTREZGENE
  ENSCLAT00000004359 ENTREZGENE
  ENSCLAT00000004361 ENTREZGENE
NCBI Gene Lef1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Lef1  lymphoid enhancer binding factor 1    lymphoid enhancer-binding factor 1  Symbol and/or name change 5135510 APPROVED