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ONTOLOGY REPORT - ANNOTATIONS

Term:neurotrophin signaling pathway
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Accession:GO:0038179 term browser browse the term
Definition:The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.
Comment:There are two classes of receptors for neurotrophins: p75 and the Trk family of tyrosine kinase receptors.
Synonyms:exact_synonym: neurotrophin receptor signaling pathway


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neurotrophin signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032 		JBrowse link
G NTRK3 neurotrophic receptor tyrosine kinase 3 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:51,131,470...51,491,112
Ensembl chr 3:51,138,751...51,513,024 		JBrowse link
negative regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G AGTR2 angiotensin II receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:88,703,551...88,708,451
Ensembl chr  X:88,705,765...88,706,853 		JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F ISO NGF stimulated neurite outgrowth in PC12 cells RGD PMID:10699984 RGD:1642748 NCBI chr15:16,590,908...16,666,673
Ensembl chr15:16,591,308...16,666,673 		JBrowse link
G SPRY1 sprouty RTK signaling antagonist 1 acts_upstream_of_or_within ISO (PMID:11585837) MGI PMID:11585837 NCBI chr19:16,969,869...16,976,573
Ensembl chr19:16,970,904...16,972,089 		JBrowse link
G SPRY2 sprouty RTK signaling antagonist 2 acts_upstream_of_or_within ISO (PMID:11585837) MGI PMID:11585837 NCBI chr22:33,366,139...33,371,102
Ensembl chr22:33,366,931...33,367,878 		JBrowse link
nerve growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BDNF brain derived neurotrophic factor involved_in IBA GO_Central GO_REF:0000033 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480 		JBrowse link
G BDNF brain derived neurotrophic factor involved_in IBA GO_Central GO_REF:0000033
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011 		JBrowse link
G CORO1A coronin 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24270184) Ensembl
MGI		 PMID:24270184 GO_REF:0000107 NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818 		JBrowse link
G KIDINS220 kinase D interacting substrate 220 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:5,983,208...6,077,609
Ensembl chr17:5,982,938...6,071,165 		JBrowse link
G MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr18:17,973,058...19,098,785
Ensembl chr18:17,918,928...18,930,059 		JBrowse link
G NGF nerve growth factor acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:24270184)
(PMID:7854358)		 MGI
GO_Central		 PMID:7854358 PMID:24270184 GO_REF:0000033 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607 		JBrowse link
G NTF3 neurotrophin 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr27:39,383,017...39,454,613
Ensembl chr27:39,383,152...39,454,601 		JBrowse link
G NTF4 neurotrophin 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:107,371,335...107,377,238
Ensembl chr 1:107,371,335...107,376,987 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:7854358)
(PMID:24270184)		 Ensembl
GO_Central
MGI		 PMID:7854358 PMID:24270184 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288 		JBrowse link
G RAP1A RAP1A, member of RAS oncogene family involved_in ISO PMID:17724123 UniProt PMID:17724123 RGD:8554481 NCBI chr17:63,725,812...63,795,359
Ensembl chr17:63,726,248...63,746,881 		JBrowse link
G RAPGEF1 Rap guanine nucleotide exchange factor 1 involved_in ISO (PMID:17724123) UniProt PMID:17724123 NCBI chr 9:52,429,204...52,566,775
Ensembl chr 9:52,450,597...52,563,778 		JBrowse link
G RAPGEF2 Rap guanine nucleotide exchange factor 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr15:56,133,094...56,353,609
Ensembl chr15:56,174,578...56,352,569 		JBrowse link
G SHOC2 SHOC2 leucine rich repeat scaffold protein ISO RGD PMID:25514808 RGD:155804270 NCBI chr28:22,241,886...22,338,418
Ensembl chr28:22,285,125...22,336,545 		JBrowse link
G SORT1 sortilin 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 6:42,454,091...42,521,251
Ensembl chr 6:42,453,942...42,516,740 		JBrowse link
neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1S1 AKT1 substrate 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:106,686,349...106,694,854
Ensembl chr 1:106,687,024...106,693,928 		JBrowse link
G BCAR1 BCAR1 scaffold protein, Cas family member involved_in ISO PMID:8631760 UniProt PMID:8631760 RGD:8553306 NCBI chr 5:75,463,906...75,499,557
Ensembl chr 5:75,463,926...75,512,476 		JBrowse link
G CASP3 caspase 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23954828) MGI
Ensembl		 PMID:23954828 GO_REF:0000107 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CD2AP CD2 associated protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27076424) Ensembl
MGI		 PMID:27076424 GO_REF:0000107 NCBI chr12:15,538,215...15,683,619
Ensembl chr12:15,538,356...15,681,011 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 involved_in ISO PMID:21368030 UniProt PMID:21368030 RGD:8554300 NCBI chr 4:22,916,718...22,918,893
Ensembl chr 4:22,916,096...22,964,035 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:21,065,770...21,074,462
Ensembl chr 9:21,065,846...21,072,991 		JBrowse link
G NDN necdin, MAGE family member involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16049186) Ensembl
MGI		 PMID:16049186 GO_REF:0000107 NCBI chr 3:36,313,977...36,315,661
Ensembl chr 3:36,314,104...36,315,081 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12482708) Ensembl
MGI		 PMID:12482708 GO_REF:0000107 NCBI chr26:9,989,218...10,072,245
Ensembl chr26:9,989,425...10,067,481 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9852579) Ensembl
MGI		 PMID:9852579 GO_REF:0000107 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090 		JBrowse link
G SORT1 sortilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,454,091...42,521,251
Ensembl chr 6:42,453,942...42,516,740 		JBrowse link
G SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO RGD PMID:15728722 RGD:1581104 NCBI chr17:31,007,940...31,181,569
Ensembl chr17:31,009,257...31,142,063 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:15546918 RGD:1580675 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
G ZFYVE27 zinc finger FYVE-type containing 27 involved_in IBA GO_Central GO_REF:0000033 NCBI chr28:10,966,158...10,987,822
Ensembl chr28:10,966,142...11,036,946 		JBrowse link
positive regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYFIP1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:27605705) UniProt PMID:27605705 NCBI chr 3:32,096,471...32,170,107
Ensembl chr 3:32,097,037...32,187,781 		JBrowse link
G CYFIP2 cytoplasmic FMR1 interacting protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:52,769,638...52,875,080
Ensembl chr 4:52,743,048...52,880,589 		JBrowse link
G NGF nerve growth factor acts_upstream_of_or_within ISO PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr17:52,900,647...52,901,607
Ensembl chr17:52,900,647...52,901,607 		JBrowse link
G PPP2R5B protein phosphatase 2 regulatory subunit B'beta acts_upstream_of_or_within ISO PMID:19029245 MGI PMID:19029245 RGD:8553977 NCBI chr18:52,244,588...52,253,055
Ensembl chr18:52,244,736...52,252,237 		JBrowse link
G SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 ISO RGD PMID:18768694 RGD:13504749 NCBI chr 6:61,439,414...61,471,414
Ensembl chr 6:61,439,415...61,462,087 		JBrowse link
G TMEM108 transmembrane protein 108 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:29,992,038...30,331,791
Ensembl chr23:29,992,021...30,396,840 		JBrowse link
G WASF1 WASP family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:66,833,776...66,897,500
Ensembl chr12:66,833,995...66,897,483 		JBrowse link
regulation of neurotrophin TRK receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DOK5 docking protein 5 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23954828) MGI
Ensembl		 PMID:23954828 GO_REF:0000107 NCBI chr24:40,156,235...40,282,059
Ensembl chr24:40,130,265...40,282,249 		JBrowse link
G SLC9A6 solute carrier family 9 member A6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24035762) Ensembl
MGI		 PMID:24035762 GO_REF:0000107 NCBI chr  X:106,408,789...106,465,504
Ensembl chr  X:106,398,850...106,463,252 		JBrowse link
G ULK1 unc-51 like autophagy activating kinase 1 acts_upstream_of_or_within ISO (PMID:17389358) MGI PMID:17389358 NCBI chr26:968,714...982,244
Ensembl chr26:970,138...982,229 		JBrowse link
G ZDHHC17 zinc finger DHHC-type palmitoyltransferase 17 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:19,631,719...19,727,089
Ensembl chr15:19,499,445...19,724,341 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22103
    cellular process 21633
      signal transduction 6370
        cell surface receptor signaling pathway 2800
          neurotrophin signaling pathway 43
            nerve growth factor signaling pathway 15
            neurotrophin TRK receptor signaling pathway + 30
Path 2
Term Annotations click to browse term
  biological_process 22103
    biological regulation 12539
      regulation of biological process 12154
        signaling 6918
          signal transduction 6370
            cell surface receptor signaling pathway 2800
              neurotrophin signaling pathway 43
                nerve growth factor signaling pathway 15
                neurotrophin TRK receptor signaling pathway + 30
paths to the root