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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-12-mediated signaling pathway
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Accession:GO:0035722 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-12-mediated signaling pathway;   interleukin-12-mediated signalling pathway


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interleukin-12-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12a interleukin 12A involved_in ISO
IEA		 (PMID:10899108), (PMID:7584494)
GO_REF:0000107		 RGD
Ensembl		 PMID:7584494 PMID:10899108 GO_REF:0000107 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:7584494) RGD PMID:7584494 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 involved_in ISO (PMID:8943050) RGD PMID:8943050 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 involved_in ISO (PMID:8943050) RGD PMID:8943050 NCBI chr 4:96,426,396...96,515,251
Ensembl chr 4:96,426,842...96,515,289 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO (PMID:7528775) RGD PMID:7528775 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11743656)		 Ensembl
RGD		 PMID:11743656 GO_REF:0000107 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Stat4 signal transducer and activator of transcription 4 involved_in ISO (PMID:7638186) RGD PMID:7638186 NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tyk2 tyrosine kinase 2 involved_in ISO (PMID:7528775) RGD PMID:7528775 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18168
      signal transduction 7006
        cell surface receptor signaling pathway 2815
          cytokine-mediated signaling pathway 484
            interleukin-12-mediated signaling pathway 8
Path 2
Term Annotations click to browse term
  biological_process 19692
    response to stimulus 10511
      response to chemical 5851
        response to peptide 1236
          response to cytokine 1212
            cellular response to cytokine stimulus 1076
              cytokine-mediated signaling pathway 484
                interleukin-12-mediated signaling pathway 8
paths to the root