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ONTOLOGY REPORT - ANNOTATIONS

Term:sequestering of BMP in extracellular matrix
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Accession:GO:0035582 term browser browse the term
Definition:Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
Comment:Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
Synonyms:exact_synonym: BMP sequestration in the ECM;   negative regulation of BMP signaling pathway by extracellular sequestering of BMP;   negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP;   negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein


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sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in IDA
ISO
IBA		 (PMID:10748465) BHF-UCL
GO_Central		 PMID:10748465 GO_REF:0000033 GO_REF:0000119 NCBI chr 4:82,799,988...82,803,388
Ensembl chr 4:82,799,988...82,803,385 		JBrowse link
G Dand5 DAN domain family member 5, BMP antagonist involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:85,542,034...85,558,894
Ensembl chr 8:85,542,033...85,559,038 		JBrowse link
G Fbn1 fibrillin 1 involved_in IMP (PMID:20855508) BHF-UCL PMID:20855508 NCBI chr 2:125,142,514...125,348,417
Ensembl chr 2:125,142,514...125,349,913 		JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in IDA (PMID:9660951) BHF-UCL PMID:9660951 NCBI chr 4:138,809,602...138,820,437
Ensembl chr 4:138,809,595...138,820,304 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28635
    negative regulation of biological process 6093
      negative regulation of response to stimulus 2022
        negative regulation of cellular response to growth factor stimulus 151
          negative regulation of BMP signaling pathway 78
            sequestering of BMP in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 28635
    biological regulation 13450
      regulation of biological process 13009
        regulation of cellular process 12632
          signal transduction 6924
            cell surface receptor signaling pathway 3020
              enzyme-linked receptor protein signaling pathway 1118
                cell surface receptor protein serine/threonine kinase signaling pathway 472
                  transforming growth factor beta receptor superfamily signaling pathway 432
                    BMP signaling pathway 195
                      regulation of BMP signaling pathway 127
                        negative regulation of BMP signaling pathway 78
                          sequestering of BMP in extracellular matrix 4
paths to the root