Dand5 (DAN domain family member 5, BMP antagonist) - Rat Genome Database

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Gene: Dand5 (DAN domain family member 5, BMP antagonist) Mus musculus
Analyze
Symbol: Dand5
Name: DAN domain family member 5, BMP antagonist
RGD ID: 1620875
MGI Page MGI
Description: Enables morphogen activity. Involved in determination of left/right asymmetry in lateral mesoderm; heart development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within determination of left/right symmetry and negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in extracellular space. Is expressed in embryo; gut; node; and primitive streak. Orthologous to human DAND5 (DAN domain BMP antagonist family member 5); INTERACTS WITH 1,2-dimethylhydrazine; pirinixic acid; all-trans-retinoic acid (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cer; cerberus-like 2; cerberus-like protein 2; Cerl; Cerl-2; Cerl2; Cerr2; co; coco; DAN domain family member 5; DAN domain family, member 5; dante; Dte; GREM; GREM3; MGC144570; MGC144571
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,542,034 - 85,558,894 (-)NCBIGRCm39mm39
GRCm39 Ensembl885,542,033 - 85,559,038 (-)Ensembl
GRCm38884,815,405 - 84,832,265 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,815,404 - 84,832,409 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,339,304 - 87,356,164 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,705,510 - 87,712,928 (-)NCBImm8
Celera889,114,555 - 89,131,184 (-)NCBICelera
Cytogenetic Map8C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7867496   PMID:10208746   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12361961   PMID:12466851   PMID:12477932   PMID:14525956   PMID:14610273   PMID:14721776  
PMID:15132998   PMID:15466485   PMID:16141072   PMID:16141073   PMID:16801545   PMID:17210915   PMID:17481602   PMID:17507406   PMID:17884984   PMID:17967808   PMID:18697220   PMID:18773491  
PMID:18799693   PMID:18981480   PMID:19409822   PMID:19906859   PMID:20643351   PMID:21224256   PMID:21267068   PMID:21307093   PMID:21419113   PMID:21873635   PMID:22202776   PMID:22357932  
PMID:22412348   PMID:22554696   PMID:22627279   PMID:22983710   PMID:23271656   PMID:23544137   PMID:23707899   PMID:23742838   PMID:24585447   PMID:24780629   PMID:24801048   PMID:25033293  
PMID:25712475   PMID:27272319   PMID:27305836   PMID:28182636   PMID:29257953   PMID:29650695   PMID:29992973   PMID:31818953   PMID:31887266  


Genomics

Comparative Map Data
Dand5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,542,034 - 85,558,894 (-)NCBIGRCm39mm39
GRCm39 Ensembl885,542,033 - 85,559,038 (-)Ensembl
GRCm38884,815,405 - 84,832,265 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,815,404 - 84,832,409 (-)EnsemblGRCm38mm10GRCm38
MGSCv37887,339,304 - 87,356,164 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,705,510 - 87,712,928 (-)NCBImm8
Celera889,114,555 - 89,131,184 (-)NCBICelera
Cytogenetic Map8C3NCBI
DAND5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,965,159 - 12,974,760 (+)EnsemblGRCh38hg38GRCh38
GRCh381912,969,576 - 12,974,760 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371913,080,390 - 13,085,574 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,941,432 - 12,946,567 (+)NCBINCBI36hg18NCBI36
Build 341912,941,431 - 12,946,567NCBI
Celera1912,970,172 - 12,975,308 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,652,352 - 12,657,486 (+)NCBIHuRef
CHM1_11913,080,941 - 13,086,074 (+)NCBICHM1_1
Dand5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21923,330,917 - 23,340,486 (+)NCBI
Rnor_6.0 Ensembl1925,930,601 - 25,936,026 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01925,929,704 - 25,937,852 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01936,903,899 - 36,913,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,989,652 - 24,995,307 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1922,889,653 - 22,897,568 (+)NCBICelera
Cytogenetic Map19q11NCBI
Dand5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541532,012,637 - 32,015,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541532,012,637 - 32,015,965 (+)NCBIChiLan1.0ChiLan1.0
DAND5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01912,529,830 - 12,536,052 (+)NCBIMhudiblu_PPA_v0panPan3
DAND5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,225,351 - 49,228,940 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,225,990 - 49,228,940 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,097,579 - 49,101,217 (-)NCBI
ROS_Cfam_1.02049,742,161 - 49,745,799 (-)NCBI
UMICH_Zoey_3.12048,953,402 - 48,957,039 (-)NCBI
UNSW_CanFamBas_1.02049,379,663 - 49,383,301 (-)NCBI
UU_Cfam_GSD_1.02049,622,424 - 49,626,062 (-)NCBI
Dand5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,328,998 - 208,332,049 (-)NCBI
SpeTri2.0NW_0049366592,022,657 - 2,025,353 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DAND5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1266,068,722 - 66,073,537 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,432,010 - 66,436,411 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DAND5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,648,881 - 11,652,815 (+)NCBI
ChlSab1.1 Ensembl611,649,331 - 11,652,567 (+)Ensembl
Vero_WHO_p1.0NW_0236660748,132,746 - 8,136,701 (-)NCBI
Dand5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901534,828 - 538,923 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir375mmu-miR-375-3pOncomiRDBexternal_infoNANA21945323
Mir29b-1mmu-miR-29b-3pOncomiRDBexternal_infoNANA20385359
Mir22mmu-miR-22-3pOncomiRDBexternal_infoNANA21502362
Mir149mmu-miR-149-5pOncomiRDBexternal_infoNANA22821729
Mir29b-2mmu-miR-29b-3pOncomiRDBexternal_infoNANA20385359

Predicted Target Of
Summary Value
Count of predictions:348
Count of miRNA genes:259
Interacting mature miRNAs:295
Transcripts:ENSMUST00000065539
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065539   ⟹   ENSMUSP00000070057
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,815,404 - 84,822,823 (-)Ensembl
RefSeq Acc Id: ENSMUST00000238279
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,815,405 - 84,832,409 (-)Ensembl
RefSeq Acc Id: NM_201227   ⟹   NP_957679
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,542,034 - 85,549,452 (-)NCBI
GRCm38884,815,405 - 84,822,823 (-)NCBI
MGSCv37887,339,304 - 87,356,164 (-)RGD
Celera889,114,555 - 89,131,184 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_033145
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,542,034 - 85,558,894 (-)NCBI
GRCm38884,815,405 - 84,832,265 (-)ENTREZGENE
MGSCv37887,339,304 - 87,356,164 (-)RGD
Celera889,114,555 - 89,131,184 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_957679 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI15660 (Get FASTA)   NCBI Sequence Viewer  
  AAR25615 (Get FASTA)   NCBI Sequence Viewer  
  BAC82439 (Get FASTA)   NCBI Sequence Viewer  
  BAE25362 (Get FASTA)   NCBI Sequence Viewer  
  Q76LW6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_957679   ⟸   NM_201227
- Peptide Label: precursor
- UniProtKB: Q76LW6 (UniProtKB/Swiss-Prot),   Q3UPN3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000070057   ⟸   ENSMUST00000065539
Protein Domains
CTCK

Promoters
RGD ID:8667689
Promoter ID:EPDNEW_M11876
Type:multiple initiation site
Name:Dand5_1
Description:Mus musculus DAN domain family member 5, BMP antagonist , transcriptvariant 2, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,832,245 - 84,832,305EPDNEW
RGD ID:6843000
Promoter ID:MM_KWN:55096
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   MEF_B4,   MEF_B6
Transcripts:NR_033145
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,356,111 - 87,356,757 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344365 AgrOrtholog
Ensembl Genes ENSMUSG00000053226 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000070057 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000065539 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000238279 ENTREZGENE
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cerberus UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23863 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1344365 ENTREZGENE
NCBI Gene 23863 ENTREZGENE
PANTHER PTHR15273 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dand5 PhenoGen
PIRSF Cerberus UniProtKB/Swiss-Prot
SMART SM00041 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DAND5_MOUSE UniProtKB/Swiss-Prot
  Q3UPN3 ENTREZGENE, UniProtKB/TrEMBL
  Q76LW6 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Dand5  DAN domain family member 5, BMP antagonist    DAN domain family, member 5  Symbol and/or name change 5135510 APPROVED