Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
sequestering of BMP in extracellular matrix (GO:0035582)
Annotations: Rat: (4) Mouse: (4) Human: (5) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (3) Pig: (3)
Parent Terms Term With Siblings Child Terms
negative regulation of BMP signaling pathway by negative regulation of BMP secretion 
negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry 
sequestering of BMP from receptor via BMP binding  
sequestering of BMP in extracellular matrix  
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
sequestering of nodal from receptor via nodal binding  
sequestering of TGFbeta from receptor via TGFbeta binding 
sequestering of TGFbeta in extracellular matrix  

Synonyms
Exact Synonyms: BMP sequestration in the ECM ;   negative regulation of BMP signaling pathway by extracellular sequestering of BMP ;   negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP ;   negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein
Definition Sources: GOC:BHF, PMID:20855508

paths to the root