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ONTOLOGY REPORT - ANNOTATIONS


Term:sequestering of BMP in extracellular matrix
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Accession:GO:0035582 term browser browse the term
Definition:Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.
Comment:Confining BMP in the extracellular matrix may be achieved by binding BMP directly, or by binding to members of a BMP-containing complex.
Synonyms:exact_synonym: BMP sequestration in the ECM;   negative regulation of BMP signaling pathway by extracellular sequestering of BMP;   negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP;   negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein


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sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in IDA
ISO
IBA
(MGI:1858315|PMID:10748465)
(MGI:6201960|PMID:21873635)
BHF-UCL
MGI
GO_Central
PMID:10748465 PMID:21873635 GO_REF:0000096 MGI:1858315 MGI:4834177 MGI:6201960 NCBI chr 4:82,881,751...82,885,151
Ensembl chr 4:82,881,751...82,885,148
JBrowse link
G Dand5 DAN domain family member 5, BMP antagonist involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:84,815,405...84,832,265
Ensembl chr 8:84,815,404...84,832,409
JBrowse link
G Fbn1 fibrillin 1 involved_in IMP (MGI:4836762|PMID:20855508) BHF-UCL PMID:20855508 MGI:4836762 NCBI chr 2:125,300,594...125,506,485
Ensembl chr 2:125,300,594...125,507,993
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in IDA (MGI:1203284|PMID:9660951) BHF-UCL PMID:9660951 MGI:1203284 NCBI chr 4:139,082,291...139,093,126
Ensembl chr 4:139,082,284...139,092,993
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28599
    cellular process 17589
      negative regulation of cellular process 5204
        negative regulation of cellular response to growth factor stimulus 104
          negative regulation of BMP signaling pathway 56
            sequestering of BMP in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 28599
    biological regulation 13246
      regulation of biological process 12592
        regulation of cellular process 12028
          signal transduction 6498
            cell surface receptor signaling pathway 2793
              enzyme linked receptor protein signaling pathway 981
                transmembrane receptor protein serine/threonine kinase signaling pathway 400
                  BMP signaling pathway 174
                    regulation of BMP signaling pathway 102
                      negative regulation of BMP signaling pathway 56
                        sequestering of BMP in extracellular matrix 4
paths to the root