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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of BMP signaling pathway
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Accession:GO:0030514 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
Synonyms:exact_synonym: down regulation of BMP signaling pathway;   downregulation of BMP signaling pathway;   negative regulation of BMP signalling pathway;   negative regulation of bone morphogenetic protein signaling pathway;   negative regulation of bone morphogenetic protein signalling pathway
 narrow_synonym: inhibition of BMP signaling pathway;   negative regulation of decapentaplegic receptor signaling pathway;   negative regulation of decapentaplegic receptor signalling pathway;   negative regulation of decapentaplegic signaling pathway
 related_synonym: negative regulation of BMP receptor signaling pathway
 alt_id: GO:0090099


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negative regulation of BMP signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO MGI:104738 (MGI:5449665|PMID:22729085) RGD PMID:22729085 MGI:5449665 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor acts_upstream_of_or_within ISO (PMID:21743293) RGD PMID:21743293 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
JBrowse link
G Bmper BMP-binding endothelial regulator acts_upstream_of_or_within ISO (MGI:2670247|PMID:12897139) RGD PMID:12897139 MGI:2670247 NCBI chr 8:24,369,916...24,615,484
Ensembl chr 8:24,369,916...24,615,479
JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:15657086) RGD PMID:15657086 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist acts_upstream_of_or_within ISO (MGI:1101446|PMID:9431803), (MGI:1197794|PMID:9501024) RGD PMID:9431803 PMID:9501024 MGI:1101446 MGI:1197794 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Chrd chordin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3577114|PMID:15780974), (MGI:4429763|PMID:19850029)
(PMID:11472837)
Ensembl
RGD
PMID:11472837 PMID:15780974 PMID:19850029 GO_REF:0000107 MGI:3577114 MGI:4429763 NCBI chr11:83,858,503...83,867,543
Ensembl chr11:83,858,503...83,867,203
JBrowse link
G Chrdl1 chordin-like 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5492288|PMID:23676271)
Ensembl
RGD
PMID:23676271 GO_REF:0000107 MGI:5492288 NCBI chr  X:114,554,359...114,658,975
Ensembl chr  X:114,554,359...114,658,931
JBrowse link
G Chrdl2 chordin-like 2 acts_upstream_of_or_within ISO (MGI:2683044|PMID:14660436) RGD PMID:14660436 MGI:2683044 NCBI chr 1:165,008,997...165,036,431
Ensembl chr 1:165,008,912...165,036,435
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 acts_upstream_of_or_within ISO (PMID:21743293) RGD PMID:21743293 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Ctdspl2 CTD small phosphatase like 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5613417|PMID:25100727)
Ensembl
RGD
PMID:25100727 GO_REF:0000107 MGI:5613417 NCBI chr 3:113,906,803...113,957,289
Ensembl chr 3:113,918,629...113,960,101
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in ISO (MGI:3055649|PMID:15466485) RGD PMID:15466485 MGI:3055649 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 acts_upstream_of_or_within ISO (MGI:4429763|PMID:19850029) RGD PMID:19850029 MGI:4429763 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dlx1 distal-less homeobox 1 involved_in ISO
ISS
IEA
(PMID:14671321)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:14671321 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:58,164,931...58,169,521
Ensembl chr 3:58,164,931...58,169,521
JBrowse link
G Fstl3 follistatin like 3 involved_in
acts_upstream_of_or_within
ISO (PMID:17878677)
(MGI:1929020|PMID:11010968)
RGD PMID:11010968 PMID:17878677 MGI:1929020 NCBI chr 7:12,806,031...12,810,556
Ensembl chr 7:12,804,919...12,810,570
JBrowse link
G Fzd1 frizzled class receptor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3033512|PMID:14627707)
Ensembl
RGD
PMID:14627707 GO_REF:0000107 MGI:3033512 NCBI chr 4:26,470,864...26,475,262
Ensembl chr 4:26,470,864...26,475,262
JBrowse link
G Gdf3 growth differentiation factor 3 involved_in ISO (PMID:18823971) RGD PMID:18823971 NCBI chr 4:155,417,667...155,422,014
Ensembl chr 4:155,417,004...155,421,998
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in
acts_upstream_of_or_within
ISO
ISS
(PMID:15539560), (PMID:16816361), (PMID:27036124)
MGI:3046937 (MGI:3714585|PMID:17522159)
GO_REF:0000024
RGD
UniProt
PMID:15539560 PMID:16816361 PMID:17522159 PMID:27036124 GO_REF:0000024 MGI:3714585 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Grem2 gremlin 2, DAN family BMP antagonist involved_in ISO (MGI:5507937|PMID:23063586) RGD PMID:23063586 MGI:5507937 NCBI chr13:92,894,431...92,988,137
Ensembl chr13:92,894,431...92,988,137
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 involved_in ISO (PMID:12874272) RGD PMID:12874272 NCBI chr 4:66,438,390...66,625,183
Ensembl chr 4:66,445,266...66,624,912
JBrowse link
G Hjv hemojuvelin BMP co-receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:88177 (MGI:4455113|PMID:20065295)
Ensembl
RGD
PMID:20065295 GO_REF:0000107 MGI:4455113 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317
JBrowse link
G Htra1 HtrA serine peptidase 1 acts_upstream_of_or_within ISO (MGI:3034116|PMID:14973287) RGD PMID:14973287 MGI:3034116 NCBI chr 1:201,499,067...201,548,508
Ensembl chr 1:201,499,028...201,548,513
JBrowse link
G Htra3 HtrA serine peptidase 3 involved_in ISS
ISO
GO_REF:0000024
(MGI:3046453|PMID:15206957)
UniProt
RGD
PMID:15206957 GO_REF:0000024 MGI:3046453 NCBI chr14:80,248,140...80,276,534
Ensembl chr14:80,248,140...80,276,534
JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:5,779,742...5,786,213
Ensembl chr20:6,545,083...6,556,350
JBrowse link
G Lemd3 LEM domain containing 3 involved_in ISO
IBA
(PMID:15647271)
PMID:21873635
RGD PMID:15647271, PMID:21873635 RGD:13792537 NCBI chr 7:62,976,671...63,045,860
Ensembl chr 7:62,996,336...63,045,728
JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5908338|PMID:20460439)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20460439 GO_REF:0000024 GO_REF:0000107 MGI:5908338 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Mir675 microRNA 675 acts_upstream_of_or_within ISO (MGI:5566551|PMID:24532688) RGD PMID:24532688 MGI:5566551 NCBI chr 1:215,745,981...215,746,064
Ensembl chr 1:215,745,981...215,746,064
JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO (MGI:3654744|PMID:16801560) RGD PMID:16801560 MGI:3654744 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(MGI:5492288|PMID:23676271)
(PMID:23063586), (PMID:25561725)
UniProt
RGD
PMID:23063586 PMID:23676271 PMID:25561725 GO_REF:0000024 MGI:5492288 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664
JBrowse link
G Nog noggin involved_in
acts_upstream_of_or_within
ISS
ISO
IBA
IEA
GO_REF:0000024
MGI:1862000|MGI:88177|MGI:88182 (MGI:3044331|PMID:15110716), (MGI:3590430|PMID:15975920), (MGI:3640733|PMID:16712836), (MGI:4397715|PMID:19852960), (MGI:4415813|PMID:18462699), (MGI:4429763|PMID:19850029)
(MGI:3703823|PMID:17360443), (MGI:3715084|PMID:17400546)
PMID:21873635
(PMID:10780858), (PMID:15539560), (PMID:8752214)
GO_REF:0000104
UniProt
RGD
PMID:8752214 PMID:10780858 PMID:15110716 PMID:15539560 PMID:15975920 PMID:16712836 PMID:17360443 PMID:17400546 PMID:18462699 PMID:19850029 PMID:19852960, PMID:21873635 GO_REF:0000024 GO_REF:0000104 MGI:3044331 MGI:3590430 MGI:3640733 MGI:3703823 MGI:3715084 MGI:4397715 MGI:4415813 MGI:4429763, RGD:13792537 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:4412151|PMID:19695258) RGD PMID:19695258 MGI:4412151 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of_or_within ISO (PMID:21743293) RGD PMID:21743293 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5613417|PMID:25100727)
Ensembl
RGD
PMID:25100727 GO_REF:0000107 MGI:5613417 NCBI chr 6:94,433,658...94,484,979
Ensembl chr 6:94,429,068...94,484,351
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108078 (MGI:4429763|PMID:19850029)
Ensembl
RGD
PMID:19850029 GO_REF:0000107 MGI:4429763 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:892014 (MGI:4429763|PMID:19850029) RGD PMID:19850029 MGI:4429763 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Ski SKI proto-oncogene involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:14699069), (PMID:17054724)
MGI:88177 (MGI:5300220|PMID:21937600)
PMID:21873635
RGD PMID:14699069 PMID:17054724 PMID:21937600, PMID:21873635 MGI:5300220, RGD:13792537 NCBI chr 5:172,556,196...172,623,878
Ensembl chr 5:172,559,135...172,623,899
JBrowse link
G Skil SKI-like proto-oncogene involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:115,862,932...115,891,304
Ensembl chr 2:115,866,701...115,891,097
JBrowse link
G Skor1 SKI family transcriptional corepressor 1 involved_in ISO
IBA
(PMID:17292623)
PMID:21873635
RGD PMID:17292623, PMID:21873635 RGD:13792537 NCBI chr 8:68,029,930...68,040,504
Ensembl chr 8:68,030,621...68,038,533
JBrowse link
G Skor2 SKI family transcriptional corepressor 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:88177 (MGI:5300220|PMID:21937600)
RGD PMID:21937600, PMID:21873635 MGI:5300220, RGD:13792537 NCBI chr18:73,145,596...73,199,395
Ensembl chr18:73,157,973...73,193,377
JBrowse link
G Smad6 SMAD family member 6 involved_in ISO (PMID:22275001), (PMID:30848080), (PMID:9436979) RGD PMID:9436979 PMID:22275001 PMID:30848080 NCBI chr 8:68,897,746...68,967,221
Ensembl chr 8:68,898,296...68,966,108
JBrowse link
G Smad7 SMAD family member 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:4429763|PMID:19850029)
(PMID:17438144)
Ensembl
RGD
PMID:17438144 PMID:19850029 GO_REF:0000107 MGI:4429763 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 involved_in IBA
ISO
PMID:21873635
(PMID:27214554)
RGD PMID:27214554, PMID:21873635 RGD:13792537 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Smurf2 SMAD specific E3 ubiquitin protein ligase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:95,018,050...95,118,107
Ensembl chr10:95,018,059...95,062,987
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:5704270|PMID:26584636) RGD PMID:26584636 MGI:5704270 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Sost sclerostin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:14633986)
(MGI:3766170|PMID:17002572)
RGD PMID:14633986 PMID:17002572, PMID:21873635 MGI:3766170, RGD:13792537 NCBI chr10:89,897,087...89,900,131
Ensembl chr10:89,897,087...89,900,131
JBrowse link
G Sostdc1 sclerostin domain containing 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:88180 (MGI:2681048|PMID:14623234), (MGI:3603904|PMID:16179481)
(PMID:15020244)
RGD PMID:14623234 PMID:15020244 PMID:16179481, PMID:21873635 MGI:2681048 MGI:3603904, RGD:13792537 NCBI chr 6:55,812,820...55,816,994
Ensembl chr 6:55,812,747...55,817,066
JBrowse link
G Spart spartin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5430946 (MGI:5430704|PMID:22619377)
RGD PMID:22619377, PMID:21873635 MGI:5430704, RGD:13792537 NCBI chr 2:144,522,382...144,548,968
Ensembl chr 2:144,522,072...144,548,917
JBrowse link
G Tcf7l2 transcription factor 7 like 2 acts_upstream_of_or_within ISO MGI:1926344 (MGI:3763872|PMID:17919533) RGD PMID:17919533 MGI:3763872 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Tmprss6 transmembrane serine protease 6 acts_upstream_of_or_within ISO MGI:1321394|MGI:1916835|MGI:88177|MGI:88180 (MGI:5314735|PMID:19751239) RGD PMID:19751239 MGI:5314735 NCBI chr 7:119,659,323...119,689,953
Ensembl chr 7:119,659,324...119,689,938
JBrowse link
G Tob1 transducer of ErbB-2.1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:1928565|PMID:11163184)
Ensembl
RGD
PMID:11163184 GO_REF:0000107 MGI:1928565 NCBI chr10:81,913,689...81,915,727
Ensembl chr10:81,913,689...81,915,716
JBrowse link
G Trim33 tripartite motif-containing 33 involved_in ISO (PMID:19135894) RGD PMID:19135894 NCBI chr 2:205,783,252...205,863,426
Ensembl chr 2:205,783,252...205,858,433
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 acts_upstream_of_or_within ISO MGI:2655736 (MGI:2654977|PMID:12665593), (MGI:3577114|PMID:15780974) RGD PMID:12665593 PMID:15780974 MGI:2654977 MGI:3577114 NCBI chr 9:113,699,151...113,732,601
Ensembl chr 9:113,699,170...113,732,622
JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 involved_in IBA
ISO
PMID:21873635
(MGI:3715084|PMID:17400546)
RGD PMID:17400546, PMID:21873635 MGI:3715084, RGD:13792537 NCBI chr14:91,201,141...91,348,219
Ensembl chr14:91,201,730...91,348,219
JBrowse link
G Vwc2l von Willebrand factor C domain containing 2 like involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:88177|MGI:88182 (MGI:4397715|PMID:19852960)
RGD PMID:19852960, PMID:21873635 MGI:4397715, RGD:13792537 NCBI chr 9:77,833,534...78,024,670
Ensembl chr 9:77,834,091...78,021,846
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:16194878) RGD PMID:16194878 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link
G Wnt5a Wnt family member 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857617 (MGI:3777488|PMID:18351662)
Ensembl
RGD
PMID:18351662 GO_REF:0000107 MGI:3777488 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
sequestering of BMP from receptor via BMP binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Grem2 gremlin 2, DAN family BMP antagonist involved_in IBA
ISO
PMID:21873635
(MGI:5507937|PMID:23063586)
RGD PMID:23063586, PMID:21873635 MGI:5507937, RGD:13792537 NCBI chr13:92,894,431...92,988,137
Ensembl chr13:92,894,431...92,988,137
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in ISO
IEA
IBA
(PMID:23063586)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:23063586, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664
JBrowse link
sequestering of BMP in extracellular matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cer1 cerberus 1, DAN family BMP antagonist involved_in ISO
IBA
(PMID:9660951)
(MGI:1858315|PMID:10748465)
PMID:21873635
RGD PMID:9660951 PMID:10748465, PMID:21873635 MGI:1858315, RGD:13792537 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375
JBrowse link
G Dand5 DAN domain BMP antagonist family member 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:25,929,704...25,937,852
Ensembl chr19:25,930,601...25,936,026
JBrowse link
G Fbn1 fibrillin 1 involved_in ISO (MGI:4836762|PMID:20855508) RGD PMID:20855508 MGI:4836762 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Nbl1 NBL1, DAN family BMP antagonist involved_in IEA
ISO
GO_REF:0000107
(MGI:1203284|PMID:9660951)
Ensembl
RGD
PMID:9660951 GO_REF:0000107 MGI:1203284 NCBI chr 5:157,524,569...157,535,701
Ensembl chr 5:157,524,513...157,535,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      negative regulation of cellular process 5117
        negative regulation of cellular response to growth factor stimulus 104
          negative regulation of BMP signaling pathway 56
            negative regulation of BMP signaling pathway by negative regulation of BMP secretion 0
            negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry 0
            sequestering of BMP from receptor via BMP binding 3
            sequestering of BMP in extracellular matrix 4
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological process 12773
        regulation of cellular process 12275
          signal transduction 6881
            cell surface receptor signaling pathway 2774
              enzyme linked receptor protein signaling pathway 978
                transmembrane receptor protein serine/threonine kinase signaling pathway 391
                  BMP signaling pathway 172
                    regulation of BMP signaling pathway 102
                      negative regulation of BMP signaling pathway 56
                        negative regulation of BMP signaling pathway by negative regulation of BMP secretion 0
                        negative regulation of BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry 0
                        sequestering of BMP from receptor via BMP binding 3
                        sequestering of BMP in extracellular matrix 4
paths to the root