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ONTOLOGY REPORT - ANNOTATIONS

Term:cGMP-mediated signaling
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Accession:GO:0019934 term browser browse the term
Definition:An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.
Synonyms:exact_synonym: cGMP-mediated signalling

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cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adnp activity dependent neuroprotector homeobox ISO RGD PMID:11438390 RGD:1358228 NCBI chrNW_004936514:3,855,113...3,883,036
Ensembl chrNW_004936514:3,855,672...3,885,718 		JBrowse link
G Adora2b adenosine A2b receptor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:18340377) Ensembl
MGI		 PMID:18340377 GO_REF:0000107 NCBI chrNW_004936821:583,463...608,189
Ensembl chrNW_004936821:580,675...608,245 		JBrowse link
G Aqp1 aquaporin 1 (Colton blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:7,146,997...7,160,369
Ensembl chrNW_004936478:7,147,027...7,160,401 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G Cgas cyclic GMP-AMP synthase involved_in ISO (PMID:23258413), (PMID:24077100) UniProt PMID:23258413 PMID:24077100 NCBI chrNW_004936859:797,469...807,036 JBrowse link
G Ednrb endothelin receptor type B ISO RGD PMID:17585504 RGD:4892585 NCBI chrNW_004936511:3,446,864...3,478,434
Ensembl chrNW_004936511:3,446,839...3,478,434 		JBrowse link
G Guca2b guanylate cyclase activator 2B ISO RGD PMID:9094754 RGD:731150 NCBI chrNW_004936474:23,632,836...23,634,330
Ensembl chrNW_004936474:23,632,781...23,634,496 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425 		JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936551:1,573,930...1,814,685
Ensembl chrNW_004936551:1,575,356...1,814,697 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936576:2,427,451...2,469,946
Ensembl chrNW_004936576:2,427,416...2,470,072 		JBrowse link
G Gucy2d guanylate cyclase 2D, retinal ISO RGD PMID:9153227 RGD:1599625 NCBI chrNW_004936595:1,235,747...1,250,294
Ensembl chrNW_004936595:1,235,711...1,250,354 		JBrowse link
G Gucy2f guanylate cyclase 2F, retinal ISO RGD PMID:9153227 RGD:1599625 NCBI chrNW_004936499:5,653,384...5,752,732 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936525:5,711,894...5,729,074
Ensembl chrNW_004936525:5,712,329...5,729,831 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936499:1,002,083...1,109,446
Ensembl chrNW_004936499:1,004,732...1,109,377 		JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15483626) MGI
TreeGrafter		 PMID:15483626 GO_REF:0000118 NCBI chrNW_004936528:7,663,732...7,781,679
Ensembl chrNW_004936528:7,704,901...7,778,452 		JBrowse link
G LOC101964576 guanylate cyclase soluble subunit beta-2-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936565:3,877,047...3,930,198 JBrowse link
G Nos2 nitric oxide synthase 2 ISO RGD PMID:12107056 RGD:625635 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nppa natriuretic peptide A involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:12217425 GO_REF:0000118 RGD:729410 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nppb natriuretic peptide B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665 		JBrowse link
G Nppc natriuretic peptide C ISO RGD PMID:14691198 RGD:1601491 NCBI chrNW_004936525:5,092,675...5,099,344
Ensembl chrNW_004936525:5,092,635...5,099,331 		JBrowse link
G Npr1 natriuretic peptide receptor 1 ISO RGD PMID:2563900 PMID:12217425 RGD:729265 RGD:729410 NCBI chrNW_004936580:3,479,858...3,496,896
Ensembl chrNW_004936580:3,480,267...3,495,643 		JBrowse link
G Npr2 natriuretic peptide receptor 2 ISO RGD PMID:14691198 RGD:1601491 NCBI chrNW_004936524:3,779,398...3,798,074
Ensembl chrNW_004936524:3,779,392...3,798,501 		JBrowse link
G Pde2a phosphodiesterase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:1,856,256...1,944,405
Ensembl chrNW_004936498:1,856,144...1,944,412 		JBrowse link
G Pde3a phosphodiesterase 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936548:5,758,634...6,072,195
Ensembl chrNW_004936548:5,762,507...6,070,576 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15483626) Ensembl
MGI		 PMID:15483626 GO_REF:0000107 NCBI chrNW_004936787:330,390...1,491,994
Ensembl chrNW_004936787:332,342...1,491,285 		JBrowse link
negative regulation of cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtnr1b melatonin receptor 1B ISO RGD PMID:18363673 RGD:9588673 NCBI chrNW_004936674:1,703,814...1,713,860
Ensembl chrNW_004936674:1,703,814...1,713,860 		JBrowse link
G Nherf4 NHERF family PDZ scaffold protein 4 involved_in ISO (PMID:11950846) UniProt PMID:11950846 NCBI chrNW_004936542:4,121,275...4,126,611 JBrowse link
G Pde11a phosphodiesterase 11A ISO RGD PMID:11502204 RGD:633590 NCBI chrNW_004936509:6,943,758...7,322,192
Ensembl chrNW_004936509:6,948,710...7,322,156 		JBrowse link
G Pde2a phosphodiesterase 2A involved_in ISO (PMID:21724846) UniProt PMID:21724846 NCBI chrNW_004936498:1,856,256...1,944,405
Ensembl chrNW_004936498:1,856,144...1,944,412 		JBrowse link
G Thbs1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
nitric oxide-cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr2 angiotensin II receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936479:13,252,678...13,255,570
Ensembl chrNW_004936479:13,252,678...13,255,570 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:8995232) BHF-UCL PMID:8995232 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:19278978) Ensembl
BHF-UCL		 PMID:19278978 GO_REF:0000107 NCBI chrNW_004936567:944,825...1,039,920
Ensembl chrNW_004936567:950,797...993,245 		JBrowse link
G Cd36 CD36 molecule (CD36 blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936810:791,823...838,303
Ensembl chrNW_004936810:758,182...838,365 		JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936576:2,353,874...2,411,747
Ensembl chrNW_004936576:2,353,761...2,411,425 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936576:2,427,451...2,469,946
Ensembl chrNW_004936576:2,427,416...2,470,072 		JBrowse link
G Ins insulin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936816:1,002,137...1,003,357
Ensembl chrNW_004936816:1,002,137...1,003,357 		JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 involved_in ISO PMID:11281123 UniProt PMID:11281123 RGD:10047322 NCBI chrNW_004936568:3,508,212...3,694,459
Ensembl chrNW_004936568:3,511,244...3,694,781 		JBrowse link
G Nos1 nitric oxide synthase 1 involved_in ISO PMID:19278978 BHF-UCL PMID:19278978 RGD:10047220 NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414 		JBrowse link
G Thbs1 thrombospondin 1 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:17416590) Ensembl
BHF-UCL		 PMID:17416590 GO_REF:0000107 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
positive regulation of cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2b receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18340377) Ensembl
MGI		 PMID:18340377 GO_REF:0000107 NCBI chrNW_004936821:583,463...608,189
Ensembl chrNW_004936821:580,675...608,245 		JBrowse link
G Guca1a guanylate cyclase activator 1A ISO RGD PMID:12545196 RGD:1599357 NCBI chrNW_004936476:17,690,484...17,701,288
Ensembl chrNW_004936476:17,691,045...17,701,859 		JBrowse link
G Nppa natriuretic peptide A ISO RGD PMID:7552344 PMID:12608696 RGD:1626242 RGD:1626243 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Nppb natriuretic peptide B ISO RGD PMID:7552344 RGD:1626243 NCBI chrNW_004936474:683,325...684,662
Ensembl chrNW_004936474:683,325...684,665 		JBrowse link
G Nppc natriuretic peptide C ISO RGD PMID:12746286 RGD:1580115 NCBI chrNW_004936525:5,092,675...5,099,344
Ensembl chrNW_004936525:5,092,635...5,099,331 		JBrowse link
G Npr1 natriuretic peptide receptor 1 ISO RGD PMID:7552344 RGD:1626243 NCBI chrNW_004936580:3,479,858...3,496,896
Ensembl chrNW_004936580:3,480,267...3,495,643 		JBrowse link
G Npr2 natriuretic peptide receptor 2 ISO RGD PMID:7552344 RGD:1626243 NCBI chrNW_004936524:3,779,398...3,798,074
Ensembl chrNW_004936524:3,779,392...3,798,501 		JBrowse link
G Rundc3a RUN domain containing 3A involved_in ISO
IEA		 atrial natriuretic factor-mediated RGD
TreeGrafter		 PMID:11071862 GO_REF:0000118 RGD:1299631 NCBI chrNW_004936541:758,815...768,050
Ensembl chrNW_004936541:758,790...770,686 		JBrowse link
regulation of cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde2a phosphodiesterase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:1,856,256...1,944,405
Ensembl chrNW_004936498:1,856,144...1,944,412 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16037
    cellular process 15650
      signal transduction 5694
        intracellular signal transduction 2819
          intracellular signaling cassette 1835
            cGMP-mediated signaling 37
              negative regulation of cGMP-mediated signaling + 5
              nitric oxide-cGMP-mediated signaling + 10
              positive regulation of cGMP-mediated signaling + 8
              regulation of cGMP-mediated signaling + 13
Path 2
Term Annotations click to browse term
  biological_process 16037
    biological regulation 11269
      regulation of biological process 10908
        signaling 6187
          signal transduction 5694
            intracellular signal transduction 2819
              intracellular signaling cassette 1835
                cGMP-mediated signaling 37
                  negative regulation of cGMP-mediated signaling + 5
                  nitric oxide-cGMP-mediated signaling + 10
                  positive regulation of cGMP-mediated signaling + 8
                  regulation of cGMP-mediated signaling + 13
paths to the root