Guca2b (guanylate cyclase activator 2B) - Rat Genome Database

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Gene: Guca2b (guanylate cyclase activator 2B) Ictidomys tridecemlineatus
Analyze
Symbol: Guca2b
Name: guanylate cyclase activator 2B
RGD ID: 12637738
Description: ENCODES a protein that exhibits guanylate cyclase activator activity (inferred); INVOLVED IN adipose tissue development (ortholog); body fluid secretion (ortholog); cGMP-mediated signaling (ortholog); PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease dominant intermediate C (ortholog); end stage renal disease (ortholog); genetic disease (ortholog); FOUND IN photoreceptor outer segment (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505857,807,471 - 57,809,709 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,632,781 - 23,634,496 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,632,836 - 23,634,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Guca2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505857,807,471 - 57,809,709 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647423,632,781 - 23,634,496 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647423,632,836 - 23,634,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,153,410 - 42,155,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,153,410 - 42,155,820 (+)EnsemblGRCh38hg38GRCh38
GRCh37142,619,081 - 42,621,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36142,391,679 - 42,394,082 (+)NCBINCBI36Build 36hg18NCBI36
Build 34142,288,184 - 42,290,588NCBI
Celera140,901,379 - 40,903,782 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef140,738,645 - 40,741,048 (+)NCBIHuRef
CHM1_1142,736,196 - 42,738,599 (+)NCBICHM1_1
T2T-CHM13v2.0142,024,047 - 42,026,457 (+)NCBIT2T-CHM13v2.0
Guca2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,513,798 - 119,516,142 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,513,804 - 119,516,151 (-)EnsemblGRCm39 Ensembl
GRCm384119,656,601 - 119,658,945 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,656,607 - 119,658,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv374119,329,206 - 119,331,550 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364119,154,547 - 119,156,877 (-)NCBIMGSCv36mm8
Celera4118,380,210 - 118,382,528 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.48NCBI
Guca2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,532,160 - 138,534,210 (-)NCBIGRCr8
mRatBN7.25133,246,891 - 133,248,941 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5133,246,909 - 133,248,966 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,975,549 - 135,977,599 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,731,991 - 137,734,041 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,752,591 - 137,754,641 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,695,591 - 138,697,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,695,591 - 138,697,641 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,497,885 - 142,499,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45140,237,184 - 140,239,234 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15140,242,411 - 140,244,482 (-)NCBI
Celera5131,770,229 - 131,772,279 (-)NCBICelera
Cytogenetic Map5q36NCBI
Guca2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555371,798,249 - 1,801,673 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555371,798,249 - 1,801,673 (+)NCBIChiLan1.0ChiLan1.0
GUCA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,656,603 - 184,659,049 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,798,643 - 183,801,089 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,452,722 - 41,455,192 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1142,832,809 - 42,835,202 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl142,832,196 - 42,835,425 (+)Ensemblpanpan1.1panPan2
GUCA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,094,283 - 1,096,605 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,094,276 - 1,096,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha151,351,322 - 1,353,606 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0151,181,767 - 1,184,052 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,181,761 - 1,184,098 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,086,868 - 1,089,152 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,148,603 - 1,150,888 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0151,163,515 - 1,165,799 (-)NCBIUU_Cfam_GSD_1.0
GUCA2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6169,152,179 - 169,154,551 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16169,152,172 - 169,154,557 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GUCA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12090,767,183 - 90,770,403 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2090,767,609 - 90,770,198 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603326,135,158 - 26,137,524 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Guca2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248921,506,303 - 1,508,840 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248921,506,517 - 1,508,751 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005317882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000020359   ⟹   ENSSTOP00000019982
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647423,632,781 - 23,634,496 (+)Ensembl
RefSeq Acc Id: XM_005317882   ⟹   XP_005317939
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505857,807,471 - 57,809,709 (+)NCBI
SpeTri2.0NW_00493647423,632,836 - 23,634,330 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005317939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000019982.1
GenBank Protein KAG3282896 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005317939   ⟸   XM_005317882
- Sequence:
RefSeq Acc Id: ENSSTOP00000019982   ⟸   ENSSTOT00000020359


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000027358 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020359.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1450.10 UniProtKB/TrEMBL
InterPro Guanylin UniProtKB/TrEMBL
  Guanylin_sf UniProtKB/TrEMBL
NCBI Gene Guca2b ENTREZGENE
PANTHER GUANYLATE CYCLASE ACTIVATOR 2B UniProtKB/TrEMBL
  PTHR11318 UniProtKB/TrEMBL
Pfam Guanylin UniProtKB/TrEMBL
PIRSF Guanylin UniProtKB/TrEMBL
PRINTS GUANYLIN UniProtKB/TrEMBL
Superfamily-SCOP SSF89890 UniProtKB/TrEMBL
UniProt I3N6I6_ICTTR UniProtKB/TrEMBL