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ONTOLOGY REPORT - ANNOTATIONS

Term:NuRD complex
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Accession:GO:0016581 term browser browse the term
Definition:An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
Synonyms:exact_synonym: NRD complex;   nucleosome remodeling and histone deacetylation complex
 narrow_synonym: Mi-2 complex


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NuRD complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2ap1 cyclin dependent kinase 2 associated protein 1 part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:124,483,502...124,492,691
Ensembl chr 5:124,483,480...124,501,145 		JBrowse link
G Cdk2ap1rt cyclin dependent kinase 2 associated protein 1 retrotransposed part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:48,716,173...48,717,439
Ensembl chr11:48,716,173...48,717,482 		JBrowse link
G Cdk2ap2 cyclin dependent kinase 2 associated protein 2 part_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:4,146,204...4,149,019
Ensembl chr19:4,147,182...4,149,019 		JBrowse link
G Chd3 chromodomain helicase DNA binding protein 3 part_of ISO
IDA
NAS
IBA		 (PMID:10204490)
(MGI:6867152|PMID:16428440)		 MGI
ComplexPortal
GO_Central		 PMID:10204490 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr11:69,234,099...69,260,325
Ensembl chr11:69,234,099...69,260,232 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 part_of ISO
NAS
IBA
IDA		 (MGI:6867152|PMID:16428440)
(PMID:22075476)		 MGI
ComplexPortal
GO_Central		 PMID:16428440 PMID:22075476 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr 6:125,073,144...125,107,554
Ensembl chr 6:125,072,944...125,107,554 		JBrowse link
G Chd5 chromodomain helicase DNA binding protein 5 part_of IDA
IBA		 (MGI:5559665|PMID:21931736) UniProt
GO_Central		 PMID:21931736 GO_REF:0000033 MGI:5559665 NCBI chr 4:152,423,103...152,474,651
Ensembl chr 4:152,423,108...152,474,651 		JBrowse link
G Gatad2a GATA zinc finger domain containing 2A part_of ISO
IBA
NAS		 (MGI:6867152|PMID:16428440) MGI
GO_Central
ComplexPortal		 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr 8:70,359,719...70,450,093
Ensembl chr 8:70,359,726...70,449,034 		JBrowse link
G Gatad2b GATA zinc finger domain containing 2B part_of ISO
IBA
NAS		 (MGI:6867152|PMID:16428440) MGI
GO_Central
ComplexPortal		 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr 3:90,200,488...90,270,712
Ensembl chr 3:90,200,485...90,270,714 		JBrowse link
G Hdac1 histone deacetylase 1 part_of ISO
IBA
IPI
IDA
NAS		 (PMID:14645126)
(PMID:11836251), (PMID:22075476)
(MGI:6867152|PMID:16428440)
(PMID:16462733)		 MGI
GO_Central
ComplexPortal		 PMID:11836251 PMID:14645126 PMID:16428440 PMID:16462733 PMID:22075476 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr 4:129,409,897...129,436,516
Ensembl chr 4:129,409,897...129,436,506 		JBrowse link
G Hdac2 histone deacetylase 2 part_of ISO
NAS
IBA		 (MGI:6867152|PMID:16428440) MGI
ComplexPortal
GO_Central		 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 part_of ISO
NAS		 (MGI:6867152|PMID:16428440) MGI
ComplexPortal		 PMID:16428440 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 part_of ISO
NAS
IPI		 (MGI:6867152|PMID:16428440)
(PMID:16462733)		 MGI
ComplexPortal		 PMID:16428440 PMID:16462733 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384 		JBrowse link
G Mta1 metastasis associated 1 part_of ISO
IPI
NAS
IBA		 (PMID:16462733)
(MGI:6867152|PMID:16428440)		 MGI
ComplexPortal
GO_Central		 PMID:16428440 PMID:16462733 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr12:113,061,830...113,100,826
Ensembl chr12:113,061,898...113,100,826 		JBrowse link
G Mta2 metastasis-associated gene family, member 2 part_of ISO
IDA
IPI
NAS
IBA		 (PMID:14645126)
(PMID:16462733)
(MGI:6867152|PMID:16428440)		 MGI
ComplexPortal
GO_Central		 PMID:14645126 PMID:16428440 PMID:16462733 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr19:8,919,239...8,929,659
Ensembl chr19:8,919,239...8,929,667 		JBrowse link
G Mta3 metastasis associated 3 part_of ISO
NAS
IBA		 (MGI:6867152|PMID:16428440) MGI
ComplexPortal
GO_Central		 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr17:84,013,483...84,131,144
Ensembl chr17:84,013,592...84,128,945 		JBrowse link
G Rbbp4 retinoblastoma binding protein 4, chromatin remodeling factor part_of ISO
NAS
IBA
IDA		 (MGI:6867152|PMID:16428440)
(PMID:14645126)		 MGI
ComplexPortal
GO_Central		 PMID:14645126 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr 4:129,200,893...129,229,163
Ensembl chr 4:129,200,893...129,229,163 		JBrowse link
G Rbbp7 retinoblastoma binding protein 7, chromatin remodeling factor part_of ISO
IBA
NAS
IDA		 (MGI:6867152|PMID:16428440)
(PMID:14645126)		 MGI
GO_Central
ComplexPortal		 PMID:14645126 PMID:16428440 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:6867152 NCBI chr  X:161,543,368...161,562,086
Ensembl chr  X:161,543,398...161,562,088 		JBrowse link
G Sall1 spalt like transcription factor 1 part_of IDA (PMID:11836251) MGI PMID:11836251 NCBI chr 8:89,753,867...89,770,790
Ensembl chr 8:89,753,863...89,770,790 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 28585
    protein-containing complex 6177
      transcription regulator complex 563
        NuRD complex 18
          SHREC complex 0
Path 2
Term Annotations click to browse term
  cellular_component 28585
    cellular anatomical entity 19619
      organelle 13553
        membrane-bounded organelle 12559
          intracellular membrane-bounded organelle 12011
            nucleus 7488
              nuclear lumen 4317
                nucleoplasm 3823
                  histone deacetylase complex 79
                    NuRD complex 18
                      SHREC complex 0
paths to the root