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ONTOLOGY REPORT - ANNOTATIONS

Term:microtubule nucleation
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Accession:GO:0007020 term browser browse the term
Definition:The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).
Synonyms:xref: Wikipedia:Microtubule_nucleation


show annotations for term's descendants           Sort by:
microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP9 A-kinase anchoring protein 9 involved_in IMP
IBA		 (PMID:19242490) UniProt
GO_Central		 PMID:19242490 GO_REF:0000033 NCBI chr 7:91,940,862...92,110,673
Ensembl chr 7:91,940,840...92,110,673 		JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in NAS (PMID:15381421) UniProt PMID:15381421 NCBI chr10:100,273,278...100,286,680
Ensembl chr10:100,273,280...100,286,680 		JBrowse link
G CCDC57 coiled-coil domain containing 57 involved_in IDA
IBA		 (PMID:32402286) UniProt
GO_Central		 PMID:32402286 GO_REF:0000033 NCBI chr17:82,101,470...82,212,842
Ensembl chr17:82,101,460...82,212,878 		JBrowse link
G CENPJ centromere protein J involved_in TAS (PMID:11003675) UniProt PMID:11003675 NCBI chr13:24,882,279...24,934,000
Ensembl chr13:24,882,279...24,922,889 		JBrowse link
G CLASP1 cytoplasmic linker associated protein 1 involved_in IMP (PMID:17543864) UniProt PMID:17543864 NCBI chr 2:121,337,776...121,649,462
Ensembl chr 2:121,337,776...121,649,476 		JBrowse link
G CLASP2 cytoplasmic linker associated protein 2 involved_in IMP (PMID:17543864) UniProt PMID:17543864 NCBI chr 3:33,496,245...33,718,254
Ensembl chr 3:33,496,245...33,718,356 		JBrowse link
G CSNK1D casein kinase 1 delta acts_upstream_of_or_within IMP (PMID:24648492) SYSCILIA_CCNET PMID:24648492 NCBI chr17:82,239,019...82,273,750
Ensembl chr17:82,239,023...82,273,700 		JBrowse link
G GOLGA2 golgin A2 involved_in IMP
IDA		 (PMID:19242490)
(PMID:26165940)		 UniProt PMID:19242490 PMID:26165940 NCBI chr 9:128,255,829...128,276,007
Ensembl chr 9:128,255,829...128,276,026 		JBrowse link
G HAUS2 HAUS augmin like complex subunit 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:42,548,838...42,569,994
Ensembl chr15:42,548,828...42,569,994 		JBrowse link
G NDE1 nudE neurodevelopment protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:11163258) Ensembl
MGI
GO_Central		 PMID:11163258 GO_REF:0000033 GO_REF:0000107 NCBI chr16:15,643,382...15,726,353
Ensembl chr16:15,643,267...15,734,691 		JBrowse link
G NDEL1 nudE neurodevelopment protein 1 like 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:8,413,131...8,474,328
Ensembl chr17:8,413,131...8,490,411 		JBrowse link
G NEDD1 NEDD1 gamma-tubulin ring complex targeting factor involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:96,907,257...96,953,780
Ensembl chr12:96,907,224...96,953,780 		JBrowse link
G PCNT pericentrin involved_in IBA GO_Central GO_REF:0000033 NCBI chr21:46,324,156...46,445,769
Ensembl chr21:46,324,124...46,445,769 		JBrowse link
G RANBP9 RAN binding protein 9 involved_in TAS
NAS		 (PMID:9817760)
(PMID:12220523)		 PINC
UniProt		 PMID:9817760 PMID:12220523 NCBI chr 6:13,621,498...13,711,835
Ensembl chr 6:13,621,498...13,711,835 		JBrowse link
G SLAIN1 SLAIN motif family member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:77,697,687...77,764,229
Ensembl chr13:77,697,687...77,764,242 		JBrowse link
G SLAIN2 SLAIN motif family member 2 involved_in IMP
IBA		 (PMID:21646404) UniProt
GO_Central		 PMID:21646404 GO_REF:0000033 NCBI chr 4:48,341,529...48,426,201
Ensembl chr 4:48,341,529...48,426,201 		JBrowse link
G SSNA1 SS nuclear autoantigen 1 involved_in IDA (PMID:34970964) UniProt PMID:34970964 NCBI chr 9:137,188,676...137,190,366
Ensembl chr 9:137,188,660...137,190,370 		JBrowse link
G TPX2 TPX2 microtubule nucleation factor involved_in IDA (PMID:26414402) CACAO PMID:26414402 NCBI chr20:31,739,290...31,801,800
Ensembl chr20:31,739,271...31,801,805 		JBrowse link
G TUBG1 tubulin gamma 1 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr17:42,609,683...42,615,238
Ensembl chr17:42,609,641...42,615,238 		JBrowse link
G TUBG2 tubulin gamma 2 involved_in IEA
IBA		 InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr17:42,659,284...42,667,006
Ensembl chr17:42,659,284...42,667,006 		JBrowse link
G TUBGCP2 tubulin gamma complex component 2 involved_in IEA
IBA
TAS		 (PMID:9566967) InterPro
GO_Central
PINC		 PMID:9566967 GO_REF:0000002 GO_REF:0000033 NCBI chr10:133,278,635...133,312,337
Ensembl chr10:133,278,635...133,318,823 		JBrowse link
G TUBGCP3 tubulin gamma complex component 3 involved_in IEA
IBA
NAS		 (PMID:11694571), (PMID:9566969) InterPro
GO_Central
UniProt		 PMID:9566969 PMID:11694571 GO_REF:0000002 GO_REF:0000033 NCBI chr13:112,485,011...112,605,630
Ensembl chr13:112,485,011...112,588,205 		JBrowse link
G TUBGCP4 tubulin gamma complex component 4 involved_in NAS
IBA
IEA		 (PMID:10562286) UniProt
GO_Central
InterPro		 PMID:10562286 GO_REF:0000002 GO_REF:0000033 NCBI chr15:43,371,101...43,409,771
Ensembl chr15:43,369,221...43,409,771 		JBrowse link
G TUBGCP5 tubulin gamma complex component 5 involved_in IDA
IBA
IEA		 (PMID:11694571) UniProt
GO_Central
InterPro		 PMID:11694571 GO_REF:0000002 GO_REF:0000033 NCBI chr15:22,983,025...23,039,569
Ensembl chr15:22,983,192...23,039,572 		JBrowse link
G TUBGCP6 tubulin gamma complex component 6 involved_in IEA
IBA
IDA		 (PMID:11694571) InterPro
GO_Central
UniProt		 PMID:11694571 GO_REF:0000002 GO_REF:0000033 NCBI chr22:50,217,694...50,245,023
Ensembl chr22:50,217,689...50,245,023 		JBrowse link
astral microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPJ centromere protein J acts_upstream_of_or_within IDA (PMID:11003675) MGI PMID:11003675 NCBI chr13:24,882,279...24,934,000
Ensembl chr13:24,882,279...24,922,889 		JBrowse link
centrosome-templated microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CEP192 centrosomal protein 192 involved_in IMP
IEA		 (PMID:17980596) UniProt
InterPro		 PMID:17980596 GO_REF:0000002 NCBI chr18:12,991,362...13,125,036
Ensembl chr18:12,991,362...13,125,052 		JBrowse link
G NIN ninein involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:15784680) Ensembl
MGI
GO_Central		 PMID:15784680 GO_REF:0000033 GO_REF:0000107 NCBI chr14:50,719,763...50,831,503
Ensembl chr14:50,719,763...50,831,162 		JBrowse link
microtubule nucleation by interphase microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MZT1 mitotic spindle organizing protein 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:72,708,367...72,727,629
Ensembl chr13:72,708,367...72,727,629 		JBrowse link
microtubule nucleation by microtubule organizing center term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPPP tubulin polymerization promoting protein involved_in IDA (PMID:31522887) UniProt PMID:31522887 NCBI chr 5:659,862...700,727
Ensembl chr 5:659,862...693,352 		JBrowse link
negative regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARHGEF7 Rho guanine nucleotide exchange factor 7 involved_in IMP (PMID:27012601) UniProt PMID:27012601 NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737 		JBrowse link
positive regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CKAP5 cytoskeleton associated protein 5 involved_in IDA (PMID:26414402) CACAO PMID:26414402 NCBI chr11:46,743,048...46,846,280
Ensembl chr11:46,743,048...46,846,308 		JBrowse link
G DCTN1 dynactin subunit 1 involved_in IDA (PMID:23874158) UniProt PMID:23874158 NCBI chr 2:74,361,155...74,391,866
Ensembl chr 2:74,361,154...74,392,087 		JBrowse link
G GIT1 GIT ArfGAP 1 involved_in IMP (PMID:27012601) UniProt PMID:27012601 NCBI chr17:29,573,475...29,589,648
Ensembl chr17:29,573,475...29,594,054 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A involved_in IMP (PMID:27137183) UniProt PMID:27137183 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B involved_in IMP (PMID:27137183) UniProt PMID:27137183 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254 		JBrowse link
G MECP2 methyl-CpG binding protein 2 involved_in IMP (PMID:25527496) CAFA PMID:25527496 NCBI chr  X:154,021,573...154,097,717
Ensembl chr  X:154,021,573...154,137,103 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 involved_in IMP (PMID:27012601) UniProt PMID:27012601 NCBI chr11:77,322,017...77,530,009
Ensembl chr11:77,322,017...77,474,635 		JBrowse link
G PDE4DIP phosphodiesterase 4D interacting protein involved_in IMP (PMID:29162697) UniProt PMID:29162697 NCBI chr 1:148,808,434...149,033,016
Ensembl chr 1:148,808,140...149,048,286 		JBrowse link
regulation of microtubule nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EML2 EMAP like 2 involved_in IDA (PMID:11694528) UniProt PMID:11694528 NCBI chr19:45,609,400...45,645,629
Ensembl chr19:45,606,994...45,645,602 		JBrowse link
G HAUS1 HAUS augmin like complex subunit 1 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr18:46,104,385...46,128,333
Ensembl chr18:46,104,378...46,128,333 		JBrowse link
G HAUS2 HAUS augmin like complex subunit 2 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr15:42,548,838...42,569,994
Ensembl chr15:42,548,828...42,569,994 		JBrowse link
G HAUS3 HAUS augmin like complex subunit 3 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr 4:2,228,349...2,242,121
Ensembl chr 4:2,227,464...2,242,133 		JBrowse link
G HAUS4 HAUS augmin like complex subunit 4 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr14:22,946,228...22,957,090
Ensembl chr14:22,946,228...22,957,161 		JBrowse link
G HAUS5 HAUS augmin like complex subunit 5 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr19:35,612,735...35,625,355
Ensembl chr19:35,612,735...35,625,355 		JBrowse link
G HAUS6 HAUS augmin like complex subunit 6 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr 9:19,053,141...19,102,904
Ensembl chr 9:19,053,141...19,102,904 		JBrowse link
G HAUS7 HAUS augmin like complex subunit 7 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr  X:153,447,668...153,495,465
Ensembl chr  X:153,447,668...153,495,516 		JBrowse link
G HAUS8 HAUS augmin like complex subunit 8 involved_in NAS (PMID:30044976) ComplexPortal PMID:30044976 NCBI chr19:17,049,729...17,075,533
Ensembl chr19:17,049,729...17,075,625 		JBrowse link
G NME7 NME/NM23 family member 7 involved_in IMP (PMID:24807905) UniProt PMID:24807905 NCBI chr 1:169,132,531...169,367,797
Ensembl chr 1:169,132,531...169,367,948 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19710
    cellular process 18962
      microtubule-based process 1096
        microtubule cytoskeleton organization 720
          microtubule nucleation 47
            chromatin-templated microtubule nucleation 0
            microtubule nucleation by microtubule organizing center + 5
            mitotic spindle-templated microtubule nucleation 0
            negative regulation of microtubule nucleation 1
            positive regulation of microtubule nucleation + 8
            regulation of microtubule nucleation + 19
Path 2
Term Annotations click to browse term
  biological_process 19710
    cellular process 18962
      cellular component organization or biogenesis 7847
        cellular component organization 7624
          organelle organization 3954
            cytoskeleton organization 1650
              microtubule cytoskeleton organization 720
                microtubule polymerization or depolymerization 157
                  microtubule polymerization 107
                    microtubule nucleation 47
                      chromatin-templated microtubule nucleation 0
                      microtubule nucleation by microtubule organizing center + 5
                      mitotic spindle-templated microtubule nucleation 0
                      negative regulation of microtubule nucleation 1
                      positive regulation of microtubule nucleation + 8
                      regulation of microtubule nucleation + 19
paths to the root