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ONTOLOGY REPORT - ANNOTATIONS

Term:cyclin-dependent protein serine/threonine kinase inhibitor activity
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Accession:GO:0004861 term browser browse the term
Definition:Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase.
Synonyms:exact_synonym: cyclin dependent protein kinase inhibitor activity
 related_synonym: CDK inhibitor;   cyclin dependent kinase inhibitor
 xref: Reactome:R-HSA-187934 "Inactivation of Cyclin A:Cdk2 complexes by p27/p21";   reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21"


show annotations for term's descendants           Sort by:
cyclin-dependent protein serine/threonine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd42 ankyrin repeat domain 42 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:146,648,080...146,691,086
Ensembl chr 1:146,648,080...146,691,108 		JBrowse link
G Casp3 caspase 3 enables ISO MGI:2178778 (PMID:12970760) RGD PMID:12970760 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A enables ISO (PMID:12130539)
(PMID:11463845)		 RGD PMID:11463845 PMID:12130539 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B enables ISO
IBA		 (PMID:10918569), (PMID:28666995), (PMID:8033212)
GO_REF:0000033
(PMID:12130539), (PMID:8033213)		 RGD
GO_Central		 PMID:8033212 PMID:8033213 PMID:10918569 PMID:12130539 PMID:28666995 GO_REF:0000033 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A enables ISO (PMID:7739547), (PMID:8259215)
(PMID:12130539), (PMID:7651726)		 RGD PMID:7651726 PMID:7739547 PMID:8259215 PMID:12130539 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B enables ISO
IBA		 (PMID:8078588)
GO_REF:0000033		 RGD
GO_Central		 PMID:8078588 GO_REF:0000033 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C enables TAS
ISO		 (PMID:8001816)
(PMID:7739547)		 RGD PMID:7739547 PMID:8001816 PMID:11969268 RGD:1298749 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D enables ISO
IBA		 (PMID:8741839)
GO_REF:0000033		 RGD
GO_Central		 PMID:8741839 GO_REF:0000033 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 enables ISO
ISS
IBA		 (PMID:14580347)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:14580347 GO_REF:0000024 GO_REF:0000033 NCBI chr10:88,562,889...88,565,001
Ensembl chr10:88,062,803...88,066,189 		JBrowse link
G Hexim2 HEXIM P-TEFb complex subunit 2 enables ISO (PMID:15713662) RGD PMID:15713662 NCBI chr10:88,572,102...88,584,856
Ensembl chr10:88,079,014...88,084,775 		JBrowse link
G Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 enables ISO
IBA		 (PMID:21540187)
GO_REF:0000033		 RGD
GO_Central		 PMID:21540187 GO_REF:0000033 NCBI chr10:55,401,989...55,414,364
Ensembl chr10:55,401,982...55,414,114 		JBrowse link
G Kat2b lysine acetyltransferase 2B enables ISO (PMID:19773423) RGD PMID:19773423 NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21091
    molecular function regulator activity 2257
      enzyme regulator activity 1370
        kinase regulator activity 299
          protein kinase regulator activity 261
            cyclin-dependent protein serine/threonine kinase regulator activity 47
              cyclin-dependent protein serine/threonine kinase inhibitor activity 13
Path 2
Term Annotations click to browse term
  molecular_function 21091
    molecular function regulator activity 2257
      molecular function inhibitor activity 596
        enzyme inhibitor activity 451
          kinase inhibitor activity 92
            protein kinase inhibitor activity 85
              protein serine/threonine kinase inhibitor activity 50
                cyclin-dependent protein serine/threonine kinase inhibitor activity 13
paths to the root