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ONTOLOGY REPORT - ANNOTATIONS

Term:cyclin-dependent protein serine/threonine kinase regulator activity
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Accession:GO:0016538 term browser browse the term
Definition:Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
Synonyms:narrow_synonym: G1/S-specific cyclin;   G2/M-specific cyclin;   cyclin-dependent protein kinase, intrinsic regulator activity
 broad_synonym: cyclin;   cyclin-dependent protein kinase regulator activity
 alt_id: GO:0003751;   GO:0003752;   GO:0003753
 xref: reactome:R-HSA-3215385 "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77"


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cyclin-dependent protein serine/threonine kinase regulator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkaip1 aurora kinase A interacting protein 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:166,435,177...166,436,888
Ensembl chr 5:166,417,508...166,436,882 		JBrowse link
G Ccna1 cyclin A1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccna2 cyclin A2 enables ISO
IBA		 (PMID:1312467)
PMID:21873635		 RGD PMID:1312467 PMID:21873635 RGD:13792537 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 enables IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnb2-ps2 cyclin B2, pseudogene 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:20,099,753...20,101,246
Ensembl chr 1:20,099,733...20,101,248 		JBrowse link
G Ccnb3 cyclin B3 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:15,478,050...15,543,292
Ensembl chr  X:15,478,065...15,542,885 		JBrowse link
G Ccnc cyclin C enables IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Ccnd1 cyclin D1 enables ISO
IBA		 (MGI:2448203|PMID:12502791)
PMID:21873635		 RGD PMID:12502791 PMID:21873635 MGI:2448203, RGD:13792537 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne1 cyclin E1 enables IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(MGI:2675510|PMID:12970171)		 Ensembl
RGD		 PMID:12970171 PMID:21873635 GO_REF:0000107 MGI:2675510, RGD:13792537 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Ccne2 cyclin E2 enables ISO
IBA		 (MGI:1315092|PMID:9840927)
PMID:21873635		 RGD PMID:9840927 PMID:21873635 MGI:1315092, RGD:13792537 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Ccnf cyclin F enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101 		JBrowse link
G Ccng1 cyclin G1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Ccng2 cyclin G2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830 		JBrowse link
G Ccnh cyclin H enables ISO
IBA
IEA		 (PMID:21778139)
PMID:21873635
GO_REF:0000002		 RGD
InterPro		 PMID:21778139 PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 2:15,834,833...15,855,643
Ensembl chr 2:15,834,833...15,855,819 		JBrowse link
G Ccni cyclin I enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510 		JBrowse link
G Ccnjl cyclin J-like enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:27,995,682...28,053,428
Ensembl chr10:27,995,679...28,053,426 		JBrowse link
G Ccnl1 cyclin L1 enables IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368 		JBrowse link
G Ccnl2 cyclin L2 enables IEA
IBA		 GO_REF:0000002
PMID:21873635		 InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr 5:166,416,940...166,428,997
Ensembl chr 5:166,417,508...166,436,882 		JBrowse link
G Ccno cyclin O enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:44,630,640...44,633,914
Ensembl chr 2:44,626,369...44,633,914 		JBrowse link
G Ccnq cyclin Q enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961 		JBrowse link
G Ccny cyclin Y enables ISO (PMID:19524571), (PMID:20059949) RGD PMID:19524571 PMID:20059949 NCBI chr17:57,385,002...57,512,860
Ensembl chr17:57,384,176...57,522,378 		JBrowse link
G Cnppd1 cyclin Pas1/PHO80 domain containing 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188 		JBrowse link
G LOC100362620 CDC28 protein kinase regulatory subunit 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr17:24,271,431...24,271,897
Ensembl chr17:24,271,431...24,271,670 		JBrowse link
cyclin-dependent protein serine/threonine kinase activator activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 enables ISO (PMID:24746669) RGD PMID:24746669 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 enables ISO (PMID:19237565) RGD PMID:19237565 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd2 cyclin D2 enables ISO (PMID:18827403) RGD PMID:18827403 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495 		JBrowse link
G Ccnd3 cyclin D3 enables IEA
ISO		 GO_REF:0000107
(PMID:8114739)		 Ensembl
RGD		 PMID:8114739 GO_REF:0000107 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccnk cyclin K enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191 		JBrowse link
G Ccnt1 cyclin T1 enables ISO
IBA		 (PMID:29849146), (PMID:35393539)
PMID:21873635		 RGD PMID:29849146 PMID:35393539 PMID:21873635 RGD:13792537 NCBI chr 7:129,687,146...129,718,082
Ensembl chr 7:129,691,209...129,717,871 		JBrowse link
G Ccnt2 cyclin T2 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:39,251,573...39,293,172
Ensembl chr13:39,251,573...39,292,019 		JBrowse link
G Ccny cyclin Y enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:57,385,002...57,512,860
Ensembl chr17:57,384,176...57,522,378 		JBrowse link
G Ccnyl1 cyclin Y-like 1 enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:66,071,721...66,121,742
Ensembl chr 9:66,071,543...66,107,999 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 enables IDA
ISO
IBA		 MGI:1931885 (MGI:2149271|PMID:11517264)
PMID:21873635		 RGD PMID:11517264 PMID:8662984 PMID:21873635 MGI:2149271, RGD:632374, RGD:13792537 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456 		JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 enables ISO
IBA		 MGI:2387662 (MGI:2149271|PMID:11517264), (MGI:6158991|PMID:10683146)
PMID:21873635		 RGD PMID:10683146 PMID:11517264 PMID:21873635 MGI:2149271 MGI:6158991, RGD:13792537 NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344 		JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636 		JBrowse link
G Cks1l CDC28 protein kinase regulatory subunit 1-like enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:106,982,447...106,983,199
Ensembl chr 5:106,982,882...106,983,121 		JBrowse link
G LOC120102505 cyclin-dependent kinases regulatory subunit 2-like enables IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:144,220,612...144,220,990
Ensembl chr 4:144,220,751...144,220,990 		JBrowse link
G Mnat1 MNAT1 component of CDK activating kinase enables IEA GO_REF:0000002
GO_REF:0000104		 InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr 6:91,814,703...91,971,945
Ensembl chr 6:91,814,749...91,970,744 		JBrowse link
cyclin-dependent protein serine/threonine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 enables ISO MGI:2178778 (MGI:2677082|PMID:12970760) RGD PMID:12970760 MGI:2677082 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A enables ISO (MGI:2183076|PMID:12130539) RGD PMID:12130539 MGI:2183076 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B enables ISO
IBA		 (PMID:10918569), (PMID:28666995), (PMID:8033212)
(MGI:2183076|PMID:12130539), (MGI:67412|PMID:8033213)
PMID:21873635		 RGD PMID:8033212 PMID:8033213 PMID:10918569 PMID:12130539 PMID:28666995 More... MGI:2183076 MGI:67412, RGD:13792537 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A enables ISO (MGI:2183076|PMID:12130539), (MGI:75940|PMID:7651726)
(PMID:7739547), (PMID:8259215)		 RGD PMID:7651726 PMID:7739547 PMID:8259215 PMID:12130539 MGI:2183076 MGI:75940 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B enables ISO
IBA		 (PMID:8078588)
PMID:21873635		 RGD PMID:8078588 PMID:21873635 RGD:13792537 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C enables TAS
ISO		 (MGI:72259|PMID:7739547)
(PMID:8001816)		 RGD PMID:7739547 PMID:8001816 PMID:11969268 MGI:72259, RGD:1298749 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D enables ISO (PMID:8741839) RGD PMID:8741839 NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674 		JBrowse link
G Hexim1 HEXIM P-TEFb complex subunit 1 enables ISO
IBA
ISS		 (PMID:14580347)
PMID:21873635
GO_REF:0000024		 RGD
UniProt		 PMID:14580347 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:88,062,808...88,064,920
Ensembl chr10:88,062,803...88,066,189 		JBrowse link
G Hexim2 HEXIM P-TEFb complex subunit 2 enables ISO
IBA		 (PMID:15713662)
PMID:21873635		 RGD PMID:15713662 PMID:21873635 RGD:13792537 NCBI chr10:88,077,870...88,084,776
Ensembl chr10:88,079,014...88,084,775 		JBrowse link
G Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 enables IBA
ISO		 PMID:21873635
(PMID:21540187)		 RGD PMID:21540187 PMID:21873635 RGD:13792537 NCBI chr10:55,401,982...55,414,364
Ensembl chr10:55,401,982...55,414,114 		JBrowse link
G Kat2b lysine acetyltransferase 2B enables ISO (MGI:4410401|PMID:19773423) RGD PMID:19773423 MGI:4410401 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20537
    molecular function regulator activity 2150
      enzyme regulator activity 1332
        kinase regulator activity 285
          protein kinase regulator activity 239
            cyclin-dependent protein serine/threonine kinase regulator activity 48
              cyclin-dependent protein serine/threonine kinase activator activity 15
              cyclin-dependent protein serine/threonine kinase inhibitor activity 12
paths to the root