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ONTOLOGY REPORT - ANNOTATIONS

Term:NK T cell differentiation
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Accession:GO:0001865 term browser browse the term
Definition:The process in which a precursor cell type acquires the specialized features of a NK T cell.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: NK T lymphocyte differentiation;   NKT cell differentiation;   NT cell differentiation;   natural T cell differentiation;   natural killer T cell differentiation
 related_synonym: NK T cell development


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NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IEA
ISO		 GO_REF:0000107
MGI:3696689 (PMID:16223777)		 Ensembl
RGD		 PMID:16223777 GO_REF:0000107 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Cd1d1 CD1d1 molecule involved_in ISO (PMID:9133426) RGD PMID:9133426 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3521818 (PMID:19620306)		 Ensembl
RGD		 PMID:19620306 GO_REF:0000107 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034 		JBrowse link
G Itk IL2-inducible T-cell kinase involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:102960|MGI:2178928 (PMID:18292523)		 GO_Central
RGD		 PMID:18292523 GO_REF:0000033 NCBI chr10:30,753,344...30,814,685
Ensembl chr10:30,753,344...30,814,685 		JBrowse link
G Psap prosaposin acts_upstream_of_or_within ISO MGI:1888378 (PMID:14684827) RGD PMID:14684827 NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498 		JBrowse link
G Txk TXK tyrosine kinase acts_upstream_of_or_within ISO MGI:96621 (PMID:18292523) RGD PMID:18292523 NCBI chr14:35,463,369...35,519,448
Ensembl chr14:35,463,944...35,519,448 		JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (PMID:23105140) RGD PMID:23105140 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236 		JBrowse link
G Zfp683 zinc finger protein 683 acts_upstream_of_or_within ISO MGI:4276801 (PMID:22885984) RGD PMID:22885984 NCBI chr 5:146,277,972...146,285,856
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
NK T cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tox thymocyte selection-associated high mobility group box involved_in ISO (PMID:18195075) RGD PMID:18195075 NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272 		JBrowse link
positive regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap3b1 adaptor related protein complex 3 subunit beta 1 acts_upstream_of_or_within ISO MGI:1856989 (PMID:14557411) RGD PMID:14557411 NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935 		JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 acts_upstream_of_or_within ISO MGI:1856083 (PMID:14557411) RGD PMID:14557411 NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643 		JBrowse link
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO MGI:2180711|MGI:2180713 (PMID:10201995), (PMID:9133426) RGD PMID:9133426 PMID:10201995 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2183502|MGI:2386448 (PMID:16973387)		 Ensembl
RGD		 PMID:16973387 GO_REF:0000107 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
regulation of NK T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdm1 PR/SET domain 1 involved_in ISO (PMID:27102484) RGD PMID:27102484 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Zfp683 zinc finger protein 683 involved_in ISO (PMID:27102484) RGD PMID:27102484 NCBI chr 5:146,277,972...146,285,856
Ensembl chr 5:146,278,978...146,285,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20075
    immune system process 3008
      leukocyte activation 1055
        lymphocyte activation 855
          T cell activation 607
            T cell differentiation 330
              alpha-beta T cell differentiation 148
                NK T cell differentiation 13
                  NK T cell lineage commitment 1
                  negative regulation of NK T cell differentiation 0
                  positive regulation of NK T cell differentiation 4
                  regulation of NK T cell differentiation + 6
Path 2
Term Annotations click to browse term
  biological_process 20075
    cellular process 19154
      cellular developmental process 4781
        cell differentiation 4780
          cell development 3326
            hemopoiesis 1075
              leukocyte differentiation 681
                mononuclear cell differentiation 546
                  lymphocyte differentiation 444
                    T cell differentiation 330
                      alpha-beta T cell differentiation 148
                        NK T cell differentiation 13
                          NK T cell lineage commitment 1
                          negative regulation of NK T cell differentiation 0
                          positive regulation of NK T cell differentiation 4
                          regulation of NK T cell differentiation + 6
paths to the root